Summary
In this review we provide evidence for the existence of genes associated with primary malignant brain tumors. We summarize the current knowledge from studies of familial cancer aggregation, hereditary syndromes, and molecular and cytogenetic studies. The epidemiologic evidence is suggestive but inconclusive for an association between brain tumors and cancers in other family members, including cancers of the breast, lung and colon. Central nervous system (CNS) tumors have been associated with several hereditary syndromes including the Li-Fraumeni cancer family syndrome, neurofibromatosis (types 1 and 2), tuberous sclerosis, nevoid basal cell carcinoma syndrome, familial polyposis, and von Hippel-Lindau disease. Significant studies leading to the recognition of molecular and cytogenetic abnormalities in malignant gliomas are described in detail. The genetic studies conducted thus far suggest a role for inherited susceptibility in some CNS tumors.
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References
Weinberg RA: Oncogenes, tumor suppressor genes, and cell transformation: trying to put it all together. In: Brugge J, Curran T, Harlow Eet al. (eds) Origins of Human Cancer. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, 1991
Li FP, Fraumeni JF Jr: Soft tissue sarcoma, breast cancer, and other neoplasms. A family syndrome? Ann Int Med 71: 747–752, 1969
Li FP, Fraumeni JF Jr: Soft tissue, breast cancer and other neoplasms. Ann Med 83: 833–834, 1975
Li FP, Fraumeni JF Jr: Prospective study of a family syndrome. JAMA 247: 2692–2694, 1982
Li FP, Fraumeni JF Jr, Mulvihill JJ, Blattner WA, Dreyfus MG, Tucker MA, Miller RW: A cancer family syndrome in twenty-four kindreds. Cancer Res 48: 5358–5362, 1988
Tijssen CC, Halprin MR, Endtz LJ: Familial Brain Tumours. A Commented Register. Martinus Nijhoff, Boston, 1982
Farwell J, Flannery JT: Cancer in relatives of children with central nervous system neoplasms. N Engl J Med 311: 749–753, 1984
Miller RW: Deaths from childhood leukemia and solid tumors among twins and other sibs in the United States, 1960–67. J Natl Cancer Inst 46: 203–209, 1971
Draper GJ, Heaf MM, Kinnier Wilson LM: Occurrence of childhood cancers among sibs and estimation of familial risks. J Med Genet 14: 81–90, 1977
Lynch HT, Guirgis HA, Lynch PM, Lynch JF, Harris RE: Familial cancer syndromes. A survey. Cancer 39: 1867–1881, 1977
Lynch JT, Mulcahy GM, Harris RE, Guirgis HA, Lynch JF: Genetic and pathologic findings in a kindred with hereditary sarcoma, breast cancer, brain tumors, leukemia, lung, laryngeal and adrenal cortical carcinoma. Cancer 41: 2055–2064, 1978
Harvald B, Hauge M: On the heredity of glioblastoma. J Natl Cancer Inst 17: 289–296, 1956
Choi NW, Schuman LM, Gullen WH: Epidemiology of primary central nervous system neoplasms. II. Case-control study. Am J Epidemiol 91: 467–485, 1970
Burch JD, Craib KJ, Choi BC, Miller AB, Risch HA, Howe GR: An exploratory case-control study of brain tumors in adults. J Natl Cancer Inst 78: 601–609, 1987
Preston-Martin S, Mack W, Henderson BE: Risk factors for gliomas and meningiomas in males in Los Angeles County. Cancer Res 49: 6137–6143, 1989
Wrensch MR, Barger GR: Familial factors associated with malignant gliomas. Genet Epidemiol 7: 291–301, 1990
Ryan P, Lee MW, North B, McMichael AJ: Risk factors for tumors of the brain and meninges: results from the Adelaide adult brain tumor study. Int J Cancer 51: 20–27, 1992
