Skip to main content
SpringerLink
Log in

Epidemiology of Brain Tumors

  • Chapter
Brain Tumors

Part of the book series: Contemporary Cancer Research ((CCR))

Abstract

Brain cancer accounts for approx 1.4% of all cancers and 2.3% of all cancer-related deaths. The incidence of primary cerebral malignancies varies between 4 and 10/100,000 in the general population. This incidence tends to increase with age (4/100,000 up to the age of 12 yr; 6/100,000 up to the age of 35 yr; 18/100,000 up to the age of 55 yr; 70/100,000 up to the age of 75 yr).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Airewele G.E., Sigurdson A.J., Wiley K.J., Frieden B.E., Caldarera L.W., Riccardi V.M., et al. 2001. Neoplasms in neurofibromatosis 1 are related to gender but not to family history of cancer. Genet. Epidemiol. 20:75–86.

    Article  PubMed  CAS  Google Scholar 

  2. Altermatt H.J., Shepherd C.W., Scheitauer B.W., and Gomez M.R. 1991. Subependymal giant cell astrocytoma. Zentralbl. Pathol. 137:105–116.

    PubMed  CAS  Google Scholar 

  3. American Cancer Society 2002. Cancer Facts and Figures. American Cancer Society, Inc.

    Google Scholar 

  4. Bello M.J., De Campos J.M., Kusak M.E., Sarasa J.L., Saez-Castresana J., Pestana A., et al. 1994. Molecular analysis of chromosome 1 abnormalities in human gliomas reveals frequent loss of 1p in oligodendroglial tumors. Int. J. Cancer 57:172–175.

    Article  PubMed  CAS  Google Scholar 

  5. Bernard S.M., Cartwright R.A., Darwin C.M. et al. 1987. Hodgkin’s disease: case control epidemiological study in Yorkshire. Br. J. Cancer 55:85–90.

    PubMed  CAS  Google Scholar 

  6. Biernat W., Tohma Y., Yonekawa Y., Kleihues P., Ohgaki H. 1997. Alterations of cell cycle regulatory genes in primary (de novo) and secondary glioblastomas. Acta. Neuropathol. 94:303–309.

    Article  PubMed  CAS  Google Scholar 

  7. Bigner S.H., Mark J., Burger P.C., Mahaley M.S., Bullard D.E., Muhlbaier L.H., et al. 1988. Specific chromosomal abnormalities in malignant gliomas. Cancer Res. 88:405–411.

    Google Scholar 

  8. Blatt J., Jaffee R., Deutsch M., et al. 1986. Neurofibromatosis and childhood tumors. Cancer 57:1225–1229.

    Article  PubMed  CAS  Google Scholar 

  9. Bodmer W.F., Bailey C.J., Ellis A., et al. 1987. Localization of the gene for familial adenomatous polyposis on chromosome 5. Nature 328:614–616.

    Article  PubMed  CAS  Google Scholar 

  10. Bondy M., Ligon B.L. 1996. Epidemiology and etiology of intracranial meningiomas: a review. J. Neurooncol. 29:197–205.

    Article  PubMed  CAS  Google Scholar 

  11. Bondy M., Wiencke J., Wrensch, M., Kyritsis, A.P. 1994. Genetics of primary brain tumors: a review. J. Neurooncol. 18:69–81.

    Article  PubMed  CAS  Google Scholar 

  12. Bondy M.L, Kryitsis A.P., Gu J., de Andrade M., Cunningham J., Levin V.A., et al. 1996. Mutagen sensitivity and risk of gliomas: a case-control study. Cancer Res. 56:1484–1486.

    PubMed  CAS  Google Scholar 

  13. Bondy M.L., Lustbader E.D., Buffler P.A. et al. 1991. Genetic epidemiology of childhood brain tumors. Genet. Epidemiol. 8:253–267.

    Article  PubMed  CAS  Google Scholar 

  14. Bondy M.L., Wang, L.E., El-Zein R., de Andrade, M., Selvan, M.S., Bruner, J.M., et al. 2001. Gamma-radiation sensitivity and risk of glioma. J. Natl. Cancer Inst. 93:1553–1557.

    Article  PubMed  CAS  Google Scholar 

  15. Brauch H., Kishida T., Glavac D., Chen F., Pausch F., Hofler H., et al. 1995. Von Hippel-Lindau (VHL) disease with pheochromocytoma in the Black Forest region of Germany: evidence for a founder effect. Hum. Genet. 95:551–556.

