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Anatomic and Morphologic Classifications of Cholangiocarcinoma

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Diagnosis and Management of Cholangiocarcinoma

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Abstract

Cholangiocarcinoma (CCA) is a malignant tumor that can arise from any part of the biliary tree. Anatomically, these tumors are separated into three categories based on their site of origin: intrahepatic, perihilar, and distal CCA. The morphologies, risk factors, presentation, treatment, and outcomes for each anatomic category are often variable but sometimes overlap. To that end, the American Joint Committee on Cancer (AJCC) assesses CCA by the three anatomic categories. This chapter explores the anatomic classifications and the common morphologies for each. We also review clinical and pathological staging according to the AJCC staging manual.

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Abbreviations

AJCC:

American Joint Committee on Cancer

CCA:

Cholangiocarcinoma

dCCA:

Distal cholangiocarcinoma

iCCA:

Intrahepatic cholangiocarcinoma

IG:

Intraductal growing

LCSGJ:

The Liver Cancer Study Group of Japan

MF:

Mass-forming

MSKCC:

Memorial Sloan Kettering Cancer Center

pCCA:

Perihilar cholangiocarcinoma

PI:

Periductal infiltrating

TNM:

Tumor, lymph node, metastases

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Authors and Affiliations

  1. Department of Surgery, University of California, Los Angeles, Los Angeles, CA, USA

    Michael A. Mederos & Mark D. Girgis

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  1. Michael A. Mederos
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  2. Mark D. Girgis
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Corresponding author

Correspondence to Mark D. Girgis .

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Editors and Affiliations

  1. Division of Gastroenterology, Department of Medicine, Olive View-UCLA Medical Center, Sylmar, CA, USA

    James H. Tabibian

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Mederos, M.A., Girgis, M.D. (2021). Anatomic and Morphologic Classifications of Cholangiocarcinoma. In: Tabibian, J.H. (eds) Diagnosis and Management of Cholangiocarcinoma. Springer, Cham. https://doi.org/10.1007/978-3-030-70936-5_2

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  • DOI: https://doi.org/10.1007/978-3-030-70936-5_2

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-70935-8

  • Online ISBN: 978-3-030-70936-5

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