Abstract
Many IONPs-based nanoplatforms have been created to use for successful cancer treatment. Both traditional chemotherapies based on drug delivery and alternative treatment techniques like photothermal therapy have made use of these nanoplatforms. The crucial and often researched therapy approaches are covered in this chapter. The below figure presents the most popular strategies that are used for treating cancer.
Abstract’s hierarchical chart of the most common strategies for cancer therapy based on iron oxide nanoparticles (discussed in depth in this chapter)
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Abadeer NS, Murphy CJ (2016) Recent progress in cancer thermal therapy using gold nanoparticles. J Phys Chem C 120(9):4691–4716
Abdal Dayem A, Hossain MK, Lee SB, Kim K, Saha SK, Yang G-M, Choi HY, Cho S-G (2017) The role of reactive oxygen species (ROS) in the biological activities of metallic nanoparticles. Int J Mol Sci 18(1):120
Abenojar EC, Wickramasinghe S, Bas-Concepcion J, Samia ACS (2016) Structural effects on the magnetic hyperthermia properties of iron oxide nanoparticles. Prog Nat Sci Mater Int 26(5):440–448
Agostinis P, Breyssens H, Buytaert E, Hendrickx N (2004) Regulatory pathways in photodynamic therapy induced apoptosis. Photochem Photobiol Sci 3:721–729
Ahmadkhani L, Akbarzadeh A, Abbasian M (2018) Development and characterization dual responsive magnetic nanocomposites for targeted drug delivery systems. Artif Cells Nanomed Biotechnol 46(5):1052–1063
Ahn T-G, Lee B-R, Choi E-Y, Kim DW, Han S-J (2012) Photodynamic therapy for breast cancer in a BALB/c mouse model. J Gynecol Oncol 23(2):115–119
Akbarzadeh A, Rezaei-Sadabady R, Davaran S, Joo SW, Zarghami N, Hanifehpour Y, Samiei M, Kouhi M, Nejati-Koshki K (2013) Liposome: classification, preparation, and applications. Nanoscale Res Lett 8(1):1–9
Akimoto J, Nakayama M, Okano T (2014) Temperature-responsive polymeric micelles for optimizing drug targeting to solid tumors. J Control Release 193:2–8
Al-Waili, NS, Butler GJ, Beale J, Hamilton RW, Lee BY, Lucas P (2005). Hyperbaric oxygen and malignancies: a potential role in radiotherapy, chemotherapy, tumor surgery and phototherapy. Med Sci Monit 11(9):RA279
Alex MA, Nehate C, Veeranarayanan S, Kumar DS, Kulshreshtha R, Koul V (2017) Self assembled dual responsive micelles stabilized with protein for co-delivery of drug and siRNA in cancer therapy. Biomaterials 133:94–106
Ali EM, Elashkar AA, El-Kassas HY, Salim EI (2018) Methotrexate loaded on magnetite iron nanoparticles coated with chitosan: Biosynthesis, characterization, and impact on human breast cancer MCF-7 cell line. Int J Biol Macromol 120:1170–1180
Aljarrah K, Mhaidat NM, Al-Akhras M-AH, Aldaher AN, Albiss B, Aledealat K, Alsheyab FM (2012) Magnetic nanoparticles sensitize MCF-7 breast cancer cells to doxorubicin-induced apoptosis. World J Surg Oncol 10(1):1–5
Allison RR (2014) Photodynamic therapy: oncologic horizons. Future Oncol 10(1):123–124
Allison RR, Moghissi K (2013) Oncologic photodynamic therapy: clinical strategies that modulate mechanisms of action. Photodiagn Photodyn Ther 10(4):331–341
Allison RR, Sibata CH (2010) Oncologic photodynamic therapy photosensitizers: a clinical review. Photodiagn Photodyn Ther 7(2):61–75
Alomari M, Jermy BR, Ravinayagam V, Akhtar S, Almofty SA, Rehman S, Bahmdan H, AbdulAzeez S, Borgio JF (2019) Cisplatin-functionalized three-dimensional magnetic SBA-16 for treating breast cancer cells (MCF-7). Artificial Cells Nanomed Biotechnol 47(1):3079–3086
Alric C, Hervé-Aubert K, Aubrey N, Melouk S, Lajoie L, Même W, Même S, Courbebaisse Y, Ignatova AA, Feofanov AV (2018) Targeting HER2-breast tumors with scFv-decorated bimodal nanoprobes. J Nanobiotechnol 16:1–13
Alvarez-Lorenzo C, Concheiro A (2013) Smart materials for drug delivery. Royal Society of Chemistry.
Amirshaghaghi A, Yan L, Miller J, Daniel Y, Stein JM, Busch TM, Cheng Z, Tsourkas A (2019) Chlorin e6-coated superparamagnetic iron oxide nanoparticle (SPION) nanoclusters as a theranostic agent for dual-mode imaging and photodynamic therapy. Sci Rep 9(1):1–9
Assikar S, Labrunie A, Kerob D, Couraud A, Bédane C (2020) Daylight photodynamic therapy with methyl aminolevulinate cream is as effective as conventional photodynamic therapy with blue light in the treatment of actinic keratosis: a controlled randomized intra-individual study. J Eur Acad Dermatol Venereol 34(8):1730–1735
Attaluri A, Kandala SK, Wabler M, Zhou H, Cornejo C, Armour M, Hedayati M, Zhang Y, DeWeese TL, Herman C (2015) Magnetic nanoparticle hyperthermia enhances radiation therapy: A study in mouse models of human prostate cancer. Int J Hyperth 31(4):359–374
Attari E, Nosrati H, Danafar H, Kheiri Manjili H (2019) Methotrexate anticancer drug delivery to breast cancer cell lines by iron oxide magnetic based nanocarrier. J Biomed Mater Res, Part A 107(11):2492–2500
Bae YH, Park K (2011) Targeted drug delivery to tumors: myths, reality and possibility. J Control Release 153(3):198
Bai F, Zhang X, Hou X, Liu H, Chen J, Yang T (2019) Individual and simultaneous voltammetric determination of Cd (II), Cu (II) and Pb (II) applying amino functionalized Fe3O4@ carbon microspheres modified electrode. Electroanalysis 31(8):1448–1457
Baldwin AD, Kiick KL (2013) Reversible maleimide–thiol adducts yield glutathione-sensitive poly (ethylene glycol)–heparin hydrogels. Polym Chem 4(1):133–143
Balk SP, Ko Y-J, Bubley GJ (2003) Biology of prostate-specific antigen. J Clin Oncol 21(2):383–391
Bañobre-López M, Teijeiro A, Rivas J (2013) Magnetic nanoparticle-based hyperthermia for cancer treatment. Rep Pract Oncol Radiother 18(6):397–400
Barani M, Nematollahi MH, Zaboli M, Mirzaei M, Torkzadeh-Mahani M, Pardakhty A, Karam GA (2019) In silico and in vitro study of magnetic niosomes for gene delivery: the effect of ergosterol and cholesterol. Mater Sci Eng, C 94:234–246
Bauer CA, Kim EY, Marangoni F, Carrizosa E, Claudio NM, Mempel TR (2014) Dynamic Treg interactions with intratumoral APCs promote local CTL dysfunction. J Clin Investig 124(6):2425–2440
Benyettou F, Alhashimi M, O’Connor M, Pasricha R, Brandel J, Traboulsi H, Mazher J, Olsen J-C, Trabolsi A (2017) Sequential delivery of doxorubicin and zoledronic acid to breast cancer cells by CB [7]-modified iron oxide nanoparticles. ACS Appl Mater Interfaces 9(46):40006–40016
Bhattacharya D, Behera B, Sahu SK, Ananthakrishnan R, Maiti TK, Pramanik P (2016) Design of dual stimuli responsive polymer modified magnetic nanoparticles for targeted anti-cancer drug delivery and enhanced MR imaging. New J Chem 40(1):545–557
Blasi F (1997) UPA, uPAR, PAI-I: Key intersection of proteolytic, adhesive and chemotacfic highways? Immunol Today 18(9):415–417
Bourne Y, Henrissat B (2001) Glycoside hydrolases and glycosyltransferases: families and functional modules. Curr Opin Struct Biol 11(5):593–600
Brancaleon L, Moseley H (2002) Laser and non-laser light sources for photodynamic therapy. Lasers Med Sci 17:173–186
Brazel CS (2009) Magnetothermally-responsive nanomaterials: combining magnetic nanostructures and thermally-sensitive polymers for triggered drug release. Pharm Res 26:644–656
Bruniaux J, Djemaa SB, Hervé-Aubert K, Marchais H, Chourpa I, David S (2017) Stealth magnetic nanocarriers of siRNA as platform for breast cancer theranostics. Int J Pharm 532(2):660–668
Bruniaux, J, Allard-Vannier E, Aubrey N, Lakhrif Z, Djemaa SB, Eljack S, Marchais H, Hervé-Aubert K, Chourpa I, David S (2019) Magnetic nanocarriers for the specific delivery of siRNA: contribution of breast cancer cells active targeting for down-regulation efficiency. Int J Pharm 569:118572
Bui QN, Li Y, Jang M-S, Huynh DP, Lee JH, Lee DS (2015) Redox-and pH-sensitive polymeric micelles based on poly (β-amino ester)-grafted disulfide methylene oxide poly (ethylene glycol) for anticancer drug delivery. Macromolecules 48(12):4046–4054
Burdon RH (1995) Superoxide and hydrogen peroxide in relation to mammalian cell proliferation. Free Radical Biol Med 18(4):775–794
Byrne JD, Betancourt T, Brannon-Peppas L (2008) Active targeting schemes for nanoparticle systems in cancer therapeutics. Adv Drug Deliv Rev 60(15):1615–1626
Cabral Filho PE, Cabrera MP, Cardoso AL, Santana OA, Geraldes CF, Santos BS, de Lima MCP, Pereira GA, Fontes A (2018) Multimodal highly fluorescent-magnetic nanoplatform to target transferrin receptors in cancer cells. Biochim Biophys Acta (BBA)-Gen Subj 1862(12):2788–2796
Canavese G, Ancona A, Racca L, Canta M, Dumontel B, Barbaresco F, Limongi T, Cauda V (2018) Nanoparticle-assisted ultrasound: A special focus on sonodynamic therapy against cancer. Chem Eng J 340:155–172
Cantisani C, Paolino G, Bottoni U, Calvieri S (2015) Daylight-photodynamic therapy for the treatment of actinic keratosis in different seasons. J Drugs Dermatol 14(11):1349–1353
Carroll L, Humphreys TR (2006) LASER-tissue interactions. Clin Dermatol 24(1):2–7
Casas A, Di Venosa G, Hasan T, Batlle A (2011) Mechanisms of resistance to photodynamic therapy. Curr Med Chem 18(16):2486–2515
Catalona WJ, Richie JP, Ahmann FR, M’Liss AH, Scardino PT, Flanigan RC, Dekernion JB, Ratliff TL, Kavoussi LR, Dalkin BL (1994) Comparison of digital rectal examination and serum prostate specific antigen in the early detection of prostate cancer: results of a multicenter clinical trial of 6,630 men. J Urol 151(5):1283–1290
Catalona WJ, Richie JP, Ahmann FR, Hudson MLA, Scardino PT, Flanigan RC, DeKernion JB, Ratliff TL, Kavoussi LR, Dalkin BL (2017) Comparison of digital rectal examination and serum prostate specific antigen in the early detection of prostate cancer: results of a multicenter clinical trial of 6,630 men. J Urol 197(2S):S200–S207
Cędrowska E, Pruszyński M, Gawęda W, Żuk M, Krysiński P, Bruchertseifer F, Morgenstern A, Karageorgou M-A, Bouziotis P, Bilewicz A (2020) Trastuzumab conjugated superparamagnetic iron oxide nanoparticles labeled with 225AC as a perspective tool for combined α-radioimmunotherapy and magnetic hyperthermia of HER2-positive breast cancer. Molecules 25(5):1025
Ceradini DJ, Kulkarni AR, Callaghan MJ, Tepper OM, Bastidas N, Kleinman ME, Capla JM, Galiano RD, Levine JP, Gurtner GC (2004) Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1. Nat Med 10(8):858–864
Ceylan H, Yasa IC, Yasa O, Tabak AF, Giltinan J, Sitti M (2019) 3D-printed biodegradable microswimmer for theranostic cargo delivery and release. ACS Nano 13(3):3353–3362
Chance B, Sies H, Boveris A (1979) Hydroperoxide metabolism in mammalian organs. Physiol Rev 59(3):527–605
Chang D, Lim M, Goos JA, Qiao R, Ng YY, Mansfeld FM, Jackson M, Davis TP, Kavallaris M (2018) Biologically targeted magnetic hyperthermia: potential and limitations. Front Pharmacol 9:831
Chen X, Mao SS (2007) Titanium dioxide nanomaterials: synthesis, properties, modifications, and applications. Chem Rev 107(7):2891–2959
Chen DS, Mellman I (2013) Oncology meets immunology: the cancer-immunity cycle. Immunity 39(1):1–10
Chen DS, Mellman I (2017) Elements of cancer immunity and the cancer–immune set point. Nature 541(7637):321–330
Chen Q, Chen H, Hetzel F (1996) Tumor oxygenation changes post-photodynamic therapy. Photochem Photobiol 63(1):128–131
Chen J, Keltner L, Christophersen J, Zheng F, Krouse M, Singhal A, Wang S-S (2002a) New technology for deep light distribution in tissue for phototherapy. Cancer J 8(2):154–163
Chen Q, Huang Z, Chen H, Shapiro H, Beckers J, Hetzel FW (2002b) Improvement of tumor response by manipulation of tumor oxygenation during photodynamic therapy¶. Photochem Photobiol 76(2):197–203
Chen F-H, Zhang L-M, Chen Q-T, Zhang Y, Zhang Z-J (2010) Synthesis of a novel magnetic drug delivery system composed of doxorubicin-conjugated Fe3O4 nanoparticle cores and a PEG-functionalized porous silica shell. Chem Commun 46(45):8633–8635
Chen J, Qiu X, Ouyang J, Kong J, Zhong W, Xing MM (2011) PH and reduction dual-sensitive copolymeric micelles for intracellular doxorubicin delivery. Biomacromolecules 12(10):3601–3611
Chen J, Guo Z, Wang H-B, Gong M, Kong X-K, Xia P, Chen Q-W (2013) Multifunctional Fe3O4@ C@ Ag hybrid nanoparticles as dual modal imaging probes and near-infrared light-responsive drug delivery platform. Biomaterials 34(2):571–581
