Skip to main content

Effects of Interferon and Its Inducers on Leucocytes and Their Immunologic Functions

  • Chapter
Interferons and Their Applications

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 71))

Abstract

In addition to the antiviral and anticellular effects caused by interferon, im-munomodulation mediated by interferon undoubtedly contributes to the inter-feron-induced resistance to overwhelming and sometimes fatal viral infections and also to regression or retardation of growth of certain tumors in animals and humans.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Blomgren H, Strander H, Cantell K (1974) Effect of human leukocyte interferon on the response of lymphocytes to mitogenic stimuli in vitro. Scand J Immunol 3:697–705

    PubMed  CAS  Google Scholar 

  • Bloom B, Minato N, Neighbour A, Reid L, Marcus D (1980) Interferon and NK cells in resistance to persistently virus-infected cells and tumors. In: Herberman RB (ed) Natural cell-mediated immunity against tumors. Academic, New York, p 505

    Google Scholar 

  • Braun W, Levy HB (1972) Interferon preparations as modifiers of immune responses. Proc Soc Exp Biol Med 141:769–773

    PubMed  CAS  Google Scholar 

  • Brodeur BR, Merigan TC (1974) Suppressive effect of interferon on the humoral immune response to sheep red blood cells in mice. I Immunol 113:1319–1325

    CAS  Google Scholar 

  • Brodeur BR, Merigan tC (1975) Mechanism of the suppressive effect of interferon on antibody synthesis in vivo. J Immunol 114:1323–1328

    PubMed  CAS  Google Scholar 

  • Chester TJ, Paucker K, Merigan TC (1973) Suppression of mouse antibody producing spleen cells by various interferon preparations. Nature 246:92–94

    PubMed  CAS  Google Scholar 

  • Chirigos MA, Schultz RM, Stylos WA (1980) Interaction of interferon, macrophage and lymphocyte tumoricidal activity with prostaglandin effect. Ann NY Acad Sci 350:91–101

    PubMed  CAS  Google Scholar 

  • Clinton BA, Magoc TJ, Aspinall RL, Rapoza NP (1976) The influence upon mitogenic and cellular immunologic reactive systems in vitro by Poly (I : C) and BCG murine interferons induced in vivo. Cell Immunol 27:60–70

    PubMed  CAS  Google Scholar 

  • DeMaeyer E (1976) Interferon and delayed-typed hypersensitivity to a viral antigen. J Infect Dis 133: A63–A65

    Google Scholar 

  • DeMaeyer E, DeMaeyer-Guignard J, Vandeputte M (1975) Inhibition by interferon of de-layed-type hypersensitivity in the mouse. Proc Natl Acad Sci USA 72:1753–1757

    CAS  Google Scholar 

  • DeMaeyer-Guignard J, Cachard A, DeMaeyer E (1975) Delayed-type hypersensitivity to sheep red blood cells: inhibition of sensitization by interferon. Science 190:574–576

    CAS  Google Scholar 

  • Dent PB, Fish LA, White JF, Good RA (1966) Chediak-higashi syndrome observations on the nature of the associated malignancy. Lab Invest 15:1634–1642

    PubMed  CAS  Google Scholar 

  • Djeu JY, Heinbaugh JA, Holden HT, Herberman RB (1979) Augmentation of mouse natural killer cell activity by interferon and interferon inducers. J Immunol 122:175–181

    PubMed  CAS  Google Scholar 

  • Donahoe RM, Huang KY (1973) Neutralization of the phagocytosis-enhancing activity of interferon preparations by anti-interferon serum. Infect Immun 7:501–503

    PubMed  CAS  Google Scholar 

  • Donahoe RM, Huang KY (1976) Interferon preparations enhance phagocytosis in vivo. Infect Immun 13:1250–1257

    PubMed  CAS  Google Scholar 

  • Droller MJ, Borg H, Perlmann P (1979) In vitro enhancement of natural and antibody-dependent lymphocyte-mediated cytotoxicity against tumor target cells by interferon. Cell Immunol 47:248–260

    PubMed  CAS  Google Scholar 

  • Einhorn S (1980) Enhancement of human NK activity by interferon. In vivo and in vitro studies. In: Herberman RB (ed) Natural cell-mediated immunity against tumors. Academic, New York, p 529

    Google Scholar 

  • Einhorn S, Blomgren H, Strander H (1978 a) Interferon and spontaneous cytotoxicity in man. I. Enhancement of the spontaneous cytotoxicity of peripheral lymphocytes by human leukocyte interferon. Int J Cancer 22:405–412

