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Association Between Obesity and Poor Sleep: A Review of Epidemiological Evidence

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Pathophysiology of Obesity-Induced Health Complications

Part of the book series: Advances in Biochemistry in Health and Disease ((ABHD,volume 19))

Abstract

Sleep is a multifaceted biological process linked with biochemical pathways of growth, maturation, and energy homeostasis. Due to the growing complaints of poor sleep in the general population, there has been a significant increase in sleep research aiming to identify the determinants of poor sleep. This review aims to explore the current state of the knowledge on obesity-sleep association and evaluate the role of weight loss in sleep improvement and vice versa. Current evidence suggests three directions of association between obesity and sleep: obesity leading to poor sleep, poor sleep leading to obesity and co-occurrence of obesity and poor sleep. People with obesity often report poor sleep, and obstructive sleep apnoea (OSA), and poor sleepers are often overweight or obese. Weight gain is not only associated with poor sleep and OSA prevalence but also affects the severity of OSA. Poor sleep, specifically OSA, affects metabolic hormones and influence behavioural pathways favouring unhealthy lifestyle leading to further worsening of obesity. Weight loss has shown potential in improving the quality of sleep, reducing OSA severity and decreasing metabolic abnormalities related to obesity. However, weight management is yet to be established as a clinical intervention with a long-lasting effect in improving sleep. Evidence also suggests that improvement in sleep quality lowers the odds of future obesity. Despite, the growing evidence base, the current literature has methodological limitations and fails to establish a causal link between obesity and poor sleep. Nonetheless, it is prudent to advise that weight management should be an important component of the clinical management plans for improving sleep.

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References

  1. Nathaniel K (1957) Sleep, wakefulness, and consciousness. Psychol Bull 54(4):354–359

    Article  Google Scholar 

  2. Pieron H (1913) Le Probleme Physiologique du Sommeil. Masson, Paris

    Google Scholar 

  3. Gregory AM et al (2009) The direction of longitudinal associations between sleep problems and depression symptoms: a study of twins aged 8 and 10 years. Sleep 32(2):189–199

    Article  PubMed  PubMed Central  Google Scholar 

  4. Liu J, Hay J, Faught BE (2013) The association of sleep disorder, obesity status, and diabetes mellitus among US adults-the NHANES 2009–2010 survey results. Int J Endocrinol 2013:234129

    PubMed  PubMed Central  Google Scholar 

  5. Colten HR, Altevogt B (2006) Sleep disorders and sleep deprivation: an unmet public health problem. In: Colten HR, Altevogt BM (eds). National Academy of Sciences, Washington DC

    Google Scholar 

  6. Marshall NS, Bin YS, Glozier N (2013) Sleeping at the limits: the changing prevalence of short and long sleep durations in 10 countries. Am J Epidemiol 177(8):826–833

    Article  PubMed  Google Scholar 

  7. Senaratna CV et al (2017) Prevalence of obstructive sleep apnea in the general population: a systematic review. Sleep Med Rev 34:70–81

    Article  PubMed  Google Scholar 

  8. Singh-Manoux A et al (2011) Sleep epidemiology—a rapidly growing field. Int J Epidemiol 40(6):1431–1437

    Article  PubMed  Google Scholar 

  9. Chan WS, Levsen MP, McCrae CS (2018) A meta-analysis of associations between obesity and insomnia diagnosis and symptoms. Sleep Med Rev 40:170–182

    Article  PubMed  Google Scholar 

  10. Mavanji V et al (2012) Sleep and obesity: a focus on animal models. Neurosci Biobehav Rev 36(3):1015–1029

    Article  PubMed  PubMed Central  Google Scholar 

  11. Ritter PS et al (2016) Comparison of subjective and objective sleep estimations in patients with bipolar disorder and healthy control subjects. Sleep Disorders 2016:5

    Article  Google Scholar 

  12. Lee W et al (2008) Epidemiology of obstructive sleep apnea: a population-based perspective. Expert Rev Respir Med 2(3):349–364

    Article  PubMed  PubMed Central  Google Scholar 

  13. Vorona RD et al (2005) Overweight and obese patients in a primary care population report less sleep than patients with a normal body mass index. Arch Intern Med 165(1):25–30