Chen J, Huang L, Lai H, Lu C, Fang M, Zhang Q, Luo X (2014a) Methotrexate-loaded PEGylated chitosan nanoparticles: synthesis, characterization, and in vitro and in vivo antitumoral activity. Mol Pharm 11(7):2213–2223
Chen J, Shi M, Liu P, Ko A, Zhong W, Liao W, Xing MM (2014b) Reducible polyamidoamine-magnetic iron oxide self-assembled nanoparticles for doxorubicin delivery. Biomaterials 35(4):1240–1248
Chen S, Guo CX, Zhao Q, Lu X (2014c) One‐pot synthesis of CO2‐responsive magnetic nanoparticles with switchable hydrophilicity. Chemistry–A Eur J 20(43):14057–14062
Chen Y-W, Liu T-Y, Chang P-H, Hsu P-H, Liu H-L, Lin H-C, Chen S-Y (2016) A theranostic nrGO@ MSN-ION nanocarrier developed to enhance the combination effect of sonodynamic therapy and ultrasound hyperthermia for treating tumor. Nanoscale 8(25):12648–12657
Chen H, Luan X, Paholak HJ, Burnett JP, Stevers NO, Sansanaphongpricha K, He M, Chang AE, Li Q, Sun D (2020) Depleting tumor-associated Tregs via nanoparticle-mediated hyperthermia to enhance anti-CTLA-4 immunotherapy. Nanomedicine 15(1):77–92
Chen X, Cheng D, Ding M, Yu N, Liu J, Li J, Lin L (2022) Tumor-targeting biomimetic sonosensitizer-conjugated iron oxide nanocatalysts for combinational chemodynamic–sonodynamic therapy of colorectal cancer. J Mater Chem B 10(24):4595–4604
Cheng Y-J, Luo G-F, Zhu J-Y, Xu X-D, Zeng X, Cheng D-B, Li Y-M, Wu Y, Zhang X-Z, Zhuo R-X (2015) Enzyme-induced and tumor-targeted drug delivery system based on multifunctional mesoporous silica nanoparticles. ACS Appl Mater Interfaces 7(17):9078–9087
Chiang C-S, Lin Y-J, Lee R, Lai Y-H, Cheng H-W, Hsieh C-H, Shyu W-C, Chen S-Y (2018) Combination of fucoidan-based magnetic nanoparticles and immunomodulators enhances tumour-localized immunotherapy. Nat Nanotechnol 13(8):746–754
Chinnappan R, Al Faraj A, Abdel Rahman AM, Abu-Salah KM, Mouffouk F, Zourob M (2020) Anti-VCAM-1 and anti-IL4Rα aptamer-conjugated super paramagnetic iron oxide nanoparticles for enhanced breast cancer diagnosis and therapy. Molecules 25(15):3437
Chivate A, Garkal A, Dhas N, Mehta T (2021) Hot-Melt Extrusion: An Emerging Technique for Solubility Enhancement of Poorly Water-Soluble Drugs. PDA J Pharm Sci Technol 75(4):357–373
Cho N-H, Cheong T-C, Min JH, Wu JH, Lee SJ, Kim D, Yang J-S, Kim S, Kim YK, Seong S-Y (2011) A multifunctional core–shell nanoparticle for dendritic cell-based cancer immunotherapy. Nat Nanotechnol 6(10):675–682
Cho M, Cervadoro A, Ramirez MR, Stigliano C, Brazdeikis A, Colvin VL, Civera P, Key J, Decuzzi P (2017) Assembly of iron oxide nanocubes for enhanced cancer hyperthermia and magnetic resonance imaging. Nanomaterials 7(4):72
Chong ZX, Yeap SK, Ho WY (2021) Transfection types, methods and strategies: a technical review. PeerJ 9:e11165
Chouly C, Pouliquen D, Lucet I, Jeune J, Jallet P (1996) Development of superparamagnetic nanoparticles for MRI: effect of particle size, charge and surface nature on biodistribution. J Microencapsul 13(3):245–255
Ciechanover A, Schwartz A, Dautry-Varsat A, Lodish HF (1983) Kinetics of internalization and recycling of transferrin and the transferrin receptor in a human hepatoma cell line. Effect of lysosomotropic agents. J Biol Chem 258(16):9681–9689
Cotin G, Blanco-Andujar C, Perton F, Asín L, de La Fuente JM, Reichardt W, Schaffner D, Ngyen D-V, Mertz D, Kiefer C (2021) Unveiling the role of surface, size, shape and defects of iron oxide nanoparticles for theranostic applications. Nanoscale 13(34):14552–14571
Cowman MK, Lee H-G, Schwertfeger KL, McCarthy JB, Turley EA (2015) The content and size of hyaluronan in biological fluids and tissues. Front Immunol 6:261
Cui Y-N, Xu Q-X, Davoodi P, Wang D-P, Wang C-H (2017) Enhanced intracellular delivery and controlled drug release of magnetic PLGA nanoparticles modified with transferrin. Acta Pharmacol Sin 38(6):943–953
Dähring H, Grandke J, Teichgräber U, Hilger I (2015) Improved hyperthermia treatment of tumors under consideration of magnetic nanoparticle distribution using micro-CT imaging. Mol Imag Biol 17:763–769
Dalmina M, Pittella F, Sierra JA, Souza GRR, Silva AH, Pasa AA, Creczynski-Pasa TB (2019) Magnetically responsive hybrid nanoparticles for in vitro siRNA delivery to breast cancer cells. Mater Sci Eng C 99:1182–1190
Danhier F, Feron O, Préat V (2010) To exploit the tumor microenvironment: passive and active tumor targeting of nanocarriers for anti-cancer drug delivery. J Control Release 148(2):135–146
Dani RK, Schumann C, Taratula O, Taratula O (2014) Temperature-tunable iron oxide nanoparticles for remote-controlled drug release. AAPS Pharmscitech 15:963–972
Daniels TR, Delgado T, Helguera G, Penichet ML (2006a) The transferrin receptor part II: targeted delivery of therapeutic agents into cancer cells. Clin Immunol 121(2):159–176
Daniels TR, Delgado T, Rodriguez JA, Helguera G, Penichet ML (2006b) The transferrin receptor part I: biology and targeting with cytotoxic antibodies for the treatment of cancer. Clin Immunol 121(2):144–158
Das P, Colombo M, Prosperi D (2019) Recent advances in magnetic fluid hyperthermia for cancer therapy. Colloids Surf B Biointerfaces 174:42–55
Dawar S, Singh N, Kanwar RK, Kennedy RL, Veedu RN, Zhou S-F, Krishnakumar S, Hazra S, Sasidharan S, Duan W (2013) Multifunctional and multitargeted nanoparticles for drug delivery to overcome barriers of drug resistance in human cancers. Drug Discovery Today 18(23–24):1292–1300
de Bruijn HS, Brooks S, van der Ploeg-van den Heuvel A, ten Hagen TL, de Haas ER, Robinson DJ (2016) Light fractionation significantly increases the efficacy of photodynamic therapy using BF-200 ALA in normal mouse skin. PLoS One 11(2):e0148850
Deatsch AE, Evans BA (2014) Heating efficiency in magnetic nanoparticle hyperthermia. J Magn Magn Mater 354:163–172
Debbage P, Jaschke W (2008) Molecular imaging with nanoparticles: giant roles for dwarf actors. Histochem Cell Biol 130:845–875
Deng L, Li Q, Al-Rehili SA, Omar H, Almalik A, Alshamsan A, Zhang J, Khashab NM (2016) Hybrid iron oxide–graphene oxide–polysaccharides microcapsule: a micro-matryoshka for on-demand drug release and antitumor therapy in vivo. ACS Appl Mater Interfaces 8(11):6859–6868
Deng K, Chen Y, Li C, Deng X, Hou Z, Cheng Z, Han Y, Xing B, Lin J (2017) 808 nm light responsive nanotheranostic agents based on near-infrared dye functionalized manganese ferrite for magnetic-targeted and imaging-guided photodynamic/photothermal therapy. J Mater Chem B 5(9):1803–1814
Deng S, Zhang W, Zhang B, Hong R, Chen Q, Dong J, Chen Y, Chen Z, Wu Y (2015) Radiolabeled cyclic arginine-glycine-aspartic (RGD)-conjugated iron oxide nanoparticles as single-photon emission computed tomography (SPECT) and magnetic resonance imaging (MRI) dual-modality agents for imaging of breast cancer. J Nanopart Res 17:1–11
Deshmukh S, Avachat A, Garkal A, Khurana N, Cardot J-M (2016) Optimization of a dissolution method in early development based on IVIVC using small animals: application to a BCS class II drug. Dissolution Technol 23(4):34–41
Dey C, Ghosh A, Ahir M, Ghosh A, Goswami MM (2018) Improvement of anticancer drug release by cobalt ferrite magnetic nanoparticles through combined pH and temperature responsive technique. ChemPhysChem 19(21):2872–2878
Dhas N, Mehta T (2020) Cationic biopolymer functionalized nanoparticles encapsulating lutein to attenuate oxidative stress in effective treatment of Alzheimer’s disease: a non-invasive approach. Int J Pharma 586:119553
Dhas N, Parekh K, Pandey A, Kudarha R, Mutalik S, Mehta T (2019a) Two dimensional carbon based nanocomposites as multimodal therapeutic and diagnostic platform: a biomedical and toxicological perspective. J Control Release 308:130–161
Dhas NL, Kudarha RR, Mehta TA (2019b) Intranasal delivery of nanotherapeutics/nanobiotherapeutics for the treatment of Alzheimer's disease: a proficient approach. Critical Reviews™ Ther Drug Carr Syst 36(5)
Dhas N, Kudarha R, Garkal A, Ghate V, Sharma S, Panzade P, Khot S, Chaudhari P, Singh A, Paryani M (2021) Molybdenum-based hetero-nanocomposites for cancer therapy, diagnosis and biosensing application: current advancement and future breakthroughs. J Control Release 330:257–283
Dilnawaz F, Singh A, Mohanty C, Sahoo SK (2010) Dual drug loaded superparamagnetic iron oxide nanoparticles for targeted cancer therapy. Biomaterials 31(13):3694–3706
Ding Z, Liu P, Hu D, Sheng Z, Yi H, Gao G, Wu Y, Zhang P, Ling S, Cai L (2017) Redox-responsive dextran based theranostic nanoparticles for near-infrared/magnetic resonance imaging and magnetically targeted photodynamic therapy. Biomater Sci 5(4):762–771
Djemaa SB, David S, Hervé-Aubert K, Falanga A, Galdiero S, Allard-Vannier E, Chourpa I, Munnier E (2018) Formulation and in vitro evaluation of a siRNA delivery nanosystem decorated with gH625 peptide for triple negative breast cancer theranosis. Eur J Pharm Biopharm 131:99–108
Dolmans DE, Fukumura D, Jain RK (2003) Photodynamic therapy for cancer. Nat Rev Cancer 3(5):380–387
Dong H, Strome SE, Salomao DR, Tamura H, Hirano F, Flies DB, Roche PC, Lu J, Zhu G, Tamada K (2002) Tumor-associated B7–H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. Nat Med 8(8):793–800
dos Santos AlF, De Almeida DRQ, Terra LF, Baptista MS, Labriola L (2019) Photodynamic therapy in cancer treatment-an update review. J Cancer Metastasis Treat 5: 25
Doughty AC, Hoover AR, Layton E, Murray CK, Howard EW, Chen WR (2019) Nanomaterial applications in photothermal therapy for cancer. Materials 12(5):779
Du B, Liu J, Ding G, Han X, Li D, Wang E, Wang J (2017) Positively charged graphene/Fe3O4/polyethylenimine with enhanced drug loading and cellular uptake for magnetic resonance imaging and magnet-responsive cancer therapy. Nano Res 10:2280–2295
Du J, Lane LA, Nie S (2015) Stimuli-responsive nanoparticles for targeting the tumor microenvironment. J Control Release 219:205–214
Duan X, Li Y (2013) Physicochemical characteristics of nanoparticles affect circulation, biodistribution, cellular internalization, and trafficking. Small 9(9–10):1521–1532
Duan M, Xia F, Li T, Shapter JG, Yang S, Li Y, Gao G, Cui D (2019) Matrix metalloproteinase-2-targeted superparamagnetic Fe3O4-PEG-G5-MMP2@ Ce6 nanoprobes for dual-mode imaging and photodynamic therapy. Nanoscale 11(39):18426–18435
Dubuc C, Langlois R, Bénard F, Cauchon N, Klarskov K, Tone P, van Lier JE (2008) Targeting gastrin-releasing peptide receptors of prostate cancer cells for photodynamic therapy with a phthalocyanine–bombesin conjugate. Bioorg Med Chem Lett 18(7):2424–2427
Dumoulin F, Durmuş M, Ahsen V, Nyokong T (2010) Synthetic pathways to water-soluble phthalocyanines and close analogs. Coord Chem Rev 254(23–24):2792–2847
Dunn MR, Jimenez RM, Chaput JC (2017) Analysis of aptamer discovery and technology. Nat Rev Chem 1(10):0076
Ebrahimi E, Akbarzadeh A, Abbasi E, Khandaghi AA, Abasalizadeh F, Davaran S (2016) RETRACTED ARTICLE: Novel drug delivery system based on doxorubicin-encapsulated magnetic nanoparticles modified with PLGA-PEG1000 copolymer. Artif Cells Nanomed Biotechnol 44(1):290–297
Edjekouane L, Benhadjeba S, Jangal M, Fleury H, Gévry N, Carmona E, Tremblay A (2016) Proximal and distal regulation of the HYAL1 gene cluster by the estrogen receptor α in breast cancer cells. Oncotarget 7(47):77276
El-Sawy HS, Al-Abd AM, Ahmed TA, El-Say KM, Torchilin VP (2018) Stimuli-responsive nano-architecture drug-delivery systems to solid tumor micromilieu: past, present, and future perspectives. ACS Nano 12(11):10636–10664
Ellington AD, Szostak JW (1990) In vitro selection of RNA molecules that bind specific ligands. Nature 346(6287):818–822
Endo T, Nagai D, Monma T, Yamaguchi H, Ochiai B (2004) A novel construction of a reversible fixation—release system of carbon dioxide by amidines and their polymers. Macromolecules 37(6):2007–2009
Erbas-Cakmak S, Akkaya EU (2013) Cascading of molecular logic gates for advanced functions: a self-reporting, activatable photosensitizer. Angew Chem 125(43):11574–11578
Erkiert-Polguj A, Halbina A, Polak-Pacholczyk I, Rotsztejn H (2016) Light-emitting diodes in photodynamic therapy in non-melanoma skin cancers–own observations and literature review. J Cosmet Laser Ther 18(2):105–110