    PubMed  CAS  Google Scholar 

  • Einhorn S, Blomgren H, Strander H (1978 b) Interferon and spontaneous cytotoxicity in man. II. Studies in patients receiving exogenous leukocyte interferon. Acta Med Scand 204:477–484

    PubMed  CAS  Google Scholar 

  • Einhorn S, Blomgren H, Strander H (1980) Interferon and spontaneous cytotoxicity in man. V. Enhancement of spontaneous cytotoxicity in patients receiving human leukocyte interferon. Int J Cancer 26:419–428

    PubMed  CAS  Google Scholar 

  • Epstein LB (1977) The effects of interferon on the immune response in vitro and in vivo. In: Stewart WE II (ed) Interferons and their actions. CRC, Cleveland, p 91

    Google Scholar 

  • Evans R, Alexander P (1972) Mechanism of immunologically specific killing of tumour cells by macrophages. Nature 236:168–170

    PubMed  CAS  Google Scholar 

  • Evans R, Alexander P (1976) Mechanisms of extracellular killing of nucleated mammalian cells by macrophages. In: Nelson DS (ed) Immunobiology of the macrophage. Academic, New York, p 535

    Google Scholar 

  • Fellous M, Kamoun M, Gresser I, Bono R (1979) Enhanced expression of HLA antigens and β2-microglobulin on in terfer on-treated human lymphoid cells. Eur J Immunol 9:446–449

    PubMed  CAS  Google Scholar 

  • Gidlund M, Orn A, Wigzell H, Senik A, Gresser I (1978) Enhanced NK cell activity in mice injected with interferon and interferon inducers. Nature 273:759–761

    PubMed  CAS  Google Scholar 

  • Gisler RH, Lindahl P, Gresser I (1974) Effects of interferon on antibody synthesis in vitro. J Immunol 113:438–444

    PubMed  CAS  Google Scholar 

  • Gresser I, Bourali C (1970) Antitumor effects of interferon preparations in mice. J Natl Cancer Inst 45:365–375

    PubMed  CAS  Google Scholar 

  • Haller O, Hansson M, Kiessling R, Wigzell H (1977) Role of non-conventional natural killer cells in resistance against syngeneic tumour cells in vivo. Nature 270:609–611

    PubMed  CAS  Google Scholar 

  • Herberman RB, Nunn ME, Lavrin DH (1975) Natural cytotoxic reactivity of mouse lymphoid cells against syngeneic and allogeneic tumors. I. Distribution of reactivity and specificity. Int J Cancer 16:216–229

    PubMed  CAS  Google Scholar 

  • Herberman RB, Nunn ME, Holden HT, Staal S, Djeu JY (1977) Augmentation of natural cytotoxic reactivity of mouse lymphoid cells against syngeneic and allogeneic target cells. Int J Cancer 19:555–564

    PubMed  CAS  Google Scholar 

  • Herberman RB, Djeu JY, Kay HD, Ortaldo JR, Riccardi C, Bonnard GD, Holden HT, Fagnani R, Santoni A, Puccetti P (1979) Natural killer cells: characteristics and regulation of activity. Immunol Rev 44:43–70

    PubMed  CAS  Google Scholar 

  • Herberman RB, Ortaldo JR, Djeu JY, Holden HT, Jett J, Lang NP, Rubinstein M, Pestka S (1980) Role of interferon in regulation of cytotoxicity by natural killer cells and macrophages. Ann NY Acad Sci 350:63–71

    PubMed  CAS  Google Scholar 

  • Heron I, Berg K (1979) Human leukocyte interferon: analysis of effect on MLC and effector cell generation. Scand J Immunol 9:517–526

    PubMed  CAS  Google Scholar 

  • Heron I, Berg K, Cantell K (1976) Regulatory effect of interferon on T cells in vitro. J Immunol 117:1370–1373

    PubMed  CAS  Google Scholar 

  • Heron I, Hokland M, Berg K (1978) Enhanced expression of β2-microglobulin and HLA antigens on human lymphoid cells by interferon. Proc Natl Acad Sci USA 75:6215–6219

    PubMed  CAS  Google Scholar 

  • Hewlett G, Opitz HG, Schlumberger HD, Lemke H (1977) Growth regulation of a murine lymphoma cell line by a 2-mercaptoethanol or macrophage-activated serum factor. Eur J Immunol 7:781–785

