Synthesis and antimicrobial activity of sulfide and sulfone derivatives of 4-(2-chloro-4-fluorophenyl)-1,3-thiazol-2-amine/acetamide

A series of 4-(2-chloro-4-fluorophenyl)-5-(4-substituted phenylsulfanyl)-thiazole-2-ylamines/acetamides (3a – 5b) and 5-(4-substituted benzenesulfonyl)-4-(2-chloro-4-fluorophenyl)-thiazole-2-ylamines/acetamides (6a – 8b) derivatives have been synthesized. The title compounds (3a – 5b) were obtained by the nucleophilic substitution of bromo derivatives (2a – 2b) with various substituted thiophenols. Structures of all the newly synthesized compounds were established by analytical and spectral data. The synthesized compounds have been screened for their antimicrobial activity against Gram-negative (Escherichia coli) and Gram-positive (methicillin resistant Staphylococcus aureus) bacteria and Aspergillus niger and Candida albicans fungi.