Estrela JM, Ortega A, Obrador E (2006) Glutathione in cancer biology and therapy. Crit Rev Clin Lab Sci 43(2):143–181
Etheridge M, Bischof J (2013) Optimizing magnetic nanoparticle based thermal therapies within the physical limits of heating. Ann Biomed Eng 41:78–88
Etheridge ML, Hurley KR, Zhang J, Jeon S, Ring HL, Hogan C, Haynes CL, Garwood M, Bischof JC (2014) Accounting for biological aggregation in heating and imaging of magnetic nanoparticles. Technology 2(3):214–228
Fan JH, Fan GL, Yuan P, Deng FA, Liu LS, Zhou X, Yu XY, Cheng H, Li SY (2019) A theranostic nanoprobe for hypoxia imaging and photodynamic tumor therapy. Front Chem 7:868
Fang C, Wang K, Stephen ZR, Mu Q, Kievit FM, Chiu DT, Press OW, Zhang M (2015) Temozolomide nanoparticles for targeted glioblastoma therapy. ACS Appl Mater Interfaces 7(12):6674–6682
Fang Z, Li X, Xu Z, Du F, Wang W, Shi R, Gao D (2019) Hyaluronic acid-modified mesoporous silica-coated superparamagnetic Fe3O4 nanoparticles for targeted drug delivery. Int J Nanomed 5785–5797
Fard AE, Zarepour A, Zarrabi A, Shanei A, Salehi H (2015) Synergistic effect of the combination of triethylene-glycol modified Fe3O4 nanoparticles and ultrasound wave on MCF-7 cells. J Magn Magn Mater 394:44–49
Feng Q, Zhang Y, Zhang W, Hao Y, Wang Y, Zhang H, Hou L, Zhang Z (2017) Programmed near-infrared light-responsive drug delivery system for combined magnetic tumor-targeting magnetic resonance imaging and chemo-phototherapy. Acta Biomater 49:402–413
Feng Q, Liu Y, Huang J, Chen K, Huang J, Xiao K (2018) Uptake, distribution, clearance, and toxicity of iron oxide nanoparticles with different sizes and coatings. Sci Rep 8(1):1–13
Filippousi M, Angelakeris M, Katsikini M, Paloura E, Efthimiopoulos I, Wang Y, Zamboulis D, Van Tendeloo G (2014) Surfactant effects on the structural and magnetic properties of iron oxide nanoparticles. J Phys Chem C 118(29):16209–16217
Fingar VH, Wieman TJ, Park YJ, Henderson BW (1992) Implications of a pre-existing tumor hypoxic fraction on photodynamic therapy. J Surg Res 53(5):524–528
Fleige E, Quadir MA, Haag R (2012) Stimuli-responsive polymeric nanocarriers for the controlled transport of active compounds: concepts and applications. Adv Drug Deliv Rev 64(9):866–884
Fonović M, Turk B (2014) Cysteine cathepsins and extracellular matrix degradation. Biochim Biophy Acta (BBA)-Gen Subj 1840(8): 2560–2570
Fortin J-P, Wilhelm C, Servais J, Ménager C, Bacri J-C, Gazeau F (2007) Size-sorted anionic iron oxide nanomagnets as colloidal mediators for magnetic hyperthermia. J Am Chem Soc 129(9):2628–2635
Fowler CI, Jessop PG, Cunningham MF (2012) Aryl amidine and tertiary amine switchable surfactants and their application in the emulsion polymerization of methyl methacrylate. Macromolecules 45(7):2955–2962
Frangioni JV (2003) In vivo near-infrared fluorescence imaging. Curr Opin Chem Biol 7(5):626–634
Fu S, Xu X, Ma Y, Zhang S, Zhang S (2019) RGD peptide-based non-viral gene delivery vectors targeting integrin αvβ3 for cancer therapy. J Drug Target 27(1):1–11
Fuchs J, Thiele J (1998) The role of oxygen in cutaneous photodynamic therapy. Free Radical Biol Med 24(5):835–847
Gadde S (2015) Multi-drug delivery nanocarriers for combination therapy. MedChemComm 6(11):1916–1929
Gao GH, Li Y, Lee DS (2013) Environmental pH-sensitive polymeric micelles for cancer diagnosis and targeted therapy. J Control Release 169(3):180–184
Gao P, Zhang X, Wang H, Zhang Q, Li H, Li Y, Duan Y (2016) Biocompatible and colloidally stabilized mPEG-PE/calcium phosphate hybrid nanoparticles loaded with siRNAs targeting tumors. Oncotarget 7(3):2855
Gao C, Lin Z, Wang D, Wu Z, Xie H, He Q (2019) Red blood cell-mimicking micromotor for active photodynamic cancer therapy. ACS Appl Mater Interfaces 11(26):23392–23400
García-García G, Fernández-Álvarez F, Cabeza L, Delgado ÁV, Melguizo C, Prados JC, Arias JL (2020) Gemcitabine-loaded magnetically responsive poly (ε-caprolactone) nanoparticles against breast cancer. Polymers 12(12):2790
Gewirtz DA, Holt SE, Grant S (2007) Apoptosis, senescence and cancer. Springer Science & Business Media
Ghamkhari A, Ghorbani M, Aghbolaghi S (2018) A perfect stimuli-responsive magnetic nanocomposite for intracellular delivery of doxorubicin. Artif Cells Nanomed Biotechnol 46(Sup 3):911–921
Gibson K, Kernohant W (1993) Lasers in medicine-a review. J Med Eng Technol 17(2):51–57
Giustini AJ, Petryk AA, Cassim SM, Tate JA, Baker I, Hoopes PJ (2010) Magnetic nanoparticle hyperthermia in cancer treatment. Nano Life 1(01n02):17–32
Gneveckow U, Jordan A, Scholz R, Brüß V, Waldöfner N, Ricke J, Feussner A, Hildebrandt B, Rau B, Wust P (2004) Description and characterization of the novel hyperthermia-and thermoablation-system for clinical magnetic fluid hyperthermia. Med Phys 31(6):1444–1451
Gong F, Cheng L, Yang N, Jin Q, Tian L, Wang M, Li Y, Liu Z (2018) Bimetallic oxide MnMoOX nanorods for in vivo photoacoustic imaging of GSH and tumor-specific photothermal therapy. Nano Lett 18(9):6037–6044
Grauer O, Jaber M, Hess K, Weckesser M, Schwindt W, Maring S, Wölfer J, Stummer W (2019) Combined intracavitary thermotherapy with iron oxide nanoparticles and radiotherapy as local treatment modality in recurrent glioblastoma patients. J Neurooncol 141:83–94
Gu FX, Karnik R, Wang AZ, Alexis F, Levy-Nissenbaum E, Hong S, Langer RS, Farokhzad OC (2007) Targeted nanoparticles for cancer therapy. Nano Today 2(3):14–21
Guardia P, Di Corato R, Lartigue L, Wilhelm C, Espinosa A, Garcia-Hernandez M, Gazeau F, Manna L, Pellegrino T (2012) Water-soluble iron oxide nanocubes with high values of specific absorption rate for cancer cell hyperthermia treatment. ACS Nano 6(4):3080–3091
Guisasola E, Asín L, Beola L, de la Fuente JM, Baeza A, Vallet-Regí M (2018) Beyond traditional hyperthermia: in vivo cancer treatment with magnetic-responsive mesoporous silica nanocarriers. ACS Appl Mater Interfaces 10(15):12518–12525
Guo Z, Feng Y, Wang Y, Wang J, Wu Y, Zhang Y (2011) A novel smart polymer responsive to CO2. Chem Commun 47(33):9348–9350
Guo Z, Feng Y, He S, Qu M, Chen H, Liu H, Wu Y, Wang Y (2013) CO2-responsive “Smart” single-walled carbon nanotubes. Adv Mater 25(4):584–590
Guo J, Wang N, Wu J, Ye Q, Zhang C, Xing X-H, Yuan J (2014) Hybrid nanoparticles with CO2-responsive shells and fluorescence-labelled magnetic cores. J Mater Chem B 2(4):437–442
Guo H-W, Lin L-T, Chen P-H, Ho M-H, Huang W-T, Lee Y-J, Chiou S-H, Hsieh Y-S, Dong C-Y, Wang H-W (2015) Low-fluence rate, long duration photodynamic therapy in glioma mouse model using organic light emitting diode (OLED). Photodiagn Photodyn Ther 12(3):504–510
Guo X, Cheng Y, Zhao X, Luo Y, Chen J, Yuan W-E (2018) Advances in redox-responsive drug delivery systems of tumor microenvironment. J Nanobiotechnol 16:1–10
Guo K, Zhao X, Dai X, Zhao N, Xu FJ (2019) Organic/inorganic nanohybrids as multifunctional gene delivery systems. J Gene Med 21(5):e3084
Gupta AK, Gupta M (2005) Cytotoxicity suppression and cellular uptake enhancement of surface modified magnetic nanoparticles. Biomaterials 26(13):1565–1573
Gupta MK, Lee SH, Crowder SW, Wang X, Hofmeister LH, Nelson CE, Bellan LM, Duvall CL, Sung H-J (2015) Oligoproline-derived nanocarrier for dual stimuli-responsive gene delivery. J Mater Chem B 3(36):7271–7280
Ha PT, Le TTH, Bui TQ, Pham HN, Ho AS, Nguyen LT (2019) Doxorubicin release by magnetic inductive heating and in vivo hyperthermia-chemotherapy combined cancer treatment of multifunctional magnetic nanoparticles. New J Chem 43(14):5404–5413
Haase C, Nowak U (2012) Role of dipole-dipole interactions for hyperthermia heating of magnetic nanoparticle ensembles. Phys Rev B 85(4):045435
Haghighi AH, Faghih Z, Khorasani MT, Farjadian F (2019). Antibody conjugated onto surface modified magnetic nanoparticles for separation of HER2+ breast cancer cells. J Magn Magn Mater 490:165479.
Hajikarimi Z, Khoei S, Khoee S, Mahdavi SR (2014) Evaluation of the cytotoxic effects of PLGA coated iron oxide nanoparticles as a carrier of 5-fluorouracil and mega-voltage X-ray radiation in DU145 prostate cancer cell line. IEEE Trans Nanobiosci 13(4):403–408
Halliwell B (2006) Reactive species and antioxidants. Redox biology is a fundamental theme of aerobic life. Plant Physiol 141(2):312–322
Hamoudeh M, Kamleh MA, Diab R, Fessi H (2008) Radionuclides delivery systems for nuclear imaging and radiotherapy of cancer. Adv Drug Deliv Rev 60(12):1329–1346
Han J, Zhao D, Li D, Wang X, Jin Z, Zhao K (2018) Polymer-based nanomaterials and applications for vaccines and drugs. Polymers 10(1):31
Hao H, Ma Q, He F, Yao P (2014) Doxorubicin and Fe3O4 loaded albumin nanoparticles with folic acid modified dextran surface for tumor diagnosis and therapy. J Mater Chem B 2(45):7978–7987
Haque R, Ahmed SA, Inzhakova G, Shi J, Avila C, Polikoff J, Bernstein L, Enger SM, Press MF (2012) Impact of breast cancer subtypes and treatment on survival: an analysis spanning two decades. Cancer Epidemiol Biomark Prev 21(10):1848–1855
Harada Y, Ogawa K, Irie Y, Endo H, Feril LB Jr, Uemura T, Tachibana K (2011) Ultrasound activation of TiO2 in melanoma tumors. J Control Release 149(2):190–195
Harrison LB, Chadha M, Hill RJ, Hu K, Shasha D (2002) Impact of tumor hypoxia and anemia on radiation therapy outcomes. Oncologist 7(6):492–508
Hayashi K, Ono K, Suzuki H, Sawada M, Moriya M, Sakamoto W, Yogo T (2010) High-frequency, magnetic-field-responsive drug release from magnetic nanoparticle/organic hybrid based on hyperthermic effect. ACS Appl Mater Interfaces 2(7):1903–1911
Hayashi K, Nakamura M, Sakamoto W, Yogo T, Miki H, Ozaki S, Abe M, Matsumoto T, Ishimura K (2013) Superparamagnetic nanoparticle clusters for cancer theranostics combining magnetic resonance imaging and hyperthermia treatment. Theranostics 3(6):366
He C, Hu Y, Yin L, Tang C, Yin C (2010) Effects of particle size and surface charge on cellular uptake and biodistribution of polymeric nanoparticles. Biomaterials 31(13):3657–3666
Hedayatnasab Z, Abnisa F, Daud WMAW (2017) Review on magnetic nanoparticles for magnetic nanofluid hyperthermia application. Mater Des 123:174–196
Hegazy M, Zhou P, Wu G, Wang L, Rahoui N, Taloub N, Huang X, Huang Y (2017) Construction of polymer coated core–shell magnetic mesoporous silica nanoparticles with triple responsive drug delivery. Polym Chem 8(38):5852–5864
Hempstead J, Jones DP, Ziouche A, Cramer GM, Rizvi I, Arnason S, Hasan T, Celli JP (2015) Low-cost photodynamic therapy devices for global health settings: characterization of battery-powered LED performance and smartphone imaging in 3D tumor models. Sci Rep 5(1):10093
Henderson BW, Busch TM, Snyder JW (2006) Fluence rate as a modulator of PDT mechanisms. Lasers Surg Med Off J Am Soc Laser Med Surg 38(5):489–493
Hergt R, Dutz S (2007) Magnetic particle hyperthermia—biophysical limitations of a visionary tumour therapy. J Magn Magn Mater 311(1):187–192
Hervault A, Dunn AE, Lim M, Boyer C, Mott D, Maenosono S, Thanh NT (2016) Doxorubicin loaded dual pH-and thermo-responsive magnetic nanocarrier for combined magnetic hyperthermia and targeted controlled drug delivery applications. Nanoscale 8(24):12152–12161
Hicks JC, Drese JH, Fauth DJ, Gray ML, Qi G, Jones CW (2008) Designing adsorbents for CO2 capture from flue gas-hyperbranched aminosilicas capable of capturing CO2 reversibly. J Am Chem Soc 130(10):2902–2903
Hildebrandt B, Wust P, Ahlers O, Dieing A, Sreenivasa G, Kerner T, Felix R, Riess H (2002) The cellular and molecular basis of hyperthermia. Crit Rev Oncol Hematol 43(1):33–56
Hiremath CG, Heggnnavar GB, Kariduraganavar MY, Hiremath MB (2019) Co-delivery of paclitaxel and curcumin to foliate positive cancer cells using Pluronic-coated iron oxide nanoparticles. Prog Biomater 8:155–168
Hoang M-D, Lee H-J, Lee H-J, Jung S-H, Choi N-R, Vo M-C, Nguyen-Pham T-N, Kim H-J, Park I-K, Lee J-J (2015). Branched polyethylenimine-superparamagnetic iron oxide nanoparticles (bPEI-SPIONs) improve the immunogenicity of tumor antigens and enhance Th1 polarization of dendritic cells. J Immunol Res
Hoffman AS (2013) Stimuli-responsive polymers: Biomedical applications and challenges for clinical translation. Adv Drug Deliv Rev 65(1):10–16