    PubMed  CAS  Google Scholar 

  • Horwitz DA, Kight N, Temple A, Allison AC (1979) Spontaneous and induced cytotoxic properties of human adherent mononuclear cells: killing of non-sensitized and antibody-coated non-erythroid cells. Immunology 36:221–228

    PubMed  CAS  Google Scholar 

  • Huang KY, Donahoe RM, Gordon FB, Dressler HR (1971) Enhancement of phagocytosis by interferon-containing preparations. Infect Immun 4:581–588

    PubMed  CAS  Google Scholar 

  • Huddlestone JR, Merigan Jr TC, Oldstone MBA (1979) Induction and kinetics of natural killer cells in humans following interferon therapy. Nature 282:417–419

    PubMed  CAS  Google Scholar 

  • Jett JR, Mantovani A, Herberman RB (1980) Augmentation of human monocyte-mediated cytolysis by interferon. Cell Immunol 54:425–434

    PubMed  CAS  Google Scholar 

  • Johnson HM, Baron S (1976) The nature of the suppressive effect of interferon and interferon inducers on the in vitro immune response. Cell Immunol 25:106–115

    PubMed  CAS  Google Scholar 

  • Johnson HM, Bukovic J, Baron S (1975a) Interferon inhibition of the primary in vitro antibody response to a thymus-independent antigen. Cell Immunol 20:104–109

    PubMed  CAS  Google Scholar 

  • Johnson HM, Bukovic JA, Smith BG (1975b) Inhibitory effect of synthetic polyribonucleotides on the primary in vitro immune response. Proc Soc Exp Biol Med 149:599–603

    PubMed  CAS  Google Scholar 

  • Johnson HM, Smith BG, Baron S (1975c) Inhibition of the primary in vitro antibody response by interferon preparations. J Immunol 114:403–409

    PubMed  CAS  Google Scholar 

  • Kärre K, Klein GO, Kiessling R, Klein G, Roder JC (1980) Low natural in vivo resistance to syngeneic leukaemias in natural killer deficient mice. Nature 284:624–626

    PubMed  Google Scholar 

  • Keller R (1976a) Cytostatic and cytocidal effects of activated macrophages. In: Nelson DS (ed) Immunobiology of the macrophage. Academic, New York, p 487

    Google Scholar 

  • Keller R (1976b) Susceptibility of normal and transformed cell lines to cytostatic and cytocidal effects exerted by macrophages. J Natl Cancer Inst 56:369–374

    PubMed  CAS  Google Scholar 

  • Keller R (1978) Macrophage-mediated natural cytotoxicity against various target cells in vitro. II. Macrophages from rats of different ages. Br J Cancer 37:742–746

    PubMed  CAS  Google Scholar 

  • Kiessling R, Klein E, Wigzell H (1975) “Natural” killer cells in the mouse. I. Cytotoxic cells with specificity for mouse Moloney leukemia cells. Specificity and distribution according to genotype. Eur J Immunol 5:112–117

    PubMed  CAS  Google Scholar 

  • Killander D, Lindahl P, Lundin L, Leary P, Gresser I (1976) Relationship between the enhanced expression of histocompatibility antigens on interferon-treated L1210 cells and their position in the cell cycle. Eur J Immunol 6:56–59

    PubMed  CAS  Google Scholar 

  • Lindahl P, Leary P, Gresser I (1972) Enhancement by interferon of the specific cytotoxicity of sensitized lymphocytes. Proc Natl Acad Sci USA 69:721–725

    PubMed  CAS  Google Scholar 

  • Lindahl P, Leary P, Gresser I (1974) Enhancement of the expression of histocompatibility antigens of mouse lymphoid cells by interferon in vitro. Eur J Immunol 4:779–794

    CAS  Google Scholar 

  • Lindahl P, Gresser I, Leary P, Tovey M (1976) Interferon treatment of mice: enhanced expression of histocompatibility antigens on lymphoid cells. Proc Natl Acad Sci USA 73:1284–1287

    PubMed  CAS  Google Scholar 

  • Lindahl-Magnusson P, Leary P, Gresser I (1972) Interferon inhibits DNA synthesis induced in mouse lymphocyte suspensions by phytohaemagglutinin or by allogeneic cells. Nature 237:120–121

