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Tissue Transplantation

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Bibliography

  • Abt P, Shaked A. 2003. The allograft immune response. Graft. 6:71–79.

    Article  CAS  Google Scholar 

  • Alegre ML, Najafian N. 2006. Costimulatory molecules as targets for the induction of transplantation tolerance. Curr Mol Med. 6:843–857.

    Article  PubMed  CAS  Google Scholar 

  • Antin JH, Ferrara JL. 1992. Cytokine dysregulation and acute graft vs host disease. Blood. 80:2964–2968.

    PubMed  CAS  Google Scholar 

  • Arkelov A, Lakkis FG. 2000. The alloimmune response and effector mechanisms of allograft rejection. Semin Nephrol. 20:95–102.

    Google Scholar 

  • Azuma H, Tilney NL. 1995. Immune and nonimmune mechanisms of chronic rejection of kidney allografts. J Heat Lung Transplant. 14:S136–S142.

    CAS  Google Scholar 

  • Bellgrau D, Gold D, Selawry H, Moore J, et al. 1995. A role for CD95 ligand in preventing graft rejection. Nature. 377:630–632.

    Article  PubMed  CAS  Google Scholar 

  • Benichou G, Fedoseyeva EV. 1996. The contribution of peptides to T cell allorecognition and allograft rejection. Int Rev Immunol. 13:231–243.

    Article  PubMed  CAS  Google Scholar 

  • Benjamin LC, Allan JS, Madsen JC. 2002. Cytokines in immunity and allograft rejection. Crit Rev Immunol. 22:269–279.

    PubMed  CAS  Google Scholar 

  • Betkowski AS, Graff R, Chen JJ, Hauptman PJ. 2002. Panel- reactive antibody screening practices prior to heart transplantation. J Heart Lung Transplant. 21:644–650.

    Article  PubMed  Google Scholar 

  • Billingham RE. 1966. The biology of graft-versus-host reactions. Harvey Lect. 67:21–78.

    Google Scholar 

  • Bishop DK, Shelby J, Eichwald EJ. 1992. Mobilization of T lymphocytes following cardiac transplantation. Evidence that CD4- positive cells are required for cytotoxic T lymphocyte activation, inflammatory endothelial development, graft infiltration and acute allograft rejection. Transplantation. 53:849–857.

    Article  PubMed  CAS  Google Scholar 

  • Bishop DK, Li W, Chan SY, Ensley RD, et al. 1994. Helper T lymphocytes unresponsiveness to cardiac allografts following transient depletion of CD4-positive cells. Implications for cellular and humoral responses. Transplantation. 58:576–584.

    Article  PubMed  CAS  Google Scholar 

  • Brent L. 1997. History of Transplantation Immunology. Academic Press, San Diego, CA.

    Google Scholar 

  • Broelsch CE, Burdelski M, Rogiers X, Gundlach M, et al. 1994. Living donor for liver transplantation. Hepatology. 20:49S–55S.

    PubMed  CAS  Google Scholar 

  • Bromberg JS, Murphy B. 2001. Routes to allograft survival. J Clin Inv. 107:797–798.

    Article  CAS  Google Scholar 

  • Brook NR, Nicholson ML. 2003. Kidney transplantation from non heart-beating donors. Surgeon. 1:311–322.

    Article  PubMed  CAS  Google Scholar 

  • Bucin D. 1988. Blood transfusion in renal transplantation – The induction of tolerance by incompatibility for class I antigen. Med Hypothesis. 27:19–27.

    Article  CAS  Google Scholar 

  • Chalasani G, Li Q, Konieczny BT, Smith-Diggs L, et al. 2004. The allograft defines the type of rejection (acute vs chronic) in the face of an established effector immune response. J Immunol. 172:7813–7820.

    PubMed  CAS  Google Scholar 

  • Codarri L, Vallotton L, Ciuffreda D, Venetz JP, et al. 2007. Expansion and tissue infiltration of an allospecific CD4+CD25+CD45RO+IL-7R (alpha) high cell population in solid organ transplant recipients. J Exp Med. 204:1533–1541.

    Article  PubMed  CAS  Google Scholar 

  • Cooper DK. 1969. Transplantation of the heart and both lungs. I. Historical review. Thorax. 24:383–390.

    Article  PubMed  CAS  Google Scholar 

  • Doyle AM, Lechler RI, Turka LA. 2004. Organ transplantation: Half-way through the first century. J Am Soc Nephrol. 15:2965–2971.