    Article  PubMed  CAS  Google Scholar 

  16. Buckley J.D., Buckley C.M., Breslow N.E., Draper G.J., Roberson P.K., Mack T.M. 1996. Concordance for childhood cancer in twins. Med. Pediatr.Oncol. 26:223–229.

    Article  PubMed  CAS  Google Scholar 

  17. Burch, J.D., Craib, K.J., Choi, B.C., Miller, A.B., Risch, H.A., Howe, G.R. 1987. An exploratory case-control study of brain tumors in adults. J. Natl. Cancer. Inst. 78:601–609.

    PubMed  CAS  Google Scholar 

  18. Burk R.R. 1991. Von Hippel-Lindau disease angiomatosis of the retina and cerebellum. J. Am. Optometry Assoc. 62:382–385.

    CAS  Google Scholar 

  19. Busch D. 1994. Genetic susceptibility to radiation and chemotherapy injury: diagnosis and management. Int. J. Rad. Oncol. Biol. Phys. 30:997–1002.

    CAS  Google Scholar 

  20. Caggana M., Kilgallen J., Conroy J.M., Wiencke J.K., Kelysey K.T., Mike, R., Chen P., et al. 2001. Associations Between ERCC2 Polymorphisms and Gliomas. Cancer Epidemiology, Biomarkers and Prevention 10:355–360.

    PubMed  CAS  Google Scholar 

  21. Cheadle J.P., Reeve M.P., Sampson J.R., Kwiatkowski D.J., Cheadle J.P., Reeve M.P., Sampson J.R., et al. 2000. Hum. Genet. 107:97–114.

    Article  PubMed  CAS  Google Scholar 

  22. Chen P., Wiencke J., Aldape K., Kesler-Diaz A., Miike, R., Kelsey K., et al. 2000. Association of an ERCC1 polymorphism with adult-onset glioma. Cancer Epidemiol. Biomarkers Prev. 9:843–847.

    PubMed  CAS  Google Scholar 

  23. Choi N.W., Schuman L.M., Gullen W.H. 1970. Epidemiology of primary central nervous system neoplasms. II. Casecontrol study. Am. J. Epidemiol. 91:467–485.

    PubMed  CAS  Google Scholar 

  24. Chowdhary U.P., Boehme D.H., Al-Jishi M. 1985. Turcot syndrome glioma polyposis. J. Neurosurg. 63:804–807.

    PubMed  CAS  Google Scholar 

  25. Costa O.L., Silva D.M., Colnago F.A., et al. 1987. Turcot Syndrome autosomal dominant or recessive transmission? Dis. Colon Rectum 30:391–394.

    Article  PubMed  CAS  Google Scholar 

  26. Crossey P.A., Foster K., Richards F.M., Phipps M.E., Latif F., Tory K., et al. 1994. Molecular genetic investigations of the mechanism of tumourigenesis in von Hippel-Lindau disease: analysis of allele loss in VHL tumours. Hum. Genet. 93:53–58.

    Article  PubMed  CAS  Google Scholar 

  27. Crowe F.W., Schull W.J., Neel J.V. 1956. A Clinical, Pathological, and Genetic Study of Multiple Neurofibromatosis. Charles C. Thomas, Springfield, IL.

    Google Scholar 

  28. de Andrade, M., Barnholtz, J.S., Amos, C.I., Adatto, P., Spencer, C., Bondy, M.L. 2001. Segregation analysis of cancer in families of glioma patients. Genet. Epidemiol. 20:258–270.

    Article  PubMed  Google Scholar 

  29. Dietrich P.Y., Droz J.P., 1992. Renal cell cancer: Oncogenes and tumor suppressor genes. Rev. Pract. 42:1236–1240.

    CAS  Google Scholar 

  30. Doneda L., Ginelli E., Agresti A., Larizza L. 1989. In situ hybridization analysis of interstitial C-heterochromatin in marker chromosomes of two human melanomas. Cancer Res. 49:433–438.

    PubMed  CAS  Google Scholar 

  31. Draper G.J., Heaf M.M., Kinnier Wilson LM. 1977. Occurrence of childhood cancers among sibs and estimation of familial risks. J. Med. Genet. 14:81–90.