Kuijten RR, Bunin GR, Nass CC, Meadows AT: Gestational and familial risk factors for childhood astrocytoma: results of a case-control study. Cancer Res 50: 2608–2612, 1990
Bondy ML, Lustbader ED, Buffler PA, Schull WJ, Hardy RJ, Strong LC: Genetic epidemiology of childhood brain tumors. Genet Epidemiol 8: 253–267, 1991
Tijssen CC: Genetic aspects of brain tumors — tumors of neuroepithelial and meningeal tissue. In: Muller H, Weber W (eds) Familial Cancer. Karger, Basel, 1985
Chowdhary UP, Boehme DH, Al-Jishi M: Turcot syndrome glioma polyposis. J Neurosurg 63: 804–807, 1985
Vieregge P, Gerhard L, Nahser HC: Familial glioma: occurrence within the ‘familial cancer syndrome’ and systemic malformations. J Neurol 234: 220–232, 1987
Lynch HT, Lynch JF: Genetics and colorectal cancer. In: Muller H, Weber W (eds) Familial Cancer. Karger, Basal, 1985
Bernard SM, Cartwright RA, Darwin CM, Richards ID, Roberts B, O'Brien C, Bird CC: Hodgkin's disease: case control epidemiological study in Yorkshire. Br J Cancer 55: 85–90, 1987
Peto J: Genetic predisposition to cancer. In: Cairns J, Lyon JL, Skolnick M (eds) Cancer Incidence in Defined Populations, Banbury Report 4. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, 1980
Khoury MJ, Flanders MD: On the measurement of susceptibility to genetic factors. Genet Epidemiol 6: 699–711, 1989
Koch G: Genetic aspects of phacomatoses. In: Vinken PG, Bruyn GW (eds) Handbook of Clinical Neurology, Vol 14. North Holland, Amsterdam, 1972
Norris FD, Jackson EW: Childhood cancer deaths in California born twins — a further report on types of cancer found. Cancer 25: 212–218, 1970
Mulcahy GM, Harlan WL: Occurrences of central nervous system tumors, with special reference to relative genetic factors. In: Lynch HT (ed) Cancer Genetics. Thomas Books, Springfield, IL 1976
Chiba M, Masamune O, Mizuno M, Nakajima S: Brain tumor in a pedigree of cancer family syndrome. Intern Med 31: 1210–1212, 1992
Malkin D, Li FP, Strong LC, Fraumeni JF Jr, Nelson CE, Kim DH, Kassel J, Gryka MA, Bischoff EZ, Tainsky MA, Friend SH: Germ linep53 mutations in a familial syndrome of breast cancer, sarcoma, and other neoplasms. Science 250: 1233–1238, 1990
Borresen AL: Oncogenesis in ovarian cancer. Acta Obstet Gynecol Scand Suppl 155: 25–30, 1992
Frebourg T, Kassel J, Lam KT, Gryka MA, Barbier N, Andersen TI, Borresen AL, Friend SH: Germ-line mutations of thep53 tumor suppressor gene in patients with high risk for cancer inactivate thep53 protein. Proc Natl Acad Sci USA 89: 6413–6417, 1992
Gomez MR: Tuberous Sclerosis. Raven Press, New York, 1988
Gold EB: Epidemiology of brain tumors. Reviews in Cancer Epidemiology 1: 245–291, 1980
Haines JL, Short MP, Kwiatkowski DJ, Jewell A, Andermann E, Bejjani B, Yang CH, Gusella JF, Amos JA: Localization of one gene for tuberous sclerosis within 9q32–9q34, and further evidence for heterogeneity. Am J Hum Genet 49: 764–772, 1991
Kapp JP, Paulson GW, Odom GL: Brain tumors with tuberous sclerosis. J Neurosurg 26: 191–202, 1967
Altermatt HJ, Shepherd CW, Scheitauer BW, Gomez MR: Subependymal giant cell astrocytoma. Zentralbl Pathol 137: 105–116, 1991
Shepherd CW, Gomez MR, Lie JT, Crowson CS: Causes of death in patients with tuberous sclerosis. Mayo Clin Proc 66: 792–796, 1991
