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Neural Stem Cells for Brain and Spinal Cord Repair

  • Tanja Zigova
  • Evan Y. Snyder
  • Paul R. Sanberg

Part of the Contemporary Neuroscience book series (CNEURO)

Table of contents

  1. Front Matter
    Pages i-xix
  2. Stem Cells for and from the CNS

    1. Front Matter
      Pages 1-1
    2. Melissa K. Carpenter, Mark Mattson, Mahendra S. Rao
      Pages 3-44
    3. Angela Gritti, Angelo Vescovi, Rossella Galli
      Pages 45-68
    4. Martha Windrem, Neeta Roy, Marta Nunes, Steven A. Goldman
      Pages 69-88
    5. Eiji Nakagawa, Kozo Hatori, Atsushi Nagai, Hyun B. Choi, Myung A. Lee, Jung H. Bang et al.
      Pages 89-106
    6. Shijie Song, Paul Sanberg, Juan Sanchez-Ramos
      Pages 107-131
  3. In Vitro and/or In Vivo Manipulations of Stem/Progenitor Cells for the CNS

    1. Front Matter
      Pages 133-133
    2. Dennis A. Steindler, Bjorn Scheffler, Eric D. Laywell, Oleg N. Suslov, Tong Zheng, Thomas Reiniger et al.
      Pages 183-201
    3. Sanjay S. Magavi, Jeffrey D. Macklis
      Pages 229-267
    4. Jasodhara Ray, Daniel A. Peterson
      Pages 269-286
  4. Stem/Progenitor Cells in Representative Therapeutic Paradigms for the CNS

    1. Front Matter
      Pages 287-287
    2. Kook In Park, James J. Palacino, Roseanne Taylor, Karen S. Aboody, Barbara A. Tate, Vaclav Ourednik et al.
      Pages 289-332
    3. Yang D. Teng, Mary Katherine White, Erin Lavik, Shaoxiang Liu, Mahesh Lachyankar, Kook In Park et al.
      Pages 333-345
    4. Paul Lu, Evan Y. Snyder, Mark H. Tuszynski
      Pages 347-365
    5. Martin Marsala, Osamu Kakinohana, Tony L. Yaksh, Joho Tokumine
      Pages 367-393
    6. S. Ausim Azizi, Emily J. Schwarz, Darwin Prockop, Guillermo Alexander, Katherine A. Mortati, Barbara Krynska
      Pages 395-409
    7. Cesario V. Borlongan, Paul R. Sanberg
      Pages 411-429
  5. Back Matter
    Pages 431-434

About this book

Introduction

Although neural stem cells (NSCs) have been successfully used in animal models of various neurodegenerative diseases and of brain and spinal cord injuries, their use in studies of nervous system dysfunction is still in its infancy. In Neural Stem Cells for Brain and Spinal Cord Repair, active neuroscientists survey NSCs as potential tools for central nervous system and spinal cord repair by explaining their clinically significant fundamental properties, manipulations, and potential therapeutic paradigms. Their discussion of the fundamental biology of NSCs illustrates the signaling pathways that regulate stem cell division and differentiation, and defines the methods of NSC expansion and propagation, neuromorphogenesis, the factors determining cell fate both in vitro and in situ, and the induction of self-reparative processes within the brain. They also present strategies that may lead to fruitful clinical applications in the near future. These range from the replacement of degenerated, dysfunctional, or maldeveloped cells to the provision of factors (either produced intrinsically by the cells or induced to do so following genetic engineering) that may protect, correct, recruit, promote self-repair, or mediate the connectivity of host cells.
Comprehensive and up-to-date, Neural Stem Cells for Brain and Spinal Cord Repair provides the first systematic overview of the biological properties and functional characteristics of NSCs, as well as outlining of several possible areas of medicine and therapy where these cells may soon prove extremely helpful.

Keywords

Nervous System Vivo cell division clinical application gene transfer neurons

Editors and affiliations

  • Tanja Zigova
    • 1
  • Evan Y. Snyder
    • 2
  • Paul R. Sanberg
    • 3
  1. 1.Center for Aging and Brain Repair, Departments of Neurosurgery, Anatomy and PharmacologyUniversity of South Florida College of MedicineTampaUSA
  2. 2.Department of Neurology, Harvard Medical School, Harvard Institutes of Medicine & Beth Israel-Deaconess Medical Center, Division of Newborn MedicineChildren’s Hospital-BostonBostonUSA
  3. 3.Center for Aging and Brain Repair, Departments of Neurosurgery, Neurology, Psychiatry and PharmacologyUniversity of South Florida College of MedicineTampaUSA

Bibliographic information