Hoffman D, Sun M, Yang L, McDonagh PR, Corwin F, Sundaresan G, Wang L, Vijayaragavan V, Thadigiri C, Lamichhane N (2014) Intrinsically radiolabelled [59Fe]-SPIONs for dual MRI/radionuclide detection. Am J Nucl Med Mol Imaging 4(6):548
Hola K, Markova Z, Zoppellaro G, Tucek J, Zboril R (2015) Tailored functionalization of iron oxide nanoparticles for MRI, drug delivery, magnetic separation and immobilization of biosubstances. Biotechnol Adv 33(6):1162–1176
Hosseini V, Mirrahimi M, Shakeri-Zadeh A, Koosha F, Ghalandari B, Maleki S, Komeili A, Kamrava SK (2018) Multimodal cancer cell therapy using Au@ Fe2O3 core–shell nanoparticles in combination with photo-thermo-radiotherapy. Photodiagn Photodyn Ther 24:129–135
Hou Y, Cheng Y, Hobson T, Liu J (2010) Design and synthesis of hierarchical MnO2 nanospheres/carbon nanotubes/conducting polymer ternary composite for high performance electrochemical electrodes. Nano Lett 10(7):2727–2733
Hou H, Huang X, Wei G, Xu F, Wang Y, Zhou S (2019) Fenton reaction-assisted photodynamic therapy for cancer with multifunctional magnetic nanoparticles. ACS Appl Mater Interfaces 11(33):29579–29592
Hu P, Tirelli N (2012) Scavenging ROS: superoxide dismutase/catalase mimetics by the use of an oxidation-sensitive nanocarrier/enzyme conjugate. Bioconjug Chem 23(3):438–449
Hu X, Wang Y, Zhang L, Xu M, Zhang J, Dong W (2017) Dual-pH/magnetic-field-controlled drug delivery systems based on Fe3O4@ SiO2-incorporated Salecan graft copolymer composite hydrogels. ChemMedChem 12(19):1600–1609
Hu Y, Mignani S, Majoral J-P, Shen M, Shi X (2018) Construction of iron oxide nanoparticle-based hybrid platforms for tumor imaging and therapy. Chem Soc Rev 47(5):1874–1900
Huang Z, Chen Q, Shakil A, Chen H, Beckers J, Shapiro H, Hetzel FW (2003) Hyperoxygenation enhances the tumor cell killing of photofrin-mediated photodynamic therapy¶. Photochem Photobiol 78(5):496–502
Huang F-K, Chen W-C, Lai S-F, Liu C-J, Wang C-L, Wang C-H, Chen H-H, Hua T-E, Cheng Y-Y, Wu M (2009) Enhancement of irradiation effects on cancer cells by cross-linked dextran-coated iron oxide (CLIO) nanoparticles. Phys Med Biol 55(2):469
Huang G, Chen H, Dong Y, Luo X, Yu H, Moore Z, Bey EA, Boothman DA, Gao J (2013) Superparamagnetic iron oxide nanoparticles: amplifying ROS stress to improve anticancer drug efficacy. Theranostics 3(2):116
Huang R-Y, Chiang P-H, Hsiao W-C, Chuang C-C, Chang C-W (2015) Redox-sensitive polymer/SPIO nanocomplexes for efficient magnetofection and MR imaging of human cancer cells. Langmuir 31(23):6523–6531
Huang Y, Mao K, Zhang B, Zhao Y (2017) Superparamagnetic iron oxide nanoparticles conjugated with folic acid for dual target-specific drug delivery and MRI in cancer theranostics. Mater Sci Eng, C 70:763–771
Huh MS, Lee S-Y, Park S, Lee S, Chung H, Lee S, Choi Y, Oh Y-K, Park JH, Jeong SY (2010) Tumor-homing glycol chitosan/polyethylenimine nanoparticles for the systemic delivery of siRNA in tumor-bearing mice. J Control Release 144(2):134–143
Huo M, Yuan J, Tao L, Wei Y (2014) Redox-responsive polymers for drug delivery: from molecular design to applications. Polym Chem 5(5):1519–1528
Hurley KR, Ring HL, Etheridge M, Zhang J, Gao Z, Shao Q, Klein ND, Szlag VM, Chung C, Reineke TM (2016) Predictable heating and positive MRI contrast from a mesoporous silica-coated iron oxide nanoparticle. Mol Pharm 13(7):2172–2183
Islam T, Josephson L (2009) Current state and future applications of active targeting in malignancies using superparamagnetic iron oxide nanoparticles. Cancer Biomark 5(2):99–107
Ivkov R (2013) Magnetic nanoparticle hyperthermia: a new frontier in biology and medicine? Taylor & Francis 29:703–705
Iyer AK, Khaled G, Fang J, Maeda H (2006) Exploiting the enhanced permeability and retention effect for tumor targeting. Drug Discovery Today 11(17–18):812–818
Jacques P, Braun AM (1981) Laser flash photolysis of phthalocyanines in solution and microemulsion. Helv Chim Acta 64(6):1800–1806
Jayasena SD (1999) Aptamers: an emerging class of molecules that rival antibodies in diagnostics. Clin Chem 45(9):1628–1650
Jeon M, Lin G, Stephen ZR, Kato FL, Zhang M (2019) Paclitaxel-loaded iron oxide nanoparticles for targeted breast cancer therapy. Advanced Therapeutics 2(12):1900081
Jeun M, Kim YJ, Park KH, Paek SH, Bae S (2013) Physical contribution of Néel and Brown relaxation to interpreting intracellular hyperthermia characteristics using superparamagnetic nanofluids. J Nanosci Nanotechnol 13(8):5719–5725
Jha K, Shukla M, Pandey M (2012) Survivin expression and targeting in breast cancer. Surg Oncol 21(2):125–131
Ji W, Li N, Chen D, Qi X, Sha W, Jiao Y, Xu Q, Lu J (2013) Coumarin-containing photo-responsive nanocomposites for NIR light-triggered controlled drug release via a two-photon process. J Mater Chem B 1(43):5942–5949
Ji S, Cao W, Yu Y, Xu H (2014) Dynamic diselenide bonds: exchange reaction induced by visible light without catalysis. Angew Chem Int Ed 53(26):6781–6785
Jia Y, Duan L, Li J (2016) Hemoglobin-based nanoarchitectonic assemblies as oxygen carriers. Adv Mater 28(6):1312–1318
Jin R, Lin B, Li D, Ai H (2014) Superparamagnetic iron oxide nanoparticles for MR imaging and therapy: design considerations and clinical applications. Curr Opin Pharmacol 18:18–27
Jing Y, Zhu Y, Yang X, Shen J, Li C (2011) Ultrasound-triggered smart drug release from multifunctional core−shell capsules one-step fabricated by coaxial electrospray method. Langmuir 27(3):1175–1180
Jochum FD, Theato P (2013) Temperature-and light-responsive smart polymer materials. Chem Soc Rev 42(17):7468–7483
Johannsen M, Thiesen B, Gneveckow U, Taymoorian K, Waldöfner N, Scholz R, Deger S, Jung K, Loening SA, Jordan A (2006) Thermotherapy using magnetic nanoparticles combined with external radiation in an orthotopic rat model of prostate cancer. Prostate 66(1):97–104
Justin R, Chen B (2018) Multifunctional chitosan–magnetic graphene quantum dot nanocomposites for the release of therapeutics from detachable and non-detachable biodegradable microneedle arrays. Interface Focus 8(3):20170055
Kalber TL, Ordidge KL, Southern P, Loebinger MR, Kyrtatos PG, Pankhurst QA, Lythgoe MF, Janes SM (2016) Hyperthermia treatment of tumors by mesenchymal stem cell-delivered superparamagnetic iron oxide nanoparticles. Int J Nanomed 11:1973
Kandasamy G, Maity D (2015) Recent advances in superparamagnetic iron oxide nanoparticles (SPIONs) for in vitro and in vivo cancer nanotheranostics. Int J Pharm 496(2):191–218
Kang H, Trondoli AC, Zhu G, Chen Y, Chang Y-J, Liu H, Huang Y-F, Zhang X, Tan W (2011) Near-infrared light-responsive core–shell nanogels for targeted drug delivery. ACS Nano 5(6):5094–5099
Karimi M, Avci P, Mobasseri R, Hamblin MR, Naderi-Manesh H (2013) The novel albumin–chitosan core–shell nanoparticles for gene delivery: preparation, optimization and cell uptake investigation. J Nanopart Res 15:1–14
Karimi M, Ghasemi A, Zangabad PS, Rahighi R, Basri SMM, Mirshekari H, Amiri M, Pishabad ZS, Aslani A, Bozorgomid M (2016) Smart micro/nanoparticles in stimulus-responsive drug/gene delivery systems. Chem Soc Rev 45(5):1457–1501
Kawasaki ES, Player A (2005) Nanotechnology, nanomedicine, and the development of new, effective therapies for cancer. Nanomed Nanotechnol Biol Med 1(2):101–109
Kayal S, Ramanujan RV (2010) Anti-cancer drug loaded iron–gold core–shell nanoparticles (Fe@ Au) for magnetic drug targeting. J Nanosci Nanotechnol 10(9):5527–5539
Kelley EG, Albert JN, Sullivan MO, Epps TH III (2013) Stimuli-responsive copolymer solution and surface assemblies for biomedical applications. Chem Soc Rev 42(17):7057–7071
Khalvati B, Sheikhsaran F, Sharifzadeh S, Kalantari T, Behzad Behbahani A, Jamshidzadeh A, Dehshahri A (2017) Delivery of plasmid encoding interleukin-12 gene into hepatocytes by conjugated polyethylenimine-based nanoparticles. Artif Cells Nanomed Biotechnol 45(5):1036–1044
Khoei S, Mahdavi SR, Fakhimikabir H, Shakeri-Zadeh A, Hashemian A (2014) The role of iron oxide nanoparticles in the radiosensitization of human prostate carcinoma cell line DU145 at megavoltage radiation energies. Int J Radiat Biol 90(5):351–356
Khurshid H, Alonso J, Nemati Z, Phan M, Mukherjee P, Fdez-Gubieda M, Barandiarán J, Srikanth H (2015) Anisotropy effects in magnetic hyperthermia: a comparison between spherical and cubic exchange-coupled FeO/Fe3O4 nanoparticles. J Appl Phys 117(17):17A337
Kievit FM, Zhang M (2011) Surface engineering of iron oxide nanoparticles for targeted cancer therapy. Acc Chem Res 44(10):853–862
Kim G-W, Kang C, Oh Y-B, Ko M-H, Seo J-H, Lee D (2017) Ultrasonographic imaging and anti-inflammatory therapy of muscle and tendon injuries using polymer nanoparticles. Theranostics 7(9):2463
Kim MM, Darafsheh A (2020) Light sources and dosimetry techniques for photodynamic therapy. Photochem Photobiol 96(2):280–294
Klein S, Sommer A, Distel LV, Neuhuber W, Kryschi C (2012) Superparamagnetic iron oxide nanoparticles as radiosensitizer via enhanced reactive oxygen species formation. Biochem Biophys Res Commun 425(2):393–397
Klein S, Sommer A, Distel LV, Hazemann J-L, Kröner W, Neuhuber W, Müller P, Proux O, Kryschi C (2014) Superparamagnetic iron oxide nanoparticles as novel X-ray enhancer for low-dose radiation therapy. J Phys Chem B 118(23):6159–6166
Klein PM, Reinhard S, Lee D-J, Müller K, Ponader D, Hartmann L, Wagner E (2016) Precise redox-sensitive cleavage sites for improved bioactivity of siRNA lipopolyplexes. Nanoscale 8(42):18098–18104
Klotz L-O, Kröncke K-D, Sies H (2003) Singlet oxygen-induced signaling effects in mammalian cells. Photochem Photobiol Sci 2(2):88–94
Kong SD, Sartor M, Hu C-MJ, Zhang W, Zhang L, Jin S (2013) Magnetic field activated lipid–polymer hybrid nanoparticles for stimuli-responsive drug release. Acta Biomater 9(3):5447–5452
Kovach AK, Gambino JM, Nguyen V, Nelson Z, Szasz T, Liao J, Williams L, Bulla S, Prabhu R (2016) Prospective preliminary in vitro investigation of a magnetic iron oxide nanoparticle conjugated with ligand CD80 and VEGF antibody as a targeted drug delivery system for the induction of cell death in rodent osteosarcoma cells. BioResearch Open Access 5(1):299–307
Kovář M, Strohalm J, Etrych T, Ulbrich K, Říhová B (2002) Star structure of antibody-targeted HPMA copolymer-bound doxorubicin: a novel type of polymeric conjugate for targeted drug delivery with potent antitumor effect. Bioconjug Chem 13(2):206–215
Kresse M, Wagner S, Pfefferer D, Lawaczeck R, Elste V, Semmler W (1998) Targeting of ultrasmall superparamagnetic iron oxide (USPIO) particles to tumor cells in vivo by using transferrin receptor pathways. Magn Reson Med 40(2):236–242
Kumar CS, Mohammad F (2011) Magnetic nanomaterials for hyperthermia-based therapy and controlled drug delivery. Adv Drug Deliv Rev 63(9):789–808
Kumar A, Lale SV, Mahajan S, Choudhary V, Koul V (2015) ROP and ATRP fabricated dual targeted redox sensitive polymersomes based on pPEGMA-PCL-ss-PCL-pPEGMA triblock copolymers for breast cancer therapeutics. ACS Appl Mater Interfaces 7(17):9211–9227
Kuruppuarachchi M, Savoie H, Lowry A, Alonso C, Boyle RW (2011) Polyacrylamide nanoparticles as a delivery system in photodynamic therapy. Mol Pharm 8(3):920–931
Lacour JP, Ulrich C, Gilaberte Y, Von Felbert V, Basset-Seguin N, Dreno B, Girard C, Redondo P, Serra-Guillen C, Synnerstad I (2015) Daylight photodynamic therapy with methyl aminolevulinate cream is effective and nearly painless in treating actinic keratoses: a randomised, investigator-blinded, controlled, phase III study throughout Europe. J Eur Acad Dermatol Venereol 29(12):2342–2348
Lambeau G, Gelb MH (2008) Biochemistry and physiology of mammalian secreted phospholipases A2. Annu Rev Biochem 77:495–520
Larsen EK, Nielsen T, Wittenborn T, Birkedal H, Vorup-Jensen T, Jakobsen MH, Østergaard L, Horsman MR, Besenbacher F, Howard KA (2009) Size-dependent accumulation of PEGylated silane-coated magnetic iron oxide nanoparticles in murine tumors. ACS Nano 3(7):1947–1951
Lartigue L, Hugounenq P, Alloyeau D, Clarke SP, Lévy M, Bacri J-C, Bazzi R, Brougham DF, Wilhelm C, Gazeau F (2012) Cooperative organization in iron oxide multi-core nanoparticles potentiates their efficiency as heating mediators and MRI contrast agents. ACS Nano 6(12):10935–10949