Shepherd CW, Scheithauer BW, Gomez MR, Altermatt HJ, Katzmann JA: Subependymal giant cell astrocytoma: a clinical, pathological, and flow cytometric study. Neurosurgery 28: 864–868, 1991
Crowe FW, Schull WJ, Neel JV: A clinical, pathological, and genetic study of multiple neurofibromatosis. Charles C. Thomas, Springfield, IL, 1956
Rubenstein AE: Neurofibromatosis: a review of the clinical problem. Ann N Y Acad Sci, 486: 1–13, 1986
Jadayel D, Fain P, Upadhyaya M, Ponder MA, Huson SM, Carey J, Fryer A, Mathew CG, Barker DF, Ponder BA: Paternal origin of new mutations in von Recklinghausen neurofibromatosis. Nature 343: 558–559, 1990
Riccardi VM: Von Recklinghausen neurofibromatosis. N Engl J Med 305: 1617–1627, 1981
Blatt J, Jaffee R, Deutsch M, Adkins JC: Neurofibromatosis and childhood tumors. Cancer 57: 1225–1229, 1986
Hope DG, Mulvihill JJ: Malignancy in neurofibromatosis. Adv Neurol 29: 33–56, 1981
Sorenson SA, Mulvihill JJ, Nielson A: Long-term follow up of von Recklinghausen neurofibromatosis: survival and malignant neoplasms. N Engl J Med 314: 1010–1015, 1986
Barker D, Wright E, Nguyen K, Cannon L, Fain P, Goldgar D, Bishop DT, Carey J, Baty B, Kivlin J: Gene for von Recklinghausen neurofibromatosis is in the pericentromeric region of chromosome 17. Science 236: 1100–1102, 1987
Seizinger BR, Rouleau GA, Ozeluis LJ, Lane AH, Faryniarz AG, Chao MJ, Huson S, Korf BR, Parry DM, Perleak-Vance MA: Genetic linkage of von Recklinghausen neurofibromatosis to the nerve growth factor receptor gene. Cell 49: 589–594, 1987
Cawthon RM, O'Connell P, Buchberg AM, Viskochil D, Weiss RB, Culver M, Stevens J, Jenkins NA, White R: Identification and characterization of transcripts from the neurofibromatosis 1 region: the sequence and genomic structure of EVI2 and mapping of other transcripts. Genomics 7: 555–565, 1990
Viskochil D, Buchberg AM, Xu G, Cawthon RM, Stevens J, Wolff RK, Culver M, Carey JC, Copeland NG, Jenkins NA, White R, O'Connell P: Deletions and a translocation interrupt a cloned gene at the neurofibromatosis type 1 locus. Cell 62: 187–192, 1990
Wallace MR, Marchuk DA, Andersen LB, Letcher R, Odeh HM, Saulino AM, Fountain JW, Brereton A, Nicholson J, Mitchell AL, Brownstein BH, Collins F: Type 1 neurofibromatosis gene: identification of a large transcript disrupted in three NF-1 patients. Science 249: 181–186, 1990
Xu GF, O'Connell P, Viskochil D, Cawthon R, Robertson M, Culver M, Dunn D, Stevens J, Gesteland R, White R, Weiss R: The neurofibromatosis type 1 gene encodes a protein related to GAP. Cell 62: 599–608, 1990
Trahey M, McCormick F: Cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants. Science 238: 542–545, 1987
Nishi T, Saya H: Neurofibromatosis type 1 (NF-1) gene: implication in neuroectodermal differentiation and genesis of brain tumors. Cancer Metastasis Rev 10: 301–310, 1991
Nishi T, Lee PS, Oka K, Levin VA, Tanase S, Morino Y, Saya H: Differential expression of two types of the neurofibromatosis type 1 (NF-1) gene transcripts related to neuronal differentiation. Oncogene 6: 1555–1559, 1991
Mochizuki H, Nishi T, Lee PSY, Bruner JM, Levin VA, Saya H: Alteration of splicing pattern of Neurofibromatosis type 1 gene transcript in malignant brain tumors: PCR analysis of frozen-section tissue. Mol Carcino 6: 83–87, 1992
