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Advanced Nanotechnology Approaches as Emerging Tools in Cellular-Based Technologies

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Cell Biology and Translational Medicine, Volume 18

Part of the book series: Advances in Experimental Medicine and Biology ((CBTMED,volume 1409))

Abstract

Stem cells are valuable tools in regenerative medicine because they can generate a wide variety of cell types and tissues that can be used to treat or replace damaged tissues and organs. However, challenges related to the application of stem cells in the scope of regenerative medicine have urged scientists to utilize nanomedicine as a prerequisite to circumvent some of these hurdles. Nanomedicine plays a crucial role in this process and manipulates surface biology, the fate of stem cells, and biomaterials. Many attempts have been made to modify cellular behavior and improve their regenerative ability using nano-based strategies. Notably, nanotechnology applications in regenerative medicine and cellular therapies are controversial because of ethical and legal considerations. Therefore, this review describes nanotechnology in cell-based applications and focuses on newly proposed nano-based approaches. Cutting-edge strategies to engineer biological tissues and the ethical, legal, and social considerations of nanotechnology in regenerative nanomedicine applications are also discussed.

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Abbreviations

2D:

Two-dimensional

3D:

Three-dimensional

Ab:

Antibody

AuNP:

Gold nanoparticle

BM:

Bone marrow

CD:

Cluster of differentiation

CLNP:

Cationic lipid nanoparticle

CNT:

Carbon nanotube

CPP:

Cell-penetrating peptide

DDS:

Drug delivery system

Dex:

Dexamethasone

ECM:

Extracellular matrix

EMA:

European Medicines Agency

ESC:

Embryonic stem cell

EU:

European Union

EV:

Extracellular vesicle

FDA:

Food and Drug Administration

FITC:

Fluorescein isothiocyanate

GAG:

Glycosaminoglycan

GF:

Growth factor

GO:

Graphene oxide

hASC:

Human adipose stem cell

hESC:

Human embryonic stem cell

hMSC:

Human mesenchymal stromal cell

HA:

Hyaluronic acid

HIV-1 Tat:

Human immunodeficiency virus-1 trans-activating regulatory protein

iPSC:

Induced pluripotent stem cell

IVF:

In vitro fertilization

kPa:

Kilopascal

MNP:

Magnetic nanoparticle

MPI:

Magnetic particle imaging

MRI:

Magnetic resonance imaging

MACS:

Magnetic-activated cell sorting

MSC:

Mesenchymal stromal cell

NGF:

Nerve growth factor

NKT:

Natural killer T cell

NP:

Nanoparticle

PA:

Photoacoustic

PBAE:

Poly(β-amino ester)

PCL:

(poly-É›-caprolactone)

PEG:

Polyethylene glycol

PEI:

Polyethyleneimine

PET:

Positron emission tomography

PGA:

Polyglycolic acid

PLA:

Polylactic acid

PNIPAM:

Poly-N-Isopropylacrylamide

PVA:

Polyvinyl alcohol

PVP:

Polyvinylpyrrolidone

QD:

Quantum dot

RM:

Regenerative medicine

siRNA:

Small interfering RNA

SLNP:

Solid lipid nanoparticle

SPION:

Superparamagnetic iron oxide nanoparticle

TDN:

Tetrahedral DNA nanostructure

VEGF:

Vascular endothelial growth factor

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  1. Department of Applied Cell Sciences, Faculty of Basic Sciences and Advanced Medical Technologies, Royan Institute, ACECR, Tehran, Iran

    Mehdi Soleymani-Goloujeh

  2. Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran

    Mehdi Soleymani-Goloujeh, Samaneh Hosseini & Mohamadreza Baghaban Eslaminejad

  3. Department of Cell Engineering, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran

    Samaneh Hosseini

Authors
  1. Mehdi Soleymani-Goloujeh
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  2. Samaneh Hosseini
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  3. Mohamadreza Baghaban Eslaminejad
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Corresponding authors

Correspondence to Samaneh Hosseini or Mohamadreza Baghaban Eslaminejad .

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Editors and Affiliations

  1. Ottawa Hospital Research Institute, Ottawa, ON, Canada

    Kursad Turksen

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Soleymani-Goloujeh, M., Hosseini, S., Baghaban Eslaminejad, M. (2022). Advanced Nanotechnology Approaches as Emerging Tools in Cellular-Based Technologies. In: Turksen, K. (eds) Cell Biology and Translational Medicine, Volume 18. Advances in Experimental Medicine and Biology(), vol 1409. Springer, Cham. https://doi.org/10.1007/5584_2022_725

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