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Antioxidant and anti-inflammatory properties of Chinese ilicifolius vegetable (Acanthopanax trifoliatus (L) Merr) and its reference compounds

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Abstract

Stems and leaves of Acanthopanax trifoliatus (L) Merr (AT) are commonly used as an edible vegetable in China. The scientific basis of antioxidant and antiinflammatory activities of AT was investigated. The polyphenol contents and free radical scavenging activities of AT ethanol extracts (EAT) were determined. Chlorogenic acid, isochlorogenic acid A, isochlorogenic acid C, and rutin were identified as major components in EAT. LPS-induced NO production in RAW264.7 cells was decreased significantly (p<0.05) after EAT treatment, compared with controls. In vivo studies indicated that EAT had more activity than chlorogenic acid per mg of dry weight for inhibition of TPA-induced ear edema. TPA-induced increases in cytokine production (TNF-α, IL-6, MMP-9, and TIMP-1) were significantly (p<0.05) reduced by EAT treatment, compared with controls. EAT exerts anti-inflammatory activities probably due, at least in part, to chlorogenic acid.

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Authors and Affiliations

  1. School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou, Guangdong, 510006, China

    Huaqian Wang, Dongli Li, Zhiyun Du, Yujing Lu, Allan H. Conney, Xi Zheng & Kun Zhang

  2. Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, 08854, USA

    Mou-Tuan Huang, Xiaoxing Cui, Allan H. Conney & Xi Zheng

  3. Research and Development Center of Nutritional Supplements, Perfect (China) Co., Ltd., Zhongshan City, Guangdong, 528402, China

    Chenyue Li & Swee Lian Woo

  4. Wuyi University, Jiangmen City, Guangdong, 529020, China

    Kun Zhang

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  1. Huaqian Wang
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Correspondence to Kun Zhang.

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Wang, H., Li, D., Du, Z. et al. Antioxidant and anti-inflammatory properties of Chinese ilicifolius vegetable (Acanthopanax trifoliatus (L) Merr) and its reference compounds. Food Sci Biotechnol 24, 1131–1138 (2015). https://doi.org/10.1007/s10068-015-0144-6

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  • DOI: https://doi.org/10.1007/s10068-015-0144-6

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