Skip to main content

Advertisement

Log in

Epidemiology of heart failure and left ventricular dysfunction after acute myocardial infarction

  • Published:
Current Heart Failure Reports Aims and scope Submit manuscript

Abstract

The development of heart failure and/or left ventricular systolic dysfunction has long been regarded as an ominous complication, significantly increasing the morbidity and short- and long-term mortality of survivors of acute myocardial infarction. Although the incidence of heart failure after myocardial infarction has fallen over the last few decades, it remains common, complicating up to 45% of infarcts. Moreover, up to 60% of myocardial infarcts will result in left ventricular systolic dysfunction, depending on the exact definition used. Those at greatest risk of developing heart failure are the elderly, females, and those with prior myocardial infarction. Advances in the management of acute myocardial infarction have led to reduced in-hospital mortality (even when complicated by heart failure), but longerterm mortality remains high in these patients.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References and Recommended Reading

  1. Tunstall-Pedoe H, Kuulasmaa K, Mahonen M, et al.: Contribution of trends in survival and coronary-event rates to changes in coronary heart disease mortality: 10-year results from 37 WHO MONICA project populations. Monitoring trends and determinants in cardiovascular disease. Lancet 1999, 353:1547–1557.

    Article  PubMed  CAS  Google Scholar 

  2. Capewell S, Livingston BM, MacIntyre K, et al.: Trends in case-fatality in 117 718 patients admitted with acute myocardial infarction in Scotland. Eur Heart J 2000, 21:1833–1840.

    Article  PubMed  CAS  Google Scholar 

  3. Goldberg RJ, Spencer FA, Yarzebski J, et al.: A 25-year perspective into the changing landscape of patients hospitalized with acute myocardial infarction (the Worcester Heart Attack Study). Am J Cardiol 2004, 94:1373–1378.

    Article  PubMed  Google Scholar 

  4. Hanania G, Cambou JP, Gueret P, et al.: USIC 2000 Investigators. Management and in-hospital outcome of patients with acute myocardial infarction admitted to intensive care units at the turn of the century: results from the French nationwide USIC 2000 registry. Heart 2004, 90:1404–1410. This important survey is particularly relevant as it separates AMI into STEMI and non-STEMI, and provides data on prevalence of HF, LVSD, in-hospital management, and in-hospital complications (including 5-day mortality) according to infarct type.

    Article  PubMed  CAS  Google Scholar 

  5. Moller JE, Brendorp B, Ottesen M, et al.: Congestive heart failure with preserved left ventricular systolic function after acute myocardial infarction: clinical and prognostic implications. Eur J Heart Fail 2003, 5:811–819.

    Article  PubMed  Google Scholar 

  6. Hellermann JP, Jacobsen SJ, Redfield MM, et al.: Heart failure after myocardial infarction: clinical presentation and survival. Eur J Heart Fail 2005, 7:119–125. This study reports on the development of HF and the trends over time in the risk of developing this important complication in all patients with incident AMI and no prior history of HF in a community over two decades.

    Article  PubMed  Google Scholar 

  7. Weir RA, McMurray JJ, Velazquez EJ: Epidemiology of heart failure and left ventricular systolic dysfunction after acute myocardial infarction: prevalence, clinical characteristics, and prognostic importance. Am J Cardiol 2006, 97:13F-25F.

    Article  PubMed  Google Scholar 

  8. Myocardial infarction redefined—a consensus document of The Joint European Society of Cardiology/American College of Cardiology Committee for the redefinition of myocardial infarction. Eur Heart J 2000, 21:1502–1513.

  9. Goldberg RJ, Cui J, Olendzki B, et al.: Excess body weight, clinical profile, management practices, and hospital prognosis in men and women after acute myocardial infarction. Am Heart J 2006, 151:1297–1304.

    Article  PubMed  Google Scholar 

  10. Spencer FA, Meyer TE, Gore JM, Goldberg RJ: Heterogeneity in the management and outcomes of patients with acute myocardial infarction complicated by heart failure: the National Registry of Myocardial Infarction. Circulation 2002, 105:2605–2610.

    Article  PubMed  Google Scholar 

  11. Every NR, Frederick PD, Robinson M, et al.: A comparison of the national registry of myocardial infarction 2 with the cooperative cardiovascular project. J Am Coll Cardiol 1999, 33:1886–1894.

