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Breast Cancer

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Family Medicine

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Abstract

Except for skin cancer, breast cancer is the most common cancer in women worldwide, and it is the leading cause of cancer-related mortality, with almost 50 % of cases and nearly 60 % of deaths occurring in lower-income countries. For women in the United States (USA), it is the most common cancer, the second most common cause of cancer-related mortality, and the leading cause of cancer-related mortality in women age 20–59. Family physicians play an important role in screening, diagnosis, and follow-up of breast cancer patients and can be a valuable part of a multidisciplinary team approach.

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References

  1. Shah R, Rosso K, Nathanson DS. Pathogenesis, prevention, diagnosis and treatment of breast cancer. World J Clin Oncol. 2014;5(3):283–98.

    Article  PubMed Central  PubMed  Google Scholar 

  2. Tirona MT. Breast cancer screening update. Am Fam Physician. 2013;87(4):274–8.

    Google Scholar 

  3. DeSantis C, Siegel R, Bandi P, et al. Breast cancer statistics, 2011. CA Cancer J Clin. 2011;61:409–18.

    Article  PubMed  Google Scholar 

  4. Siegel R, Ma J, Zou Z, Jemal A. Cancer statistics, 2014. CA Cancer J Clin. 2014;64(1):9–29.

    Article  PubMed  Google Scholar 

  5. Maly RC, Liu Y, Diamant AL, et al. The impact of primary care physicians on follow-up care of underserved breast cancer survivors. J Am Board Fam Med. 2013;26:628–36.

    Article  PubMed Central  PubMed  Google Scholar 

  6. Afonso N. Women at high risk for breast cancer-what the primary care provider needs to know. J Am Board Fam Med. 2009;22:43–50.

    Article  PubMed  Google Scholar 

  7. Thind A, Liu Y, Maly R. Patient satisfaction with breast cancer follow-up care provided by family physicians. J Am Board Fam Med. 2011;24(6):701–16.

    Article  Google Scholar 

  8. Lewis RA, Neal RD, Williams NH, et al. Follow-up of cancer in primary care versus secondary care: systematic review. Br J Gen Pract. 2009;59(564):e234–47.

    Article  PubMed Central  PubMed  Google Scholar 

  9. Vanhuyse M, Bedard PL, Sheiner J, et al. Transfer of follow-up care to family physicians for early-stage breast cancer. Clin Oncol. 2007;9(3):172–6.

    Article  Google Scholar 

  10. Bowman M, Neale AV. Family physicians improve patient health care quality and outcomes. J Am Board Fam Med. 2013;26:617–9.

    Article  PubMed  Google Scholar 

  11. Jemal A, Siegel R, Ward E, et al. Cancer statistics. CA Cancer J Clin. 2009;59:225–49.

    Article  PubMed  Google Scholar 

  12. Hicks DG, Lester SC. Diagnostic pathology breast. Utah: Amirsys; 2012.

    Google Scholar 

  13. DeSantis CE, Lin CC, Mariotto AB, et al. Cancer treatment and survivorship statistics. CA Cancer J Clin. 2014;64:252–71.

    Article  PubMed  Google Scholar 

  14. Lifetime risk (percent) of being diagnosed with cancer by site and race/ethnicity: males, 18 SEER areas, 2009–2011 (Table 1.16). http://seer.cancer.gov/csr/1975_2011/results_merged/topic_lifetime_risk_diagnosis.pdf. Accessed 22 Dec 2014.

  15. Lifetime risk (percent) of dying from cancer by site and race/ethnicity: males, total US, 2009–2011 (Table 1.19). http://seer.cancer.gov/csr/1975_2011/results_merged/topic_lifetime_risk_death.pdf. Accessed 22 Dec 2014.

  16. Anderson GL, Chlebowski RT, Aragaki AK, et al. Conjugated equine oestrogen and breast cancer incidence and mortality in postmenopausal women with hysterectomy: extended follow-up of the Women’s Health Initiative randomized placebo-controlled trial. Lancet Oncol. 2012;13:476–86.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  17. Lakhani SR, Ellis IO, Schnitt SJ, et al., editors. WHO classification of tumours of the breast, vol. 4. Lyon: IARC press; 2012.

