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Potential Value and Application of Liquid Biopsy in Tumor, Neurodegeneration, and Muscle Degenerative Diseases

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Liquid Biopsies

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2695))

Abstract

Liquid biopsy provides a promising alternative for the detection of disease-specific markers due to its superior noninvasive and original tissue representativeness. Liquid biopsies have a wide range of health and disease applications involving components ranging from circulating cells to acellular nucleic acid molecules and other metabolites. Here, we review the different components of liquid biopsy and investigate the most advanced noninvasive methods for detecting these components as well as their existing problems and trends. In particular, we emphasize the importance of analyzing liquid biopsy data from extracellular vesicles and small nucleic acids in neurological and muscle degeneration, with the aim of using this technique to enhance personalized healthcare. Although previous reviews have focused on cancer, this review mainly emphasizes the potential application of extracellular vesicles and microRNAs in liquid biopsy in neurodegeneration and muscle degeneration.

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Acknowledgments

This work was supported by the National Natural Science Foundation of China (Grant No. 81971775 to Lin Chen, 82071970 to Yuxiang Wu and 82272123 to Guodong Xu) and Science and Technology Innovation Project of Jianghan University (Grant No.2021kjzx008 to Yuxiang Wu).

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Authors and Affiliations

  1. Department of Health and Physical Education, Jianghan University, Wuhan, Hubei, People’s Republic of China

    Lin Chen, Guodong Xu & Yuxiang Wu

  2. Jianghan University Library, Wuhan, Hubei, People’s Republic of China

    Jun Yang

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  1. Lin Chen
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  2. Jun Yang
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  3. Guodong Xu
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  4. Yuxiang Wu
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Correspondence to Yuxiang Wu .

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  1. CAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai, China

    Tao Huang

  2. Geneis Beijing Co. Ltd., Beijing, China

    Jialiang Yang

  3. Geneis Beijing Co. Ltd., Beijing, China

    Geng Tian

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Chen, L., Yang, J., Xu, G., Wu, Y. (2023). Potential Value and Application of Liquid Biopsy in Tumor, Neurodegeneration, and Muscle Degenerative Diseases. In: Huang, T., Yang, J., Tian, G. (eds) Liquid Biopsies. Methods in Molecular Biology, vol 2695. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-3346-5_22

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  • DOI: https://doi.org/10.1007/978-1-0716-3346-5_22

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