Laurent UB, Tengblad A (1980) Determination of hyaluronate in biological samples by a specific radioassay technique. Anal Biochem 109(2):386–394
Laurent S, Dutz S, Häfeli UO, Mahmoudi M (2011) Magnetic fluid hyperthermia: focus on superparamagnetic iron oxide nanoparticles. Adv Coll Interface Sci 166(1–2):8–23
Laurent S, Saei AA, Behzadi S, Panahifar A, Mahmoudi M (2014) Superparamagnetic iron oxide nanoparticles for delivery of therapeutic agents: opportunities and challenges. Expert Opin Drug Deliv 11(9):1449–1470
Lee S, Xie J, Chen X (2010) Peptide-based probes for targeted molecular imaging. Biochemistry 49(7):1364–1376
Lee D-J, He D, Kessel E, Padari K, Kempter S, Lächelt U, Rädler JO, Pooga M, Wagner E (2016a) Tumoral gene silencing by receptor-targeted combinatorial siRNA polyplexes. J Control Release 244:280–291
Lee D-J, Kessel E, Edinger D, He D, Klein PM, von Voithenberg LV, Lamb DC, Lächelt U, Lehto T, Wagner E (2016b) Dual antitumoral potency of EG5 siRNA nanoplexes armed with cytotoxic bifunctional glutamyl-methotrexate targeting ligand. Biomaterials 77:98–110
Lehto T, Simonson OE, Mäger I, Ezzat K, Sork H, Copolovici D-M, Viola JR, Zaghloul EM, Lundin P, Moreno PM (2011) A peptide-based vector for efficient gene transfer in vitro and in vivo. Mol Ther 19(8):1457–1467
Lemine O (2019) Magnetic hyperthermia therapy using hybrid magnetic nanostructures. Hybrid nanostructures for cancer theranostics, Elsevier, pp 125–138
Leuschner C, Kumar CS, Hansel W, Soboyejo W, Zhou J, Hormes J (2006) LHRH-conjugated magnetic iron oxide nanoparticles for detection of breast cancer metastases. Breast Cancer Res Treat 99:163–176
Li H, Qian ZM (2002) Transferrin/transferrin receptor-mediated drug delivery. Med Res Rev 22(3):225–250
Li R, Xie Y (2017) Nanodrug delivery systems for targeting the endogenous tumor microenvironment and simultaneously overcoming multidrug resistance properties. J Control Release 251:49–67
Li X, Xu H, Chen Z-S, Chen G (2011) Biosynthesis of nanoparticles by microorganisms and their applications. J Nanomater 2011:1–16
Li Y, Gao GH, Lee DS (2013) PH-sensitive polymeric micelles based on amphiphilic polypeptide as smart drug carriers. J Polym Sci, Part a: Polym Chem 51(19):4175–4182
Li W-P, Liao P-Y, Su C-H, Yeh C-S (2014) Formation of oligonucleotide-gated silica shell-coated Fe3O4-Au core–shell nanotrisoctahedra for magnetically targeted and near-infrared light-responsive theranostic platform. J Am Chem Soc 136(28):10062–10075
Li H, Yan K, Shang Y, Shrestha L, Liao R, Liu F, Li P, Xu H, Xu Z, Chu PK (2015a) Folate-bovine serum albumin functionalized polymeric micelles loaded with superparamagnetic iron oxide nanoparticles for tumor targeting and magnetic resonance imaging. Acta Biomater 15:117–126
Li W-M, Chiang C-S, Huang W-C, Su C-W, Chiang M-Y, Chen J-Y, Chen S-Y (2015b) Amifostine-conjugated pH-sensitive calcium phosphate-covered magnetic-amphiphilic gelatin nanoparticles for controlled intracellular dual drug release for dual-targeting in HER-2-overexpressing breast cancer. J Control Release 220:107–118
Li Y, Wang J, Zhang X, Guo W, Li F, Yu M, Kong X, Wu W, Hong Z (2015c) Highly water-soluble and tumor-targeted photosensitizers for photodynamic therapy. Org Biomol Chem 13(28):7681–7694
Li X, Wei J, Aifantis KE, Fan Y, Feng Q, Cui FZ, Watari F (2016a) Current investigations into magnetic nanoparticles for biomedical applications. J Biomed Mater Res, Part A 104(5):1285–1296
Li Y, Yang HY, Lee DS (2016b) Polymer-based and pH-sensitive nanobiosensors for imaging and therapy of acidic pathological areas. Pharm Res 33:2358–2372
Li E, Yang Y, Hao G, Yi X, Zhang S, Pan Y, Xing B, Gao M (2018a) Multifunctional magnetic mesoporous silica nanoagents for in vivo enzyme-responsive drug delivery and MR imaging. Nanotheranostics 2(3):233
Li X, Kwon N, Guo T, Liu Z, Yoon J (2018b) Innovative strategies for hypoxic-tumor photodynamic therapy. Angew Chem Int Ed 57(36):11522–11531
Li S, Yuan C, Chen J, Chen D, Chen Z, Chen W, Yan S, Hu P, Xue J, Li R (2019) Nanoparticle binding to urokinase receptor on cancer cell surface triggers nanoparticle disintegration and cargo release. Theranostics 9(3):884
Li H, Peng E, Zhao F, Li J, Xue J (2021) Supramolecular surface functionalization of iron oxide nanoparticles with α-cyclodextrin-based cationic star polymer for magnetically-enhanced gene delivery. Pharmaceutics 13(11):1884
Lin S, Theato P (2013) CO2-responsive polymers. Macromol Rapid Commun 34(14):1118–1133
Lin G, Zhu W, Yang L, Wu J, Lin B, Xu Y, Cheng Z, Xia C, Gong Q, Song B (2014) Delivery of siRNA by MRI-visible nanovehicles to overcome drug resistance in MCF-7/ADR human breast cancer cells. Biomaterials 35(35):9495–9507
Ling D, Park W, Park S-J, Lu Y, Kim KS, Hackett MJ, Kim BH, Yim H, Jeon YS, Na K (2014) Multifunctional tumor pH-sensitive self-assembled nanoparticles for bimodal imaging and treatment of resistant heterogeneous tumors. J Am Chem Soc 136(15):5647–5655
Ling Y, Tang X, Wang F, Zhou X, Wang R, Deng L, Shang T, Liang B, Li P, Ran H (2017) Highly efficient magnetic hyperthermia ablation of tumors using injectable polymethylmethacrylate–Fe3O4. RSC Adv 7(5):2913–2918
Liu Y, Miyoshi H, Nakamura M (2007) Nanomedicine for drug delivery and imaging: a promising avenue for cancer therapy and diagnosis using targeted functional nanoparticles. Int J Cancer 120(12):2527–2537
Liu XL, Fan HM, Yi JB, Yang Y, Choo ESG, Xue JM, Ding J (2012a) Optimization of surface coating on Fe3O4 nanoparticles for high performance magnetic hyperthermia agents. J Mater Chem 22(17):8235–8244
Liu Y, Zhou T, Crowley D, Li L, Liu D, Zheng J, Yu X, Pan G, Hussain Q, Zhang X (2012b) Decline in topsoil microbial quotient, fungal abundance and C utilization efficiency of rice paddies under heavy metal pollution across South China. PLoS One 7(6):e38858
Liu G, Shen H, Mao J, Zhang L, Jiang Z, Sun T, Lan Q, Zhang Z (2013) Transferrin modified graphene oxide for glioma-targeted drug delivery: in vitro and in vivo evaluations. ACS Appl Mater Interfaces 5(15):6909–6914
Liu B, Zhang X, Li C, He F, Chen Y, Huang S, Jin D, Yang P, Cheng Z, Lin J (2016a) Magnetically targeted delivery of DOX loaded Cu 9 S 5@ mSiO2@ Fe3O4-PEG nanocomposites for combined MR imaging and chemo/photothermal synergistic therapy. Nanoscale 8(25):12560–12569
Liu H, Sui X, Xu H, Zhang L, Zhong Y, Mao Z (2016b) Self-healing polysaccharide hydrogel based on dynamic covalent enamine bonds. Macromol Mater Eng 301(6):725–732
Liu Y, Bhattarai P, Dai Z, Chen X (2019a) Photothermal therapy and photoacoustic imaging via nanotheranostics in fighting cancer. Chem Soc Rev 48(7):2053–2108
Liu Y, Li Y, Rao Z, Xu J, Zhao S, Zhao C, Zhu H, Hao J, Yang T, Yang Y (2019b) Physiochemical properties and paclitaxel release behaviors of dual-stimuli responsive copolymer-magnetite superparamagnetic nanocomposites. Nanotechnology 30(10):105602
Locasale JW (2013) Serine, glycine and one-carbon units: cancer metabolism in full circle. Nat Rev Cancer 13(8):572–583
Loh XJ, Lee T-C, Dou Q, Deen GR (2016) Utilising inorganic nanocarriers for gene delivery. Biomaterials Science 4(1):70–86
Lorkowski ME, Atukorale PU, Ghaghada KB, Karathanasis E (2021) Stimuli-responsive iron oxide nanotheranostics: a versatile and powerful approach for cancer therapy. Adv Healthcare Mater 10(5):2001044
Lu Y, Low PS (2003) Immunotherapy of folate receptor-expressing tumors: review of recent advances and future prospects. J Control Release 91(1–2):17–29
Lu Z, Li Y, Shi Y, Li Y, Xiao Z, Zhang X (2017) Traceable nanoparticles with spatiotemporally controlled release ability for synergistic glioblastoma multiforme treatment. Adv Func Mater 27(46):1703967
Lugert S, Unterweger H, Mühlberger M, Janko C, Draack S, Ludwig F, Eberbeck D, Alexiou C, Friedrich RP (2019) Cellular effects of paclitaxel-loaded iron oxide nanoparticles on breast cancer using different 2D and 3D cell culture models. Int J Nanomed 14:161
Lungoci A-L, Turin-Moleavin I-A, Corciova A, Mircea C, Arvinte A, Fifere A, Marangoci NL, Pinteala M (2019) Multifunctional magnetic cargo-complexes with radical scavenging properties. Mater Sci Eng, C 94:608–618
Luo Z, Cai K, Hu Y, Li J, Ding X, Zhang B, Xu D, Yang W, Liu P (2012) Redox-responsive molecular nanoreservoirs for controlled intracellular anticancer drug delivery based on magnetic nanoparticles. Adv Mater 24(3):431–435
Luo Y, Li Y, Li J, Fu C, Yu X, Wu L (2019) Hyaluronic acid-mediated multifunctional iron oxide-based MRI nanoprobes for dynamic monitoring of pancreatic cancer. RSC Adv 9(19):10486–10493
Ma X, Wang Y, Liu X-L, Ma H, Li G, Li Y, Gao F, Peng M, Fan HM, Liang X-J (2019) Fe3O4–Pd Janus nanoparticles with amplified dual-mode hyperthermia and enhanced ROS generation for breast cancer treatment. Nanoscale Horizons 4(6):1450–1459
Ma Z-Z, Shi Z-F, Wang L-T, Zhang F, Wu D, Yang D-W, Chen X, Zhang Y, Shan C-X, Li X-J (2020) Water-induced fluorescence enhancement of lead-free cesium bismuth halide quantum dots by 130% for stable white light-emitting devices. Nanoscale 12(6):3637–3645
Maas AL, Carter SL, Wileyto EP, Miller J, Yuan M, Yu G, Durham AC, Busch TM (2012) Tumor vascular microenvironment determines responsiveness to photodynamic therapy. Can Res 72(8):2079–2088
Maeda H, Wu J, Sawa T, Matsumura Y, Hori K (2000) Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review. J Control Release 65(1–2):271–284
Mai BT, Balakrishnan PB, Barthel MJ, Piccardi F, Niculaes D, Marinaro F, Fernandes S, Curcio A, Kakwere H, Autret G (2019) Thermoresponsive iron oxide nanocubes for an effective clinical translation of magnetic hyperthermia and heat-mediated chemotherapy. ACS Appl Mater Interfaces 11(6):5727–5739
Maier-Hauff K, Rothe R, Scholz R, Gneveckow U, Wust P, Thiesen B, Feussner A, Von Deimling A, Waldoefner N, Felix R (2007) Intracranial thermotherapy using magnetic nanoparticles combined with external beam radiotherapy: results of a feasibility study on patients with glioblastoma multiforme. J Neurooncol 81:53–60
Maier-Hauff K, Ulrich F, Nestler D, Niehoff H, Wust P, Thiesen B, Orawa H, Budach V, Jordan A (2011) Efficacy and safety of intratumoral thermotherapy using magnetic iron-oxide nanoparticles combined with external beam radiotherapy on patients with recurrent glioblastoma multiforme. J Neurooncol 103:317–324
Majidi S, Zeinali Sehrig F, Samiei M, Milani M, Abbasi E, Dadashzadeh K, Akbarzadeh A (2016) Magnetic nanoparticles: applications in gene delivery and gene therapy. Artif Cells Nanomed Biotechnol 44(4):1186–1193
Martinkova P, Brtnicky M, Kynicky J, Pohanka M (2018) Iron oxide nanoparticles: innovative tool in cancer diagnosis and therapy. Adv Healthcare Mater 7(5):1700932
Masanori N, Ryuji H, Teruo K, Naofumi H, Hirofumi A, Masayuki N, Tadakazu S (1985) Molecular cloning of cDNA coding for human preprourokinase. Gene 36(1–2):183–188
Mdlovu NV, Mavuso FA, Lin K-S, Chang T-W, Chen Y, Wang SS-S, Wu C-M, Mdlovu NB, Lin Y-S (2019) Iron oxide-pluronic F127 polymer nanocomposites as carriers for a doxorubicin drug delivery system. Colloids Surf, A 562:361–369
Mehta T (2020) Application and functional characterization of Kollicoat smartseal 30D as a solid dispersion carrier for improving solubility. Asian J Pharm (AJP) 14(2)
Mehta TA, Shah N, Parekh K, Dhas N, Patel JK (2019) Surface-modified PLGA nanoparticles for targeted drug delivery to neurons. Surf Modif Nanoparticles Target Drug Deliv 33–71
Meidanchi A, Akhavan O, Khoei S, Shokri AA, Hajikarimi Z, Khansari N (2015) ZnFe2O4 nanoparticles as radiosensitizers in radiotherapy of human prostate cancer cells. Mater Sci Eng C 46:394–399
Melamed JR, Edelstein RS, Day ES (2015) Elucidating the fundamental mechanisms of cell death triggered by photothermal therapy. ACS Nano 9(1):6–11
Mellman I, Coukos G, Dranoff G (2011) Cancer immunotherapy comes of age. Nature 480(7378):480–489
Meng F, Hennink WE, Zhong Z (2009) Reduction-sensitive polymers and bioconjugates for biomedical applications. Biomaterials 30(12):2180–2198
Meng Q-F, Rao L, Zan M, Chen M, Yu G-T, Wei X, Wu Z, Sun Y, Guo S-S, Zhao X-Z (2018) Macrophage membrane-coated iron oxide nanoparticles for enhanced photothermal tumor therapy. Nanotechnology 29(13):134004
Mikhaylov G, Vasiljeva O (2011) Promising approaches in using magnetic nanoparticles in oncology.