    Google Scholar 

  18. Kassirer J, Wong J, Kopelman R. Learning clinical reasoning. 2nd ed. Baltimore: Lippincott Williams & Wilkins; 2010.

    Google Scholar 

  19. Ohm F, Vogel D, Sehner S, et al. Details acquired from medical history and patients’ experience of empathy – two sides of the same coin. BMC Med Educ. 2013;13:67.

    Article  PubMed Central  PubMed  Google Scholar 

  20. Sabatino SA, McCarthy EP, Phillips RS, et al. Breast cancer risk assessment and management in primary care: provider attitudes, practices, and barriers. Cancer Detect Prev. 2007;31(5):375–83.

    Article  PubMed  Google Scholar 

  21. Malone KE, Daling JR, Doody DR. Prevalence and predictors of BRCA1 and BRCA2 mutations in a population-based study of breast cancer in white and black american women ages 35–64 years. Cancer Res. 2006;66:8297–308.

    Article  CAS  PubMed  Google Scholar 

  22. Karami F, Parvin M. A comprehensive focus on global spectrum of BRCA1 and BRCA2 in breast cancer. BioMed Res Int. 2013;2013:1–21.

    Article  Google Scholar 

  23. Hartmann LC, Radisky DC, Frost MH, et al. Understanding the premalignant potential of atypical hyperplasia through its natural history: a longitudinal cohort study. Cancer Prev Res. 2014;7(2):211–7.

    Article  CAS  Google Scholar 

  24. Danforth DN. Disparities in breast cancer outcomes between Caucasian and African-American women: a model for describing the relationship of biological and nonbiological factors. Breast Cancer Res. 2013;15(3):208.

    Article  PubMed Central  PubMed  Google Scholar 

  25. The Women’s Health Initiative Study Group. Design of the Women’s Health Initiative clinical trial and observational study. Control Clin Trials. 1998;19(1):61–109.

    Google Scholar 

  26. Anderson GL, Limacher M, Assaf AR. Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women’s Health Initiative randomized controlled trial. JAMA. 2004;29(14):1701–12.

    Google Scholar 

  27. Schmidt P. The 2012 hormone therapy position statement of the North American Menopause Society. Menopause. 2012;19:257–71.

    PubMed Central  Google Scholar 

  28. Gurney EP, Nachtigall MJ, Nachtigall LE, et al. The women’s health initiative trial and related studies: 10 years later: a clinician’s view. J Steroid Biochem Mol Biol. 2014;142:4–11.

    Article  CAS  PubMed  Google Scholar 

  29. Chlebowski RT, Anderson GL. Changing concepts: menopausal hormone therapy and breast cancer. Natl Cancer Inst. 2012;104:517–27.

    Article  CAS  Google Scholar 

  30. Gail MH, Brinton LA, Byar DP, et al. Projecting individualized probabilities of developing breast cancer for white females who are being examined annually. J Natl Cancer Inst. 1989;81:1879–86.

    Article  CAS  PubMed  Google Scholar 

  31. Benichou J, Gail MH, Mulvihill JJ. Graphs to estimate an individualized risk of breast cancer. J Clin Oncol. 1996;14:103–10.

    CAS  PubMed  Google Scholar 

  32. Claus EB, Risch N, Thompson WD. Autosomal dominant inheritance of early-onset breast cancer. Implications for risk prediction. Cancer. 1994;73:643–51.

    Article  CAS  PubMed  Google Scholar 

  33. Berry DA, Iversen ES, Gudbjartsson DF, et al. BRCAPRO validation, sensitivity of genetic testing of BRCA1/BRCA2, and prevalence of other breast cancer susceptibility genes. J Clin Oncol. 2002;20:2701–12.

    Article  CAS  PubMed  Google Scholar 

  34. Parmigiani G, Chen S, Iversen ES, et al. Validity of models for predicting BRCA1 and BRCA2 mutations. Ann Intern Med. 2007;147:441–50.

    Article  PubMed Central  PubMed  Google Scholar 

  35. Tyrer J, Duffy SW, Cuzick J. A breast cancer prediction model incorporating familial and personal risk factors. Stat Med. 2004;23:1111–30.