    PubMed  CAS  Google Scholar 

  32. El-Zein R., Bondy M.L., Wang L.E., de Andrade M., Sigurdson A.J., Bruner J.M., et al. 1999. Increased chromosomal instability in peripheral lymphocytes and risk of human gliomas. Carcinogenesis. 20: 811–815.

    Article  PubMed  CAS  Google Scholar 

  33. Elexpuru-Camiruaga, J., Buxton, N., Kandula, V., Dias P.S., Campbell, D., McIntosh, J., et al. 1995. Susceptibility to astrocytoma and meningioma: influence of allelism at glutathione-S-transferase (GSTT1 and GSTM1) and cytochrome P-450 (CYP2D6) loci. Cancer Res. 55:4237–4239.

    PubMed  CAS  Google Scholar 

  34. Farndon P.A., Del Mastro R.G., Evans D.G., Kilpatick M.W. 1992. Location of gene for Gorlin syndrome. Lancet 339:581,582.

    Article  PubMed  CAS  Google Scholar 

  35. Farwell J. and Flannery J.T. 1984. Cancer in relatives of children with central nervous system neoplasms. N. Engl. J. Med. 311:749–753.

    Article  PubMed  CAS  Google Scholar 

  36. Farwell, J.R., Dohrmann, G.J., Flannery, J.T. 1984. Medulloblastoma in childhood: an epidemiological study. J. Neurosurg. 61:657–664.

    PubMed  CAS  Google Scholar 

  37. Fults D., Tippets R.H., Thomas G.A., Nakamura Y., White R. 1989. Loss of heterozygosity for loci on chromosome 17p in human malignant astrocytoma. Cancer Res. 49:6572–6577.

    PubMed  CAS  Google Scholar 

  38. Gailani M.R., Bale S.J., Leffell D.J., et al. 1992. Developmental defects in Gorlin syndrome related to a putative tumor suppressor gene on chromsome 9. Cell 69:111–117.

    Article  PubMed  CAS  Google Scholar 

  39. Gao, L., Liu, L., van Meyel, D., Cairncross, G., Forsyth, P., Kimmel, D., Jenkins, R.B., Lassam, N.J., Hogg, D. 1997. Lack of germ-line mutations of CDK4, p16(INK4A), and p15(INK4B) in families with glioma. Clin. Cancer Res. 3:977–981.

    PubMed  CAS  Google Scholar 

  40. Gold E.B. Epidemiology of brain tumors. 1980. Reviews in Cancer Epidemiology 1:245–254.

    Google Scholar 

  41. Gomez MR. Tuberous Sclerosis. Raven Press, New York, 1988.

    Google Scholar 

  42. Gorlin RJ. 1987. Nevoid basal cell carcinoma syndrome. Medicine 66:98–113.

    Article  PubMed  CAS  Google Scholar 

  43. Grosovsky A.J., Parks K.K., Giver C.R., Nelson S.L. 1996. Clonal analysis of delayed karyotypic abnormalities and gene mutations in radiation-induced genetic instability. Mol. Cell Biol. 16: 6252–6262.

    PubMed  CAS  Google Scholar 

  44. Grossman S.A., Osman M., Hruban R., and Piantadosi S. 1999. Central nervous system cancers in first-degree relatives and spouse. Cancer Investigation 17:299–308.

    PubMed  CAS  Google Scholar 

  45. Haines J.L., Short M.P., Kwiatkowski D.J., et al. 1991. Localization of one gene for tuberous sclerosis within 9q32-9q34, and further evidence for heterogeneity. Am. J. Hum. Genet. 49:764–772.

    PubMed  CAS  Google Scholar 

  46. Harvald B., Hauge M. 1956. On the heredity of glioblastoma. J⋁20Natl Cancer Inst. 17:289–296.

    CAS  Google Scholar 

  47. Hass-Kogan D.A., Kogan S.S., Yount G., Hsu J., Haas M., Deen D.F., Israel M.A. 1999. P53 function influences the effect of fractionated raditherapy on glioblastoma tumors. Int. J. Radiat. Oncol. Biol. Phys. 43:399–403.

    Article  Google Scholar 

  48. Hemminki K., Li, Vaittinen X., Dong P., 2000. Cancers in the first degree relatives of children with brain tumors. Br. J. Cancer 83:407–411.