Mirrahimi M, Hosseini V, Shakeri-Zadeh A, Alamzadeh Z, Kamrava S, Attaran N, Abed Z, Ghaznavi H, Hosseini Nami S (2019) Modulation of cancer cells’ radiation response in the presence of folate conjugated Au@Fe2O3 nanocomplex as a targeted radiosensitizer. Clin Transl Oncol 21:479–488
Misra S, Heldin P, Hascall VC, Karamanos NK, Skandalis SS, Markwald RR, Ghatak S (2011) Hyaluronan–CD44 interactions as potential targets for cancer therapy. FEBS J 278(9):1429–1443
Moan J, Sommer S (1985) Oxygen dependence of the photosensitizing effect of hematoporphyrin derivative in NHIK 3025 cells. Can Res 45(4):1608–1610
Montazerabadi A-R, Sazgarnia A, Bahreyni-Toosi MH, Ahmadi A, Shakeri-Zadeh A, Aledavood A (2012) Mitoxantrone as a prospective photosensitizer for photodynamic therapy of breast cancer. Photodiagn Photodyn Ther 9(1):46–51
Montazerabadi A, Beik J, Irajirad R, Attaran N, Khaledi S, Ghaznavi H, Shakeri-Zadeh A (2019) Folate-modified and curcumin-loaded dendritic magnetite nanocarriers for the targeted thermo-chemotherapy of cancer cells. Artif Cells Nanomed Biotechnol 47(1):330–340
Moon HJ, Park MH, Joo MK, Jeong B (2012) Temperature-responsive compounds as in situ gelling biomedical materials. Chem Soc Rev 41(14):4860–4883
Mordon S, Cochrane C, Tylcz JB, Betrouni N, Mortier L, Koncar V (2015) Light emitting fabric technologies for photodynamic therapy. Photodiagn Photodyn Ther 12(1):1–8
Morovati A, Ahmadian S, Jafary H (2019) Cytotoxic effects and apoptosis induction of cisplatin-loaded iron oxide nanoparticles modified with chitosan in human breast cancer cells. Mol Biol Rep 46:5033–5039
Motoyama J, Hakata T, Kato R, Yamashita N, Morino T, Kobayashi T, Honda H (2008) Size dependent heat generation of magnetite nanoparticles under AC magnetic field for cancer therapy. Biomagn Res Technol 6(1):1–9
Mourant JR, Canpolat M, Brocker C, Esponda-Ramos O, Johnson TM, Matanock A, Stetter K, Freyer JP (2000) Light scattering from cells: the contribution of the nucleus and the effects of proliferative status. J Biomed Opt 5(2):131–137
Mu K, Zhang S, Ai T, Jiang J, Yao Y, Jiang L, Zhou Q, Xiang H, Zhu Y, Yang X (2015) Monoclonal antibody–conjugated superparamagnetic iron oxide nanoparticles for imaging of epidermal growth factor receptor–targeted cells and gliomas. Mol Imaging 14(5):7290.2015. 00002
Mu J, Lin J, Huang P, Chen X (2018) Development of endogenous enzyme-responsive nanomaterials for theranostics. Chem Soc Rev 47(15):5554–5573
Mühlberger M, Unterweger H, Band J, Lehmann C, Heger L, Dudziak D, Alexiou C, Lee G, Janko C (2020) Loading of primary human T Lymphocytes with citrate-coated superparamagnetic iron oxide nanoparticles does not impair their activation after polyclonal stimulation. Cells 9(2):342
Munnier E, Cohen-Jonathan S, Hervé K, Linassier C, Soucé M, Dubois P, Chourpa I (2011) Doxorubicin delivered to MCF-7 cancer cells by superparamagnetic iron oxide nanoparticles: effects on subcellular distribution and cytotoxicity. J Nanopart Res 13:959–971
Murphy MP, Holmgren A, Larsson N-G, Halliwell B, Chang CJ, Kalyanaraman B, Rhee SG, Thornalley PJ, Partridge L, Gems D (2011) Unraveling the biological roles of reactive oxygen species. Cell Metab 13(4):361–366
Nakamura Y, Mochida A, Choyke PL, Kobayashi H (2016) Nanodrug delivery: is the enhanced permeability and retention effect sufficient for curing cancer? Bioconjug Chem 27(10):2225–2238
Natfji AA, Ravishankar D, Osborn HM, Greco F (2017) Parameters affecting the enhanced permeability and retention effect: the need for patient selection. J Pharm Sci 106(11):3179–3187
Neha R, Jaiswal A, Bellare J, Sahu N (2017) Synthesis of surface grafted mesoporous magnetic nanoparticles for cancer therapy. J Nanosci Nanotechnol 17(8):5181–5188
Nemati Z, Alonso J, Martinez L, Khurshid H, Garaio E, Garcia J, Phan M, Srikanth H (2016) Enhanced magnetic hyperthermia in iron oxide nano-octopods: size and anisotropy effects. J Phys Chem C 120(15):8370–8379
Nie Z, Vahdani Y, Cho WC, Bloukh SH, Edis Z, Haghighat S, Falahati M, Kheradmandi R, Jaragh-Alhadad LA, Sharifi M (2022) 5-Fluorouracil-containing inorganic iron oxide/platinum nanozymes with dual drug delivery and enzyme-like activity for the treatment of breast cancer. Arab J Chem 15(8):103966
Nigam S, Bahadur D (2018). Doxorubicin-loaded dendritic-Fe3O4 supramolecular nanoparticles for magnetic drug targeting and tumor regression in spheroid murine melanoma model. Nanomed Nanotechnol Biol Med 14(3):759–768
Ninomiya K, Noda K, Ogino C, Kuroda S-I, Shimizu N (2014) Enhanced OH radical generation by dual-frequency ultrasound with TiO2 nanoparticles: its application to targeted sonodynamic therapy. Ultrason Sonochem 21(1):289–294
Noh S-H, Na W, Jang J-T, Lee J-H, Lee EJ, Moon SH, Lim Y, Shin J-S, Cheon J (2012) Nanoscale magnetism control via surface and exchange anisotropy for optimized ferrimagnetic hysteresis. Nano Lett 12(7):3716–3721
Nosrati H, Salehiabar M, Davaran S, Danafar H, Manjili HK (2018) Methotrexate-conjugated L-lysine coated iron oxide magnetic nanoparticles for inhibition of MCF-7 breast cancer cells. Drug Dev Ind Pharm 44(6):886–894
Nosrati H, Tarantash M, Bochani S, Charmi J, Bagheri Z, Fridoni M, Abdollahifar M-A, Davaran S, Danafar H, Kheiri Manjili H (2019) Glutathione (GSH) peptide conjugated magnetic nanoparticles as blood–brain barrier shuttle for MRI-monitored brain delivery of paclitaxel. ACS Biomater Sci Eng 5(4):1677–1685
O’Neal DP, Hirsch LR, Halas NJ, Payne JD, West JL (2004) Photo-thermal tumor ablation in mice using near infrared-absorbing nanoparticles. Cancer Lett 209(2):171–176
Ortega D, Pankhurst Q (2013) Magnetic hyperthermia in nanoscience: Vol. 1: nanostructures through chemistry. Royal Society of Chemistry UK
ÖSTERLIN S (1977) On the molecular biology of the vitreous in the aphakic eye. Acta Ophthalmol 55(3):353–361
Pala K, Serwotka A, Jeleń F, Jakimowicz P, Otlewski J (2014) Tumor-specific hyperthermia with aptamer-tagged superparamagnetic nanoparticles. Int J Nanomed 9:67
Palanisamy S, Wang Y-M (2019) Superparamagnetic iron oxide nanoparticulate system: synthesis, targeting, drug delivery and therapy in cancer. Dalton Trans 48(26):9490–9515
Pan C, Liu Y, Zhou M, Wang W, Shi M, Xing M, Liao W (2018) Theranostic pH-sensitive nanoparticles for highly efficient targeted delivery of doxorubicin for breast tumor treatment. Int J Nanomed 13:1119
Pan J, Hu P, Guo Y, Hao J, Ni D, Xu Y, Bao Q, Yao H, Wei C, Wu Q (2020) Combined magnetic hyperthermia and immune therapy for primary and metastatic tumor treatments. ACS Nano 14(1):1033–1044
Panda J, Satapathy BS, Majumder S, Sarkar R, Mukherjee B, Tudu B (2019) Engineered polymeric iron oxide nanoparticles as potential drug carrier for targeted delivery of docetaxel to breast cancer cells. J Magn Magn Mater 485:165–173
Pandey A, Singh D, Dhas N, Tewari AK, Pathak K, Chatap V, Rathore KS, Mutalik S (2020) Complex injectables: development, delivery, and advancement. Delivery of drugs, Elsevier, pp 191–213
Pandey N, Dhiman S, Srivastava T, Majumder S (2016) Transition metal oxide nanoparticles are effective in inhibiting lung cancer cell survival in the hypoxic tumor microenvironment. Chem Biol Interact 254:221–230
Pandey A, Singh K, Patel S, Singh R, Patel K, Sawant K (2019) Hyaluronic acid tethered pH-responsive alloy-drug nanoconjugates for multimodal therapy of glioblastoma: An intranasal route approach. Mater Sci Eng C 98:419–436
Paris JL, Cabañas MV, Manzano M, Vallet-Regí M (2015) Polymer-grafted mesoporous silica nanoparticles as ultrasound-responsive drug carriers. ACS Nano 9(11):11023–11033
Pariser D, Loss R, Jarratt M, Abramovits W, Spencer J, Geronemus R, Bailin P, Bruce S (2008) Topical methyl-aminolevulinate photodynamic therapy using red light-emitting diode light for treatment of multiple actinic keratoses: a randomized, double-blind, placebo-controlled study. J Am Acad Dermatol 59(4):569–576
Park S-C, Kim N-H, Yang W, Nah J-W, Jang M-K, Lee D (2016) Polymeric micellar nanoplatforms for Fenton reaction as a new class of antibacterial agents. J Control Release 221:37–47
Park YI, Kwon S-H, Lee G, Motoyama K, Kim MW, Lin M, Niidome T, Choi JH, Lee R (2021) PH-sensitive multi-drug liposomes targeting folate receptor β for efficient treatment of non-small cell lung cancer. J Control Release 330:1–14
Parsian M, Unsoy G, Mutlu P, Yalcin S, Tezcaner A, Gunduz U (2016) Loading of Gemcitabine on chitosan magnetic nanoparticles increases the anti-cancer efficacy of the drug. Eur J Pharmacol 784:121–128
Patra JK, Das G, Fraceto LF, Campos EVR, Rodriguez-Torres MDP, Acosta-Torres LS, Diaz-Torres LA, Grillo R, Swamy MK, Sharma S (2018) Nano based drug delivery systems: recent developments and future prospects. J Nanobiotechnol 16(1):1–33
Peng X-H, Qian X, Mao H, Wang AY, Chen Z, Nie S, Shin DM (2008) Targeted magnetic iron oxide nanoparticles for tumor imaging and therapy. Int J Nanomed 3(3):311–321
Pérez-Hernández M, Del Pino P, Mitchell SG, Moros M, Stepien G, Pelaz B, Parak WJ, Gálvez EM, Pardo J, de la Fuente JM (2015) Dissecting the molecular mechanism of apoptosis during photothermal therapy using gold nanoprisms. ACS Nano 9(1):52–61
Pitarresi G, Craparo E, Palumbo F, Carlisi B, Giammona G (2007) Composite nanoparticles based on hyaluronic acid chemically cross-linked with α, β-polyaspartylhydrazide. Biomacromolecules 8(6):1890–1898
Purushotham S, Ramanujan R (2010) Thermoresponsive magnetic composite nanomaterials for multimodal cancer therapy. Acta Biomater 6(2):502–510
Quinto CA, Mohindra P, Tong S, Bao G (2015) Multifunctional superparamagnetic iron oxide nanoparticles for combined chemotherapy and hyperthermia cancer treatment. Nanoscale 7(29):12728–12736
Raha S, Paunesku T, Woloschak G (2011) Peptide-mediated cancer targeting of nanoconjugates. Wiley Interdiscip Rev Nanomed Nanobiotechnol 3(3):269–281
Rahman W, Kadian S, Ab Rashid R, Abdullah R, Razak KA, Pham B, Hawkett B, Geso M (2019) Radiosensitization characteristic of superparamagnetic iron oxide nanoparticles in electron beam radiotherapy and brachytherapy. Journal of Physics: Conference Series. IOP Publishing
Ramzy L, Nasr M, Metwally AA, Awad GA (2017) Cancer nanotheranostics: a review of the role of conjugated ligands for overexpressed receptors. Eur J Pharm Sci 104:273–292
Rasheed T, Bilal M, Abu-Thabit NY, Iqbal HM (2018) The smart chemistry of stimuli-responsive polymeric carriers for target drug delivery applications. Stimuli responsive polymeric nanocarriers for drug delivery applications. Elsevier vol 1, pp 61–99
Rastegar R, Akbari Javar H, Khoobi M, Dehghan Kelishadi P, Hossein Yousefi G, Doosti M, Hossien Ghahremani M, Shariftabrizi A, Imanparast F, Gholibeglu E (2018) Evaluation of a novel biocompatible magnetic nanomedicine based on beta-cyclodextrin, loaded doxorubicin-curcumin for overcoming chemoresistance in breast cancer. Artif Cells Nanomed Biotechnol 46(Sup 2):207–216
Raza A, Hayat U, Rasheed T, Bilal M, Iqbal HM (2019a) “Smart” materials-based near-infrared light-responsive drug delivery systems for cancer treatment: a review. J Market Res 8(1):1497–1509
Raza A, Rasheed T, Nabeel F, Hayat U, Bilal M, Iqbal HM (2019b) Endogenous and exogenous stimuli-responsive drug delivery systems for programmed site-specific release. Molecules 24(6):1117
Rejinold NS, Thomas RG, Muthiah M, Lee HJ, Jeong YY, Park I-K, Jayakumar R (2016) Breast tumor targetable Fe3O4 embedded thermo-responsive nanoparticles for radiofrequency assisted drug delivery. J Biomed Nanotechnol 12(1):43–55
Revia RA, Zhang M (2016) Magnetite nanoparticles for cancer diagnosis, treatment, and treatment monitoring: recent advances. Mater Today 19(3):157–168
Ricci-Júnior E, Marchetti JM (2006) Zinc (II) phthalocyanine loaded PLGA nanoparticles for photodynamic therapy use. Int J Pharm 310(1–2):187–195
Ricci M, Miola M, Multari C, Borroni E, Canuto RA, Congiusta N, Vernè E, Follenzi A, Muzio G (2018) PPARs are mediators of anti-cancer properties of superparamagnetic iron oxide nanoparticles (SPIONs) functionalized with conjugated linoleic acid. Chem Biol Interact 292:9–14
Rizvi I, Celli JP, Evans CL, Abu-Yousif AO, Muzikansky A, Pogue BW, Finkelstein D, Hasan T (2010) Synergistic enhancement of carboplatin efficacy with photodynamic therapy in a three-dimensional model for micrometastatic ovarian cancer. Can Res 70(22):9319–9328
Robinson DJ, de Bruijn HS, van der Veen N, Stringer MR, Brown SB, Star WM (1998) Fluorescence photobleaching of ALA-induced protoporphyrin IX during photodynamic therapy of normal hairless mouse skin: the effect of light dose and irradiance and the resulting biological effect. Photochem Photobiol 67(1):140–149
Roch A, Gossuin Y, Muller RN, Gillis P (2005) Superparamagnetic colloid suspensions: water magnetic relaxation and clustering. J Magn Magn Mater 293(1):532–539
Rosen JE, Chan L, Shieh D-B, Gu FX (2012) Iron oxide nanoparticles for targeted cancer imaging and diagnostics. Nanomed Nanotechnol Biol Med 8(3):275–290
Ross JF, Chaudhuri PK, Ratnam M (1994) Differential regulation of folate receptor isoforms in normal and malignant tissues in vivo and in established cell lines. Physiologic and clinical implications. Cancer 73(9):2432–2443
Rossetti FC, Lopes LB, Carollo ARH, Thomazini JA, Tedesco AC, Bentley MVLB (2011) A delivery system to avoid self-aggregation and to improve in vitro and in vivo skin delivery of a phthalocyanine derivative used in the photodynamic therapy. J Control Release 155(3):400–408
Rousseau J, Nakamura M, Rio-Maior H, Álvares F, Choquet R, Madeira de Carvalho L, Godinho R, Santos N (2021) Non-invasive molecular survey of sarcoptic mange in wildlife: diagnostic performance in wolf faecal samples evaluated by multi-event capture-recapture models. Pathogens 10(2):243
Ruoslahti E (2012) Peptides as targeting elements and tissue penetration devices for nanoparticles. Adv Mater 24(28):3747–3756