    Article  PubMed  CAS  Google Scholar 

  12. Velazquez EJ, Francis GS, Armstrong PW, et al.: An international perspective on heart failure and left ventricular systolic dysfunction complicating myocardial infarction: the VALIANT registry. Eur Heart J 2004, 25:1911–1919. This registry provides a very complete dataset on both incidence of HF and prevalence of LVSD (and in-hospital mortality) in a large number (> 5500) of AMI patients recruited from nine countries and importantly includes patients with cardiogenic shock, who are frequently excluded from epidemiologic studies and clinical trials.

    Article  PubMed  Google Scholar 

  13. Yan AT, Tan M, Fitchett D, et al.: One-year outcome of patients after acute coronary syndromes (from the Canadian Acute Coronary Syndromes Registry). Am J Cardiol 2004, 94:25–29.

    Article  PubMed  Google Scholar 

  14. Krumholz HM, Gross CP, Peterson ED, et al.: Is there evidence of implicit exclusion criteria for elderly subjects in randomized trials? Evidence from the GUSTO-1 study. Am Heart J 2003, 146:839–847.

    Article  PubMed  Google Scholar 

  15. Hasdai D, Topol EJ, Kilaru R, et al.: Frequency, patient characteristics, and outcomes of mild-to-moderate heart failure complicating ST-segment elevation acute myocardial infarction: lessons from 4 international fibrinolytic therapy trials. Am Heart J 2003, 145:73–79.

    Article  PubMed  Google Scholar 

  16. Kashani A, Giugliano RP, Antman EM, et al.: Severity of heart failure, treatments, and outcomes after fibrinolysis in patients with ST-elevation myocardial infarction. Eur Heart J 2004, 25:1702–1710.

    Article  PubMed  Google Scholar 

  17. Magnesium in Coronaries (MAGIC) Trial Investigators: Early administration of intravenous magnesium to high-risk patients with acute myocardial infarction in the Magnesium in Coronaries (MAGIC) Trial: a randomised controlled trial. Lancet 2002, 360:1189–1196.

    Article  Google Scholar 

  18. Armstrong PW: A comparison of pharmacologic therapy with/without timely coronary intervention vs. primary percutaneous intervention early after ST-elevation myocardial infarction: the WEST (Which Early ST-elevation Myocardial Infarction Therapy) study. Eur Heart J 2006, 27:1530–1538.

    Article  PubMed  Google Scholar 

  19. Hasdai D, Behar S, Wallentin L, et al.: A prospective survey of the characteristics, treatments and outcomes of patients with acute coronary syndromes in Europe and the Mediterranean basin; the Euro Heart Survey of Acute Coronary Syndromes (Euro Heart Survey ACS). Eur Heart J 2002, 23:1190–1201.

    Article  PubMed  CAS  Google Scholar 

  20. Brieger D, Eagle KA, Goodman SG, et al.: Acute coronary syndromes without chest pain, an underdiagnosed and undertreated high-risk group: insights from the Global Registry of Acute Coronary Events. Chest 2004, 126:461–469.

    Article  PubMed  Google Scholar 

  21. Dorsch MF, Lawrance RA, Sapsford RJ, et al.: Poor prognosis of patients presenting with symptomatic myocardial infarction but without chest pain. Heart 2001, 86:494–498.

    Article  PubMed  CAS  Google Scholar 

  22. Danchin N, Vaur L, Genes N, et al.: Management of acute myocardial infarction in intensive care units in 1995: a nationwide French survey of practice and early hospital results. J Am Coll Cardiol 1997, 30:1598–1605.

    Article  PubMed  CAS  Google Scholar 

  23. Torp-Pedersen C, Kober L: Effect of ACE inhibitor trandolapril on life expectancy of patients with reduced left-ventricular function after acute myocardial infarction. TRACE Study Group. Trandolapril Cardiac Evaluation. Lancet 1999, 354:9–12.

    Article  PubMed  CAS  Google Scholar 

  24. Kober L, Bloch Thomsen PE, Moller M, et al.: Effect of dofetilide in patients with recent myocardial infarction and left-ventricular dysfunction: a randomised trial. Lancet 2000, 356:2052–2058.

    Article  PubMed  CAS  Google Scholar 

  25. Rott D, Behar S, Hod H, et al.: Improved survival of patients with acute myocardial infarction with significant left ventricular dysfunction undergoing invasive coronary procedures. Am Heart J 2001, 141:267–276.

    Article  PubMed  CAS  Google Scholar 

  26. Galasko GI, Basu S, Lahiri A, Senior R: A prospective comparison of echocardiographic wall motion score index and radionuclide ejection fraction in predicting outcome following acute myocardial infarction. Heart 2001, 86:271–276.

