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Renal repair: role of bone marrow stem cells

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Abstract

Acute kidney injury carries severe consequences and has limited treatment options. Bone marrow stem cells may offer the potential for treatment of acute kidney injury. The purpose of this review is twofold. The first purpose is to provide a concise overview of the biology of bone marrow stem cells, including hematopoietic stem cells and mesenchymal stem cells, for clinical nephrologists and renal researchers. The second purpose is to summarize published data regarding the role of bone marrow stem cells in renal repair after acute kidney injury. Currently, much of our knowledge of renal protective effect of bone marrow stem cells is obtained through animal research. Our goal is to understand the mechanism of renal protection by bone marrow stem cells and to develop strategies utilizing these stem cells for the eventual treatment of humans with kidney disease.

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Acknowledgments

This work was supported by National Institutes of Health (NIH) grants K08 DK062839 and R01 DK66535, and American Society of Nephrology Gottschalk Award. FL is the first recipient of the Norman Siegel Pediatric Research Grant Award. I thank Drs. Peter Igarashi and Michel Baum for helpful discussion and Laurel Johnson for secretarial support.

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  1. Department of Pediatrics and Division of Basic Science, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, 75390, USA

    Fangming Lin

  2. Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX, 75390–9063, USA

    Fangming Lin

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Correspondence to Fangming Lin.

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Lin, F. Renal repair: role of bone marrow stem cells. Pediatr Nephrol 23, 851–861 (2008). https://doi.org/10.1007/s00467-007-0634-8

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  • DOI: https://doi.org/10.1007/s00467-007-0634-8

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