    CAS  Google Scholar 

  • Lindahl-Magnusson P, Leary P, Gresser I (1973) Enhancement by interferon of the expression of surface antigens on murine leukemia L1210 cells. Proc Natl Acad Sci USA 70:2785–2788

    Google Scholar 

  • Lonai P, Steinman L (1977) Physiological regulation of antigen binding to T cells: role of a soluable macrophage factor and of interferon. Proc Natl Acad Sci USA 74:5662–5666

    PubMed  CAS  Google Scholar 

  • Lucero MA, Fridman WH, Provost MA, Billardon C, Pouillart P, Dumont J, Falcoff E (1981) Effect of various interferons on the spontaneous cytotoxicity exerted by lymphocytes from normal and tumor-bearing patients. Cancer Res 41:294–299

    PubMed  CAS  Google Scholar 

  • MacFarlan RI, Burns WH, White DO (1977) Two cytotoxic cells in peritoneal cavity of virus-infected mice: antibody-dependent macrophages and nonspecific killer cells. J Immunol 119:1569–1574

    PubMed  CAS  Google Scholar 

  • Mantovani A (1978) Effects on in vitro tumor growth of murine macrophages isolated from sarcoma lines differing in immunogenicity and metastasizing capacity. Int J Cancer 22:741–746

    PubMed  CAS  Google Scholar 

  • Mantovani A, Allavena P, Sessa C, Bolis G, Mangioni C (1980a) Natural killer activity of lymphoid cells isolated from human ascitic ovarian tumors. Int J Cancer 25:573–582

    PubMed  CAS  Google Scholar 

  • Mantovani A, Peri G, Polentarutti N, Allavena P, Bordignon C, Sessa C, Mangioni C (1980b) Natural cytotoxicity on tumor cells of human monocytes and macrophages. In: Herberman RB (ed) Natural cell-mediated immunity against tumors. Academic, New York, p 1271

    Google Scholar 

  • Mantovani A, Polentarutti N, Peri G, Bar Shavit Z, Vecchi A, Bolis G, Mangioni C (1980c) Cytotoxicity on tumor cells of peripheral blood monocytes and tumor-associated macrophages in patients with ascites ovarian tumors. J Natl Cancer Inst 64:1307–1315

    PubMed  CAS  Google Scholar 

  • Masucci MG, Szigeti R, Klein E, Klein G, Gruest J, Montagnier L, Taira H, Hall A, Nagata S, Weissmann C (1980) Effect of interferon-αl from E. coli on some cell functions. Science 209:1431–1435

    PubMed  CAS  Google Scholar 

  • Mazzur SR, Paucker K (1967) Studies on the effect of interferon on the formation of antibody in mouse spleen cells. J Immunol 98:689–696

    PubMed  CAS  Google Scholar 

  • McCoy JL, Herberman RB, Rosenberg EB, Donnelly FC, Levine PH, Alford C (1973) 51Chromium-release assay for cell-mediated cytotoxicity of human leukemia and lymphoid tissue-culture cells. Natl Cancer Inst Monogr 37:59–67

    PubMed  CAS  Google Scholar 

  • Merigan TC, Chester TJ, Paucker K (1975) Suppression of antibody-producing spleen cells in mice by various interferon preparations versus enhancement by double-stranded RNA. In: Geraldes A (ed) Effects of interferon on cells, viruses, and the immune system, Academic, London, p 347

    Google Scholar 

  • Minato N, Bloom BR, Jones C, Holland J, Reid LM (1979) Mechanism of rejection of virus persistently infected tumor cells by athymic nude mice. J Exp Med 149:1117–1133

    PubMed  CAS  Google Scholar 

  • Minato N, Reid L, Cantor H, Lengyel P, Bloom BR (1980) Mode of regulation of natural killer cell activity by interferon. J Exp Med 152:124–137

    PubMed  CAS  Google Scholar 

  • Miörner H, Landström L, Larner E, Larsson I, Lungren E, Strannegard Ö (1978) Regulation of mitogen-induced lymphocyte DNA synthesis by human interferon of different origins. Cell Immunol 35:15–24

    PubMed  Google Scholar 

  • Moore M, Kimber I (1980) Augmentation of human NK and ADCC by interferon. In: Herberman RB (ed) Natural cell-mediated immunity against tumors. Academic, New York, p 569

    Google Scholar 

  • Ngan J, Lee SHS, Kind LS (1976) Suppressive effect of interferon on ability of mouse spleen cells synthesizing IgE to sensitize rat skin for heterologous adoptive cutaneous anaphylaxis. J Immunol 117:1063–1075

