Abstract
Purpose
In theory, a slow oxygen uptake (\(\dot VO_2\)) kinetics leads to a greater accumulation of anaerobic by-products, which can, in turn, induce more neuromuscular fatigue. However, the existence of this relationship has never been tested.
Methods
After two sessions to measure peak \(\dot VO_2\), peak power output (POpeak), and \(\dot VO_2\) kinetics responses in the unfatigued state (τ \(\dot VO_2\) MOD), 10 healthy young adults performed a 6-min cycling bout at 80% POpeak (INT6-min). \(\dot VO_2\) kinetics responses were also measured during INT6-min. Neuromuscular fatigue was measured isometrically pre- and post-INT6-min (immediately post- and 15-s post-INT6-min) with an innovative cycle ergometer.
Results
Maximal voluntary contraction (MVC) force, high-frequency doublet amplitude, and the ratio of low- to high-frequency doublet amplitudes decreased by 34 ± 7, 43 ± 11, and 31 ± 13%, respectively (all P < 0.01). A significant Spearman’s rank correlation was observed between the change in low-frequency doublet force (ΔDb10) immediately after INT6-min and both τ \(\dot VO_2\) MOD and τ \(\dot VO_2\) INT6-min (ρ = −0.68 and ρ = −0.67, both P < 0.05). When considering the largest responses from the two neuromuscular evaluations post-INT6-min, significant correlations were also found between τ \(\dot VO_2\) MOD and ΔDb10 (ρ = −0.74; P < 0.05) and between τ\(\dot VO_2\) INT6-min and both ΔDb10 and low-frequency fatigue (ρ = −0.70 and ρ = −0.66; both P < 0.05).
Conclusion
The present results suggest that subjects with slow \(\dot VO_2\) kinetics experience more peripheral fatigue, in particular more excitation–contraction coupling failure, likely due to a greater accumulation of protons and/or inorganic phosphates.
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Abbreviations
- Amp:
-
Steady-state increase in \(\dot VO_2\) above baseline cycling
- Db10:
-
Force evoked by 10-Hz paired-pulse femoral nerve stimulation
- Db100:
-
Force evoked by 100-Hz paired-pulse femoral nerve stimulation
- GET:
-
Gas exchange threshold
- INT6-min :
-
6-min cycling bout at 80% of peak power output
- [La]:
-
Blood lactate concentration
- MOD:
-
Three step transitions from baseline to an intensity corresponding to the \(\dot VO_2\) at 90% of the GET, performed in session 2
- MVC:
-
Maximal voluntary contraction
- Pi:
-
Inorganic phosphate
- PO:
-
Power output
- POpeak :
-
Peak power output
- POST:
-
Neuromuscular evaluation performed immediately post-exercise
- POST2:
-
Largest responses from the two neuromuscular evaluations post-exercise
- RCP:
-
Respiratory compensation point
- RF:
-
Rectus femoris
- RPE:
-
Rating of perceived exertion
- TD:
-
Time delay
- TwPot:
-
Potentiated twitch
- \(\dot VCO_2\) :
-
Carbon dioxide production
- \(\dot VE\) :
-
Minute ventilation
- VL:
-
Vastus lateralis
- \(\dot VO_2\) :
-
Oxygen uptake
- \(\dot VO_{2peak}\) :
-
Peak oxygen uptake
- Y(t) :
-
\(\dot VO_2\) at any given time (t)
- YBsln :
-
\(\dot VO_2\) at the 20-W baseline
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Acknowledgements
Special thanks are given to John Holash, Andrzej Stano, and the Science Workshop at the University of Calgary for their help in designing the new cycle ergometer.
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Communicated by Nicolas Place.
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Temesi, J., Mattioni Maturana, F., Peyrard, A. et al. The relationship between oxygen uptake kinetics and neuromuscular fatigue in high-intensity cycling exercise. Eur J Appl Physiol 117, 969–978 (2017). https://doi.org/10.1007/s00421-017-3585-1
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DOI: https://doi.org/10.1007/s00421-017-3585-1