Saeed M, Ren W, Wu A (2018) Therapeutic applications of iron oxide based nanoparticles in cancer: basic concepts and recent advances. Biomaterials Science 6(4):708–725
Saeed M, Gao J, Shi Y, Lammers T, Yu H (2019) Engineering nanoparticles to reprogram the tumor immune microenvironment for improved cancer immunotherapy. Theranostics 9(26):7981
Sahin U, Türeci Ö (2018) Personalized vaccines for cancer immunotherapy. Science 359(6382):1355–1360
Sahle FF, Gulfam M, Lowe TL (2018) Design strategies for physical-stimuli-responsive programmable nanotherapeutics. Drug Discovery Today 23(5):992–1006
Sahu NK, Singh NS, Pradhan L, Bahadur D (2014) Ce 3+ sensitized GdPO 4: Tb 3+ with iron oxide nanoparticles: a potential biphasic system for cancer theranostics. Dalton Trans 43(30):11728–11738
Sahu NK, Gupta J, Bahadur D (2015) PEGylated FePt–Fe3O4 composite nanoassemblies (CNAs): in vitro hyperthermia, drug delivery and generation of reactive oxygen species (ROS). Dalton Trans 44(19):9103–9113
Sahu A, Choi WI, Tae G (2018) Recent progress in the design of hypoxia-specific nano drug delivery systems for cancer therapy. Advanced Therapeutics 1(4):1800026
Salaheldin TA, Loutfy SA, Ramadan MA, Youssef T, Mousa SA (2019) IR-enhanced photothermal therapeutic effect of graphene magnetite nanocomposite on human liver cancer HepG2 cell model. Int J Nanomed 4397–4412
Salimi F, Dilmaghani KA, Alizadeh E, Akbarzadeh A, Davaran S (2018) Enhancing cisplatin delivery to hepatocellular carcinoma HepG2 cells using dual sensitive smart nanocomposite. Artif Cells Nanomed Biotechnol 46(5):949–958
Samrot AV, Sahithya CS, Selvarani J, Purayil SK, Ponnaiah P (2021) A review on synthesis, characterization and potential biological applications of superparamagnetic iron oxide nanoparticles. Curr Res Green Sustain Chem 4:100042
Sánchez-Cabezas S, Montes-Robles R, Gallo J, Sancenón F, Martínez-Máñez R (2019) Combining magnetic hyperthermia and dual T 1/T 2 MR imaging using highly versatile iron oxide nanoparticles. Dalton Trans 48(12):3883–3892
Saravanakumar G, Lee J, Kim J, Kim WJ (2015) Visible light-induced singlet oxygen-mediated intracellular disassembly of polymeric micelles co-loaded with a photosensitizer and an anticancer drug for enhanced photodynamic therapy. Chem Commun 51(49):9995–9998
Savari MN (2022) Multifunctional biocompatible nanoparticles to solve the challenges of resistance to treatment, real-time tracking, and reduce the side effects of destructing the cancerous tissues with radiotherapy. 5th International Conference on Bioscience: Fundamentals and Applications (ICBFA), http://icbfa.rf.gd/ICBFA27.htm?i=1
Scherer F, Anton M, Schillinger U, Henke J, Bergemann C, Krüger A, Gänsbacher B, Plank C (2002) Magnetofection: enhancing and targeting gene delivery by magnetic force in vitro and in vivo. Gene Ther 9(2):102–109
Schleich N, Po C, Jacobs D, Ucakar B, Gallez B, Danhier F, Préat V (2014) Comparison of active, passive and magnetic targeting to tumors of multifunctional paclitaxel/SPIO-loaded nanoparticles for tumor imaging and therapy. J Control Release 194:82–91
Schuster A, Schwab T, Bischof M, Klotz M, Lemor R, Degel C, Schäfer K-H (2013) Cell specific ultrasound effects are dose and frequency dependent. Ann Anat-Anat Anzeiger 195(1):57–67
See KL, Forbes I, Betts W (1984) Oxygen dependency of photocytotoxicity with haematoporphyrin derivative. Photochem Photobiol 39(5):631–634
Sekar TV, Dhanabalan A, Paulmurugan R (2011) Imaging cellular receptors in breast cancers: an overview. Curr Pharm Biotechnol 12(4):508–527
Sekhosana KE, Nyokong T (2014) Synthesis of ytterbium bisphthalocyanines: photophysicochemical properties and nonlinear absorption behavior. Opt Mater 37:139–146
Serpe L, Foglietta F, Canaparo R (2012) Nanosonotechnology: the next challenge in cancer sonodynamic therapy. Nanotechnol Rev 1(2):173–182
Sethi M, Chakarvarti S (2015) Hyperthermia techniques for cancer treatment: a review. Int. J. Pharmtech Res 8(6):292–299
Shah SA, Reeves DB, Ferguson RM, Weaver JB, Krishnan KM (2015) Mixed Brownian alignment and Néel rotations in superparamagnetic iron oxide nanoparticle suspensions driven by an ac field. Phys Rev B 92(9):094438
Shanmugam V, Selvakumar S, Yeh C-S (2014) Near-infrared light-responsive nanomaterials in cancer therapeutics. Chem Soc Rev 43(17):6254–6287
Sharma RA, Plummer R, Stock JK, Greenhalgh TA, Ataman O, Kelly S, Clay R, Adams RA, Baird RD, Billingham L (2016) Clinical development of new drug–radiotherapy combinations. Nat Rev Clin Oncol 13(10):627–642
Sharma K, Ningthoujam R, Dubey A, Chattopadhyay A, Phapale S, Juluri R, Mukherjee S, Tewari R, Shetake NG, Pandey B (2018) Synthesis and characterization of monodispersed water dispersible Fe3O4 nanoparticles and in vitro studies on human breast carcinoma cell line under hyperthermia condition. Sci Rep 8(1):14766
Shen Y, Zhan Y, Tang J, Xu P, Johnson PA, Radosz M, Van Kirk EA, Murdoch WJ (2008) Multifunctioning pH-responsive nanoparticles from hierarchical self-assembly of polymer brush for cancer drug delivery. AIChE J 54(11):2979–2989
Shen S, Wang S, Zheng R, Zhu X, Jiang X, Fu D, Yang W (2015) Magnetic nanoparticle clusters for photothermal therapy with near-infrared irradiation. Biomaterials 39:67–74
Shen Z, Chen T, Ma X, Ren W, Zhou Z, Zhu G, Zhang A, Liu Y, Song J, Li Z (2017) Multifunctional theranostic nanoparticles based on exceedingly small magnetic iron oxide nanoparticles for T 1-weighted magnetic resonance imaging and chemotherapy. ACS Nano 11(11):10992–11004
Shi H, Magaye R, Castranova V, Zhao J (2013) Titanium dioxide nanoparticles: a review of current toxicological data. Part Fibre Toxicol 10:1–33
Shoji M, Sun A, Kisiel W, Lu YJ, Shim H, McCarey BE, Nichols C, Parker ET, Pohl J, Mosley CA (2008) Targeting tissue factor-expressing tumor angiogenesis and tumors with EF24 conjugated to factor VIIa. J Drug Target 16(3):185–197
Shubayev VI, Pisanic TR II, Jin S (2009) Magnetic nanoparticles for theragnostics. Adv Drug Deliv Rev 61(6):467–477
Singh A, Sahoo SK (2014) Magnetic nanoparticles: a novel platform for cancer theranostics. Drug Discovery Today 19(4):474–481
Singha K, Namgung R, Kim WJ (2011) Polymers in small-interfering RNA delivery. Nucleic Acid Ther 21(3):133–147
Singhal P, Gill AR, Sharma PK, Kumar R, Bhusal N, Kaur A, Sharma P (2019) Aptamers: novel therapeutic and diagnostic molecules. Aptamers: Biotechnol Appl of a Next Gener Tool 73–89
Sirsi SR, Borden MA (2014) State-of-the-art materials for ultrasound-triggered drug delivery. Adv Drug Deliv Rev 72:3–14
Soares PI, Lochte F, Echeverria C, Pereira LC, Coutinho JT, Ferreira IM, Novo CM, Borges JP (2015) Thermal and magnetic properties of iron oxide colloids: influence of surfactants. Nanotechnology 26(42):425704
Sodipo BK, Aziz AA (2016) Recent advances in synthesis and surface modification of superparamagnetic iron oxide nanoparticles with silica. J Magn Magn Mater 416:275–291
Song XR, Li SH, Dai J, Song L, Huang G, Lin R, Li J, Liu G, Yang HH (2017) Polyphenol-inspired facile construction of smart assemblies for ATP-and pH-responsive tumor MR/Optical imaging and photothermal therapy. Small 13(20):1603997
Sonwane MP, Bhusnure O, Gaikwad V, Ali SS, Atul G, Santosh K (2015) A review formulation and development of orodispersible tablet. Indo Am J Pharm Res 5:3868–3881
Srinivasarao M, Galliford CV, Low PS (2015) Principles in the design of ligand-targeted cancer therapeutics and imaging agents. Nat Rev Drug Discovery 14(3):203–219
Star WM, Marijnissen HP, van den Berg-Blok AE, Versteeg JA, Franken KA, Reinhold HS (1986) Destruction of rat mammary tumor and normal tissue microcirculation by hematoporphyrin derivative photoradiation observed in vivo in sandwich observation chambers. Can Res 46(5):2532–2540
Stavarache CE, Paniwnyk L (2018) Controlled rupture of magnetic LbL polyelectrolyte capsules and subsequent release of contents employing high intensity focused ultrasound. J Drug Deliv Sci Technol 45:60–69
Stephen ZR, Kievit FM, Veiseh O, Chiarelli PA, Fang C, Wang K, Hatzinger SJ, Ellenbogen RG, Silber JR, Zhang M (2014) Redox-responsive magnetic nanoparticle for targeted convection-enhanced delivery of O 6-benzylguanine to brain tumors. ACS Nano 8(10):10383–10395
Stolik S, Delgado J, Pérez A, Anasagasti L (2000) Measurement of the penetration depths of red and near infrared light in human “ex vivo” tissues. J Photochem Photobiol, B 57(2–3):90–93
Sudame A, Kandasamy G, Maity D (2019) Single and dual surfactants coated hydrophilic superparamagnetic iron oxide nanoparticles for magnetic fluid hyperthermia applications. J Nanosci Nanotechnol 19(7):3991–3999
Sudimack J, Lee RJ (2000) Targeted drug delivery via the folate receptor. Adv Drug Deliv Rev 41(2):147–162
Sun S, Hu J, Tang H, Wu P (2010) Chain collapse and revival thermodynamics of poly (N-isopropylacrylamide) hydrogel. J Phys Chem B 114(30):9761–9770
Sun D, Lu J, Zhang L, Chen Z (2019a) Aptamer-based electrochemical cytosensors for tumor cell detection in cancer diagnosis: a review. Anal Chim Acta 1082:1–17
Sun X, Liu B, Chen X, Lin H, Peng Y, Li Y, Zheng H, Xu Y, Ou X, Yan S (2019b) Aptamer-assisted superparamagnetic iron oxide nanoparticles as multifunctional drug delivery platform for chemo-photodynamic combination therapy. J Mater Sci - Mater Med 30:1–15
Sundaresan V, Menon JU, Rahimi M, Nguyen KT, Wadajkar AS (2014) Dual-responsive polymer-coated iron oxide nanoparticles for drug delivery and imaging applications. Int J Pharm 466(1–2):1–7
Tagde P, Kulkarni GT, Mishra DK, Kesharwani P (2020) Recent advances in folic acid engineered nanocarriers for treatment of breast cancer. J Drug Deliv Sci Technol 56:101613
Taherian A, Esfandiari N, Rouhani S (2021) Breast cancer drug delivery by novel drug-loaded chitosan-coated magnetic nanoparticles. Cancer Nanotechnol 12(1):1–20
Tammi R, Ågren UM, Tuhkanen A-L, Tammi M (1994). Hyaluronan metabolism in skin. Prog Histochem Cytochem 29(2):III-77
Tang Z, Zhang L, Wang Y, Li D, Zhong Z, Zhou S (2016) Redox-responsive star-shaped magnetic micelles with active-targeted and magnetic-guided functions for cancer therapy. Acta Biomater 42:232–246
Tapeinos C, Pandit A (2016) Physical, chemical, and biological structures based on ROS-sensitive moieties that are able to respond to oxidative microenvironments. Adv Mater 28(27):5553–5585
Tarvirdipour S, Vasheghani-Farahani E, Soleimani M, Bardania H (2016) Functionalized magnetic dextran-spermine nanocarriers for targeted delivery of doxorubicin to breast cancer cells. Int J Pharm 501(1–2):331–341
Taurin S, Nehoff H, Greish K (2012) Anticancer nanomedicine and tumor vascular permeability; Where is the missing link? J Control Release 164(3):265–275
Thambi T, Deepagan V, Yoon HY, Han HS, Kim S-H, Son S, Jo D-G, Ahn C-H, Suh YD, Kim K (2014) Hypoxia-responsive polymeric nanoparticles for tumor-targeted drug delivery. Biomaterials 35(5):1735–1743
Thambi T, Park JH, Lee DS (2016) Hypoxia-responsive nanocarriers for cancer imaging and therapy: recent approaches and future perspectives. Chem Commun 52(55):8492–8500
Thomas CE, Ehrhardt A, Kay MA (2003) Progress and problems with the use of viral vectors for gene therapy. Nat Rev Genet 4(5):346–358
Thorstensen K, Romslo I (1993) The transferrin receptor: its diagnostic value and its potential as therapeutic target. Scand J Clin Lab Invest 53(Sup 215):113–120
Tian X, Lara H, Wagner KT, Saripalli S, Hyder SN, Foote M, Sethi M, Wang E, Caster JM, Zhang L (2015) Improving DNA double-strand repair inhibitor KU55933 therapeutic index in cancer radiotherapy using nanoparticle drug delivery. Nanoscale 7(47):20211–20219
Topalian SL, Drake CG, Pardoll DM (2015) Immune checkpoint blockade: a common denominator approach to cancer therapy. Cancer Cell 27(4):450–461
Tung Y-S, Liu H-L, Wu C-C, Ju K-C, Chen W-S, Lin W-L (2006) Contrast-agent-enhanced ultrasound thermal ablation. Ultrasound Med Biol 32(7):1103–1110
Tuntland T, Ethell B, Kosaka T, Blasco F, Zang RX, Jain M, Gould T, Hoffmaster K (2014) Implementation of pharmacokinetic and pharmacodynamic strategies in early research phases of drug discovery and development at Novartis Institute of Biomedical Research. Front Pharmacol 5:174
Turan O, Bielecki PA, Perera V, Lorkowski M, Covarrubias G, Tong K, Yun A, Loutrianakis G, Raghunathan S, Park Y (2019) Treatment of glioblastoma using multicomponent silica nanoparticles. Advanced Therapeutics 2(11):1900118
Turkoglu G, Koygun GK, Yurt MNZ, Demirok N, Erbas-Cakmak S (2020) Self-reporting heavy atom-free photodynamic therapy agents. Org Biomol Chem 18(46):9433–9437
Unger EC, McCreery TP, Sweitzer RH, Caldwell VE, Wu Y (1998) Acoustically active lipospheres containing paclitaxel: a new therapeutic ultrasound contrast agent. Invest Radiol 33(12):886–892
Ura T, Okuda K, Shimada M (2014) Developments in viral vector-based vaccines. Vaccines 2(3):624–641
Van der Zee J (2002) Heating the patient: a promising approach? Ann Oncol 13(8):1173–1184
Van Straten D, Mashayekhi V, De Bruijn HS, Oliveira S, Robinson DJ (2017) Oncologic photodynamic therapy: basic principles, current clinical status and future directions. Cancers 9(2):19
Vaupel P, Thews O, Hoeckel M (2001) Treatment resistance of solid tumors: role of hypoxia and anemia. Med Oncol 18:243–259
Veiseh O, Gunn JW, Zhang M (2010) Design and fabrication of magnetic nanoparticles for targeted drug delivery and imaging. Adv Drug Deliv Rev 62(3):284–304
Velloso FJ, Bianco AF, Farias JO, Torres NE, Ferruzo PY, Anschau V, Jesus-Ferreira HC, Chang TH-T, Sogayar MC, Zerbini LF (2017) The crossroads of breast cancer progression: insights into the modulation of major signaling pathways. Onco Targets Ther 10:5491
Wadajkar AS, Menon JU, Tsai Y-S, Gore C, Dobin T, Gandee L, Kangasniemi K, Takahashi M, Manandhar B, Ahn J-M (2013) Prostate cancer-specific thermo-responsive polymer-coated iron oxide nanoparticles. Biomaterials 34(14):3618–3625