    PubMed  CAS  Google Scholar 

  • Nunn ME, Djeu JY, Glaser M, Lavrin DH, Herberman RB (1976) Natural cytotoxic reactivity of rat lymphocytes against syngeneic Grossvirus-induced lymphoma. J Natl Cancer Inst 56:393–399

    PubMed  CAS  Google Scholar 

  • Oehler JR, Lindsay LR, Nunn ME, Herberman RB (1978) Natural cell-mediated cytotoxicity in rats. I. Tissue and stain distribution, and demonstration of a membrane receptor for the Fc portion of IgG. Int J Cancer 21:204–209

    PubMed  CAS  Google Scholar 

  • Pfizenmaier K, Trostmann H, Röllinghoff M, Wagner H (1975) Temporary presence of self-reactive cytotoxic T lymphocytes during murine lymphocytic choriomeningitis. Nature 258:238–240

    PubMed  CAS  Google Scholar 

  • Pross HF, Jondal M (1975) Cytotoxic lymphocytes from normal donors: a functional marker of non-T lymphocytes. Clin Exp Immunol 21:226–235

    PubMed  CAS  Google Scholar 

  • Pross HF, Kerbel RS (1976) An assessment of intratumor phagocytic and surface marker-bearing cells in a series of autochthonous and early passaged chemically induced murine sarcomas. J Natl Cancer Inst 57:1157–1167

    PubMed  CAS  Google Scholar 

  • Rabinovitch M, Manejias RE, Russo M, Abbey EE (1977) Increased spreading of macrophages from mice treated with interferon inducers. Cell Immunol 29:86–95

    PubMed  CAS  Google Scholar 

  • Reid L, Jones C, Holland J (1979) Virus carrier state suppresses tumorigenicity of tumor cells in athymic (nude) mice. J Gen Virol 42:609–614

    PubMed  CAS  Google Scholar 

  • Remington JS, Merigan TC (1970) Synthetic polyanions protect mice against intracellular bacterial infections. Nature 226:361–363

    PubMed  CAS  Google Scholar 

  • Rinehart JJ, Lange P, Gormus BJ, Kaplan ME (1978) Human monocyte-induced tumor cell cytotoxicity. Blood 52:211–220

    PubMed  CAS  Google Scholar 

  • Roder JC, Kiessling R, Biberfeld P, Andersson B (1978) Target-effector interaction in the natural killer (NK) cell system. II. The isolation of NK cells and studies on the mechanism of killing. J Immunol 121:2509–2517

    PubMed  CAS  Google Scholar 

  • Roder JC, Haliotis T, Klein M, Korec S, Jett JR, Ortaldo J, Herberman RB, Katz P, Fauci AS (1980) A new immunodeficiency disorder in humans involving NK cells. Nature 284:553–555

    PubMed  CAS  Google Scholar 

  • Rosenberg EB, McCoy JL, Green SS, Donnelly FC, Siwarski DF, Levine PH, Herberman RB (1974) Destruction of human lymphoid tissue culture cell lines by human peripheral lymphocytes in 51Cr-release cellular cytotoxicity assay. J Natl Cancer Inst 52:345–352

    PubMed  CAS  Google Scholar 

  • Rozee KR, Lee SHS, Ngan J (1973) Effect of priming on interferon inhibition of Con A induced spleen cell blastogenesis. Nature 245:16–18

    CAS  Google Scholar 

  • Russell SW, Mcintosh AT (1977) Macrophages isolated from regressing moloney sarcomas are more cytotoxic than those recovered from progressing sarcomas. Nature 268:69–71

    PubMed  CAS  Google Scholar 

  • Schellekens H, Weimar W, Cantell K, Stitz L (1979) Antiviral effect of interferon in vivo may be mediated by the host. Nature 278:742

    PubMed  CAS  Google Scholar 

  • Schultz RM, Papamatheakis JD, Chirigos MA (1977) Interferon: an inducer of macrophage activation by poly anions. Science 197:674–676

    PubMed  CAS  Google Scholar 

  • Schultz RM, Pavlidis NA, Stylos WA, Chirigos MA (1978) Regulation of macrophage tu-moricidal function: a role for prostaglandins of the E series. Science 202:320–321