    Article  PubMed  Google Scholar 

  14. Vgontzas AN et al (2008) Short sleep duration and obesity: the role of emotional stress and sleep disturbances. Int J Obes (Lond) 32(5):801–809

    Article  CAS  Google Scholar 

  15. Akinnusi ME et al (2012) Sleep disorders in morbid obesity. Eur J Intern Med 23(3):219–226

    Article  PubMed  Google Scholar 

  16. Vgontzas AN, Bixler EO (2008) Short sleep and obesity: are poor sleep, chronic stress, and unhealthy behaviors the link? Sleep 31(9):1203

    PubMed  PubMed Central  Google Scholar 

  17. Leinum CJ, Dopp JM, Morgan BJ (2009) Sleep-disordered breathing and obesity: pathophysiology, complications, and treatment. Nutr Clin Pract 24(6):675–687

    Article  PubMed  PubMed Central  Google Scholar 

  18. Punjabi NM (2008) The epidemiology of adult obstructive sleep apnea. Proc Am Thorac Soc 5(2):136–143

    Article  PubMed  PubMed Central  Google Scholar 

  19. Ong JC, Crawford MR (2013) Insomnia and obstructive sleep apnea. Sleep Med Clin 8(3):389–398

    Article  PubMed  PubMed Central  Google Scholar 

  20. Schulz R et al (2006) Obstructive sleep apnea-related cardiovascular disease. Med Klin (Munich) 101(4):321–327

    Article  Google Scholar 

  21. Capdevila OS et al (2008) Pediatric obstructive sleep apnea: complications, management, and long-term outcomes. Proc Am Thorac Soc 5(2):274–282

    Article  PubMed  PubMed Central  Google Scholar 

  22. Yoon SY, Jain U, Shapiro C (2012) Sleep in attention-deficit/hyperactivity disorder in children and adults: past, present, and future. Sleep Med Rev 16(4):371–388

    Article  PubMed  Google Scholar 

  23. Chan J, Edman JC, Koltai PJ (2004) Obstructive sleep apnea in children. Am Fam Phys 69(5):1147–1154

    Google Scholar 

  24. Heinzer R et al (2015) Prevalence of sleep-disordered breathing in the general population: the HypnoLaus study. Lancet Respir Med 3(4):310–318

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Tuomilehto H, Seppa J, Uusitupa M (2013) Obesity and obstructive sleep apnea–clinical significance of weight loss. Sleep Med Rev 17(5):321–329

    Article  PubMed  Google Scholar 

  26. Hamilton GS, Joosten SA (2017) Obstructive sleep apnoea and obesity. Aust Fam Physician 46(7):460–463

    PubMed  Google Scholar 

  27. Romero-Corral A et al (2010) Interactions between obesity and obstructive sleep apnea: implications for treatment. Chest 137(3):711–719

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Resta O et al (2001) Sleep-related breathing disorders, loud snoring and excessive daytime sleepiness in obese subjects. Int J Obes Relat Metab Disord 25(5):669–675

    Article  CAS  PubMed  Google Scholar 

  29. Peppard PE et al (2000) Longitudinal study of moderate weight change and sleep-disordered breathing. JAMA 284(23):3015–3021

    Article  CAS  PubMed  Google Scholar 

  30. Rudnick EF et al (2007) Prevalence and ethnicity of sleep-disordered breathing and obesity in children. Otolaryngol Head Neck Surg 137(6):878–882

    Article  PubMed  Google Scholar 

  31. Shelton KE et al (1993) Pharyngeal fat in obstructive sleep apnea. Am Rev Respir Dis 148(2):462–466

    Article  CAS  PubMed  Google Scholar 

  32. Newman AB et al (2005) Progression and regression of sleep-disordered breathing with changes in weight: the Sleep Heart Health Study. Arch Intern Med 165(20):2408–2413

    Article  PubMed  Google Scholar 

  33. Cowan DC, Livingston E (2012) Obstructive sleep apnoea syndrome and weight loss: review. Sleep Disord 2012:163296

    PubMed  PubMed Central  Google Scholar 

  34. Araghi MH et al (2013) Effectiveness of lifestyle interventions on obstructive sleep apnea (OSA): systematic review and meta-analysis. Sleep 36(10):1553–1562

    Article  PubMed  PubMed Central  Google Scholar 

  35. St-Onge M-P, Shechter A (2014) Sleep disturbances, body fat distribution, food intake and/or energy expenditure: pathophysiological aspects. Horm Mol Biol Clin Invest 17(1):29–37

