Abstract
As shown in Chap. 2, the short interfering RNA (siRNA) system was thought to be the same as the microRNA (miRNA) system. The miRNA genes are information because they are protein-noncoding RNAs. RNA informational genes (Rigs) are usually located in approximately 98% of the noncoding regions on the human genome. In contrast, miRNAs are deeply connected to the protein system. Rig is the master regulator of Central Dogma. Fine-tuning of protein expression by Rigs has been implicated in infection and cancer disease control. Traditional biogenesis of miRNAs is now a common pathway, but after biosynthesis, linear single-stranded miRNAs target linear single-stranded messenger RNA (mRNA), and miRNA seed regions target the 3′ untranslated region (3′ UTR) of mRNAs with a helix-like shape. The mature miRNA duplexes with mRNA in the Argonaute (Ago) protein. However, many human loop RNAs (loRNAs) have recently been reported, and the miRNA loop (lomiRNA) can be associated with Ago. Therefore, it is unknown whether helix recognition structures are common between miRNAs and mRNAs. Its helix geometry is unlikely to serve circular mRNA–miRNA interactions, and miRNA biogenesis or function has many exceptions, as does RNA interference. Thus, the miRNA machinery in circularity differs from RNA interference by Fire and Mellow. Due to the complexity of miRNA biogenesis and function, the biological relevance of circular mRNAs may be superimposed on circular torus miRNAs in RNA Wave 2000, suggesting that the coherence of torus miRNAs and torus mRNAs has implications for human health life. Beyond helices, the biosynthetic potential of tori could be a keystone for demonstrating this idea according to the quantum RNA language. In reality, circular RNA (circRNA) has been detected. Additionally, the miRNA quantum code was created from circular miRNA/miRNA relationships. Therefore, miRNA differs from RNA interference.
The old but often overlooked principles were simple.
Garrett, L. The Coming Plague
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Fujii, Y.R. (2023). Mobile MicroRNAs: Potential for MicroRNA Biogenesis. In: The MicroRNA 2000 Transformer. Springer, Singapore. https://doi.org/10.1007/978-981-99-3165-1_3
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