Abstract
Lung cancer is the most devastating cause of death among all cancers worldwide, and non-small cell lung cancer (NSCLC) accounts for 80% of all the lung cancer cases. Beyond common genetic research and epigenomic studies, the extraordinary investigations of non-coding RNAs have provided insights into the molecular basis of cancer. Existing evidence from various cancer models highlights that the regulation of non-coding RNAs is crucial and that their deregulation may be a common reason for the development and progression of cancer, and competition of cancer therapeutics. Non-coding RNAs, such as long non-coding RNAs (lncRNAs) and microRNAs (miRNAs), are increasingly recognized as potential cancer biomarkers for early detection and application of therapeutic strategies. The miRNAs have gained importance as master regulators of target mRNAs by negatively regulating their expression. The lncRNAs function as both tumor suppressors and oncogenes, and also compete with miRNAs that influence the translational inhibition processes. This review addresses the role of lncRNAs in lung cancer development, highlights their mechanisms of action, and provides an overview of the impact of lncRNAs on lung cancer survival and progression via miRNA sponging. The improved understanding of lung cancer mechanisms has opened opportunities to analyze molecular markers and their potential therapeutics.
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References
Molina JR, Yang P, Cassivi SD et al (2008) Non-small cell lung cancer: epidemiology, risk factors, treatment, and survivorship. Mayo Clin Proc 83:584–594. https://doi.org/10.4065/83.5.584
Lemjabbar-Alaoui H, Hassan OUI, Yang YW, Buchanan P (2015) Lung cancer: biology and treatment options. Biochim Biophys Acta Rev Cancer 1856:189–210. https://doi.org/10.1016/J.BBCAN.2015.08.002
Zheng M (2016) Classification and pathology of Lung Cancer. Surg Oncol Clin N Am. https://doi.org/10.1016/j.soc.2016.02.003
Barrows ED, Blackburn MJ, Liu SV (2022) Evolving role of immunotherapy in small cell lung cancer. Semin Cancer Biol. https://doi.org/10.1016/J.SEMCANCER.2022.02.021
Lu Z, Li Y, Wang J et al (2017) (2017) Long non-coding RNA NKILA inhibits migration and invasion of non-small cell lung cancer via NF-κB/Snail pathway. J Exp Clin Cancer Res 361(36):1–13. https://doi.org/10.1186/S13046-017-0518-0
W S, S F, X C, et al (2018) Silencing of long noncoding RNA MIR22HG triggers cell survival/death signaling via oncogenes YBX1, MET, and p21 in lung cancer. Cancer Res 78:3207–3219. https://doi.org/10.1158/0008-5472.CAN-18-0222
Chen Y, Fu LL, Wen X et al (2014) (2014) Oncogenic and tumor suppressive roles of microRNAs in apoptosis and autophagy. Apoptosis 198(19):1177–1189. https://doi.org/10.1007/S10495-014-0999-7
Ransohoff JD, Wei Y, Khavari PA (2018) The functions and unique features of long intergenic non-coding RNA. Nat Rev Mol Cell Biol 19:143. https://doi.org/10.1038/NRM.2017.104
Sánchez Y, Huarte M (2013) Long non-coding RNAs: challenges for diagnosis and therapies. Nucleic Acid Ther 23:15–20. https://doi.org/10.1089/NAT.2012.0414
Jiang L, Li Z, Wang R (2019) Long non-coding rnas in lung cancer: regulation patterns, biologic function and diagnosis implications (review). Int J Oncol 55:585–596. https://doi.org/10.3892/IJO.2019.4850/HTML
