Abstract
The aim of this chapter is to comprehensively compile the current body of knowledge relating to the blood supply and microcirculation of the peripheral nerve. Key findings are summarized to convey to readers which important aspects have been discovered and which further studies could be of special interest. The complex anatomy of the peripheral nerve’s microcirculatory system, its physiology, and pathophysiology as well as its crucial involvement in nerve regeneration are discussed. Special emphasis is placed on the lymphatic system, the involvement of which in peripheral nerve injury and regeneration remains to be elucidated. This chapter focuses on experimental concepts and emerging techniques to deepen our understanding of the peripheral nerve vascular system, both in regard to its function and how it could be modified to enhance nerve regeneration. It concludes with an outlook on clinical applications to improve peripheral nerve (re)vascularization, ranging from vascularized nerve grafts and surgical angiogenesis to bioengineered conduits and the use of stems cells. With the help of this chapter, researchers interested in tissue-engineering will be provided with a broad fundament of knowledge, intended as an aid for the development of new approaches to improve peripheral nerve regeneration.
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Prahm, C., Heinzel, J., Kolbenschlag, J. (2021). Blood Supply and Microcirculation of the Peripheral Nerve. In: Phillips, J., Hercher, D., Hausner, T. (eds) Peripheral Nerve Tissue Engineering and Regeneration. Reference Series in Biomedical Engineering(). Springer, Cham. https://doi.org/10.1007/978-3-030-06217-0_21-1
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