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Utilization of Marrow Stromal Cells for Gene Transfer into the CNS

  • Chapter
Neural Stem Cells for Brain and Spinal Cord Repair

Part of the book series: Contemporary Neuroscience ((CNEURO))

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Abstract

In the past several decades, neurotransplantation has been investigated for the study of development of the normal nervous system and possible functional restoration and repair of diseased and damaged nervous tissue (1,2). In patients with Parkinson’s disease, transplantation of dopamine-producing human and pig fetal tissues has resulted in varying degrees of clinical improvements, which correlated with graft survival and anatomical integration of the grafted fetal cells into the host brain (3–5), albeit, the control of dopamine release remains an issue (5). In animal studies, implantation of neural stem cells and partially differentiated embryonic stem cells into lesioned brain and spinal cord resulted in more rapid behavioral improvement in experimental models of spinal cord injury, stroke, and neurotrauma (6–11). Although implantation of embryonic stem cells can be a promising method of cell therapy, obtaining fetal and embryonic tissues has presented major logistical, ethical, and immunological barriers (12,13). Thus, autologous cells from the bone marrow, marrow stromal cells, can be an attractive alternative source of tissue for grafting and treatment of neurological diseases (11).

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Authors
  1. S. Ausim Azizi
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  2. Emily J. Schwarz
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  3. Darwin Prockop
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  4. Guillermo Alexander
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  5. Katherine A. Mortati
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  6. Barbara Krynska
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Editor information

Editors and Affiliations

  1. Center for Aging and Brain Repair, Departments of Neurosurgery, Anatomy and Pharmacology, University of South Florida College of Medicine, Tampa, FL, USA

    Tanja Zigova PhD

  2. Department of Neurology, Harvard Medical School, Harvard Institutes of Medicine & Beth Israel-Deaconess Medical Center, Division of Newborn Medicine, Children’s Hospital-Boston, Boston, MA, USA

    Evan Y. Snyder MD, PhD

  3. Center for Aging and Brain Repair, Departments of Neurosurgery, Neurology, Psychiatry and Pharmacology, University of South Florida College of Medicine, Tampa, FL, USA

    Paul R. Sanberg PhD, DSc

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© 2003 Springer Science+Business Media New York

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Azizi, S.A., Schwarz, E.J., Prockop, D., Alexander, G., Mortati, K.A., Krynska, B. (2003). Utilization of Marrow Stromal Cells for Gene Transfer into the CNS. In: Zigova, T., Snyder, E.Y., Sanberg, P.R. (eds) Neural Stem Cells for Brain and Spinal Cord Repair. Contemporary Neuroscience. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-298-2_15

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  • DOI: https://doi.org/10.1007/978-1-59259-298-2_15

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-298-8

  • Online ISBN: 978-1-59259-298-2

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