Rouleau GA, Wertelecki W, Haines JL, Hobbs WJ, Trofatter JA, Seizinger BR, Martuza RL, Superneau DW, Conneally PM, Gusella JF: Genetic linkage of bilateral acoustic neurofibromatosis to a DNA marker on chromosome 22. Nature 329: 246–248, 1987
Martuza RL, Eldridge R: Neurofibromatosis 2: bilateral acoustic neurofibromatosis. New Engl J Med 318: 684–688, 1988
Wolff RK, Frazer KA, Jackler RK, Lanser HJ, Pitts LH, Cox DR: Analysis of chromosome 22 deletions in neurofibromatosis type 2-related tumors. Am J Hum Genet 51: 478–485, 1992
Gorlin RJ: Nevoid basal cell carcinoma syndrome. Medicine 66: 98–113, 1987
Gailani MR, Bale SJ, Leffell DJ, DiGiovanna JJ, Peck GL, Poliak S, Drum MA, Pastakin B, McBride OW, Kase R: Developmental defects in Gorlin syndrome related to a putative tumor suppressor gene on chromosome 9. Cell 69: 111–117, 1992
Farndon PA, Del Mastro RG, Evans DG, Kilpatrick MW: Location of gene for Gorlin syndrome. Lancet 339: 581–582, 1992
Bare JW, Lebo RV, Epstein EH Jr: Loss of heterozygosity at chromosome 1q22 in basal cell carcinomas and exclusion of the basal cell nevus syndrome gene from this site. Cancer Res 52: 1494–1498, 1992
Costa OL, Silva DM, Colnago FA, Vieira MS, Musso C: Turcot Syndrome: autosomal dominant or recessive transmission? Dis Colon Rectum 30: 391–394, 1987
Lewis JH, Ginsberg AL, Toomey KE: Turcot's syndrome: evidence for autosomal dominant inheritance. Cancer 51: 524–528, 1983
Bodmer WF, Bailey CJ, Bodmer J, Bussey HJ, Ellis A, Gorman P, Lucibello FC, Murday VA, Rider SH, Scambler P: Localization of the gene for familial adenomatous polyposis on chromosome 5. Nature 328: 614–616, 1987
Haggitt RC, Reid BJ: Hereditary gastrointestinal polyposis syndromes. Am J Surg Pathol 12: 871–887, 1986
Tops CM, Vasen HF, van Berge Henegouwen G, Simoons PP, van de Klift HM, van Leeuwen SJ, Breukel C, Fodde R, den Hartog Jager FC, Nagengast FM: Genetic evidence that Turcot syndrome is not allelic to familial adenomatous polyposis. Am J Med Genet 43: 888–893, 1992
Kikuchi T, Rempel SA, Rutz HP, de Tribolet N, Mulligan L, Cavenee WK, Jothy S, Leduy L, Van Meir EG: Turcot's syndrome of glioma and polyposis occurs in the absence of germ line mutations of exons 5 to 9 of thep53 gene. Cancer Res 53: 957–961, 1993
Levine C, Skimming J, Levine E: Familial pheochromocytomas with unusual associations. J Pediatr Surg 27: 447–451, 1992
Burk RR: Von Hippel-Lindau disease angiomatosis of the retina and cerebellum. J Am Optom Assoc 62: 382–388, 1991
Maher ER, Bentley E, Yates JR, Latif F, Lerman M, Zbar B, Affara NA, Ferguson-Smith MA: Mapping of the Von Hippel-Lindau disease locus to a small region of chromosome 3p by genetic linkage analysis. Genomics 10: 957–960, 1991
Maher ER, Iselius L, Yates JR, Littler M, Benjamin C, Harris R, Sampson J, Williams A, Ferguson-Smith MA, Morton N: Von Hippel-Lindau disease: a genetic study. J Med Genet 28: 443–447, 1991
Seizinger BR, Smith DI, Filling-Katz MR, Neumann H, Green JS, Choyke PL, Anderson KM, Freiman RN, Klacick SM, Whaley J: Genetic flanking markers refine diagnostic criteria and provide insights into the genetics of von Hippel Lindau disease. Proc Natl Acad Sci USA 88: 2864–2868, 1991
Yamakawa K, Morita R, Takahashi E, Hori T, Ishikawa J, Nakamura Y: A detailed deletion mapping of the short arm of chromosome 3 in sporadic renal cell carcinoma. Cancer Res 51: 4707–4711, 1991
Dietrich PY, Droz JP: Renal cell cancer: oncogenes and tumor suppressor genes. Rev Prat 42: 1236–1240, 1992
