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Creutzfeldt-Jakob Disease

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Hybrid PET/MR Neuroimaging

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Abstract

Creutzfeldt-Jakob disease (CJD) is a rare, fatal disease caused by prions, with rapidly progressive dementia leading to death in most patients within a year of clinical onset.

Sporadic CJD, the most common form, is characterized by widespread deposition of abnormal prion protein aggregates in the brain, leading to spongiform change, gliosis, and neuronal loss. A definitive diagnosis requires histopathological analysis. However, in vivo diagnosis can be established with high accuracy by combining clinical diagnostic criteria, cerebrospinal fluid assays, and imaging, although effective therapies are not yet available.

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Authors and Affiliations

  1. NewYork Presbyterian-Weill Cornell, Department of Radiology, New York, NY, USA

    Ilhami Kovanlikaya & Gloria C. Chiang

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  1. Ilhami Kovanlikaya
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  1. Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, The Feinstein Institutes for Medical Research, Manhasset, NY, USA

    Ana M. Franceschi

  2. Stony Brook University Hospital, Stony Brook, NY, USA

    Dinko Franceschi

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Kovanlikaya, I., Chiang, G.C. (2022). Creutzfeldt-Jakob Disease. In: Franceschi, A.M., Franceschi, D. (eds) Hybrid PET/MR Neuroimaging. Springer, Cham. https://doi.org/10.1007/978-3-030-82367-2_33

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