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Anatomic radical retropubic prostatectomy—long-term recurrence-free survival rates for localized prostate cancer

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Abstract

Radical prostatectomy remains the mainstay for the treatment of localized prostate cancer. Long-term follow-up data showed excellent cancer control rates in several prostatectomy series. We report biochemical recurrence (BCR) outcomes after radical retropubic prostatectomy (RRP) in a European single center series of patients treated over a 13-year period. Between 1992 and 06/2005, 4,277 consecutive men underwent a RRP at the University Hospital Hamburg Eppendorf, Germany. Kaplan-Meier probabilities of BCR-free survival were determined for those patients with complete preoperative data, postoperative data, and follow-up information. Uni-and multivariate Cox regression models addressed PSA recurrence, defined as a PSA level ≥0.1 ng/ml. Overall, BCR-free survival ranged between 84, 70 and 61% for 2, 5, and 8 years, respectively. In univariate and multivariate analyses, except for age and type of nerve-sparing technique, all traditional clinical and pathological variables represented statistically independent predictors of PSA recurrence-free survival (all P≤0.001). In organ-confined disease, the 10-year recurrence free survival rate was 80 and 30% in non-organ-confined cancers. Our findings confirm excellent long-term biochemical cancer-control outcomes after RRP. High grade prostate cancer at final pathology and seminal vesicle invasion proved to be the strongest risk factors of BCR after surgery.

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Authors and Affiliations

  1. Department of Urology, University Medical Center Eppendorf, Hamburg, Germany

    Felix K.-H. Chun, Markus Graefen, Mario Zacharias, Alexander Haese, Thomas Steuber, Thorsten Schlomm, Jochen Walz & Hartwig Huland

  2. Martini-Clinic, Prostate Cancer Center, University Medical Center Eppendorf, MartinistraBe 52, 20246, Hamburg, Germany

    Markus Graefen & Hartwig Huland

  3. Cancer Prognostics and Health Outcomes Unit, University of Montreal, Montreal, Quebec, Canada

    Felix K.-H. Chun & Pierre I. Karakiewicz

Authors
  1. Felix K.-H. Chun
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  2. Markus Graefen
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  3. Mario Zacharias
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  4. Alexander Haese
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  5. Thomas Steuber
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  6. Thorsten Schlomm
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  7. Jochen Walz
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  8. Pierre I. Karakiewicz
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  9. Hartwig Huland
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Correspondence to Markus Graefen.

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Chun, F.KH., Graefen, M., Zacharias, M. et al. Anatomic radical retropubic prostatectomy—long-term recurrence-free survival rates for localized prostate cancer. World J Urol 24, 273–280 (2006). https://doi.org/10.1007/s00345-006-0058-2

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  • DOI: https://doi.org/10.1007/s00345-006-0058-2

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