    Article  PubMed  CAS  Google Scholar 

  49. Hill J.R., Kuriyama N., Kuriyama H., Israel M.A. 1999. Molecular genetics of brain tumors. Arch. Neurol. 56:439–441.

    Article  PubMed  CAS  Google Scholar 

  50. Hittelman W.N., Sen P. Heterogeneity in chromosome damage and repair rates after bleomycin in ataxia telangiectasia cells. Cancer Res. 48:276–279.

    Google Scholar 

  51. Hoang-Xuan K, Aguirre-Cruz L, Mokhtari K, Marie Y, Sanson M. 2002. OLIG-1 and 2 gene expression and oligodendroglial tumours. Neuropathol. Appl. Neurobiol. 28:89–94.

    Article  PubMed  CAS  Google Scholar 

  52. Hoang-Xuan K., He J., Huguet S., Mokhtari K., Marie Y., Kujas M., et al. 2001. Molecular heterogeneity of oligodendrogliomas suggests alternative pathways in tumor progression. Neurology 57:1278–1281.

    PubMed  CAS  Google Scholar 

  53. Hope D.G., Mulvihill J.J. 1981. Malignancy in neurofibromatosis, in Advances in Neurology Vol 29: Neurofibromatosis von Reckinghausen Disease (Riccardi V.M., Mulvihill J.J., eds.). Raven Press, New York.

    Google Scholar 

  54. Hsu T.C., Johnston D.A., Cherry L.M., Ramkisson D., Schantz S.P., Jessup J.M., et al. 1989. Sensitivity to genotoxic effect of bleomycin in humans: possible relationship to environmental carcinogenesis. Int. J. Cancer 43:403–409.

    Article  PubMed  CAS  Google Scholar 

  55. Hunter S.B., Abbot K., Varma V.A., Olson J.J., Barnett D.W., James C.D. 1995. Reliability of differential PCR for the detection of EGFR and MDM2 gene amplification in DNA extracted from FFPE glioma tissues. J. Neuropathol. Exp. Neurol. 54:57–64.

    PubMed  CAS  Google Scholar 

  56. Ichimura K., Schmidt E.E., Miyakawa A., Goike H.M., Collins V.P. 1998. Distinct patterns of deletion on 10p and 10q suggest involvement of multiple tumor suppressor genes in the development of astrocytic gliomas of different malignancy grades. Genes Chromosomes Cancer 22:9–15.

    Article  PubMed  CAS  Google Scholar 

  57. Jadayel D., Fain P., Upadhyaya M., et al. 1990. Paternal origin of new mutations in von Recklinghausen neurofibromatosis. Nature 343:558.

    Article  PubMed  CAS  Google Scholar 

  58. Jones A.C., Shyamsundar M.M., Thomas M.W., Maynard J., Idziaszczyk S., Tomkins S., et al. 1999. Comprehensive mutation analysis of TSC1 and TSC2-and phenotypic correlations in 150 families with tuberous sclerosis. Am. J. Hum. Genet. 64:1305–1315.

    Article  PubMed  CAS  Google Scholar 

  59. Kapp J.P., Paulson G.W., Odom G.L. 1967. Brain tumors with tuberous sclerosis. J. Neurosurg. 26:191.

    PubMed  CAS  Google Scholar 

  60. Kelsey K.T., Wrensch M., Zuo Z.F., Miike R., Wiencke J.K. 1997. A population-based case-control study of the CYP2D6 and GSTT1 polymorphisms and malignant brain tumors. Pharmacogenetics 7:463–468.

    Article  PubMed  CAS  Google Scholar 

  61. Kleihues P., Ohgaki H. 2000. Phenotype vs genotype in the evolution of astrocytic brain tumors. Toxicologic Pathology 28:164–170.

    PubMed  CAS  Google Scholar 

  62. Kleihues P., Soylememzoglu F., Schauble B., et al. 1995. Histopathology, classification and grading of gliomas. Glio. 15:211–221

    Article  CAS  Google Scholar 

  63. Koch G. 1972. Genetic aspects of phacomatoses, in Handbook of Clinical Neurology, Vol. 14 (Vinken P.G., Bruyn G.W., eds.). North Holland, Amsterdam.

    Google Scholar 

  64. Kuijten R.R., Bunin G.R., Nass C.C., et al. 1990. Gestational and familial risk factors for childhood astrocytoma: results of a case-control study. Cancer Res. 50:2608–2612.