    Article  PubMed  Google Scholar 

  36. Jacobi CE, de Bock GH, Siegerink B, et al. Differences and similarities in breast cancer risk assessment models in clinical practice: which model to choose? Breast Cancer Res Treat. 2009;115(2):381–90.

    Article  CAS  PubMed  Google Scholar 

  37. Nelson AL. Controversies involving mammography, breast self-examination, and clinical breast examination. Obstet Gynecol Clin North Am. 2013;40(3):413–27.

    Article  PubMed  Google Scholar 

  38. Smith RA, Saslow D, Sawyer KA, et al. American Cancer Society guidelines for breast cancer screening: update 2003. CA Cancer J Clin. 2003;53(3):141–69.

    Article  PubMed  Google Scholar 

  39. Preventive US. Services Task Force. Screening for breast cancer: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med. 2009;151(10):716–26.

    Article  Google Scholar 

  40. U.S. Preventive Services Task Force. Breast cancer: screening. http://www.uspreventiveservicestaskforce.org/Page/Document/UpdateSummaryDraft/breast-cancer-screening. Accessed 22 Dec 2014.

  41. Mainiero MB, Lourenco A, Mahoney MC, et al. ACR appropriateness criteria breast cancer screening. J Am Coll Radiol. 2013;10:11–4.

    Article  PubMed  Google Scholar 

  42. Griffin JL, Pearlman MD. Breast cancer screening in women at average risk and high risk. Obstet Gynecol. 2010;116(6):1410–21.

    Article  PubMed  Google Scholar 

  43. Smith RA, Cokkinides V, Brawley OW. Cancer screening in the United States, 2009: a review of current American Cancer Society guidelines and issues in cancer screening. CA Cancer J Clin. 2009;59(1):27–41.

    Article  PubMed  Google Scholar 

  44. National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology. Breast cancer screening and diagnosis, version 1.2014. http://www.nccn.org/professionals/physician_gls/pdf/breast-screening.pdf [registration required]. Accessed 22 Dec 2014.

  45. Scott S, Morrow M. Breast cancer. Making the diagnosis. Surg Clin North Am. 1999;79(5):991–1005.

    Article  CAS  PubMed  Google Scholar 

  46. National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology. Breast cancer, version 3.2014. http://www.nccn.org/professionals/physician_gls/pdf/breast.pdf [registration required]. Accessed 10 Dec 2014.

  47. Clarke M, Collins R, Darby S, et al. Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials. Lancet. 2005;366:2087–106.

    Article  CAS  PubMed  Google Scholar 

  48. Grunfield E, Fitzpatrick R, Mant D, et al. Comparison of breast cancer patient satisfaction with follow-up in primary care versus specialist care: results from a randomized controlled trial. Br J Gen Pract. 1999;49(446):705–10.

    Google Scholar 

  49. Grunfield E, Levine MN, Julian JA. Randomized trial of long-term follow-up for early-stage breast cancer: a comparison of family physician versus specialist care. J Clin Oncol. 2006;24(6):848–55.

    Article  Google Scholar 

  50. Edge S, Byrd DR, Compton CC, et al., editors. AJCC cancer staging manual. 7th ed. Chicago: American Joint Committee on Cancer; 2009.

    Google Scholar 

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Author information

Authors and Affiliations

  1. School of Medicine and Dentistry Strong Health Highland Hospital, University of Rochester Medical Center, 601 Elmwood Ave, Box 626, Rochester, NY, 14642, USA

    Bradley M. Turner & David G. Hicks

Authors
  1. Bradley M. Turner
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  2. David G. Hicks
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Correspondence to Bradley M. Turner .

Editor information

Editors and Affiliations

  1. Department of Family Medicine, University of Nebraska, Omaha, Nebraska, USA

    Paul Paulman

  2. Virginia Beach, Virginia, USA

    Robert Taylor

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© 2014 Springer International Publishing Switzerland

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Turner, B.M., Hicks, D.G. (2014). Breast Cancer. In: Paulman, P., Taylor, R. (eds) Family Medicine. Springer, Cham. https://doi.org/10.1007/978-1-4939-0779-3_114-1

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  • DOI: https://doi.org/10.1007/978-1-4939-0779-3_114-1

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  • Publisher Name: Springer, Cham

  • Online ISBN: 978-1-4939-0779-3

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