Abstract
Lung chemoembolization can safely and effectively treat large and multifocal lung tumors (including mediastinal lymph nodes), in patients with no other good treatment options. Most lung tumors are supplied by the bronchial artery, but they can also be supplied by a nonbronchial systemic artery, or the pulmonary artery. The angiograms must be carefully reviewed for tiny vessels that supply the spinal cord or esophagus. Cone beam CT or helical CT (in an integrated angiography/CT suite) must be performed to confirm that the artery supplies the tumor, and does not supply esophagus or spinal cord. The optimal intra-arterial drug and embolic for lung chemoembolization are unknown. Response rates range from 7–78%, but it is not known whether radiographic response will translate into improved survival or quality of life. We recommend that this new technique should generally be performed in the setting of a clinical trial.
References
Boas FE, Kemeny NE, Sofocleous CT, Yeh R, Thompson VR, Hsu M, et al. Phase I study of transarterial chemoembolization of lung metastases. Submitted to Radiology. 2021;301(2):474–84.
Milne EN, Zerhouni EA. Blood supply of pulmonary metastases. J Thorac Imaging. 1987;2(4):15–23.
Vogl TJ, Lehnert T, Zangos S, Eichler K, Hammerstingl R, Korkusuz H, et al. Transpulmonary chemoembolization (TPCE) as a treatment for unresectable lung metastases. Eur Radiol. 2008;18(11):2449–55.
Boas FE, Brown KT, Ziv E, Yarmohammadi H, Sofocleous CT, Erinjeri JP, et al. Aspirin is associated with improved liver function after embolization of hepatocellular carcinoma. AJR Am J Roentgenol. 2019;213(3):1–7.
Zener R, Yoon H, Ziv E, Covey A, Brown KT, Sofocleous CT, et al. Outcomes after transarterial embolization of neuroendocrine tumor liver metastases using spherical particles of different sizes. Cardiovasc Intervent Radiol. 2019;42(4):569–76.
Maluccio MA, Covey AM, Schubert J, Brody LA, Sofocleous CT, Getrajdman GI, et al. Treatment of metastatic sarcoma to the liver with bland embolization. Cancer. 2006;107(7):1617–23.
Shimohira M, Sato Y, Yasumoto T, Kodama Y, Masada T, Inaba Y, et al. Arterial embolization using microspheres for hypervascular liver metastases refractory to standard treatments: a multicenter prospective clinical trial. Cardiovasc Intervent Radiol. 2021;44(3):392–400.
Seki A, Hori S, Sueyoshi S, Hori A, Kono M, Murata S, et al. Transcatheter arterial embolization with spherical embolic agent for pulmonary metastases from renal cell carcinoma. Cardiovasc Intervent Radiol. 2013;36(6):1527–35.
Jin B, Wang D, Lewandowski RJ, Riaz A, Ryu RK, Sato KT, et al. Chemoembolization endpoints: effect on survival among patients with hepatocellular carcinoma. AJR Am J Roentgenol. 2011;196(4):919–28.
Maxwell AWP, Mendoza HG, Sellitti MJ, Camacho JC, Deipolyi AR, Ziv E, et al. Effects of particle density on outcomes after lobar radioembolization. Submitted to CVIR. 2022;45:958–69.
Zheng XH, Guan YS, Zhou XP, Huang J, Sun L, Li X, et al. Detection of hypervascular hepatocellular carcinoma: comparison of multi-detector CT with digital subtraction angiography and Lipiodol CT. World J Gastroenterol. 2005;11(2):200–3.
Gruber-Rouh T, Naguib NN, Eichler K, Ackermann H, Zangos S, Trojan J, et al. Transarterial chemoembolization of unresectable systemic chemotherapy-refractory liver metastases from colorectal cancer: long-term results over a 10-year period. Int J Cancer. 2014;134(5):1225–31.
Yarmohammadi H, Gonzalez-Aguirre AJ, Schook L, Ziv E, Erinjeri JP, Brown KT, et al. Treatment of pancreatic cancer by intra-arterial injection of an emulsion of lipiodol and bumetanide (an anti-glycolytic drug) in a porcine model: initial results. J Vasc Interv Radiol. 2017;28(2):S8–9.
Yoshida H, Onda M, Tajiri T, Uchida E, Arima Y, Mamada Y, et al. Experience with intraarterial infusion of styrene maleic acid neocarzinostatin (SMANCS)-lipiodol in pancreatic cancer. Hepato-Gastroenterology. 1999;46(28):2612–5.
Tsuchiya K, Uchida T, Kobayashi M, Maeda H, Konno T, Yamanaka H. Tumor-targeted chemotherapy with SMANCS in lipiodol for renal cell carcinoma: longer survival with larger size tumors. Urology. 2000;55(4):495–500.
de Baere T, Zhang X, Aubert B, Harry G, Lagrange C, Ropers J, et al. Quantification of tumor uptake of iodized oils and emulsions of iodized oils: experimental study. Radiology. 1996;201(3):731–5.
Miszczuk MA, Chapiro J, Geschwind JH, Thakur V, Nezami N, Laage-Gaupp F, et al. Lipiodol as an imaging biomarker of tumor response after conventional transarterial chemoembolization: prospective clinical validation in patients with primary and secondary liver cancer. Transl Oncol. 2020;13(3):100742.
Nakanishi M, Demura Y, Umeda Y, Mizuno S, Ameshima S, Chiba Y, et al. Multi-arterial infusion chemotherapy for non-small cell lung carcinoma–significance of detecting feeding arteries and tumor staining. Lung Cancer. 2008;61(2):227–34.
Zeng Y, Yin M, Zhao Y, Liu Y, Li X, Qi Y, et al. Combination of bronchial arterial infusion chemotherapy plus drug-eluting embolic transarterial chemoembolization for treatment of advanced lung cancer-a retrospective analysis of 23 patients. J Vasc Interv Radiol. 2020;31(10):1645–53.
Yuan Z, Li WT, Ye XD, Dong S, Peng WJ. Intra-arterial infusion chemotherapy for advanced non-small-cell lung cancer: preliminary experience on the safety, efficacy, and clinical outcomes. J Vasc Interv Radiol. 2013;24(10):1521–8.e4.
Hori A, Ohira R, Nakamura T, Kimura Y, Ueda S, Torii M, et al. Transarterial chemoembolization for pulmonary or mediastinal metastases from hepatocellular carcinoma. Br J Radiol. 2020;93(1110):20190407.
Duan F, Wang MQ, Liu FY, Wang ZJ, Song P, Wang Y. Sorafenib in combination with transarterial chemoembolization and bronchial arterial chemoinfusion in the treatment of hepatocellular carcinoma with pulmonary metastasis. Asia Pac J Clin Oncol. 2012;8(2):156–63.
Kennoki N, Hori S, Yuki T, Hori A. Transcatheter arterial chemoembolization with spherical embolic agent in patients with pulmonary or mediastinal metastases from breast cancer. J Vasc Interv Radiol. 2017;28(10):1386–94.
Vogl TJ, Mekkawy AIA, Thabet DB, El-Sharkaway M, Kamel HM, Albrecht MH, et al. Transvenous pulmonary chemoembolization (TPCE) for palliative or neoadjuvant treatment of lung metastases. Eur Radiol. 2019;29(4):1939–49.
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Boas, F.E. (2024). Embolization for Lung Tumors. In: Fong, Y., Covey, A., Ahmed, M., Kessler, J., Iannitti, D.A., Dupuy, D.E. (eds) Interventional Oncology. Springer, Cham. https://doi.org/10.1007/978-3-030-51192-0_93-1
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