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Paraneoplastische Neuropathien

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Pathologie

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Zusammenfassung

Neben einer direkten Invasion der Spinalwurzeln, der großen Nervenplexus oder isolierter peripherer Nerven durch Karzinome gibt es periphere Neuropathien, die paraneoplastisch entstehen, also nicht auf eine direkte Invasion durch maligne Zellen zurückzuführen sind. Diese treten speziell bei Bronchialkarzinomen auf und können unterteilt werden in eine subakute sensorische Neuropathie und seltenere Fälle einer sensomotorischen Neuropathie. Letztere können weiter unterteilt werden in akute, subakute und chronische Formen; rekurrierende Formen sind ebenfalls beobachtet worden. Es handelt sich um symmetrische Polyneuropathien, die in der Regel distal akzentuiert sind. Bei den lymphoretukulären Krankheiten ist manchmal nicht zu unterscheiden, ob sie paraneoplastisch oder metastatisch bedingt sind. Deshalb werden sie hier und nicht bei den Tumoren beschrieben. Im Einzelnen sind es Neuropathien bei: Lymphomen, Leukämien, Myelomen (Plasmozytomen), bei der Polyzythaemia vera rubra, den Dys- und Paraproteinämien, den benignen monoklonalen Paraproteinämien, der Waldenström-Makroglobulinämie und den Kryoglobulinämien.

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  1. Institut für Neuropathologie, Universitätsklinikum der Rheinisch-Westfälischen Technischen Hochschule (RWTH) Aachen, Pauwelsstraße 30, 52074, Aachen, Deutschland

    J. Michael Schröder

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  1. Institut für Pathologie Konsultationszentrum für Pankreas- und Endokrine Tumore, TU München, Ismaninger Straße 22, 81675, München, Deutschland

    Günter Klöppel (Werkherausgeber) (Werkherausgeber)

  2. Zentrum Pathologie und Rechtsmedizin, Medizinische Hochschule Hannover (MHH), Carl-Neuberg-Straße 1, 30625, Hannover, Deutschland

    Hans H. Kreipe (Werkherausgeber) (Werkherausgeber)

  3. Institut für Pathologie, Kliniken der Landeshauptstadt, Ludwig-Erhard-Straße 100, 65199, Wiesbaden, Deutschland

    Wolfgang Remmele (Werkherausgeber) (Werkherausgeber)

  4. Institut für Neuropathologie, Universitätsklinikum Münster, Domagkstraße 19, 48149, Münster, Deutschland

    Werner Paulus (Bandherausgeber) (Bandherausgeber)

  5. Institut für Neuropathologie, Universitätsklinikum der Rheinisch-Westfälischen Technischen Hochschule (RWTH) Aachen, Pauwelsstraße 30, 52074, Aachen, Deutschland

    J. Michael Schröder (Bandherausgeber) (Bandherausgeber)

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Schröder, J. (2012). Paraneoplastische Neuropathien. In: Klöppel, G., Kreipe, H., Remmele, W., Paulus, W., Schröder, J. (eds) Pathologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-02324-8_27

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