Baldassarre A, Masotti A (2012) Long Non-Coding RNAs and p53 Regulation. Int J Mol Sci 13:16708–16717. https://doi.org/10.3390/IJMS131216708
Dhanoa JK, Sethi RS, Verma R et al (2018) Long non-coding RNA: its evolutionary relics and biological implications in mammals: a review. J Anim Sci Technol. https://doi.org/10.1186/S40781-018-0183-7
Peng W, He D, Shan B et al (2019) (2019) LINC81507 act as a competing endogenous RNA of miR-199b-5p to facilitate NSCLC proliferation and metastasis via regulating the CAV1/STAT3 pathway. Cell Death Dis 107(10):1–15. https://doi.org/10.1038/s41419-019-1740-9
Jin H-F, Wang J-F, Song T-T et al (2020) MiR-200b inhibits tumor growth and chemoresistance via targeting p70S6K1 in lung cancer. Front Oncol. https://doi.org/10.3389/FONC.2020.00643
Zhu X, Kudo M, Huang X et al (2021) Frontiers of MicroRNA signature in non-small cell lung cancer. Front Cell Dev Biol. https://doi.org/10.3389/FCELL.2021.643942
Loewen G, Jayawickramarajah J, Zhuo Y, Shan B (2014) Functions of lncRNA HOTAIR in lung cancer. J Hematol Oncol 7:1–10. https://doi.org/10.1186/S13045-014-0090-4/FIGURES/2
Wan L, Sun M, Liu GJ et al (2016) Long non-coding RNA PVT1 promotes non-small cell lung cancer cell proliferation through epigenetically regulating LATS2 expression. Mol Cancer Ther 15:1082–1094. https://doi.org/10.1158/1535-7163.MCT-15-0707/87120/AM/LONG-NON-CODING-RNA-PVT1-PROMOTES-NON-SMALL-CELL
He W, Zhang Y, Xia S (2020) LncRNA NNT-AS1 promotes non-small cell lung cancer progression through regulating miR-22-3p/YAP1 axis. Thorac Cancer 11:549–560. https://doi.org/10.1111/1759-7714.13280
Li Y, Tian J, Guo ZJ et al (2018) Expression of microRNAs-106b in nonsmall cell lung cancer. J Cancer Res Ther 14:295. https://doi.org/10.4103/0973-1482.235344
Wei K, Pan C, Yao G et al (2017) MiR-106b-5p promotes proliferation and inhibits apoptosis by regulating BTG3 in non-small cell lung cancer. Cell Physiol Biochem 44:1545–1558. https://doi.org/10.1159/000485650
Uddin A, Chakraborty S (2018) Role of miRNAs in lung cancer. J Cell Physiol. https://doi.org/10.1002/jcp.26607
Giglio S, Vecchione A (2015) c-Met and miRs in Cancer. Biomed 3:32–44. https://doi.org/10.3390/BIOMEDICINES3010032
Mandeville I, Aubin J, LeBlanc M et al (2006) Impact of the loss of Hoxa5 function on lung alveogenesis. Am J Pathol 169:1312–1327. https://doi.org/10.2353/ajpath.2006.051333
Liu X, Lu K, Wang K et al (2012) (2012) MicroRNA-196a promotes non-small cell lung cancer cell proliferation and invasion through targeting HOXA5. BMC Cancer 121(12):1–12. https://doi.org/10.1186/1471-2407-12-348
Bian C, Yuan L, Gai H (2019) A long non-coding RNA LINC01288 facilitates non-small cell lung cancer progression through stabilizing IL-6 mRNA. Biochem Biophys Res Commun 514:443–449. https://doi.org/10.1016/J.BBRC.2019.04.132
Yu T, Zhao Y, Hu Z et al (2017) Meta Lnc9 facilitates lung cancer metastasis via a PGK1-activated AKT/mTOR pathway. Cancer Res 77:5782–5794. https://doi.org/10.1158/0008-5472.CAN-17-0671/652967/AM/METALNC9-FACILITATES-LUNG-CANCER-METASTASIS-VIA-A
Leng X, Ding X, Wang S et al (2018) Long non-coding RNA AFAP1-AS1 is upregulated in NSCLC and associated with lymph node metastasis and poor prognosis. Oncol Lett 16:727–732. https://doi.org/10.3892/OL.2018.8784/HTML
