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Advances on Resources, Biosynthesis Pathway, Bioavailability, Bioactivity, and Pharmacology of Robustaflavone

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Handbook of Dietary Flavonoids

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Abstract

Robustaflavone, a type of biflavonoid, is found in various plants, including Rhus succedanea, Garcinia multiflora, Ochna schweinfurthiana, Dietes bicolor, and Selaginella species, among others. In recent years, the utilization of robustaflavone resources has significantly increased due to advancements in natural product extraction methods. Moreover, there are well-established biotechnological approaches for its production. Robustaflavone, composed of two units of apigenin (5,7,4′-trihydroxyflavone), has been extensively characterized using techniques such as nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry (MS), and X-ray crystallography. Its pharmacological activities include anti-inflammatory, anti-cancer, anti-allergic, anti-diabetic, and anti-obesity effects. Notably, robustaflavone has shown promising activity against various viruses, such as Hepatitis B virus (HBV), Herpes viruses (HSV-1, HSV-2), and respiratory viruses (Influenza A, Influenza B). As a result, robustaflavone holds promising prospects in the fields of natural product-based therapies, pharmacological research and drug development. This chapter aims to provide a comprehensive overview on this molecule that serves as a theoretical basis for future research and development in robustaflavone.

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Acknowledgment

The research leading to these results was supported by MICINN supporting the Juan de la Cierva Incorporación for Hui Cao (IJC2020-046055-I).

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Authors and Affiliations

  1. Universidade de Vigo, Nutrition and Bromatology Group, Department of Analytical and Food Chemistry, Faculty of Sciences, Ourense, Spain

    Quanyong Wu, Boya Ouyang, Miguel A. Prieto, Hui Cao & Jesus Simal-Gandara

  2. Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt

    Mohamed Farag

Authors
  1. Quanyong Wu
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  2. Boya Ouyang
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  3. Mohamed Farag
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  4. Miguel A. Prieto
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  5. Hui Cao
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  6. Jesus Simal-Gandara
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Corresponding authors

Correspondence to Hui Cao or Jesus Simal-Gandara .

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Editors and Affiliations

  1. Department of Analytical Chemistry and Food Science, Universidade de Vigo, Vigo, Spain

    Jianbo Xiao

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Wu, Q., Ouyang, B., Farag, M., Prieto, M.A., Cao, H., Simal-Gandara, J. (2024). Advances on Resources, Biosynthesis Pathway, Bioavailability, Bioactivity, and Pharmacology of Robustaflavone. In: Xiao, J. (eds) Handbook of Dietary Flavonoids. Springer, Cham. https://doi.org/10.1007/978-3-030-94753-8_69-1

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  • DOI: https://doi.org/10.1007/978-3-030-94753-8_69-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-94753-8

  • Online ISBN: 978-3-030-94753-8

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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