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A Virus-Associated Immunopathological Theory of Schizophrenia

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Psychiatry and Biological Factors

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Abstract

Schizophrenia is a clinical syndrome which is increasingly considered to be a neurological disease with behavioral symptoms that primarily manifest as dysfunction of frontal and limbic brain areas. Hypotheses of the etiology or etiologies of schizophrenia have tended to be limited to intrinsic central nervous system (CNS) processes, such as neurotransmitter dysregulation or neuroanatomical models. These models have a correspondingly limited predictive validity. An alternate and potentially more useful perspective of the disease would be one that takes into account its pleomorphic nature. Schizophrenia has a broad spectrum of associated findings suggesting involvement of developmental processes and a pathophysiology that may be systemic in nature. Viral hypotheses have been one way that the issue of pleomorphism has been addressed.

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Authors and Affiliations

  1. Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland, 21228, USA

    Royce W. Waltrip II, Robert W. Buchanan & William T. Carpenter Jr.

  2. Department of Pathology, Medical College of Wisconsin, Milwaukee, Wisconsin, 53226, USA

    Donald R. Carrigan

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  1. Royce W. Waltrip II
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  1. Faculty of Medicine, University of Montreal, Montreal, Quebec, Canada

    Edouard Kurstak

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Waltrip, R.W., Carrigan, D.R., Buchanan, R.W., Carpenter, W.T. (1991). A Virus-Associated Immunopathological Theory of Schizophrenia. In: Kurstak, E. (eds) Psychiatry and Biological Factors. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5811-4_3

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