Abstract
In a previous study we have shown, that the OspA of Borrelia garinii (neuroinvasive strain SKT-7.1) is crucial for its transient tethering to the rat brain microvascular endothelial cells (RBMEC) via 31.8 kDa receptor CD40. Transient tethering is then followed by stationary adhesion in which ICAM-1 or VCAM-1 might be the potential molecules. Both transient and stationary adhesions are necessary steps in the traversal of Borrelia across the blood-brain barrier (BBB). Understanding the basic mechanisms involved in crossing the BBB by Borrelia will help to develop novel therapeutic approaches against neuroborreliosis.
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References
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Acknowledgements
Work was performed in collaboration with Dr. E. Chakurkar, at ICAR Goa India, mainly for transfection and in vivo protein production. Financial support was from APVV-0036-10, VEGA–1/0054/12, 2/0193/11. PM received SAIA-NSP funding for short term stay at JJG’s Lab for site-directed mutagenesis experiments.
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Mlynarcik, P. et al. (2013). Identification of amino acid residues of OspA of Borrelia involved in binding to CD40 receptor. In: de Almeida, A., et al. Farm animal proteomics 2013. Wageningen Academic Publishers, Wageningen. https://doi.org/10.3920/978-90-8686-776-9_29
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DOI: https://doi.org/10.3920/978-90-8686-776-9_29
Publisher Name: Wageningen Academic Publishers, Wageningen
Online ISBN: 978-90-8686-776-9
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