Bigner SH, Burger PC, Wong AJ, Werner MH, Hamilton SR, Muhlbaier LH, Vogelstein B, Bigner DD: Gene amplification in malignant human gliomas: clinical and histopathologic aspects. J Neuropath Exp Neurol 47: 191–205, 1988
Jenkins RB, Kimmel DW, Moertel CA, Schultz CG, Scheithauer BW, Kelly PJ, Dewald GW: A cytogenetic study of 53 human gliomas. Cancer Genet and Cytogenet 39: 253–279, 1989
Rey JA, Bello MJ, de Campos JM, Kusak ME, Ramos C, Benitz J: Chromosomal patterns in human malignant astrocytomas. Cancer Genet Cytogenet 29: 201–221, 1987
Biegel JA, Burk CD, Barr FG, Emanuel BS: Evidence for a 17p tumor related locus distinct fromp53 in pediatric primitive neuroectodermal tumors. Cancer Res 52: 3391–3395, 1992
Cogen PH, Daneshvar L, Metzger AK, Duyk G, Edwards MS, Sheffield VC: Involvement of multiple chromosome 17p loci in medulloblastoma tumorigenesis. Am J Hum Genet 50: 584–489, 1992
Heim S, Mandahl N, Jin Y, Stromblad S, Lindstrom E, Salford LG, Mitelman F: Trisomy 7 and sex chromosome loss in human brain tissue. Cytogenet Cell Genet 52: 136–138, 1989
Arnoldus EP, Noordermeer IA, Peters AC, Voormolen JH, Bots GT, Raap AK, Van der Ploeg M: Interphase cytogenetics of brain tumors. Genes Chromosom Cancer 3: 101–107, 1991
Arnoldus EP, Wolters LB, Voormolen JH, van Duinen SG, Raap AK, van der Ploeg M, Peters AL: Interphase cytogenetics: a new tool for the study of genetic changes in brain tumors. J Neurosurg 76: 997–1003, 1992
Bigner SH, Wong AJ, Mark J, Muhlbaier LH, Kinzler KW, Vogelstein B, Bigner DD: Relationship between gene amplification and chromosomal deviations in malignant human gliomas. Cancer Genet Cytogenet 29: 165–170, 1987
Libermann TA, Nusbaum HR, Razon N, Kris R, Lax I, Soreq H, Whittle N, Waterfield MD, Ullrich A, Schlessinger J: Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumors of glial origin. Nature 313: 144–147, 1985
Wong AJ, Bigner SH, Bigner DD, Kinzler KW, Hamilton SR, Vogelstein B: Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification. Proc Natl Acad Sci USA 84: 6899–6903, 1987
Yamazaki H, Fukui Y, Ueyama Y, Tamaoki N, Kawamoto T, Taniguchi S, Shibuya M: Amplification of the structurally and functionally altered epidermal growth factor receptor gene (c-erbB) in human brain tumors. Mol Cell Biol 8: 1816–1820, 1988
Ekstrand AJ, Sugawa N, James CD, Collins VP: Amplified and rearranged epidermal growth factor receptor genes in human glioblastomas reveal deletions of sequences encoding portions of the N- and/or C-terminal tails. Proc Natl Acad Sci USA 89: 4309–4313, 1992
Humphrey PA, Gangarosa LM, Wong AJ, Archer GE, Lund JM, Bjerkvig R, Laerum OD, Friedman HS, Bigner DD: Deletion-mutant epidermal growth factor receptor in human gliomas: effects of type II mutation on receptor function. Biochem Biophys Res Commun 178: 1413–1420, 1991
Wong AJ, Ruppert JM, Bigner SH, Grzeschik CH, Humphrey PA, Bigner DS, Vogelstein B: Structural alterations of the epidermal growth factor receptor gene in human gliomas. Proc Natl Acad Sci USA 89: 2965–2969, 1992
Bigner SH, Mark J, Bigner DD: Cytogenetics of human brain tumors. Cancer Genet Cytogenet 47: 141–154, 1990
Diedrich U, Soja S, Behnke J, Zoll B: Amplification of the c-erbB oncogene is associated with malignancy in primary tumours of neuroepithelial tissue. J Neurol 238: 221–224, 1991
