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Effect of Curcumin on the Process of Neuroinflammation Caused by COVID-19

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Curcumin and Neurodegenerative Diseases

Abstract

Curcumin, the main active ingredient of Curcuma longa L., has antioxidant, anti-inflammatory, antitumor, antiviral, neuroprotective, and immune system-modulating properties. Because of these properties, this curcuminoid may be helpful both before and after SARS-CoV-2 infections, enhancing health status in the various complications brought on by the illness (respiratory, enteric, hepatic, and neurological). From this perspective, this chapter aims to report on findings regarding the effect of turmeric on COVID-19-induced neuroinflammation. Thus, a literature review was conducted following the guidelines suggested by Paré and Kitsiou (Handbook of eHealth evaluation: an evidence-based approach [Internet], 2017). Some studies highlight that curcumin is effective in COVID-19 conditions by inhibiting inflammatory and neuroinflammatory signaling pathways, such as nuclear factor kappa B (NF-kB), and the induction of various pro-inflammatory cytokines and chemokines, including interleukin (IL)-6, interferon (IFN) γ, monocyte chemoattractant protein (MCP)-1, tumor necrosis factor (TNF)-α and IL-1β, however, its mechanism of action is not yet fully elucidated, which may be directly linked to its low bioavailability. Factors such as low solubility, chemical instability, rapid hepatic metabolism, and elimination of curcumin in humans are issues addressed in several technological researches aiming to improve the bioavailability of this molecule. These facts point to the need for further studies on curcumin bioavailability in order for it to effectively become a compound with clinical relevance in the treatment of COVID-19, as well as in several other pathologies or health conditions.

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Authors and Affiliations

  1. Research Laboratory II, Federal University of Piaui, Campus Senador Helvídio Nunes de Barros—Junco, Picos, PI, Brazil

    Sabrina Almondes Teixeira, Stella Regina Arcanjo Medeiros & Joilane Alves Pereira-Freire

  2. Department of Biology, Federal Institute of Mato Grosso—MT, Jaciara, Brazil

    George Laylson da Silva Oliveira

  3. Laboratory of Education and Research in Toxicology and Pharmacology (LEPTOX-F), Jaciara, Brazil

    George Laylson da Silva Oliveira

  4. Medicinal Plant Research Center, Federal University of Piaui, Campus Ministro Petronio Portela, Teresina, PI, Brazil

    Boris Timah Acha

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  3. George Laylson da Silva Oliveira
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  4. Boris Timah Acha
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  5. Joilane Alves Pereira-Freire
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Correspondence to Joilane Alves Pereira-Freire .

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  1. Department of Biotechnology, Sant Gadge Baba Amravati University, Amravati, Maharashtra, India

    Mahendra Rai

  2. Department of Chemistry, Federal University of Piauí, Teresina, Brazil

    Chistiane M. Feitosa

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Teixeira, S.A., Medeiros, S.R.A., da Silva Oliveira, G.L., Acha, B.T., Pereira-Freire, J.A. (2023). Effect of Curcumin on the Process of Neuroinflammation Caused by COVID-19. In: Rai, M., Feitosa, C.M. (eds) Curcumin and Neurodegenerative Diseases. Springer, Singapore. https://doi.org/10.1007/978-981-99-7731-4_14

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  • DOI: https://doi.org/10.1007/978-981-99-7731-4_14

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