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SH3BP2 is a Critical Regulator of Macrophage and Osteoclast Response to M-CSF and RANKL Stimulation

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HSS Journal

Abstract

The protein Src homology 3 domain-binding protein 2 (SH3BP2) is a regulator of tumor necrosis factor (TNF)-alpha generation in macrophages and of osteoclast differentiation. SH3BP2 regulates bone marrow monocyte responses to macrophage and osteoclast differentiation signals downstream of the receptors for macrophage colony-stimulating factor and receptor activator of nuclear factor kappaB ligand. SH3BP2 is a potential target for the development of novel anti-TNF-alpha therapeutic interventions as well as a target for suppression of osteoclastogenesis.

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Authors and Affiliations

  1. Department of Orthopedic Surgery, Beth Israel Deaconess Medical Center, 330 Brookline Ave., Boston, MA, 02215, USA

    Mark S. McMahon BS, MS, MD

  2. Department of Developmental Biology, Harvard School of Dental Medicine, REB 413, 188 Longwood Ave, Boston, MA, 02115, USA

    Mark S. McMahon BS, MS, MD & Yasuyoshi Ueki BS, MD, PhD

Authors
  1. Mark S. McMahon BS, MS, MD
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  2. Yasuyoshi Ueki BS, MD, PhD
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Corresponding author

Correspondence to Mark S. McMahon BS, MS, MD.

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SH3BP2 is a critical regulator of macrophage and osteoclast response to M-CSF and RANKL stimulation.

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McMahon, M.S., Ueki, Y. SH3BP2 is a Critical Regulator of Macrophage and Osteoclast Response to M-CSF and RANKL Stimulation. HSS Jrnl 5, 49–50 (2009). https://doi.org/10.1007/s11420-008-9091-6

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  • DOI: https://doi.org/10.1007/s11420-008-9091-6

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