    PubMed  CAS  Google Scholar 

  65. Kyritsis A.P., Bondy M.L., Xiao M., Berman E.L. Cunningham J.E., Lee P.S., et al. 1994. Germline p53 gene mutations in subsets of glioma patients [see comments]. J. Natl. Cancer Inst. 86:344–349.

    Article  PubMed  CAS  Google Scholar 

  66. Larizza L., Doneda L., Ginelli E., Fossati G. 1988. C-heterochromatin vartiation and transposition in tumor progression, in Cancer Metastasis: Biological and Biochemical Mechanisms and Clinical Aspects (Gprodi et al. eds.), Plenum Publishing Corp., NY, pp. 309–318.

    Google Scholar 

  67. Latif F., Tory K., Gnarra J., Yao M., Duh F.M., Orcutt M.L., et al. 1993. Identification of the von Hippel-Lindau disease tumor suppressor gene. Science 260:1317–1320.

    Article  PubMed  CAS  Google Scholar 

  68. Lengauer, C., Kinzler, K.W., Vogelstein, B. 1997. Genetic instability in colorectal cancers. Nature 386:623–627.

    Article  PubMed  CAS  Google Scholar 

  69. Levine C., Skimming J., Levine E. 1992. Familial pheochromocytomas with unusual associations. J. Pediatr. Surg. 27:447–451.

    Article  PubMed  CAS  Google Scholar 

  70. Lewis J.H., Ginsberg A.L., Toomey K.E. 1983. Turcot’s syndrome: evidence for autosomal dominant inheritance. Cancer 51:524–528.

    Article  PubMed  CAS  Google Scholar 

  71. Li F.P., Fraumeni J.F. Jr. 1982. Prospective study of a family syndrome. J. Am. Med. Assoc. 247:2692–2694.

    Article  CAS  Google Scholar 

  72. Li F.P., and Fraumeni J.F., Jr. 1975. Soft tissue, breast cancer and other neoplasms. Ann. Int. Med. 83:833,834.

    PubMed  CAS  Google Scholar 

  73. Li F.P., Fraumeni J.F. Jr. 1969. tissue sarcoma, breast cancer, and other neoplasms. A family syndrome? Ann. Int. Med. 71:747–752.

    PubMed  CAS  Google Scholar 

  74. Li F.P., Fraumeni J.F. Jr, Mulvihill J.J., et al. 1988. A cancer family syndrome in twenty-four kindreds. Cancer Res. 48:5358–5362.

    PubMed  CAS  Google Scholar 

  75. Li Y, Millikan, R.C., Carozza, S., Newman, B., Liu, E., Davis, R., Miike, R., Wrensch, M. 1998. p53 mutations in malignant gliomas. Cancer Epidemiol., Biomarkers and Prevention 7:303–308.

    CAS  Google Scholar 

  76. Lynch H.T., Guirgis H.A., Lynch P.M. et al. 1977. Familial cancer syndromes. A survey. Cancer 39:1867–1881.

    Article  PubMed  CAS  Google Scholar 

  77. Lynch H.T., Lynch J.F. 1985. Genetics and colorectal cancer, in Familial Cancer (Muller H., Weber W., eds.), Karger, Basel, Switzerland, p. 72.

    Google Scholar 

  78. Magnani I., Guerneri S., Pollo B., Cirenei N., Colombo B.M., Broggie G., et al. 1994. Increasing complexity of the karyotype in 50 human gliomas: Progressive evolution and de novo occurrence of cytogenetic alterations. Cancer Genet. Cytogenet. 75:77–89.

    Article  PubMed  CAS  Google Scholar 

  79. Malkin D., Li F.P., Strong L.C., et al. 1990. Germ line p53 mutations in a familial syndrome of breast cancer, sarcoma, and other neoplasms. Science 250:1233–1238.

    Article  PubMed  CAS  Google Scholar 

  80. Malmer B., Gronberg, H., Bergenheim, A.T., Lenner, P., Henriksson, R. 1999. Familial aggregation of astrocytoma in northern Sweden: an epidemiological cohort study. Int. J. Cancer 81:366–370.

    Article  PubMed  CAS  Google Scholar 

  81. Malmer B., Iselius, L., Holmberg, E., Collins, A., Henriksson, R., Gronberg, H. 2001. Genetic epidemiology of glioma. Br. J. Cancer 84:429–434.