Chen Z, Chen X, Chen P et al (2017) (2017) Long non-coding RNA SNHG20 promotes non-small cell lung cancer cell proliferation and migration by epigenetically silencing of P21 expression. Cell Death Dis 810(8):e3092–e3092. https://doi.org/10.1038/cddis.2017.484
Lujambio A, Ropero S, Ballestar E et al (2007) Genetic unmasking of an epigenetically silenced microrna in human cancer cells. Cancer Res 67:1424–1429. https://doi.org/10.1158/0008-5472.CAN-06-4218
Pan C, Yao G, Liu B et al (2017) Long noncoding RNA fal1 promotes cell proliferation, invasion and epithelial-mesenchymal transition through the PTEN/AKT signaling axis in non-small cell lung cancer. Cell Physiol Biochem 43:339–352. https://doi.org/10.1159/000480414
Huang S, Li C, Huang J et al (2020) (2020) LncRNA FEZF1-AS1 promotes non-small lung cancer cell migration and invasion through the up-regulation of NOTCH1 by serving as a sponge of miR-34a. BMC Pulm Med 201(20):1–7. https://doi.org/10.1186/S12890-020-1154-6
Sang Y, Zhou F, Wang D et al (2016) Up-regulation of long non-coding HOTTIP functions as an oncogene by regulating HOXA13 in non-small cell lung cancer. Am J Transl Res 8:2022
Liu JQ, Feng YH, Zeng S, Zhong MZ (2020) linc01088 promotes cell proliferation by scaffolding EZH2 and repressing p21 in human non-small cell lung cancer. Life Sci 241:117134. https://doi.org/10.1016/J.LFS.2019.117134
Sun Y, Jin S-D, Zhu Q et al (2017) Long non-coding RNA LUCAT1 is associated with poor prognosis in human non-small cell lung cancer and regulates cell proliferation via epigenetically repressing p21 and p57 expression. Oncotarget 8:28297–28311. https://doi.org/10.18632/ONCOTARGET.16044
Zhang M, Wu J, Zhong W et al (2018) Long non-coding RNA BRE-AS1 represses non-small cell lung cancer cell growth and survival via upregulating NR4A3. Arch Biochem Biophys 660:53–63. https://doi.org/10.1016/J.ABB.2018.09.013
Tian Y, Zhang N, Chen S et al (2018) The long non-coding RNA LSINCT5 promotes malignancy in non-small cell lung cancer by stabilizing HMGA2. Cell Cycle 17:1188–1198. https://doi.org/10.1080/15384101.2018.1467675/SUPPL_FILE/KCCY_A_1467675_SM5196.DOCX
Lu G, Fu D, Jia C et al (2017) Reduced miR-105-1 levels are associated with poor survival of patients with non-small cell lung cancer. Oncol Lett 14:7824–7848. https://doi.org/10.3892/OL.2017.7228/HTML
Zhang C, Wang H, Liu X et al (2018) (2018) Oncogenic microRNA-411 promotes lung carcinogenesis by directly targeting suppressor genes SPRY4 and TXNIP. Oncogene 3811(38):1892–1904. https://doi.org/10.1038/s41388-018-0534-3
Luo D, Zhang Z, Zhang Z et al (2018) Aberrant expression of mir-362 promotes lung cancer metastasis through downregulation of SEMA3A. J Immunol Res. https://doi.org/10.1155/2018/1687097
Liang W, Zhang L, Jiang G et al (2015) Development and validation of a nomogram for predicting survival in patients with resected non-small-cell lung cancer. J Clin Oncol 33:861–869. https://doi.org/10.1200/JCO.2014.56.6661
Song L, Dai Z, Zhang S et al (2018) MicroRNA-1179 suppresses cell growth and invasion by targeting sperm-associated antigen 5-mediated Akt signaling in human non-small cell lung cancer. Biochem Biophys Res Commun 504:164–170. https://doi.org/10.1016/J.BBRC.2018.08.149
Jin S, He J, Zhou Y et al (2020) LncRNA FTX activates FOXA2 expression to inhibit non–small-cell lung cancer proliferation and metastasis. J Cell Mol Med 24:4839–4849. https://doi.org/10.1111/JCMM.15163
