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In situ assessment of differential adhesion of neuroinvasive and non-neuroinvasive Borrelia strains to BMECs

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Farm animal proteomics 2013

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Abstract

Invasion of different host niches by Borrelia is associated with its translocation across various the body barriers. Neuroinvasive character is in part attributed with crossing of the blood–brain barrier (BBB). This translocation is a multi-stage process with unclear molecular principle. Main prerequisite of successful borrelial traversal seems to be adhesion of Borrelia to brain microvascular endothelial cells (BMECs) (Moriarty et al., 2008).

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References

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Acknowledgements

Work was performed in collaboration with Dr. E. Chakurkar, at ICAR Goa India, mainly for transfection and in-vivo protein production. Financial support was from APVV-0036-10 and VEGA–1/0054/12, 2/0193/11.

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Authors and Affiliations

  1. Laboratory of Biomedical Microbiology and Immunology, Department of microbiology and immunology, University of Veterinary Medicine and Pharmacy, Kosice, Slovakia

    Lucia Pulzova, Elena Bencurova, Tomas Csank, Patrik Mlynarcik & Mangesh R. Bhide

  2. Institute of Neuroimmunology, Slovak Academy of Sciences, Bratislava, Slovakia

    Lucia Pulzova & Mangesh R. Bhide

Authors
  1. Lucia Pulzova
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  2. Elena Bencurova
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  3. Tomas Csank
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  4. Patrik Mlynarcik
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  5. Mangesh R. Bhide
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Corresponding author

Correspondence to Lucia Pulzova .

Editor information

André de Almeida David Eckersall Elena Bencurova Saskia Dolinska Patrik Mlynarcik Miroslava Vincova Mangesh Bhide

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© 2013 Wageningen Academic Publishers

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Pulzova, L., Bencurova, E., Csank, T., Mlynarcik, P., Bhide, M.R. (2013). In situ assessment of differential adhesion of neuroinvasive and non-neuroinvasive Borrelia strains to BMECs. In: de Almeida, A., et al. Farm animal proteomics 2013. Wageningen Academic Publishers, Wageningen. https://doi.org/10.3920/978-90-8686-776-9_40

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