    Article  PubMed  CAS  Google Scholar 

  82. Marti-Bonmati L., Menor F., Poyatos C., Cortina H. 1992. Diagnosis of Sturge Weber syndrome: comparison of the efficacy of CT and MR imaging in 14 cases. J. Roentgenol. 158:867.

    CAS  Google Scholar 

  83. Martuza R.L., Eldridge R. 1988. Neurofibromatosis 2: bilateral acoustic neurofibromatosis. N. Engl. J. Med. 318:684.

    Article  PubMed  CAS  Google Scholar 

  84. McCarthy B.J., Surawicz T., Bruner J.M., Kruchko C., Davis F. 2002. Consensus Conference on Brain Tumor Definition for registration. November 10, 2000. Neurooncol 2:134–145.

    Google Scholar 

  85. McKinley B.P., Michalek A.M., Fenstermaker R.A., Plunkett R.J. 2000. The impact of age and sex on the incidence of glial tumors in New York state from 1976 to 1995. J. Neurosurg. 93:932–939.

    Article  PubMed  CAS  Google Scholar 

  86. Mohapatra, G., Kim D.H., Feuerstein B.G. 1995. Detection of multiple gains and losses of genetic material in ten glioma cell lines by comparative genomic hybridization. Genes Chromosomes Cancer 13:86–93.

    Article  PubMed  CAS  Google Scholar 

  87. Miller R.W. 1971. Deaths from childhood leukemia and solid tumors among twins and other sibs in the United States, 1960-67. J. Natl. Cancer Inst. 46:203–209.

    PubMed  CAS  Google Scholar 

  88. Mulcahy G.M., Harlan W.L. 1976. Occurrences of central nervous system tumors, with special reference to relative genetic factors, in Cancer Genetics. (Lynch H.T. ed.), Thomas Books, Springfield, IL.

    Google Scholar 

  89. Nichols K.E., Malkin D., Garber, J.E., Fraumeni, J.F., Jr., Li, F.P. 2001. Germ-line p53 mutations predispose to a wide spectrum of early-onset cancers. Cancer Epidemiology, Biomarkers and Prevention, 10: 83–87.

    PubMed  CAS  Google Scholar 

  90. Norris F.D., Jackson E.W. 1970. Childhood cancer deaths in California born twins—a further report on types of cancer found. Cancer 25:212–218.

    Article  PubMed  CAS  Google Scholar 

  91. O’Brien J.M. 2000. Environmental and heritable factors in the causation of cancer—analysis of cohorts of twins from Sweden, Denmark, and Finland. N. Engl. J. Med. 343:78–85.

    Article  Google Scholar 

  92. Parry L., Maynard J.H., Patel A., Hodges A.K., von Deimling A., Sampson J.R., et al. 2000. Molecular analysis of the TSC1 and TSC2 tumour suppressor genes in sporadic glial and glioneuronal tumours. Hum. Genet. 4:350–356.

    Article  Google Scholar 

  93. Peters E.S., Kelsey K.T., Wiencke J.K., Park S., Chen P., Miike R., Wrensch, M.R. 2001. NAT2 and NQO1 polymorphisms are not associated with adult glioma. Cancer Epidemiology, Biomarkers and Prevention 10: 151–152.

    PubMed  CAS  Google Scholar 

  94. Preston-Martin S., Mack W., Henderson B.E. 1989. Risk factors for gliomas and meningiomas in males in Los Angeles County. Cancer Res. 49:6137–6143.

    PubMed  CAS  Google Scholar 

  95. Riccardi V.M. 1981. Von Recklinghausen neurofibromatosis. N. Engl. J. Med. 305:1617–1627.

    Article  PubMed  CAS  Google Scholar 

  96. Richards F.M., Payne S.J., Zbar B., Affara N.A., Ferguson-Smith M.A., Maher ER. 1995. Molecular analysis of de novo germline mutations in the von Hippel-Lindau disease gene. Hum. Mol. Genet. 11:2139–2143.

    Article  Google Scholar 

  97. Ritland S.R., Ganju. V, Jenkins R.B. 1995. Region-specific loss of heterozygosity on chromosome 19 is related to the morphologic type of human glioma. Genes Chromosomes Cancer 12:277–282.