    CAS  Google Scholar 

  36. Chaput JP et al (2005) Psychobiological impact of a progressive weight loss program in obese men. Physiol Behav 86(1–2):224–232

    Article  CAS  PubMed  Google Scholar 

  37. Gonnissen HK et al (2013) Concomitant changes in sleep duration and body weight and body composition during weight loss and 3-mo weight maintenance. Am J Clin Nutr 98(1):25–31

    Article  PubMed  CAS  Google Scholar 

  38. Steinberg DM et al (2017) Preventing weight gain improves sleep quality among black women: results from a RCT. Ann Behav Med 51(4):555–566

    Article  PubMed  Google Scholar 

  39. Alfaris N et al (2015) Effects of a 2-year behavioral weight loss intervention on sleep and mood in obese individuals treated in primary care practice. Obesity (Silver Spring, Md.) 23(3):558–564

    Article  PubMed  Google Scholar 

  40. Rubin RR et al (2013) Patient-reported outcomes in the practice-based opportunities for weight reduction (POWER) trial. Qual Life Res 22(9):2389–2398

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  41. Nerfeldt P et al (2010) A two-year weight reduction program in obese sleep apnea patients. J Clin Sleep Med 6(5):479–486

    Article  PubMed  PubMed Central  Google Scholar 

  42. Buchwald H et al (2004) Bariatric surgery: a systematic review and meta-analysis. JAMA 292(14):1724–1737

    Article  CAS  PubMed  Google Scholar 

  43. Mitchell LJ et al (2014) Weight loss from lifestyle interventions and severity of sleep apnoea: a systematic review and meta-analysis. Sleep Med 15(10):1173–1183

    Article  PubMed  Google Scholar 

  44. Miller MA et al (2018) Sleep duration and incidence of obesity in infants, children, and adolescents: a systematic review and meta-analysis of prospective studies. Sleep 41(4)

    Google Scholar 

  45. Wu Y, Zhai L, Zhang D (2014) Sleep duration and obesity among adults: a meta-analysis of prospective studies. Sleep Med 15(12):1456–1462

    Article  PubMed  Google Scholar 

  46. Fatima Y, Doi SA, Mamun AA (2015) Longitudinal impact of sleep on overweight and obesity in children and adolescents: a systematic review and bias-adjusted meta-analysis. Obes Rev 16(2):137–149

    Article  CAS  PubMed  Google Scholar 

  47. Cappuccio F, Miller MA (2010) Sleep, health and society: from aetiology to public health in The epidemiology of sleep and cardiovascular risk and disease. In: Cappuccio F, Miller M, Lockley S (eds). Oxford University Press, Oxford, pp 83–110

    Google Scholar 

  48. Liu W et al (2018) Long sleep duration predicts a higher risk of obesity in adults: a meta-analysis of prospective cohort studies. J Public Health (Oxf)

    Google Scholar 

  49. Lyytikainen P et al (2011) Sleep problems and major weight gain: a follow-up study. Int J Obes (Lond) 35(1):109–114

    Article  CAS  Google Scholar 

  50. Janson C et al (2001) Insomnia in men-a 10-year prospective population based study. Sleep 24(4):425–430

    Article  CAS  PubMed  Google Scholar 

  51. Owens JF, Matthews KA (1998) Sleep disturbance in healthy middle-aged women. Maturitas 30(1):41–50

    Article  CAS  PubMed  Google Scholar 

  52. Liu J et al (2011) Sleep difficulties and obesity among preadolescents. Can J Public Health 102(2):139–143

    Article  PubMed  PubMed Central  Google Scholar 

  53. Jarrin DC, McGrath JJ, Drake CL (2013) Beyond sleep duration: distinct sleep dimensions are associated with obesity in children and adolescents. Int J Obes (Lond) 37(4):552–558

    Article  CAS  Google Scholar 

  54. Fatima Y, Doi SA, Mamun AA (2016) Sleep quality and obesity in young subjects: a meta-analysis. Obes Rev 17(11):1154–1166

    Article  CAS  PubMed  Google Scholar 

  55. Taheri S et al (2004) Short sleep duration is associated with reduced leptin, elevated ghrelin, and increased body mass index. PLoS Med 1(3):e62–e62