Hurtt MR, Moossy J, Donovan PM, Locker J: Amplification of epidermal growth factor receptor gene in gliomas: histopathology and prognosis. J Neuropathol Exp Neurol 51: 84–90, 1992
El-Azouzi M, Chung RY, Farmer GE, Martuza RL, Black PM, Rouleau GA, Hettlich C, Hedley-Whyter ET, Zervas NT, Panagopoulos K: Loss of distinct regions on the short arm of chromosome 17 associated with tumorigenesis of human astrocytomas. Proc Natl Acad Sci USA 86: 7186–7190, 1989
Fujimoto M, Fults DW, Thomas GA, Nakamura Y, Heilbrun MP, White R, Story JL, Naylor SL, Kagan-Hallet KS, Sheridan PJ: Loss of heterozygosity on chromosome 10 in human glioblastoma multiforme. Genomics 4: 210–214, 1989
Fults D, Tippets RH, Thomas GA, Nakamura Y, White R: Loss of heterozygosity for loci on chromosome 17p in human malignant astrocytoma. Cancer Res 49: 6572–6577, 1989
James CD, Carlbom E, Dumanski JP, Hansen M, Nordenskjold M, Collins VP, Cavenee WK: Clonal genomic alterations in glioma malignancy stages. Cancer Res 48: 5546–5551, 1988
James CD, Carlbom E, Nordenskjold M, Collins VP, Cavenee WK: Mitotic recombination of chromosome 17 in astrocytomas. Proc Natl Acad Sci USA 86: 2858–2862, 1989
Kastan MB, Onyekwere O, Sidransky D, Vogelstein B, Crain RW: Participation ofp53 protein in the cellular response to DNA damage. Cancer Res 51: 6304–6311, 1991
Kuerbitz SJ, Pluckett BS, Walsh WV, Kastan MB: Wild-typep53 is a cell cycle checkpoint determinant following irradiation. Proc Natl Acad Sci USA 89: 7491–7495, 1992
Martinez J, Georgoff I, Martinez J, Levine AJ: Cellular localization and cell cycle regulation by a temperature-sensitivep53 protein. Genes Dev 5: 151–159, 1991
Nigro JM, Baker SJ, Preisinger AC, Jessup JM, Hostetter R, Cleary K, Bigner SH, Davidson N, Baylin S, Devilee P: Mutations in thep53 gene occur in diverse human tumor types. Nature 342: 705–708, 1989
Frankel RH, Bayona W, Koslow M, Newcomb EW:p53 mutations human malignant gliomas: comparison of loss of heterozygosity with mutation frequency. Cancer Res 52: 1427–1433, 1992
Louis DN, von Deimling A, Chung RY, Rubio MP, Whaley JM, Eibl RH, Ohgaki H, Wiestler OD, Thor AD, Seizinger BR: Comparative study ofp53 gene and protein alterations in human astrocytic tumors. J Neuropathol Exp Neuro 52: 31–38, 1993
Saxena A, Clark WC, Robertson JT, Ikejiri B, Oldfield EH, Ali IU: Evidence for the involvement of a potential second tumor suppressor gene on chromosome 17 distinct fromp53 in malignant astrocytomas. Cancer Res 52: 6716–6721, 1992
Venter DJ, Bevan KL, Ludwig RL, Riley TE, Jat PS, Thomas DG, Noble MD: Retinoblastoma gene deletions in human glioblastomas. Oncogene 6: 445–448, 1991
Chung RY, Seizinger BR: Molecular genetics of neurological tumours. J Med Genet 29: 361–367, 1992
Fujimoto M, Sheridan PJ, Sharp ZD, Weaker FJ, Kagan-Hallet S, Story JL: Proto-oncogene analyses in brain tumors. J Neurosurg 70: 910–915, 1989
Oren M:p53: the ultimate tumor suppressor gene? FASEB J 6: 3169–3176, 1992
Akbasak A, Sunar-Arkbasak B: Oncogenes: cause or consequence in the development of glial tumors. J Neuro Sci 111: 119–133, 1992
Vogelstein B, Fearon ER, Kern SE, Hamilton SR, Preisinger AC, Nakamura Y, White R: Allelotype of colorectal carcinomas. Science 244: 207–211, 1989
Fults D, Brockmeyer D, Tullous MW, Pedone CA, Cawthon RM:p53 mutation and loss of heterozygosity on chromosomes 17 and 10 during human astrocytoma progression. Cancer Res 50: 5784–5789, 1990
