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Effects of isoniazid (INH) on the oogenesis of mice

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Summary

Mutagenic damages in female germ, cells of mice have been tested with the dominant, lethal assay and the cytogenetic analysis of unfertilized M II-oocytes. Concluding one can say that from the experimental data presented here do not show any mutagenic effect of INH on oogenesis of different strains of mice can be stated.

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References

  • Ehling, U. H., Cumming, R. B., Malling, H. W.: Induction of dominant lethal mutations by alkylating agents in male mice. Mut. Res. 5, 417–428 (1968)

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  • Röhrborn, G., Hansmann, I.: Induced chromosome aberrations in unfertilized oocytes of mice. Humangenetik 13, 184–198 (1971)

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Authors and Affiliations

  1. Institut für Humangenetik und Anthropologie der Universität, Düsseldorf, Federal Republic of Germany

    G. Röhrborn & V. Sezer

  2. Abteilung Genetik der Gesellschaft für Strahlen- und Umweltforschung, Institut für Biologie, Neuherberg bei München, Federal Republic of Germany

    I. -D. Adler & A. Schmaltz

  3. Institut für Humangenetik der Universität, Münster, Federal Republic of Germany

    I. H. Pawlowitzki & Ch. Nautsch

Authors
  1. G. Röhrborn
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  2. V. Sezer
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  3. I. -D. Adler
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  4. A. Schmaltz
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  5. I. H. Pawlowitzki
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  6. Ch. Nautsch
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Röhrborn, G., Sezer, V., Adler, I.D. et al. Effects of isoniazid (INH) on the oogenesis of mice. Hum Genet 42, 55–58 (1978). https://doi.org/10.1007/BF00291624

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  • DOI: https://doi.org/10.1007/BF00291624

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