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CyberKnife stereotactic radiotherapy for isolated recurrence in the prostatic bed

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World Journal of Urology Aims and scope Submit manuscript

Abstract

Purpose

To report a clinical experience of stereotactic body radiation therapy (SBRT) for isolated recurrence in the prostatic bed from prostate cancer.

Materials and methods

Between November 2011 and November 2013, 16 patients were treated with SBRT for a macroscopic isolated recurrence of prostate cancer in the prostatic bed. All patients were initially treated with radical prostatectomy, and half of them also received radiotherapy. Two schedules of SBRT were used: 30 Gy in 5 fractions in previously irradiated patients, 35 Gy in five fractions in radiotherapy-naïve patients.

Results

At a median follow-up of 10 months (range 2–21 months), a significant biochemical response was found in all but one patient. At imaging evaluation, no local progression was noted: 10 patients showed partial response while four stable disease. At the moment of analysis, all 16 patients were alive. Seven of them experienced distant relapse, while nine maintained biochemical control, with no further therapy. Median time to relapse was 9.3 months (range 3–15.2 months). The treatment was well tolerated: One patient experienced G2 acute genitourinary and gastrointestinal toxicity.

Conclusions

Our experience shows that SBRT with CyberKnife for isolated nodal relapse is a safe and well-tolerated treatment.

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Conflict of interest

None.

Ethical standard

This study has been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.

Informed consent

All patients gave their informed consent to treatment.

Author information

Authors and Affiliations

  1. Radiotherapy Unit, Azienda Ospedaliera Universitaria Careggi, University of Florence, Largo G.A. Brambilla 3, Florence, Italy

    B. Detti, P. Bonomo, D. Franceschini, L. Di Brina, M. Baki, G. Simontacchi, I. Meattini & L. Livi

  2. CyberKnife Center- I.F.C.A (Istituto Fiorentino di Cura ed Assistenza), University of Florence, Florence, Italy

    L. Masi, R. Doro, S. Cipressi, C. Iermano & I. Bonucci

  3. Urology Unit, Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy

    M. Carini, S. Serni & G. Nicita

Authors
  1. B. Detti
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  2. P. Bonomo
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  3. L. Masi
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  4. R. Doro
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  5. S. Cipressi
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  6. C. Iermano
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  7. I. Bonucci
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  8. D. Franceschini
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  9. L. Di Brina
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  10. M. Baki
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  11. G. Simontacchi
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  12. I. Meattini
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  13. M. Carini
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  14. S. Serni
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  15. G. Nicita
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  16. L. Livi
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Corresponding author

Correspondence to D. Franceschini.

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Cite this article

Detti, B., Bonomo, P., Masi, L. et al. CyberKnife stereotactic radiotherapy for isolated recurrence in the prostatic bed. World J Urol 34, 311–317 (2016). https://doi.org/10.1007/s00345-015-1613-5

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  • DOI: https://doi.org/10.1007/s00345-015-1613-5

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