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Impact of Curcumin on Aging: Its Manifestations and Limitations

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Curcumin and Neurodegenerative Diseases

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Abstract

Products of molecular and cellular damage accumulate over time and contribute to aging. In the long run, this results in a loss of physical and mental function, increased disease risk, and a higher mortality rate. Deteriorating cognitive function associated with aging reduces the quality of life and increases costs for those affected and their families. Several risk factors and disorders such as high blood pressure, stroke, diabetes, to name a few, contribute to cognitive impairment. Oxidative stress and inflammation contribute to cognitive decline due to homeostatic imbalances. There is a link between inflammation and dementia. Misfolded proteins elicit an immune response that results in neuronal death and cognitive impairment, a characteristic of Alzheimer’s disease (AD). Due to its potential for treating cancer and Alzheimer’s disease, turmeric, which contains curcumin, has gained considerable attention in recent years. The primary reason why curcumin is effective is its anti-inflammatory properties. Age-related redox imbalance results in overexpression of reactive oxygen species levels. Curcumin reduces oxidative stress associated with cellular senescence and can benefit aging individuals.

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Authors and Affiliations

  1. Department of Pharmacology and Toxicology, College of Pharmacy, Jazan University, Jazan, Saudi Arabia

    David Banji

  2. Department of Clinical Pharmacy, College of Pharmacy, Jazan University, Jazan, Saudi Arabia

    Otilia J. F. Banji

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  1. Department of Biotechnology, Sant Gadge Baba Amravati University, Amravati, Maharashtra, India

    Mahendra Rai

  2. Department of Chemistry, Federal University of Piauí, Teresina, Brazil

    Chistiane M. Feitosa

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Banji, D., Banji, O.J.F. (2023). Impact of Curcumin on Aging: Its Manifestations and Limitations. In: Rai, M., Feitosa, C.M. (eds) Curcumin and Neurodegenerative Diseases. Springer, Singapore. https://doi.org/10.1007/978-981-99-7731-4_13

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