    Article  PubMed  CAS  Google Scholar 

  27. Moller JE, Hillis GS, Oh JK, et al.: Wall motion score index and ejection fraction for risk stratification after acute myocardial infarction. Am Heart J 2006, 151:419–425.

    Article  PubMed  Google Scholar 

  28. Hernandez AF, Velazquez EJ, Solomon SD, et al.: Left ventricular assessment in myocardial infarction: the VALIANT registry. Arch Intern Med 2005, 165:2162–2169.

    Article  PubMed  Google Scholar 

  29. Abildstrom SZ, Ottesen MM, Rask-Madsen C, et al.: Sudden cardiovascular death following myocardial infarction: the importance of left ventricular systolic dysfunction and congestive heart failure. Int J Cardiol 2005, 104:184–189.

    Article  PubMed  Google Scholar 

  30. Waldo AL, Camm AJ, deRuyter H, et al.: Effect of d-sotalol on mortality in patients with left ventricular dysfunction after recent and remote myocardial infarction. The SWORD Investigators. Survival With Oral d-Sotalol. Lancet 1996, 348:7–12.

    Article  PubMed  CAS  Google Scholar 

  31. Julian DG, Camm AJ, Frangin G, et al.: Randomised trial of effect of amiodarone on mortality in patients with leftventricular dysfunction after recent myocardial infarction: EMIAT. European Myocardial Infarct Amiodarone Trial Investigators. Lancet 1997, 349:667–674.

    Article  PubMed  CAS  Google Scholar 

  32. Torp-Pedersen C, Kober L, Ball S, et al.: The incomplete bucindolol evaluation in acute myocardial infarction trial (BEAT). Eur J Heart Fail 2002, 4:495–499.

    Article  PubMed  CAS  Google Scholar 

  33. Pratt CM, Singh SN, Al-Khalidi HR, et al.: The efficacy of azimilide in the treatment of atrial fibrillation in the presence of left ventricular systolic dysfunction: results from the Azimilide Postinfarct Survival Evaluation (ALIVE) trial. J Am Coll Cardiol 2004, 43:1211–1216.

    Article  PubMed  CAS  Google Scholar 

  34. Dargie HJ: Effect of carvedilol on outcome after myocardial infarction in patients with left-ventricular dysfunction: the CAPRICORN randomised trial. Lancet 2001, 357:1385–1390.

    Article  PubMed  CAS  Google Scholar 

  35. Guidry UC, Evans JC, Larson MG, et al.: Temporal trends in event rates after Q-wave myocardial infarction: the Framingham Heart Study. Circulation 1999, 100:2054–2059.

    PubMed  CAS  Google Scholar 

  36. Spencer FA, Meyer TE, Goldberg RJ, et al.: Twenty year trends (1975-1995) in the incidence, in-hospital and longterm death rates associated with heart failure complicating acute myocardial infarction: a community-wide perspective. J Am Coll Cardiol 1999, 34:1378–1387.

    Article  PubMed  CAS  Google Scholar 

  37. Goldberg RJ, Samad NA, Yarzebski J, et al.: Temporal trends in cardiogenic shock complicating acute myocardial infarction. N Engl J Med 1999, 340:1162–1168.

    Article  PubMed  CAS  Google Scholar 

  38. Nicod P, Gilpin E, Dittrich H, et al.: Influence on prognosis and morbidity of left ventricular ejection fraction with and without signs of left ventricular failure after acute myocardial infarction. Am J Cardiol 1988, 61:1165–1171.

    Article  PubMed  CAS  Google Scholar 

  39. Kober L, Torp-Pedersen C, Pedersen OD, et al.: Importance of congestive heart failure and interaction of congestive heart failure and left ventricular systolic function on prognosis in patients with acute myocardial infarction. Am J Cardiol 1996, 78:1124–1128.

    Article  PubMed  CAS  Google Scholar 

  40. Hellermann JP, Jacobsen SJ, Reeder GS, et al.: Heart failure after myocardial infarction: prevalence of preserved left ventricular systolic function in the community. Am Heart J 2003, 145:742–748.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to John J. V. McMurray MD, FRCP, FESC.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Weir, R.A.P., McMurray, J.J.V. Epidemiology of heart failure and left ventricular dysfunction after acute myocardial infarction. Curr Heart Fail Rep 3, 175–180 (2006). https://doi.org/10.1007/s11897-006-0019-5

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11897-006-0019-5

Keywords

Navigation