    PubMed  CAS  Google Scholar 

  • Sendo F, Aoki T, Boyse EA, Buato CK (1975) Natural occurrence of lymphocytes showing cytotoxic activity to Balb/c radiation-induced leukemia RLO 1 cells. J Natl Cancer Inst 55:603–609

    PubMed  CAS  Google Scholar 

  • Senik A, Kolb JP, Örn A, Gidlund M (1980) Study of the mechanism for in vitro activation of mouse NK cells by interferon. Scand J Immunol 12:51–60

    PubMed  CAS  Google Scholar 

  • Shellam GR (1977) Studies on a Gross-virus-induced lymphoma in rat. V. Natural cytotoxic cells are non-T cells. Int J Cancer 19:225–235

    PubMed  CAS  Google Scholar 

  • Silva A, Bonavida B, Targan S (1980) Mode of action of interferon-mediated modulation of natural killer cytotoxic activity: recruitment of pre-NK cells and enhanced kinetics of lysis. J Immunol 125:479–484

    PubMed  CAS  Google Scholar 

  • Smith KA, Cornwell GG, Mclntyre OR (1974) The effect of poly I: C and interferon on lymphocyte DNA synthesis. In: Lindahl-Kiessling K, Osoba D (eds) Lymphocyte recognition and effector mechanisms. Academic, New York, p 101

    Google Scholar 

  • Sonnenfeld G, Mandel AD, Merigan TC (1978) Time and dosage dependence of immunoen-hancement by murine type II interferon preparations. Cell Immunol 40:285–293

    PubMed  CAS  Google Scholar 

  • Stanwick TL, Campbell DE, Nahmias AJ (1980) Spontaneous cytotoxicity mediated by human monocyte-macrophages against human fibroblasts infected with herpes simplex virus-augmentation by interferon. Cell Immunol 53:413–416

    PubMed  CAS  Google Scholar 

  • Stewart WE II (1981) Non-antiviral actions of interferon. In: Stewart WE II (ed) The interferon system. Springer, Wien New York, p 223

    Google Scholar 

  • Sykes JA, Maddox IS (1972) Prostaglandin production by experimental tumors and effects of anti-inflammatory compounds. Nature 237:59–63

    CAS  Google Scholar 

  • Szigeti R, Masucci M, Masucci G, Klein E, Klein G (1980) Interferon suppresses antigenand mitogen-induced leukocyte migration inhibition. Nature 288:594–596

    PubMed  CAS  Google Scholar 

  • Tagliabue A, Mantovani A, Kilgallen M, Herberman RB, McCoy JL (1979) Natural cytotoxicity of mouse monocytes and macrophages. J Immunol 122:2363–2370

    PubMed  CAS  Google Scholar 

  • Takasugi M, Mickey MR, Terasaki PI (1973) Reactivity of lymphocytes from normal patients on cultured tumor cells. Cancer Res 33:2898–2902

    PubMed  CAS  Google Scholar 

  • Talmadge JE, Meyers KM, Prieur DJ, Starkey JR (1980) Role of NK cells in tumour growth and metastasis in beige mice. Nature 284:622–624

    PubMed  CAS  Google Scholar 

  • Targan S, Dorey F (1980) Interferon activation of “pre-spontaneous killer” (pre-SK) cells and alteration in kinetics of lysis of both “pre-SK” and active SK cells. J Immunol 124:2157–2161

    PubMed  CAS  Google Scholar 

  • Trinchieri G, Santoli D (1978) Anti-viral activity induced by culturing lymphocytes with tumor-derived or virus-transformed cells — Enhancement of human natural killer cell activity by interferon and antagonistic inhibition of susceptibility of target cells to lysis. J Exp Med 147:1314–1333

    PubMed  CAS  Google Scholar 

  • Trinchieri G, Santoli D, Koprowski H (1978) Spontaneous cell-mediated cytotoxicity in humans: role of interferon and immunoglobulins. J Immunol 120:1849–1855

    PubMed  CAS  Google Scholar 

  • Vánky FT, Argov SA, Einhorn SA, Klein E (1980) Role of alloantigens in natural killing. Allogeneic but not autologous tumor biopsy cells are sensitive for interferon-induced cytotoxicity of human blood lymphocytes. J Exp Med 151:1151–1165

    PubMed  Google Scholar 

  • Vignaux F, Gresser I (1977) Differential effects of interferon on the expression of H-2 K, H-2 D and la antigens on mouse lymphocytes. J Immunol 118:721–723