    Article  PubMed  CAS  Google Scholar 

  98. Rosso S.M., Van Dekken H., Krishnadath K.K., Alers J.C., Kros J.M. 1997. Detection of chromosomal changes by interphase cytogenetics in biopsies of recurrent astrocytomas and oligodendrogliomas. J. Neuropathol Exp. Neurol. 56:1125–1131.

    Article  PubMed  CAS  Google Scholar 

  99. Rubenstein A.E. Neurofibromatosis: a review of the clinical problem. 1986. Ann. NY Acad. Sci. 486:1–13.

    Article  PubMed  CAS  Google Scholar 

  100. Ryan P., Lee M.W., North B., McMichael A.J. 1992. Risk factors for tumors of the brain and meninges: results from the Adelaide Adult Brain Tumor Study. Intl. J. Cancer 51:20–27.

    Article  CAS  Google Scholar 

  101. Scheil S., Bruderlein S., Liehr T., Starke H., Herms J., Schulte M., Moller P. 2001. Genome-wide analysis of sixteen chordomas by comparative genomic hybridization and cytogenetics of the first human chordoma cell line, U-CH1. Genes Chromosomes Cancer 3:203–211.

    Article  Google Scholar 

  102. Seizinger B.R., Smith D.I., Filling-Katz M.R., et al. 1991. Genetic flanking markers refine diagnostic criteria and provide insights into the genetics of von Hippel Lindau disease. Proc. Natl. Acad. Sci. USA 88:2864–2868.

    Article  PubMed  CAS  Google Scholar 

  103. Shepherd C.W., Gomez M.R., Lie J.T., Crowson C.S. 1991. Causes of death in patients with tuberous sclerosis. Mayo Clin. Proc. 66:792–796.

    PubMed  CAS  Google Scholar 

  104. Shepherd C.W., Scheithauer B.W., Gomez M.R., et al. 1991. Subependymal giant cell astrocytoma: a clinical, pathological, and flow cytometric study. Neurosurgery 28:864–868.

    Article  PubMed  CAS  Google Scholar 

  105. Sonoda Y., Iizuka M., Yasuda J., Makino R., Ono T., Kayama T., Yoshimoto T., Sekiya T. 1995. Loss of heterozygosity at 11p15 in malignant gliomas. Cancer Res. 55:2166–2168.

    PubMed  CAS  Google Scholar 

  106. Sorenson S.A., Mulvihill J.J., Nielson A., et al. 1986. Long-term follow-up of von Recklinghausen neurofibromatosis: survival and malignant neoplasms. N Engl. J. Med. 314:1010–1015.

    Article  Google Scholar 

  107. Smith L.E., Grosovsky A.J. 1993. Genetic instability on chromosome 16 in a B lymphoblastoid cell line. Somat. Cell Mol. Genet. 19:515–527.

    Article  PubMed  CAS  Google Scholar 

  108. Spitz M.R., McPherson R.S., Jiang H., Hsu T.C., Trizna Z,. Lee J.J., et al. 1997. Correlates of mutagen sensitivity in patients with upper aerodigestive tract cancer. Cancer Epidemiol. Biomarkers Prev. 6: 687–692.

    PubMed  CAS  Google Scholar 

  109. Stolle C., Glenn G., Zbar B., Humphrey J.S., Choyke P., Walther M., et al.. 1998. Improved detection of germline mutations in the von Hippel-Lindau disease tumor suppressor gene. Hum. Mutat. 12:417–423.

    Article  PubMed  CAS  Google Scholar 

  110. Surawicz T.S., McCarthy B.J., Kupelian V., Jukich P.J., Bruner J.M., Davis, F.G. 1999. Descriptive epidemiology of primary brain and CNS tumors: Results from the Central Brain Tumor Registry of the United States, 1990-1994. Neurooncol. 1:14–25.

    CAS  Google Scholar 

  111. Tijssen C.C. 1985. Genetic aspects of brain tumors—tumors of neuroepithelial and meningeal tissue, in Familial Cancer (Muller H, Weber W eds.) Karger, Basel, Switzerland.

    Google Scholar 

  112. Tijssen C.C., Halprin M.R., Endtz L.J. 1982. Familial Brain Tumours. A Commented Register. Martinus Nijhoff, Boston, MA.

    Google Scholar 

  113. The European Chromosome 16 Tuberous Sclerosis Consortium. 1993. Identification and characterization of the tuberous sclerosis gene on chromosome 16. Cell 75:1305–1315.

