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arNOX: New Mechanisms of Skin Aging and Lipoprotein Oxidation

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Textbook of Aging Skin

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Abstract

The discovery of a family of cell surface age-related ECTO-NOX proteins, designated as arNOX or ENOX3 capable of generating superoxide which can then dismutase to form hydrogen peroxide as well as the directly oxidized tyrosines and protein thiols, has led to new mechanisms of skin aging applicable, as well, to lipoprotein oxidation and atherogenesis. The arNOX proteins are shed from the cell surface where they enter body fluids and permeate interstitial spaces as a major contributor to skin aging. As introduced in an accompanying chapter, arNOX proteins increase with age beginning about age 30 to a maximum by about age 60. Their activity is reversibly blocked by coenzyme Q and by a variety of herbal infusions including savory, estragon, basil, marjoram, rosemary, and sage as well as their phenolic constituents such as gallic acid. As staples of the French diet, these herbal sources of safe and effective arNOX inhibitors offer a possible explanation for the French paradox of reduced atherogenic risk despite a cholesterol-rich diet high in butter and cheese. Formation of malondialdehyde-like products involved in serum lipoprotein oxidation correlates with arNOX levels.

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Authors and Affiliations

  1. MorNuCo, Inc, 1201B Cumberland Avenue, West Lafayette, IN, 47906, USA

    D. J. Morré & D. M. Morré

Authors
  1. D. J. Morré
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  2. D. M. Morré
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Correspondence to D. J. Morré .

Editor information

Editors and Affiliations

  1. Procter & Gamble Co., Cincinnati, Ohio, USA

    Miranda A. Farage

  2. Procter & Gamble Co., Cincinnati, Ohio, USA

    Kenneth W. Miller

  3. Department Dermatology, University of California, San Francisco School of Medicine, San Francisco, California, USA

    Howard I. Maibach

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Morré, D.J., Morré, D.M. (2015). arNOX: New Mechanisms of Skin Aging and Lipoprotein Oxidation. In: Farage, M., Miller, K., Maibach, H. (eds) Textbook of Aging Skin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27814-3_115-1

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  • DOI: https://doi.org/10.1007/978-3-642-27814-3_115-1

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-27814-3

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