Wen X, Han XR, Wang YJ et al (2018) Retracted: Effects of long non-coding RNA SPRY4-IT1-mediated EZH2 on the invasion and migration of lung adenocarcinoma. J Cell Biochem 119:1827–1840. https://doi.org/10.1002/JCB.26344
Meng Q, Liu M, Cheng R (2020) LINC00461/miR-4478/E2F1 feedback loop promotes non-small cell lung cancer cell proliferation and migration. Biosci Rep 40:20191345. https://doi.org/10.1042/BSR20191345/221872
Yang Y, Li H, Hou S et al (2013) The noncoding RNA expression profile and the effect of lncRNA AK126698 on cisplatin resistance in non-small-cell lung cancer cell. PLoS ONE 8:e65309. https://doi.org/10.1371/JOURNAL.PONE.0065309
Jiao A, Sui M, Zhang L et al (2016) MicroRNA-200c inhibits the metastasis of non-small cell lung cancer cells by targeting ZEB2, an epithelial-mesenchymal transition regulator. Mol Med Rep 13:3349–3355. https://doi.org/10.3892/MMR.2016.4901/HTML
Zhen Q, Gao LN, Wang RF et al (2018) LncRNA DANCR Promotes Lung Cancer by Sequestering miR-216a. Cancer Control. https://doi.org/10.1177/1073274818769849
Qu R, Chen X, Zhang C (2018) LncRNA ZEB1-AS1/miR-409–3p/ZEB1 feedback loop is involved in the progression of non-small cell lung cancer. Biochem Biophys Res Commun 507:450–456. https://doi.org/10.1016/J.BBRC.2018.11.059
Li H, Guo X, Li Q et al (2018) Long non-coding RNA 1308 promotes cell invasion by regulating the miR-124/ADAM 15 axis in non-small-cell lung cancer cells. Cancer Manag Res 10:6599–6609. https://doi.org/10.2147/CMAR.S187973
Yang F, Shao C, Wei K et al (2019) Retracted: miR-942 promotes tumor migration, invasion, and angiogenesis by regulating EMT via BARX2 in non-small-cell lung cancer. J Cell Physiol 234:23596–23607. https://doi.org/10.1002/JCP.28928
Miao L, Huang Z, Zengli Z et al (2016) Loss of long non-coding RNA FOXF1-AS1 regulates epithelial-mesenchymal transition, stemness and metastasis of non-small cell lung cancer cells. Oncotarget 7:68339–68349. https://doi.org/10.18632/ONCOTARGET.11630
Jin S, Yang X, Li J et al (2019) P53-targeted lincRNA-p21 acts as a tumor suppressor by inhibiting JAK2/STAT3 signaling pathways in head and neck squamous cell carcinoma. Mol Cancer 18:1–18. https://doi.org/10.1186/S12943-019-0993-3/FIGURES/7
Zhou Y, Li S, Li J et al (2017) Effect of microRNA-135a on cell proliferation, migration, invasion, apoptosis and tumor angiogenesis through the IGF-1/PI3K/Akt signaling pathway in non-small cell lung cancer. Cell Physiol Biochem 42:1431–1446. https://doi.org/10.1159/000479207
Jiang W, Zhang D, Xu B et al (2015) Long non-coding RNA BANCR promotes proliferation and migration of lung carcinoma via MAPK pathways. Biomed Pharmacother 69:90–95. https://doi.org/10.1016/J.BIOPHA.2014.11.027
Shi X, Sun M, Liu H et al (2015) A critical role for the long non-coding RNA GAS5 in proliferation and apoptosis in non-small-cell lung cancer. Mol Carcinog 54:E1–E12. https://doi.org/10.1002/MC.22120
Ratti M, Lampis A, Ghidini M et al (2020) (2020) MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) as new tools for cancer therapy: first steps from bench to bedside. Target Oncol 153(15):261–278. https://doi.org/10.1007/S11523-020-00717-X
Cao M, Jiang Y, Tang Y et al (2016) The crosstalk between lncRNA and microRNA in cancer metastasis: orchestrating the epithelial-mesenchymal plasticity. Oncotarget 8:12472–12483. https://doi.org/10.18632/ONCOTARGET.13957
