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Photosensitized Oxidation of Intracellular Targets: Understanding the Mechanisms to Improve the Efficiency of Photodynamic Therapy

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Photodynamic Therapy

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2451))

Abstract

The development of improved photosensitizers is a key aspect in the establishment of photodynamic therapy (PDT) as a reliable treatment modality. In this chapter, we discuss how molecular design can lead to photosensitizers with higher selectivity and better efficiency, with focus on the importance of specific intracellular targeting in determining the cell death mechanism and, consequently, the PDT outcome.

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Authors and Affiliations

  1. Chemistry Department, Institute of Exact Sciences, Universidade Federal de Minas Gerais, Minas Gerais, Brazil

    Thiago Teixeira Tasso

  2. Biochemistry Department, Institute of Chemistry, Universidade de São Paulo, São Paulo, Brazil

    Maurício S. Baptista

Authors
  1. Thiago Teixeira Tasso
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  2. Maurício S. Baptista
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Correspondence to Maurício S. Baptista .

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Editors and Affiliations

  1. Institute for Advanced Biosciences, Université de Grenoble Alpes, Grenoble, France

    Mans Broekgaarden

  2. van ‘t Hoff Institute for Molecular Sciences, University of Amsterdam, Amsterdam, The Netherlands

    Hong Zhang

  3. British Columbia Cancer Research Centre, Vancouver, BC, Canada

    Mladen Korbelik

  4. Laser Research Centre, University of Johannesburg, Doornfontein, South Africa

    Michael R. Hamblin

  5. Jiaxing Key Laboratory for Photonanomedicine and Experimental Therapeutics, Department of Pharmaceutics, Jiaxing University College of Medicine, Jiaxing, Zhejiang, China

    Michal Heger

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Tasso, T.T., Baptista, M.S. (2022). Photosensitized Oxidation of Intracellular Targets: Understanding the Mechanisms to Improve the Efficiency of Photodynamic Therapy. In: Broekgaarden, M., Zhang, H., Korbelik, M., Hamblin, M.R., Heger, M. (eds) Photodynamic Therapy. Methods in Molecular Biology, vol 2451. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-2099-1_18

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