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Models for Assessing Anxiety and Depression in Multiple Sclerosis: from Mouse to Man

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Translational Methods for Multiple Sclerosis Research

Part of the book series: Neuromethods ((NM,volume 166))

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Abstract

Multiple sclerosis (MS) patients often suffer from anxiety disorders and depression. An effective treatment would improve quality of life and would have a positive socioeconomic impact. However, research, diagnosis, and treatment of such mood disorders in MS have not been paid sufficient attention in the past. For that, validated and reliable models are necessary for a putative translation to the clinic. We here review animal models of anxiety and depression and summarize tools for anxiety/depression assessment in MS patients.

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Acknowledgments

We thank Rosalind Gilchrist for proofreading the manuscript.

Funding: This work was supported by the German Research Council (DFG, CRC-TR-128).

Author information

Authors and Affiliations

  1. Focus Program Translational Neurosciences (FTN) and Immunology (FZI), Rhine Main Neuroscience Network (rmn2), Department of Neurology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany

    Erik Ellwardt

  2. Scientifica Ltd, Kingfisher Court, Uckfield, East Sussex, UK

    Dirk Luchtman

Authors
  1. Erik Ellwardt
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  2. Dirk Luchtman
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Corresponding author

Correspondence to Erik Ellwardt .

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Editors and Affiliations

  1. Department of Neurology and Neuroimaging Center (NIC) of the Focus Program Translational Neuroscience (FTN), University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany

    Sergiu Groppa

  2. Department of Neurology, University of Düsseldorf, Düsseldorf, Germany

    Sven G. Meuth

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Ellwardt, E., Luchtman, D. (2021). Models for Assessing Anxiety and Depression in Multiple Sclerosis: from Mouse to Man. In: Groppa, S., G. Meuth, S. (eds) Translational Methods for Multiple Sclerosis Research. Neuromethods, vol 166. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1213-2_13

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  • DOI: https://doi.org/10.1007/978-1-0716-1213-2_13

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-1212-5

  • Online ISBN: 978-1-0716-1213-2

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