Fults D, Petrocio J, Noblett BD, Pedone CA: Chromosome 11p15 deletions in human malignant astrocytomas and primitive neuroectodermal tumors. Genomics 14: 799–801, 1992
von Deimling A, Louis DN, von Ammon K, Petersen I, Wiestler OD, Seizinger BR: Evidence for a tumor suppressor gene on chromosome 19q associated with human astrocytomas, oligodendrogliomas, and mixed gliomas. Cancer Res 52: 4277–4279, 1992
Rasheed BK, Fuller GN, Friedman AH, Bigner DD, Bigner SH: Loss of heterozygosity for 10q loci in human gliomas. Genes Chromosom Cancer 5: 75–82, 1992
Ransom DT, Ritland SR, Kimmel DW, Moertel CA, Dahl RJ, Scheithauer BW, Kelly PJ, Jenkins RB: Cytogenetic and loss of heterozygosity studies in ependymomas, pilocytic astrocytomas, and oligodendrogliomas. Genes Chromosom Cancer 5: 348–356, 1992
Nurnberg P, Thiel G, Wever F, Epplen JT: Changes of telomere lengths in human intracranial tumours. Hum Genet 91: 190–192, 1993
Ohgaki H, Eibl RH, Wiestler OD, Yasargil MG, Newcomb EW, Kleihues P:p53 mutations in nonastrocytic human brain tumors. Cancer Res 51: 6202–6205, 1991
Jones PA, Buckley JD, Henderson BE, Ross RK, Pike MC: From gene to carcinogen: a rapidly evolving field in molecular epidemiology. Cancer Res 51: 3617–3620, 1991
Krontiris TG, DiMartino NA, Mitcheson DH, Lonergan JA, Begg C, Parkinson DR: Human hypervariable sequences in risk assessment: Rare Ha-ras alleles in cancer patients. Environ Health Perspect 76: 147–153, 1987
Olopade OI, Jenkins RB, Ransom DT, Malik K, Pomykala H, Nobori T, Cowan JM, Rowley JD, Diaz MO: Molecular analysis of deletions of the short arm of chromosome 9 in human gliomas. Cancer Res 52: 2523–2539, 1992
Fleming TP, Saxena A, Clark WC, Robertson JT, Oldfield EH, Aaronson SA, Ali IU: Amplification and/or overexpression of platelet-derived growth factor receptors and epidermal growth factor receptor in human glial tumors. Cancer Res 52: 4550–4553, 1992
Fuller GN, Burger PC, Schold SC: Gene amplification in human gliomas. J Neuropathol Exp Neurol 49: 320, 1990
Kinzler KW, Ruppert JM, Bigner SH, Vogelstein B: The GLI gene is a member of the Kruppel family of zinc finger proteins. Nature 332: 371–374, 1988
Ellison DW, Gatter KC, Steart PV, Lane DP, Weiler RO: Expression of thep53 protein in a spectrum of astrocytic tumours. J Pathol 168: 383–386, 1992
Fuller GN, Bigner SH: Amplified cellular oncogenes in neoplasms of the human central nervous system. Mutat Res 276: 299–306, 1992
von Deimling A, Eibl RH, Ohgaki H, Louis DN, von Ammon K, Petersen I, Kleihues P, Chung RY, Wiestler OD, Seizinger BR:p53 mutations are associated with 17p alletic loss in grade II and III astrocytomas. Cancer Res 52: 2987–2990, 1992
Mashiyama S, Murakami Y, Yoshimoto T, Sekiya T, Hayashi K: Detection ofp53 gene mutations in human brain tumors by single-strand conformation polymorphism analysis of polymerase chain reaction products. Oncogene 6: 1313–1318, 1991
Thiel G, Losanowa T, Kintzel D, Nisch G, Martin H, Vorpahl K, Witkowski R: Karyotypes in 90 human gliomas. Cancer Genet Cytogenet 58: 109–120, 1992
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Bondy, M., Wiencke, J., Wrensch, M. et al. Genetics of primary brain tumors: a review. J Neuro-Oncol 18, 69–81 (1994). https://doi.org/10.1007/BF01324606
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DOI: https://doi.org/10.1007/BF01324606