Kong X, Hu S, Yuan Y et al (2020) Analysis of lncRNA, miRNA and mRNA-associated ceRNA networks and identification of potential drug targets for drug-resistant non-small cell lung cancer. J Cancer 11:3357–3368. https://doi.org/10.7150/JCA.40729
Zhao M, Feng J, Tang L (2021) Competing endogenous RNAs in lung cancer. Cancer Biol Med 18:1–20. https://doi.org/10.20892/J.ISSN.2095-3941.2020.0203
López-Urrutia E, Bustamante Montes LP, de Guevara L, Cervantes D et al (2019) Crosstalk between long non-coding RNAs, micro-RNAs and mRNAs: deciphering molecular mechanisms of master regulators in cancer. Front Oncol 9:669. https://doi.org/10.3389/FONC.2019.00669/BIBTEX
Ling H, Fabbri M (2013) Calin GA (2013) MicroRNAs and other non-coding RNAs as targets for anticancer drug development. Nat Rev Drug Discov 1211(12):847–865. https://doi.org/10.1038/nrd4140
Huang Z, Lei W, Hu H-B et al (2018) H19 promotes non-small-cell lung cancer (NSCLC) development through STAT3 signaling via sponging miR-17. J Cell Physiol 233:6768–6776. https://doi.org/10.1002/JCP.26530
Ghafouri-Fard S, Gholipour M, Hussen BM, Taheri M (2021) The impact of long non-coding RNAs in the pathogenesis of hepatocellular carcinoma. Front Oncol 11:1150. https://doi.org/10.3389/FONC.2021.649107/BIBTEX
Ren J, Fu J, Ma T et al (2018) LncRNA H19-elevated LIN28B promotes lung cancer progression through sequestering miR-196b. Cell Cycle 17:1372–1380. https://doi.org/10.1080/15384101.2018.1482137/SUPPL_FILE/KCCY_A_1482137_SM6325.ZIP
Li S, Mei Z, Hu HB, Zhang X (2018) The lncRNA MALAT1 contributes to non-small cell lung cancer development via modulating miR-124/STAT3 axis. J Cell Physiol 233:6679–6688. https://doi.org/10.1002/jcp.26325
Li D, Wang J, Zhang M et al (2020) LncRNA MAGI2-AS3 is regulated by BRD4 and promotes gastric cancer progression via maintaining ZEB1 overexpression by sponging miR-141/200a. Mol Ther Nucleic Acids 19:109–123. https://doi.org/10.1016/j.omtn.2019.11.003
Zhang G, Wang Q, Zhang X et al (2019) LncRNA FENDRR suppresses the progression of NSCLC via regulating miR-761/TIMP2 axis. Biomed Pharmacother 118:109309. https://doi.org/10.1016/J.BIOPHA.2019.109309
Dong L, Li G, Li Y, Zhu Z (2019) Upregulation of Long Noncoding RNA GAS5 Inhibits Lung Cancer Cell Proliferation and Metastasis via miR-205/PTEN Axis. Med Sci Monit 25:2311–2319. https://doi.org/10.12659/MSM.912581
Liu X, Liu B, Li R et al (2020) miR-146a-5p plays an oncogenic role in NSCLC via suppression of TRAF6. Front Cell Dev Biol 8:847. https://doi.org/10.3389/FCELL.2020.00847/BIBTEX
Huang Z, Lei W, Hai-Bo H, Hongyan Zhang YZ (2018) Sci-Hub H19 promotes non-small-cell lung cancer (NSCLC) development through STAT3 signaling via sponging miR-17. J Cell Physiol 233(10):6768–6776. https://doi.org/10.1002/jcp.26530
Yang Z, Lin X, Zhang P et al (2020) Long non-coding RNA LINC00525 promotes the non-small cell lung cancer progression by targeting miR-338-3p/IRS2 axis. Biomed Pharmacother 124:109858. https://doi.org/10.1016/J.BIOPHA.2020.109858
Chen Z, Chen X, Lu B et al (2020) Upregulated LINC01234 promotes non-small-cell lung cancer cell metastasis by activating VAV3 and repressing BTG2 expression. J Hematol Oncol 13:1–14. https://doi.org/10.1186/S13045-019-0842-2/FIGURES/7