    Article  PubMed  Google Scholar 

  • Dreger P, Kloss M, Petersen B, Haferlach T, et al. 1995. -Autologous progenitor cell transplantation: Prior exposure to stem cell-toxic drugs determines yield and engraftment of peripheral blood progenitor cell but not of bone marrow grafts. Blood. 86:3970–3978.

    PubMed  CAS  Google Scholar 

  • El-Asady RS, Rongwen Y, Hadley GA. 2003. The role of CD103 ([alpha]E[beta] 7 integrin) and other adhesion molecules in lymphocyte migration to organ allografts: Mechanisms of rejection. Curr Opin Organ Transplant. 8:1–6.

    Article  Google Scholar 

  • Ferrara JL, Deeg HJ. 1991. Graft-versus-host disease. NEJM. 324:667–674.

    Article  PubMed  CAS  Google Scholar 

  • Ferrara JLM, Cooke KR, Pan L, Krenger W. 1996. The immunopathophysiology of acute graft-versus-host-disease. Stem cells. 14:473–489.

    Article  PubMed  CAS  Google Scholar 

  • Field EH, Matesic D, Rigby S, Fehr T, et al. 2001. CD4+CD25+ regulatory cells in acquired MHC tolerance. Immunol Rev. 182:99–112.

    Article  PubMed  CAS  Google Scholar 

  • Flye MW (Ed.). 1989. Principles of Organ Transplantation. W. B. Saunders, Philadelphia, PA.

    Google Scholar 

  • Galili U. 1993. Interaction of the natural anti-Gal antibody with α-galactosyl epitopes: A major obstacle of xenotransplantation in humans. Immunol Today. 14:480–482.

    Article  PubMed  CAS  Google Scholar 

  • Game DS, Lechler RI. 2002. Pathways of allorecognition: Implications for transplantation tolerance. Transpl Immunol. 10:101–108.

    Article  PubMed  CAS  Google Scholar 

  • Gebel HM, Bray RA. 2000. Sensitization and sensitivity: Defining the unsensitized patients. Transplantation. 69:1370–1374.

    Article  PubMed  CAS  Google Scholar 

  • Goulmy E, Schipper R, Pool J, Blokland E, et al. 1996. Mismatches of minor histocompatibility antigens between HLA-identical donors and recipients and the development of graft-versus-host-disease after bone marrow transplantation. NEJM. 334:281–285.

    Article  PubMed  CAS  Google Scholar 

  • Griepp RB, Ergin MA. 1984. The history of experimental heart transplantation. J Heart Transplant. 3:145–145.

    Google Scholar 

  • Griffith BP, Hardesty RL, Trento A, Bahnson HT. 1985. Asynchronous rejection of heart and lungs following cardiopulmonary transplantation. Ann Thorac Surg. 40:488–493.

    Article  PubMed  CAS  Google Scholar 

  • Griffith TS, Brunner T, Fletcher SM, Green DR, et al. 1995. Fas ligand-induced apoptosis as a mechanism of immune privilege. Science. 270:11889–1192.

    Article  Google Scholar 

  • Hakim NS. 2003. Recent developments and future prospects in pancreatic transplantation. Exp Clin Transplant. 1:26–34.

    PubMed  Google Scholar 

  • Hall B, Jelbart ME, Gurley KE, Dorsch SE. 1990. Specific unresponsiveness in rats with prolonged cardiac allograft survival after treatment with cyclosporine. III. Further characterization of CD4+ suppressor cell and its mechanisms of action. J Exp Med. 171:141–157.

    Article  PubMed  CAS  Google Scholar 

  • Hall BM, Chen J, Robinson C, Xy H, et al. 2002. Therapy with mab to CD25 blocks function of CD4+CD25+ T regulatory cells which maintain transplantation tolerance. Nephrology. 7:A111–A111.

    Google Scholar 

  • Hayry P, Isoniemi H, Yilmaz A, Mennander K, et al. 1993. Chronic allograft rejection. Immunol Rev. 134:33–81.

    Article  PubMed  CAS  Google Scholar 

  • Hayry P. 1996. Pathophysiology of chronic rejection. Trans Proc. 28:7–10.

    Google Scholar 

  • Kahan BD. 1991. Transplantation timeline. Mankind’s three millennia-one maverick’s three decades in the struggle against biochemical individuality. Transplantation. 51:1–21.

    Article  PubMed  CAS  Google Scholar 

  • Kang SM, Tang Q, Bluestone JA. 2007. CD4+CD25+ regulatory T cells in transplantation: Progress, challenges and prospects. Am J Transplant. 7:1457–1463.

    Article  PubMed  CAS  Google Scholar 

  • Kaufman DB, A. 2006. Pancreas transplantation. Koffron www.emedicine.com/med/topic 2605.htm.

  • Kerman RH, Orosz CG, Lorber MI. 1997. Clinical relevance of anti-HLA antibodies pre and post transplant. Am J Med Sci. 313:275–278.

    Article  PubMed  CAS  Google Scholar 

  • Kitchens WH, Uehara S, Chase CM, Coluin RB, et al. 2006. The changing role of natural killer cells in solid organ rejection and tolerance. Transplantation. 81:811–817.

    Article  PubMed  Google Scholar 

  • Klein J. 1986. Natural History of the Major Histocompatibility Complex. Wiley, New York.

    Google Scholar 

  • Krensky AM. 2004. Immunologic tolerance. Ped Nephrol. 16:675–679.

    Article  Google Scholar 

  • Krensky AM, Clayberger C. 2004. Prospects for induction of tolerance in renal transplantation. Ped Nephrol. 8:772–779.

    Article  Google Scholar 

  • Krieger NR, Yin DP, Fathman CG. 1996. CD4+ but not CD8+ cells are essential for allorejection. J Exp Med. 184:2013–2018.

    Article  PubMed  CAS  Google Scholar 

  • LaRosa DF, Rahman AH, Turka LA. 2007. The innate immune system in allograft rejection and tolerance. J Immunol. 178:7503–7509.

    PubMed  CAS  Google Scholar 

  • Lattmann T, Hein M, HOrber S, Ortmann J, et al. 2005. Activation of pro-inflammatory and anti-inflammatory cytokines in host organs during chronic allograft rejection: Role of endothelin receptor signaling. Am J Transplant. 5:1042–1049.

    Article  PubMed  CAS  Google Scholar 

  • Lau CL, Palmer SM, Posther KE, Howell DN, et al. 2000. Influence of panel-reactive antibodies on post transplant outcomes in lung transplant recipients. Ann Thorac Surg. 69:1520–1524.

    Article  PubMed  CAS  Google Scholar 

  • Lau HT, Yu M, Fontana A, Stoeckert CJ. 1996. Prevention of islet allograft rejection with engineered myoblasts expressing FasL in mice. Science. 273:109–112.

    Article  PubMed  CAS  Google Scholar 

  • Majno G. 1975. The Healing Hand. Man and Wound in the Ancient World. Harvard University Press, Cambridge, MA.

    Google Scholar 

  • Mancini MC. 2006. Heart-lung transplantation. www.emedicine.com/med/topic2063.htm.

  • Mancini MC, Gangahar DM. 2006. Heart transplantation. www.emedicine.com/med/topic 3187.htm.

  • Mandanas RA. 2006. Graft vs. host disease. www.emedicine.com/medtopic926.htm.

  • Manzarbeitia C. 2006. Liver transplantation. www.emedicine.com/med/topic3510.htm.

  • Matthews LG. 1968. S.S. Cosmas and Damian – Patron Saints of medicine and pharmacy. Their cult in England. Med Hist. 12:281–288.

    Google Scholar 

  • Medawar PB. 1986. Memoir of a Thinking Radish. Oxford University Press, Oxford.

    Google Scholar 

  • Merrill JP, Murray JE, Harrison JH, Guild WR. 1984. Landmark article Jan. 28, 1956. Successful homotransplantation of the human kidney between identical twins. JAMA. 251:2566–2571.

    Article  PubMed  CAS  Google Scholar 

  • Morris PJ. 2004. Transplantation – A medical miracle of the 20th century. NEJM. 351:2678–2680.

    Article  PubMed  CAS  Google Scholar 

  • Murphy B, Krensky AM. 1999. HLA-derived peptides as novel immunomodulatory therapeutics. J Am Soc Nephrol. 10:1346–1355.

    PubMed  CAS  Google Scholar 

  • Norman DJ. 1998. Expected clinical outcomes/risk factors. In: Norman DJ, Suke WN, Thorofare NJ, Eds. Primer on Transplantation, Am. Soc. Transplant Physicians, Thorofare, NJ,pp. 245–250.

    Google Scholar 

  • Paul LC. 1995. Immunobiology of chronic renal transplant rejection. Blood Purif. 13:206–218.

    Article  PubMed  CAS  Google Scholar 

  • Petersdorf EW, HansenJA, Martin PJ, Woolfrey A, et al. 2001. Major-histocompatibility-complex class I alleles and antigens in hematopoietic cell transplantation. NEJM. 345:1794–1800.

    Google Scholar 

  • Philip T, Gugliemli C, Hagenbeek A, Somers R, et al. 1995. Autologous bone marrow transplantation as compared with salvage chemotherapy in relapses of chemotherapy-sensitive non-Hodgkin’s lymphoma. NEJM. 333:1540–1545.

    Article  PubMed  CAS  Google Scholar 

  • Pinderski LJ, Kirklin JK, McGiffin D, Brown R, et al. 2005. Multi-organ transplantation: Is there a protective effect against acute and chronic rejection? J Heart Lung Transplant. 24:1828–1833.

    Article  PubMed  Google Scholar 

  • Prescilla RP, Mattoo TK. 2006. Immunology of transplant rejection. www.emedicine.com/ped/ topic2841.htm.

  • Rana RE, Arora BS. 2002. History of plastic surgery in India. J Postgrad Med. 48:76–78.

    PubMed  CAS  Google Scholar 

  • Reitz BA, Wallwork JL, Hunt SA, Pennock JL, et al. 1982. Heart-lunch transplantation: Successful therapy for patients with pulmonary vascular disease. NEJM. 306:557–564.

    Article  PubMed  CAS  Google Scholar 

  • Rocha PN, Plumb TJ, Crowley SD, Coffman TM. 2003. Effector mechanisms in transplant rejection. Immunol Rev. 196:51–64.

    Article  PubMed  CAS  Google Scholar 

  • Roopenian D, Choi EY, Brown A. 2002. The immunogenomics of minor histocompatibility antigens. Immunol Rev. 190:86–94.

    Article  PubMed  CAS  Google Scholar 

  • Rosenberg AS, Singer A. 1992. Cellular basis of skin allograft rejection: An in vivo model of immune-mediated tissue destruction. Ann Rev Immunol. 10:333–358.

    Article  CAS  Google Scholar 

  • Rossini AA, Greiner DL, Mordes JP. 1999. Induction of immunologic tolerance for transplantation. Physiol Rev. 79:99–41.

    PubMed  CAS  Google Scholar 

  • Roush W. 1995. Xenotransplantation. New ways to avoid organ rejection and buoy hopes. Science. 270:234–235.

    Article  PubMed  CAS  Google Scholar 

  • Rubinstein P. 2001. HLA matching for bone marrow transplantation – How much is enough? NEJM. 345:1842–1844.

    Article  PubMed  CAS  Google Scholar 

  • Ruiz P, Sarwar S, Suterwala MS. 2006. Graft versus host disease. www.emedicinecom/ped/topic 893.htm.

  • Sablinski T, Sayegh MH, Hancock WW, Kut JP, et al. 1991. Differential role of CD4+ cells in the sensitization and effector phases of accelerated graft rejection. Transplantation. 51:226–231.

    Article  PubMed  CAS  Google Scholar 

  • Sade RM. 2005. Transplantation at 100 years: Alexis Carrel, pioneer surgeon. Ann Thorac Surg. 80:2415–2418.

    Article  PubMed  Google Scholar 

  • Sakaguchi S. 2006. Regulatory T cells: Meden again. Immunol Rev. 212:1–5.

    Google Scholar 

  • Sakaguchi S, Ono M, Setoguchi R, Yagi H, et al. 2006. Foxp3+CD25+Cd4+ natural regulatory T cells in dominant self tolerance and autoimmune disease. Immunol Rev. 212:8–27.

    Article  PubMed  CAS  Google Scholar 

  • Salvalaggio PRO, Camirand G, Ariyan CD, Deng S, et al. 2006. Antigen exposure during enhanced CTLA-4 expression promotes allograft tolerance in vivo. J Immunol. 176:2292–2298.

    PubMed  CAS  Google Scholar 

  • Sanfilippo F. 1998. Transplantation tolerance – The search continues. NEJM. 339:1700–1702.

    Article  PubMed  CAS  Google Scholar 

  • Sayegh MH, Carpenter CB. 1996. Role of indirect allorecognition in allograft rejection. Int Rev Immunol. 13:221–229.

    Article  PubMed  CAS  Google Scholar 

  • Sayegh MH, Turka LA. 1998. The role of T cell costimulatory activation pathways in transplant rejection. NEJM. 338:1813–1821.

    Article  PubMed  CAS  Google Scholar 

  • Sayegh MH, Carpenter CB. 2004. Transplantation 50 years later – Progress, challenges and promises. NEJM. 351:2761–2766.

    Article  PubMed  CAS  Google Scholar 

  • Scheinfeld NS, Kuechle MK. 2007. Graft versus host disease. www.emedicine.com/derm/ toic478.htm.

  • Shapiro AMJ, Lakey JRT, Ryan EA. 2000. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. NEJM. 343:230–238.

    Article  PubMed  CAS  Google Scholar 

  • Sho M, Kishimoto K, Harada H, Livak M, et al. 2005. Requirements for induction and maintenance of peripheral tolerance in stringent allograft models. Proc Nat Acad Sci. 102:13230–13235.

    Google Scholar 

  • Silverstein AM. 1988. A History of Immunology. Academic Press, San Diego, CA.

    Google Scholar 

  • Socie G, Mary JY, Lemann M. 2004. Prognostic value of apoptotic cells and infiltrating neutrophils in graft-versus-host disease of the gastrointestinal tract in humans: TNF and Fas expression. Blood. 103:50–57.

    Article  PubMed  CAS  Google Scholar 

  • Spierings E, Vermeulen CJ, Vogt MH, Doerner LE, et al. 2003. Identification of HLA class II restricted H-Y-specific T-helper epitope evoking CD4+ T-helper cells in H-Y-mismatched transplantation. Lancet. 362:610–615.

    Article  PubMed  CAS  Google Scholar 

  • Strom TB. 2004. Is transplantation tolerable? J Clin Inv. 113:1681–1683.

    CAS  Google Scholar 

  • Sullivan KM. 1999. Graft-versus-host disease. In: Thomas ED, Ed. Hematopoietic Cell Transplantation. 2 nd Ed. Blackwell Science, Boston, MA.

    Google Scholar 

  • Sykes M. 1996. Immunobiology of transplantation. FASEB J. 10:721–730.

    PubMed  CAS  Google Scholar 

  • Tambur AR, Pamboukian SV, Costanzo MR, Herrera ND, et al. 2005. The presence of HLA-directed antibodies after heart transplantation is associated with poor allograft outcome. Transplantation. 80:1019–1025.

    Article  PubMed  Google Scholar 

  • Terasaki PE. (Ed.). 1991. A History of Transplantation: Thirty-Five Recollections. UCLA Tissue Typing Laboratory Press, Los Angeles, CA.

    Google Scholar 

  • Thomas ED, Lochte HL Jr., Lu WC, Ferrebee JW. 1957. Intravenous infusion of bone marrow in patients receiving radiation and chemotherapy. NEJM. 257:491–496.

    Article  PubMed  CAS  Google Scholar 

  • Tilney NL. 2000. Transplantation and its biology: From fantasy to routine. J Appl Physiol. 89:1681–1689.

    PubMed  CAS  Google Scholar 

  • Valujskikh A, Lakkis FG. 2003. In remembrance of things past: Memory T cells and transplant rejection. Immunol Rev. 196:65–74.

    Article  PubMed  CAS  Google Scholar 

  • Valujskikh A. 2006. The challenge of inhibiting alloreactive T-cell memory. Am J Transplant. 6:647–651.

    Article  PubMed  CAS  Google Scholar 

  • Van Buskirk AM, Pidwell DJ, Adam PW, Orosz CG. 1997. Transplantation immunology. JAMA. 278:1993–1999.

    Article  Google Scholar 

  • Van Twuyver E, Mooijaart RJ, tenBerge IJ, Van der Horst AR, et al. 1991. Pretransplantation blood transfusion revisited. NEJM. 325:1210–1213.

    Article  PubMed  Google Scholar 

  • Zhang Q, Chen Y, Fairchild RL, Heeger PS, et al. 2006. Lymphoid sequestration of alloreactive memory CD4 T cells promotes cardiac allograft survival. J Immunol. 176:770–777.

    PubMed  CAS  Google Scholar 

  • Zheng XX, Markees TG, Hancock WW, Li Y, et al. 1999. CTLA4 signals are required to optimally induce allograft tolerance with combined donor specific transfusion and anti-CD154 monoclonal antibody treatment. J Immunol. 162:4983–4990.

    PubMed  CAS  Google Scholar 

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Khan, M.M. (2008). Tissue Transplantation. In: Immunopharmacology. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-77976-8_7

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