Wahajuddin N, Arora S (2012) Superparamagnetic iron oxide nanoparticles: magnetic nanoplatforms as drug carriers. Int J Nanomed 3445–3471
Wang S, Low PS (1998) Folate-mediated targeting of antineoplastic drugs, imaging agents, and nucleic acids to cancer cells. J Control Release 53(1–3):39–48
Wang H, Shen J, Li Y, Wei Z, Cao G, Gai Z, Hong K, Banerjee P, Zhou S (2014a) Magnetic iron oxide–fluorescent carbon dots integrated nanoparticles for dual-modal imaging, near-infrared light-responsive drug carrier and photothermal therapy. Biomater Sci 2(6):915–923
Wang H, Yi J, Mukherjee S, Banerjee P, Zhou S (2014b) Magnetic/NIR-thermally responsive hybrid nanogels for optical temperature sensing, tumor cell imaging and triggered drug release. Nanoscale 6(21):13001–13011
Wang X, Niu D, Li P, Wu Q, Bo X, Liu B, Bao S, Su T, Xu H, Wang Q (2015) Dual-enzyme-loaded multifunctional hybrid nanogel system for pathological responsive ultrasound imaging and T2-weighted magnetic resonance imaging. ACS Nano 9(6):5646–5656
Wang C, Zhang L, Li S, Zhang M, Wang T, Li L, Wang C, Su Z (2016) A designed synthesis of multifunctional Fe3O4@ carbon/zinc phosphate nanoparticles for simultaneous imaging and synergic chemo-photothermal cancer therapy. J Mater Chem B 4(35):5809–5813
Wang J, Yao C, Shen B, Zhu X, Li Y, Shi L, Zhang Y, Liu J, Wang Y, Sun L (2019) Upconversion-magnetic carbon sphere for near infrared light-triggered bioimaging and photothermal therapy. Theranostics 9(2):608
Watson DC, Bayik D, Srivatsan A, Bergamaschi C, Valentin A, Niu G, Bear J, Monninger M, Sun M, Morales-Kastresana A (2016) Efficient production and enhanced tumor delivery of engineered extracellular vesicles. Biomaterials 105:195–205
Webber MJ, Appel EA, Meijer E, Langer R (2016) Supramolecular biomaterials. Nat Mater 15(1):13–26
Weerathunge P, Pooja D, Singh M, Kulhari H, Mayes EL, Bansal V, Ramanathan R (2019) Transferrin-conjugated quasi-cubic SPIONs for cellular receptor profiling and detection of brain cancer. Sens Actuators B Chem 297:126737
Weitman SD, Lark RH, Coney LR, Fort DW, Frasca V, Zurawski VR Jr, Kamen BA (1992) Distribution of the folate receptor GP38 in normal and malignant cell lines and tissues. Can Res 52(12):3396–3401
Wells CM, Harris M, Choi L, Murali VP, Guerra FD, Jennings JA (2019) Stimuli-responsive drug release from smart polymers. J Funct Biomater 10(3):34
Weng H, Bejjanki NK, Zhang J, Miao X, Zhong Y, Li H, Xie H, Wang S, Li Q, Xie M (2019) TAT peptide-modified cisplatin-loaded iron oxide nanoparticles for reversing cisplatin-resistant nasopharyngeal carcinoma. Biochem Biophys Res Commun 511(3):597–603
Wherry EJ (2011) T cell exhaustion. Nat Immunol 12(6):492–499
Wouters A, Pauwels B, Lardon F, Vermorken JB (2007) Implications of in vitro research on the effect of radiotherapy and chemotherapy under hypoxic conditions. Oncologist 12(6):690–712
Wu G, Fang Y-Z, Yang S, Lupton JR, Turner ND (2004) Glutathione metabolism and its implications for health. J Nutr 134(3):489–492
Wu L-X, Wang H, Tu Z-Y, Ding B-B, Xiao Y, Lu J-X (2012) Synthesis of cyclic carbonates from CO2 and diols via electrogenerated N-heterocyclic carbenes. Int J Electrochem Sci 7(11):11540–11549
Wu H, Yin J-J, Wamer WG, Zeng M, Lo YM (2014) Reactive oxygen species-related activities of nano-iron metal and nano-iron oxides. J Food Drug Anal 22(1):86–94
Wu L, Chen L, Liu F, Qi X, Ge Y, Shen S (2017) Remotely controlled drug release based on iron oxide nanoparticles for specific therapy of cancer. Colloids Surf B 152:440–448
Wust P, Hildebrandt B, Sreenivasa G, Rau B, Gellermann J, Riess H, Felix R, Schlag P (2002) Hyperthermia in combined treatment of cancer. Lancet Oncol 3(8):487–497
Xiao Z, Halls S, Dickey D, Tulip J, Moore RB (2007) Fractionated versus standard continuous light delivery in interstitial photodynamic therapy of dunning prostate carcinomas. Clin Cancer Res 13(24):7496–7505
Xu H, Rudkevich DM (2004) CO2 in supramolecular chemistry: Preparation of switchable supramolecular polymers. Chemistry–A Eur J 10(21):5432–5442
Xu H, Cao W, Zhang X (2013) Selenium-containing polymers: promising biomaterials for controlled release and enzyme mimics. Acc Chem Res 46(7):1647–1658
Xu H, Zhang X, Han R, Yang P, Ma H, Song Y, Lu Z, Yin W, Wu X, Wang H (2016) Nanoparticles in sonodynamic therapy: state of the art review. RSC Adv 6(56):50697–50705
Xu L, Bai Q, Zhang X, Yang H (2017) Folate-mediated chemotherapy and diagnostics: an updated review and outlook. J Control Release 252:73–82
Xuan J, Boissiere O, Zhao Y, Yan B, Tremblay L, Lacelle S, Xia H, Zhao Y (2012) Ultrasound-responsive block copolymer micelles based on a new amplification mechanism. Langmuir 28(47):16463–16468
Yan L, Luo L, Amirshaghaghi A, Miller J, Meng C, You T, Busch TM, Tsourkas A, Cheng Z (2019) Dextran-benzoporphyrin derivative (BPD) coated superparamagnetic iron oxide nanoparticle (SPION) micelles for T2-weighted magnetic resonance imaging and photodynamic therapy. Bioconjug Chem 30(11):2974–2981
Yan Q, Zhou R, Fu C, Zhang H, Yin Y, Yuan J (2011) CO2-responsive polymeric vesicles that breathe. Angew Chem Int Ed 50(21):4923–4927
Yang J, Zhang C (2020) Regulation of cancer-immunity cycle and tumor microenvironment by nanobiomaterials to enhance tumor immunotherapy. Wiley Interdisciplinary Rev Nanomed and Nanobiotechnol 12(4):e1612
Yang L, Cao Z, Sajja HK, Mao H, Wang L, Geng H, Xu H, Jiang T, Wood WC, Nie S (2008) Development of receptor targeted magnetic iron oxide nanoparticles for efficient drug delivery and tumor imaging. J Biomed Nanotechnol 4(4):439–449
Yang Y, Aw J, Chen K, Liu F, Padmanabhan P, Hou Y, Cheng Z, Xing B (2011). Enzyme‐responsive multifunctional magnetic nanoparticles for tumor intracellular drug delivery and imaging. Chem Asian J 6(6):1381–1389
Yang G, Liu J, Wu Y, Feng L, Liu Z (2016a) Near-infrared-light responsive nanoscale drug delivery systems for cancer treatment. Coord Chem Rev 320:100–117
Yang HY, Jang M-S, Gao GH, Lee JH, Lee DS (2016b) Construction of redox/pH dual stimuli-responsive PEGylated polymeric micelles for intracellular doxorubicin delivery in liver cancer. Polym Chem 7(9):1813–1825
Yang HY, Jang M-S, Gao GH, Lee JH, Lee DS (2016c) PH-Responsive biodegradable polymeric micelles with anchors to interface magnetic nanoparticles for MR imaging in detection of cerebral ischemic area. Nanoscale 8(25):12588–12598
Yang HY, Fu Y, Jang M-S, Li Y, Yin WP, Ahn TK, Lee JH, Chae H, Lee DS (2017a) CdSe@ ZnS/ZnS quantum dots loaded in polymeric micelles as a pH-triggerable targeting fluorescence imaging probe for detecting cerebral ischemic area. Colloids Surf B 155:497–506
Yang HY, Jang M-S, Li Y, Lee JH, Lee DS (2017b) Multifunctional and redox-responsive self-assembled magnetic nanovectors for protein delivery and dual-modal imaging. ACS Appl Mater Interfaces 9(22):19184–19192
Yang B, Wang K, Zhang D, Sun B, Ji B, Wei L, Li Z, Wang M, Zhang X, Zhang H (2018) Light-activatable dual-source ROS-responsive prodrug nanoplatform for synergistic chemo-photodynamic therapy. Biomater Sci 6(11):2965–2975
Yang HY, Jang M-S, Li Y, Fu Y, Lee JH, Lee DS (2019) Hierarchical tumor acidity-responsive self-assembled magnetic nanotheranostics for bimodal bioimaging and photodynamic therapy. J Control Release 301:157–165
Yang G, Liu Y, Chen J, Ding J, Chen X (2022) Self-adaptive nanomaterials for rational drug delivery in cancer therapy. Acc Mater Res 3(12):1232–1247
Yao J, Feng J, Chen J (2016) External-stimuli responsive systems for cancer theranostic. Asian J Pharm Sci 11(5):585–595
Ye H, Zhou Y, Liu X, Chen Y, Duan S, Zhu R, Liu Y, Yin L (2019) Recent advances on reactive oxygen species-responsive delivery and diagnosis system. Biomacromolecules 20(7):2441–2463
Yu J, Ju Y, Zhao L, Chu X, Yang W, Tian Y, Sheng F, Lin J, Liu F, Dong Y (2016) Multistimuli-regulated photochemothermal cancer therapy remotely controlled via Fe5C2 nanoparticles. ACS Nano 10(1):159–169
Yu S, Ng VMH, Wang F, Xiao Z, Li C, Kong LB, Que W, Zhou K (2018) Synthesis and application of iron-based nanomaterials as anodes of lithium-ion batteries and supercapacitors. J Mater Chem A 6(20):9332–9367
Yue X, Zhang Q, Dai Z (2017) Near-infrared light-activatable polymeric nanoformulations for combined therapy and imaging of cancer. Adv Drug Deliv Rev 115:155–170
Zakharchenko A, Guz N, Laradji AM, Katz E, Minko S (2018) Magnetic field remotely controlled selective biocatalysis. Nat Catal 1(1):73–81
Zanganeh S, Hutter G, Spitler R, Lenkov O, Mahmoudi M, Shaw A, Pajarinen JS, Nejadnik H, Goodman S, Moseley M (2016) Iron oxide nanoparticles inhibit tumour growth by inducing pro-inflammatory macrophage polarization in tumour tissues. Nat Nanotechnol 11(11):986–994
Zeng J, Du P, Liu L, Li J, Tian K, Jia X, Zhao X, Liu P (2015) Superparamagnetic reduction/pH/temperature multistimuli-responsive nanoparticles for targeted and controlled antitumor drug delivery. Mol Pharm 12(12):4188–4199
Zhang Z-Q, Song S-C (2017) Multiple hyperthermia-mediated release of TRAIL/SPION nanocomplex from thermosensitive polymeric hydrogels for combination cancer therapy. Biomaterials 132:16–27
Zhang J, Zou H, Qing Q, Yang Y, Li Q, Liu Z, Guo X, Du Z (2003) Effect of chemical oxidation on the structure of single-walled carbon nanotubes. J Phys Chem B 107(16):3712–3718
Zhang C, Jugold M, Woenne EC, Lammers T, Morgenstern B, Mueller MM, Zentgraf H, Bock M, Eisenhut M, Semmler W (2007) Specific targeting of tumor angiogenesis by RGD-conjugated ultrasmall superparamagnetic iron oxide particles using a clinical 1.5-T magnetic resonance scanner. Can Res 67(4):1555–1562
Zhang L, Li Y, Jimmy CY, Chen YY, Chan KM (2014a) Assembly of polyethylenimine-functionalized iron oxide nanoparticles as agents for DNA transfection with magnetofection technique. J Mater Chem B 2(45):7936–7944
Zhang Y, Sun Y, Yang X, Hilborn J, Heerschap A, Ossipov DA (2014b) Injectable in situ forming hybrid iron oxide-hyaluronic acid hydrogel for magnetic resonance imaging and drug delivery. Macromol Biosci 14(9):1249–1259
Zhang P, Ren Z, Chen Z, Zhu J, Liang J, Liao R, Wen J (2018a) Iron oxide nanoparticles as nanocarriers to improve chlorin e6-based sonosensitivity in sonodynamic therapy. Drug Des Dev Ther 4207–4216
Zhang W, Zhou Y, Li X, Xu X, Chen Y, Zhu R, Yin L (2018b) Macrophage-targeting and reactive oxygen species (ROS)-responsive nanopolyplexes mediate anti-inflammatory siRNA delivery against acute liver failure (ALF). Biomater Sci 6(7):1986–1993
Zhang Z-T, Huang-Fu M-Y, Xu W-H, Han M (2019) Stimulus-responsive nanoscale delivery systems triggered by the enzymes in the tumor microenvironment. Eur J Pharm Biopharm 137:122–130
Zhao D, Sun X, Tong J, Ma J, Bu X, Xu R, Fan R (2012a) A novel multifunctional nanocomposite C225-conjugated Fe3O4/Ag enhances the sensitivity of nasopharyngeal carcinoma cells to radiotherapy. Acta Biochim Biophys Sin 44(8):678–684
Zhao Y, Zhang S, Cui S, Wang B, Zhang S (2012b) Peptide-based cationic liposome-mediated gene delivery. Expert Opin Drug Deliv 9(1):127–139
Zhao Q, Liu J, Zhu W, Sun C, Di D, Zhang Y, Wang P, Wang Z, Wang S (2015) Dual-stimuli responsive hyaluronic acid-conjugated mesoporous silica for targeted delivery to CD44-overexpressing cancer cells. Acta Biomater 23:147–156
Zhao C, Song X, Jin W, Wu F, Zhang Q, Zhang M, Zhou N, Shen J (2019) Image-guided cancer therapy using aptamer-functionalized cross-linked magnetic-responsive Fe3O4@ carbon nanoparticles. Anal Chim Acta 1056:108–116
Zheng J, Liu Y, Song F, Jiao L, Wu Y, Peng X (2020) A nitroreductase-activatable near-infrared theranostic photosensitizer for photodynamic therapy under mild hypoxia. Chem Commun 56(43):5819–5822
Zheng M, Pan M, Zhang W, Lin H, Wu S, Lu C, Tang S, Liu D, Cai J (2021) Poly (α-l-lysine)-based nanomaterials for versatile biomedical applications: Current advances and perspectives. Bioactive Materials 6(7):1878–1909
Zhi D, Yang T, Yang J, Fu S, Zhang S (2020) Targeting strategies for superparamagnetic iron oxide nanoparticles in cancer therapy. Acta Biomater 102:13–34
Zhou J, Rossi J (2017) Aptamers as targeted therapeutics: current potential and challenges. Nat Rev Drug Discovery 16(3):181–202
Zhou L, Dong C, Ding L, Feng W, Yu L, Cui X, Chen Y (2021) Targeting ferroptosis synergistically sensitizes apoptotic sonodynamic anti-tumor nanotherapy. Nano Today 39:101212
Zhu L, Wang D, Wei X, Zhu X, Li J, Tu C, Su Y, Wu J, Zhu B, Yan D (2013) Multifunctional pH-sensitive superparamagnetic iron-oxide nanocomposites for targeted drug delivery and MR imaging. J Control Release 169(3):228–238
Zorlu Y, Ermeydan MA, Dumoulin F, Ahsen V, Savoie H, Boyle RW (2009) Glycerol and galactose substituted zinc phthalocyanines. Synthesis and photodynamic activity. Photochem Photobiol Sci 8:312–318
Zou H, Yuan W (2015) Temperature-and redox-responsive magnetic complex micelles for controlled drug release. J Mater Chem B 3(2):260–269
Zou W, Wolchok JD, Chen L (2016) PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: mechanisms, response biomarkers, and combinations. Sci Transl Med 8(328):328rv324–328rv324
Zuvin M, Kuruoglu E, Kaya VO, Unal O, Kutlu O, Yagci Acar H, Gozuacik D, Koşar A (2019) Magnetofection of green fluorescent protein encoding DNA-bearing polyethyleneimine-coated superparamagnetic iron oxide nanoparticles to human breast cancer cells. ACS Omega 4(7):12366–12374
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
Copyright information
© 2023 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.
About this chapter
Cite this chapter
Savari, MN., Jabali, A. (2023). IONPs-Based Treatment Methods. In: Theranostic Iron-Oxide Based Nanoplatforms in Oncology. Nanomedicine and Nanotoxicology. Springer, Singapore. https://doi.org/10.1007/978-981-99-6507-6_7
Download citation
DOI: https://doi.org/10.1007/978-981-99-6507-6_7
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-99-6506-9
Online ISBN: 978-981-99-6507-6
eBook Packages: Physics and AstronomyPhysics and Astronomy (R0)