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Gum acacia polysaccharide-based pH sensitive gels for targeted delivery of neridronate

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Abstract

The preparation of polysaccharide-based gels from a combination of natural and synthetic polymers results in polymer networks with unique physicochemical properties. Polysaccharide-based gels were prepared from a combination of gum acacia, a polysaccharide, and synthetic polymers using the free radical polymerization technique. The gels were characterized by XRD, DSC, SEM, and FTIR. The swelling abilities of the gels were performed at pH 1.2 and 7.4. Release kinetic studies of neridronate from the prepared gels were performed and the release mechanism was found to be super case transport II at pH 1.2 and pH 7.4. The gels were pH sensitive and the release profile of neridronate from the gels network was influenced by the degree of cross-linking of their network and pH. The preliminary results suggest that these gels are promising devices for targeted delivery of neridronate to the gastrointestinal region.

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Acknowledgements

The financial assistance of the Medical Research Council and National Research Foundation, South Africa towards this research are hereby acknowledged. The views and opinions expressed in this manuscript are those of the authors and not of MRC or NRF.

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Authors and Affiliations

  1. Department of Chemistry, University of Fort Hare, Alice Campus, Alice, Eastern Cape, South Africa

    B. A. Aderibigbe

  2. DST/CSIR National Centre for Nanostructured Materials, Council for Scientific and Industrial Research, Pretoria, 0001, South Africa

    Suprakas Sinha Ray

  3. Department of Applied Chemistry, University of Johannesburg, Doornfontein, Johannesburg, 2028, South Africa

    Suprakas Sinha Ray

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  1. B. A. Aderibigbe
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Correspondence to B. A. Aderibigbe.

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Aderibigbe, B.A., Ray, S.S. Gum acacia polysaccharide-based pH sensitive gels for targeted delivery of neridronate. Polym. Bull. 74, 2641–2655 (2017). https://doi.org/10.1007/s00289-016-1857-2

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  • DOI: https://doi.org/10.1007/s00289-016-1857-2

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