    PubMed  CAS  Google Scholar 

  • Virelizier JL, Virelizier AM, Allison AC (1976) Role of circulating interferon in modifications of immune responsiveness by mouse hepatitis virus (MHV-3). J Immunol 117:748–764

    PubMed  CAS  Google Scholar 

  • Vose BM (1980) Natural killers in human cancer: activity of tumor-infiltrating and draining node lymphocytes. In: Herberman RB (ed) Natural cell-mediated immunity against tumors. Academic, New York, p 1081

    Google Scholar 

  • Wallen WC, Dean JH, Gauntt C, Lucas DO (1975) Suppression of lymphocyte stimulation in mouse spleen cells by interferon preparations. In: Geraldes A (ed) Effects of interferon on cells, viruses, and the immune system. Academic, London, p 355

    Google Scholar 

  • Welsh RM (1978) Cytotoxic cells induced during lymphocytic choriomeningitis virus infection of mice. I. Characterization of natural killer cell induction. J Exp Med 148:163–181

    PubMed  Google Scholar 

  • Welsh RM, Kiessling RW (1980) Activated natural killer cells induced during the lymphocytic choriomeningitis virus infection in mice. In: Herberman RB (ed) Natural cell-mediated immunity against tumors. Academic, New York, p 671

    Google Scholar 

  • Welsh RM, Zinkernagel RM (1977) Heterospecific cytotoxic cells early during acute lymphocytic choriomeningitis virus infection. Nature 268:646–648

    PubMed  Google Scholar 

  • Wolfe SA, Tracey DE, Henney CS (1976) Induction of “natural killer” cells by BCG. Nature 262:584–586

    PubMed  CAS  Google Scholar 

  • Zarling JM (1980) Augmentation of human natural killer cell activity by purified interferon and polyribonucleotides. In: Herberman RB (ed) Natural cell-mediated immunity against tumors. Academic, New York, p 687

    Google Scholar 

  • Zarling JM, Kung PC (1980) Monoclonal antibodies which distinguish between human NK cells and cytotoxic T lymphocytes. Nature 288:394–396

    PubMed  CAS  Google Scholar 

  • Zarling JM, Tevethia SS (1973) Transplantation immunity to simian virus 40-transformed cells in tumor bearing mice. II. Evidence for macrophage participation at the effector level of tumor cell rejection. J Natl Cancer Inst 50:149–157

    PubMed  CAS  Google Scholar 

  • Zarling JM, Nowinski RC, Bach FH (1975) Lysis of leukemia cells by spleen cells of normal mice. Proc Natl Acad Sci USA 72:2780–2784

    PubMed  CAS  Google Scholar 

  • Zarling JM, Sosman J, Eskra L, Borden EC, Horoszewicz JS, Carter WA (1978) Enhancement of T cell cytotoxic responses by purified human fibroblast interferon. J Immunol 121:2002–2004

    PubMed  CAS  Google Scholar 

  • Zarling JM, Eskra L, Borden E, Horoszewicz J, Carter WA (1979) Activation of human natural killer cells cytotoxic for human leukemia cells by purified interferon. J Immunol 123:63–70

    PubMed  CAS  Google Scholar 

  • Zarling JM, Schlais J, Eskra L, Greene JJ, Ts’o POP, Carter WA (1980) Augmentation of human natural killer cell activity by polyinosinic acid-polycytidylic acid and its nontoxic mismatched analogues. J Immunol 124:1852–1857

    PubMed  CAS  Google Scholar 

  • Zarling JM, Bach FH, Kung PC (1981) Sensitization of lymphocytes against pooled allogeneic cells. II. Characterization of effector cells cytotoxic for autologous lymphoblas-toid cell lines. J Immunol 125:357–378

    Google Scholar 

  • Ziegler HW, Kay NE, Zarling JM (1981) Deficiency of natural killer cell activity in patients with chronic lymphocytic leukemia. Int J Cancer 27:321–327

    PubMed  CAS  Google Scholar 

  • Zinkernagel RM, Doherty PC (1974) Restriction of in vitro T cell mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semi-allogenic system. Nature 248:701–702

    PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1984 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Zarling, J.M. (1984). Effects of Interferon and Its Inducers on Leucocytes and Their Immunologic Functions. In: Came, P.E., Carter, W.A. (eds) Interferons and Their Applications. Handbook of Experimental Pharmacology, vol 71. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69178-2_20

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-69178-2_20

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-69180-5

  • Online ISBN: 978-3-642-69178-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics