This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Antopolsky M, Azhayeva E, Tengvall U, Auriola S, Jaaskelainen I, Ronkko S, Honkakoski P, Urtti A, Lonnberg H, Azhayev A (1999) Peptide-Oligonucleotide Phosphorothioate Conjugates with Membrane Translocation and Nuclear Localization Properties. Bioconjugate Chem 10:598–606
Antopolsky M, Azhayev A (2000) Stepwise Solid-Phase Synthesis of Peptide-Oligonucleotide Phosphorothioate Conjugates Employing Fmoc Peptide Chemistry. Tetrahedron Lett 41:9113–9117
Antopolsky M, Azhayeva E, Tengvall U, Azhayev A (2002) Toward a General Method for the Stepwise Solid-Phase Synthesis of Peptide-Oligonucleotide Conjugates. Tetrahedron Lett 43:527–530
Bakalova R, Ohba H, Zhelev Z, Kubo T, Fujii M, Ishikawa M, Shinohara Y, Baba Y (2004) Atypical Protein-kinase Cζ, but Neither Conventional Ca2+-Dependent Protein-Kinase C Isoenzymes nor Ca2+-Calmodulin, Participates in Regulation of Telomerase Activity in Burkitt’s Lymphoma Cells. Cancer Chemother Pharmacol 54:161–172
Chaloin L, Vidal P, Lory P, Mery J, Lautredou N, Divita G, Heitz F (1998) Design of Carrier Peptide-Oligonucleotide Conjugate with Rapid Membrane Translocation and Nuclear Localization Properties. Biochem Biophys Res Commun 243:601–608
Crooke ST (2004) Progress in Antisense Technology. Annu Rev Med 55:61–95
Dingwell C, Laskey RA (1986) Protein Import into the Cell Nucleus. Annu Rev Cell Biol 2:367–390
Eisele F, Owen DJ, Waldmann H (1999) Peptide Conjugates as Tools for the Study of Biological Signal Transduction. Bioorg Med Chem 7:193–234
Fischer PM, Krausz E, Lane DP (2001) Cellular Delivery of Impermeable Effector Molecules in the Form of Conjugates with Peptides Capable of Mediating Membrane Translocation. Bioconjugate Chem 12:825–841
Fujii M, Yokoyama K, Kubo T, Ueki R, Abe S, Goto K, Niidome T, Aoyagi H, Iwakuma K, Ando S, Ono S (2001) Design, Synthesis and Characterization of DNA Binding Peptides. Peptide Science 2000:109–112
Goerlich D, Kutay U (1999) Transport between the Cell Nucleus and the Cytoplasm. Annu Rev Cell Dev Biol 15:607–660
Goldfarb DS, Gariepy J, Schoolnik G, Komberg RD (1986) Synthetic Peptides as Nuclear Localization Signals. Nature 322:641–642
Haralambidis J, Duncan L, Tregear GW (1987) The Solid Phase Synthesis of Oligonucleotide Containing a 3′-Peptide Moiety. Tetrahedron Lett 28:5199–5202
Kim NW, Piatyszek MA, Prowse KR, Harley CB, West MD, Ho PLC, Coviello GM, Wright WE, Weinrich SL, Shay JW (1994) Specific Association of Human Telomerase Activity with Immortal Cells and Cancer. Science 266:2011–2015
Kubo T, Fujii M (2001) Specific Binding and Stabilization of DNA and Phosphorothioate DNA by Amphiphilic α-Helical Peptides. Nucleosides Nucleotides & Nucleic Acids 20:1313–1316
Kubo T, Dubey K, Fujii M (2001) A Novel Approach for the Solid Phase Synthesis of DNAPeptide Conjugates. Nucleosides Nucleotides & Nucleic Acids 20:1321–1324
Kubo T, Morikawa M, Ohba H, Fujii M (2003) Synthesis of DNA-Peptide Conjugates by Solid-Phase Fragment Condensation. Org Lett 5:2623–2626
Kubo T, Bakalova R, Ohba H, Fujii M (2003) Antisense Efects of DNA-Peptide Conjugates. Nucleic Acids Research Suppl 3:179–180
Kubo T, Takamori K, Kanno K, Bakalova R, Ohba H, Matsukisono M, Akebiyama Y, Fujii M (2005) Efficient Cleavage of RNA, Enhanced Cellular Uptake, and Controlled Intracellular localization of Conjugate DNAzymes. Bioorg Med Chem Lett 15:167–170
Kurreck J (2003) Antisense Technologies. Eur J Biochem 270:1628–1644
Kuwabara T, Warashima M, Nakayama A, Ohkawa J, Taira K (1999) tRNA Val-Heterodimeric Maxizymes with High Potential as Gene Inactivating Agents: Simultaneous Cleavage at Two Sites in HIV-1 tat mRNA in Cultured Cells. Proc Natl Acad Sci USA 96:1886–1891
Manoharan M (2002) Oligonucleotide Conjugates as Potential Antisense Drugs with Improved Uptake, Biodistribution, Targeted Delivery, and Mechanism of Action. Antisense & Nucelic Acid Drug Development. 12:103–128
Newmeyer DD, Lucocq JM, Buerglin TR, DeRobertis EM (1986) Assembly in vitro of Nuclei Active in Nuclear Protein Transport: ATP is Required for Nucleoplasmin Accumulation. EMBO J 5:5001–510
Simeoni F, Morris MC, Heitz F and Divita G (2003) Insight into the Mechanism of the Peptide-based Gene Delivery System MPG: Implications for Delivery of siRNA into Mammalian Cells. Nucleic Acids Research 31:2717–2724
Soukchareun S, Tregear GW, Haralambidis J (1995) Preparation and Characterization of Antisense Oligonucleotide-Peptide Hybrids Containing Viral Fusion Peptides. Bioconjugate Chem 6:43–53
Stetsenko DA, Gait MJ (2000) Efficient Conjugation of Peptides to Oligonucleotides by “Native Ligation”. J Org Chem 65:4900–4908
Stetsenko DA, Gait MJ (2002) Total Stepwise Solid-Phase Synthesis of Oligonucleotide-(3′ → N)-Peptide Conjugates. Org Lett 4:3259–3262
Tung CH (2000) Preparation and Applications of Peptide-Oligonucleotide conjugates. Bioconjugate Chem 11:605–618
Warashima M, Kuwabara T, Kato Y, Sano M, Taira K (2001) RNA-Protein Hybrid Ribozyme That Efficiently Cleave Any mRNA Independently of the Structure of the Target RNA. Proc Natl Acad Sci USA 98:5572–5577
Yano M, Kubo T, Yokoyama K, Ueki R, Sasaki K, Anno Y, Ohba H, Fujii M (2003) Control of Intracellular Delivery of Oligonucleotides by Conjugation with Signal Peptides. Nucleosides Nucleotides & Nucleic Acids 22:1367–1369
Yokoyama K, Kubo T, Fujii M (2002) Synthesis and Biological Activity of DNA-NLS Conjugate. Peptide Science 2001:313–316
Zanta MA, Belguise-Valladier P, Behr JP (1999) Gene Delivery: A Single Nuclear Localization Signal Peptide is Sufficient to Carry DNA to the Cell Nucleus. Proc Natl Acad Sci USA 96:91–96
Zatsepin TS, Stetsenko DA, Arzummanov AA, Momanova EA, Gait MJ, Oretskaya TS (2002) Synthesis of Peptide-Oligonucleotide Conjugates with Single and Multiple Peptides Attached to 2′-Aldehyde through Thiazolidine, Oxime and Hydrazine Linkages. Bioconjugate Chem 13:822–830
Zubin EM, Romanova EA, Volkov EM, Tashlitsky VN, Korshunova GA, Shabarova ZA, Oretskaya TS (1999) Oligonucleotide-Peptide Conjugates as Potential Antisense Agents. FEBS Lett 456:59–62
Zubin EM, Romanova EA, Oretskaya TS (2002) Modern Methods for the Synthesis of Peptide-Oligonucleotide Conjugates. Russ Chem Rev 71:239–264
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2005 Springer-Verlag Tokyo
About this chapter
Cite this chapter
Kubo, T., Bakalova, R., Zhelev, Z., Ohba, H., Fujii, M. (2005). Controlled Intracellular Localization of Oligonucleotides by Chemical Conjugation. In: Taira, K., Kataoka, K., Niidome, T. (eds) Non-viral Gene Therapy. Springer, Tokyo. https://doi.org/10.1007/4-431-27879-6_15
Download citation
DOI: https://doi.org/10.1007/4-431-27879-6_15
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-25122-4
Online ISBN: 978-4-431-27879-5
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)