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  56. Simpson NS, Banks S, Dinges DF (2010) Sleep restriction is associated with increased morning plasma leptin concentrations, especially in women. Biol Res Nurs 12(1):47–53

    Article  CAS  PubMed  Google Scholar 

  57. Spiegel K, Leproult R, Van Cauter E (1999) Impact of sleep debt on metabolic and endocrine function. Lancet 354(9188):1435–1439

    Article  CAS  PubMed  Google Scholar 

  58. Beccuti G, Pannain S (2011) Sleep and obesity. Curr Opin Clin Nutr Metab Care 14(4):402–412

    Article  PubMed  PubMed Central  Google Scholar 

  59. Thomson CA et al (2012) Relationship between sleep quality and quantity and weight loss in women participating in a weight-loss intervention trial. Obesity (Silver Spring, Md.) 20(7):1419–1425

    Article  PubMed  Google Scholar 

  60. Nedeltcheva AV et al (2010) Insufficient sleep undermines dietary efforts to reduce adiposity. Ann Intern Med 153(7):435–441

    Article  PubMed  PubMed Central  Google Scholar 

  61. Chaput JP, Tremblay A (2012) Sleeping habits predict the magnitude of fat loss in adults exposed to moderate caloric restriction. Obes Facts 5(4):561–566

    Article  PubMed  Google Scholar 

  62. Elder CR et al (2012) Impact of sleep, screen time, depression and stress on weight change in the intensive weight loss phase of the LIFE study. Int J Obes (Lond) 36(1):86–92

    Article  CAS  Google Scholar 

  63. Sallinen BJ et al (2013) Longer weekly sleep duration predicts greater 3-month BMI reduction among obese adolescents attending a clinical multidisciplinary weight management program. Obes Facts 6(3):239–246

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  64. Van Cauter E (2011) Sleep disturbances, obesity and diabetes: Interacting epidemics. Sleep Biol Rhythms 9(4):195

    Article  Google Scholar 

  65. Rutters F et al (2012) Distinct associations between energy balance and the sleep characteristics slow wave sleep and rapid eye movement sleep. Int J Obes (Lond) 36(10):1346–1352

    Article  CAS  Google Scholar 

  66. Schmid SM et al (2008) A single night of sleep deprivation increases ghrelin levels and feelings of hunger in normal-weight healthy men. J Sleep Res 17(3):331–334

    Article  PubMed  Google Scholar 

  67. Spiegel K et al (2004) Leptin levels are dependent on sleep duration: relationships with sympathovagal balance, carbohydrate regulation, cortisol, and thyrotropin. J Clin Endocrinol Metab 89(11):5762–5771

    Article  CAS  PubMed  Google Scholar 

  68. Horne J (2008) Short sleep is a questionable risk factor for obesity and related disorders: statistical versus clinical significance. Biol Psychol 77(3):266–276

    Article  PubMed  Google Scholar 

  69. Patel SR, Hu FB (2008) Short sleep duration and weight gain: a systematic review. Obesity (Silver Spring) 16(3):643–653

    Article  Google Scholar 

  70. Potenza M, Via MA, Yanagisawa RT (2009) Excess thyroid hormone and carbohydrate metabolism. Endocr Pract 15(3):254–262

    Article  PubMed  Google Scholar 

  71. Auger RR (2006) Sleep-related eating disorders. Psychiatry (Edgmont (Pa.: Township)) 3(11):64–70

    Google Scholar 

  72. Schwartz AR et al (2008) Obesity and obstructive sleep apnea: pathogenic mechanisms and therapeutic approaches. Proc Am Thorac Soc 5(2):185–192

    Article  PubMed  PubMed Central  Google Scholar 

  73. Popko K et al (2007) Frequency of distribution of leptin receptor gene polymorphism in obstructive sleep apnea patients. J Physiol Pharmacol 58(Suppl 5):551–561

    Google Scholar 

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Fatima, Y., Mamun, A.A., Skinner, T. (2020). Association Between Obesity and Poor Sleep: A Review of Epidemiological Evidence. In: Tappia, P., Ramjiawan, B., Dhalla, N. (eds) Pathophysiology of Obesity-Induced Health Complications. Advances in Biochemistry in Health and Disease, vol 19. Springer, Cham. https://doi.org/10.1007/978-3-030-35358-2_9

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