    Google Scholar 

  114. Trizna, Z., de Andrade, M., Kyritsis, A.P., Briggs, K., Levin, V.A., Bruner, J.M., et al. 1998. Genetic polymorphisms in glutathione S-transferase mu and theta, N-acetyltransferase, and CYP1A1 and risk of gliomas. Cancer Epidemiol. Biomarkers Prev. 7:553–555.

    PubMed  CAS  Google Scholar 

  115. Ueki K., Ono Y., Henson J.W., Efird J.T., von Deimling A., Louis D.N. 1996. CDKN2/p16 or RB alterations occur in the majority of glioblastomas and are inversly correlated. Cancer Res. 56: 150–153.

    PubMed  CAS  Google Scholar 

  116. van Slegtenhorst M., de Hoogt R., Hermans C., Nellist M., Janssen B., Verhoef S., et al. 1997. Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34. Science 277:805–808.

    Article  PubMed  Google Scholar 

  117. Vieregge P., Gerhard L., and Nahser HC. 1987. Familial glioma: occurrence within the “familial cancer syndrome” and systemic malformations. J. Neurol. 234:220–232.

    Article  PubMed  CAS  Google Scholar 

  118. von Deimling A., Krone W., and Menon A.G. 1995. Neurofibromatosis type 1: pathology, clinical features and molecular genetics. Brain Pathol. 5:153–162.

    Google Scholar 

  119. Wei Q., Spitz M.R., Gu J., Cheng L., Xu X., Strom S.S., et al. 1996. DNA repair capacity correlates with mutagen sensitivity in lymphoblastoid cell lines. Cancer Epidemiol. Biomarkers Prev. 5:199–204.

    PubMed  CAS  Google Scholar 

  120. Weinberg RA. 1991. Oncogenes, tumor suppressor genes, and cell transformation: trying to put it all together, in Origins of Human Cancer. (Brugge J., Curran T., Harlow E. et al. (eds.). Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.

    Google Scholar 

  121. Wernicke C., Thiel G., Lozanova T., Vogel S., and Witkowski R. 1997. Numerical aberrations of chromosomes 1,2 and 7 in astrocytomas studied by interphase cytogenetics. Genes Chromosomes Cancer 19:6–13.

    Article  PubMed  CAS  Google Scholar 

  122. Wolff R.K., Frazer K.A., Jackler R.K., et al. 1992. Analysis of chromosome 22 deletions in neurofibromatosis type 2-related tumors. Am. J. Hum. Genet. 51:478–485.

    PubMed  CAS  Google Scholar 

  123. Wrensch M., Lee M., Miike R., Newman B., Barger G., Davis R., Wiencke J., and Neuhaus J. 1997. Familial and personal medical history of cancer and nervous system conditions among adults with glioma and controls. American Journal of Epidemiology 145:581–593.

    PubMed  CAS  Google Scholar 

  124. Wrensch M.R., Barger G.R. 1990. Familial factors associated with malignant gliomas. Genet. Epidemiol. 7:291–301.

    Article  PubMed  CAS  Google Scholar 

  125. Yamakawa K., Morita R., and Takahashi E., et al. 1991. A detailed deletion mapping of the short arm of chromosome 3 in sporadic renal cell carcinoma. Cancer Res. 51:4707–4711.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Epidemiology, The University of Texas M. D. Anderson Cancer Center, Houston, TX

    Randa El-Zein MD, PhD & Melissa Bondy PhD

  2. Department of Epidemiology and Biostatistics, School of Medicine, University of California, San Francisco, CA

    Margaret Wrensch PhD, MPH

Authors
  1. Randa El-Zein MD, PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Melissa Bondy PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Margaret Wrensch PhD, MPH
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Surgery, Duke University Medical Center, Durham, NC

    Francis Ali-Osman DSc

  2. Comprehensive Cancer Center, Duke University Medical Center, Durham, NC

    Francis Ali-Osman DSc

Rights and permissions

Reprints and permissions

Copyright information

© 2005 Humana Press Inc., Totowa, NJ

About this chapter

Cite this chapter

El-Zein, R., Bondy, M., Wrensch, M. (2005). Epidemiology of Brain Tumors. In: Ali-Osman, F. (eds) Brain Tumors. Contemporary Cancer Research. Humana Press. https://doi.org/10.1385/1-59259-843-9:003

Download citation

Publish with us

Policies and ethics

Search

Navigation