Food XenomiRNA Arise: MicroRNA Storm and Space

Abstract

MicroRNAs (miRNAs) are mobile and protein noncoding genes. Therefore, miRNA genes are informational. RNA informational genes (Rigs) can regulate most protein-coding genes as information through transcriptional and/or posttranscriptional pathways. Rigs have been linked to metabolic syndromes, including obesity, atherosclerosis, and cancer. MiRNA genes are also related to fine-tuning of α- and β-cells in the islets of Langerhans in the endocrine pancreas, insulin secretion, and brown adipose cell differentiation, which are implicated in obesity. In terms of miRNA gene function, it has recently been noted that obesity, type 2 diabetes mellitus (T2DM) as “diabesity,” and hyperlipidemia are regulated by miRNAs such as the miR-133a/b or miR-193b/miR-365 clusters. Furthermore, as an epigenetic modulator of metabolic pathways in fat accumulation and fatty acid oxidation, SIRT1 nicotinamide adenine dinucleotide (NAD)-dependent deacetylase is involved in the protection of diet-induced obesity and insulin resistance, which are regulated by miRNA genes, such as miR-9, miR-34, and miR-132. Rig is associated with food exosomes and accumulates in human serum along with nutrients after feeding, whereas Rig can control lipid homeostasis in humans in which it is incorporated. Our idea suggests that not only nutrients but also mobile miRNA genes, including dietary miRNAs, especially meat miRNAs such as xenotropic miRNA (xenomiRNA), control human metabolism and are involved in diabetes as a novel food information processor. Thus, numerous Rigs have been implicated as metabolic miRNAs in human dyslipidemia. Therefore, there is still the possible idea of the other layers of mobile Rigs. The layer may be constructed by the transmission of RNA information only that the numbers of metabolism-related circulating mobile Rigs should use cross talk with cellular miRNAs without protein systems, and Rigs each other would also be a tool for cross talk. These miRNAs are controlled by quantum energy codes that reside in the environmental quantum RNA language (QRL). If so, under cross talk, food-led evolution might be programmed by food miRNAs in exosomes, similar to food miRNA-programmed metabolic diseases. We know that human-specific miRNAs in the brain may be evolutionally independent from the original miRNAs in different species. Thus, the species origin may not have been derived from the Darwinian phylogenetic tree, as it distinctly evolved through different food Rig sources and/or environmental RNA storms, such as the iconic Noah’s Ark. Similarly, miRNA-binding sites in the 3′ untranslated region (3′UTR) of protein-coding genes have polymorphisms due to mutation and/or recombination and play an important role in programmed evolution by dietary miRNAs.

Whether humans would have evolved but no infectious virus or bacilli, or whether there would have resulted human with worse and more being at all, cannot be discerned.

Ruse, M. Darwin, and Design