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Advanced Applications of MALDI-TOF: Identification and Antibiotic Susceptibility Testing

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Application and Integration of Omics-powered Diagnostics in Clinical and Public Health Microbiology

Abstract

During the past decade, MALDI-TOF (Matrix-Assisted Laser Desorption Ionisation Time of Flight) MS (Mass Spectrometry), a method that utilises the protein content of bacteria for identification, has been widely used in clinical practice. The wide distribution of this technology in microbiology labs around the world allows the exploration of novel uses of this method for other purposes such as identifying antibiotic resistance and rapid identification of bacterial isolates directly from different clinical samples. This chapter will review the current experience with these new promising applications of proteomics in clinical practice.

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Author information

Authors and Affiliations

  1. Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Marañón and Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain

    Belén Rodríguez-Sánchez

  2. Servicio de Microbiología, Complejo Hospitalario Universitario A Coruña, La Coruña, Spain

    Marina Oviaño

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  1. Belén Rodríguez-Sánchez
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  2. Marina Oviaño
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Correspondence to Belén Rodríguez-Sánchez .

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Editors and Affiliations

  1. Ben-Gurion University of the Negev, Beer Sheva, Israel

    Jacob Moran-Gilad

  2. Ben-Gurion University of the Negev, Beer-Sheva, Israel

    Yael Yagel

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Rodríguez-Sánchez, B., Oviaño, M. (2021). Advanced Applications of MALDI-TOF: Identification and Antibiotic Susceptibility Testing. In: Moran-Gilad, J., Yagel, Y. (eds) Application and Integration of Omics-powered Diagnostics in Clinical and Public Health Microbiology . Springer, Cham. https://doi.org/10.1007/978-3-030-62155-1_10

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