Xu L, Wei B, Hui H et al (2019) Positive feedback loop of lncRNA LINC01296/miR-598/Twist1 promotes non-small cell lung cancer tumorigenesis. J Cell Physiol 234:4563–4571. https://doi.org/10.1002/JCP.27235
Li J, Li Y, Wang B et al (2019) LncRNA-PCAT-1 promotes non–small cell lung cancer progression by regulating miR-149-5p/LRIG2 axis. J Cell Biochem 120:7725–7733. https://doi.org/10.1002/JCB.28046
Wang M, Liao Q, Zou P (2020) PRKCZ-AS1 promotes the tumorigenesis of lung adenocarcinoma via sponging miR-766–5p to modulate MAPK1. Cancer Biol Ther 21:364–371. https://doi.org/10.1080/15384047.2019.1702402
Ma XR, Xu YL, Qian J, Wang Y (2019) Long non-coding RNA SNHG15 accelerates the progression of non-small cell lung cancer by absorbing miR-211–3p. Eur Rev Med Pharmacol Sci 23:1536–1544. https://doi.org/10.26355/EURREV_201902_17112
Li J, Feng Q, Wei X (2016) Yu Y (2016) MicroRNA-490 regulates lung cancer metastasis by targeting poly r(C)-binding protein 1. Tumor Biol 3711(37):15221–15228. https://doi.org/10.1007/S13277-016-5347-9
Cui Y, Zhang F, Zhu C et al (2017) Upregulated lncRNA SNHG1 contributes to progression of non-small cell lung cancer through inhibition of miR-101–3p and activation of Wnt/β-catenin signaling pathway. Oncotarget 8:17785–17794. https://doi.org/10.18632/ONCOTARGET.14854
Tang Y, Wu L, Zhao M et al (2019) LncRNA SNHG4 promotes the proliferation, migration, invasiveness, and epithelial–mesenchymal transition of lung cancer cells by regulating miR-98-5p. Biochem Cell Biol 97:767–776. https://doi.org/10.1139/BCB-2019-0065
Yang R, Li P, Zhang G et al (2017) Long non-coding RNA XLOC-008466 functions as an oncogene in human non-small cell lung cancer by targeting miR-874. Cell Physiol Biochem 42:126–136. https://doi.org/10.1159/000477121
Xia H, Jing H, Li Y, Lv X (2018) Long non-coding RNA HOXD-AS1 promotes non-small cell lung cancer migration and invasion through regulating miR-133b/MMP9 axis. Biomed Pharmacother 106:156–162. https://doi.org/10.1016/J.BIOPHA.2018.06.073
Li SD, Yang JM, Xia Y et al (2018) Long non-coding RNA NEAT1 promotes proliferation and invasion via targeting miR-181a-5p in non-small cell lung cancer. Oncol Res 26:289–296. https://doi.org/10.3727/096504017X15009404458675
Sun Y, Gao X, Li P et al (2020) LncRNA ZFAS1, as a poor prognostic indicator, promotes cell proliferation and epithelial–mesenchymal transition in endometrial carcinoma. Personal Med 18:43–53. https://doi.org/10.2217/PME-2020-0014
Zhang K, Li Y, Qu L et al (2018) Long non-coding RNA Sox2 overlapping transcript (SOX2OT) promotes non-small-cell lung cancer migration and invasion via sponging microRNA 132 (miR-132). Onco Targets Ther 11:5269–5278. https://doi.org/10.2147/OTT.S168654
Chen JH, Zhou LY, Xu S et al (2017) Overexpression of lncRNA HOXA11-AS promotes cell epithelial-mesenchymal transition by repressing miR-200b in non-small cell lung cancer. Cancer Cell Int 17:1–11. https://doi.org/10.1186/S12935-017-0433-7/FIGURES/6
Chen S, Li K (2020) HOXD-AS1 facilitates cell migration and invasion as an oncogenic lncRNA by competitively binding to miR-877-3p and upregulating FGF2 in human cervical cancer. BMC Cancer 20:1–9. https://doi.org/10.1186/S12885-020-07441-9/FIGURES/6
Zeng Z, Zhao G, Rao C et al (2020) Knockdown of lncRNA ZFAS1-suppressed non–small cell lung cancer progression via targeting the miR-150-5p/HMGA2 signaling. J Cell Biochem 121:3814–3824. https://doi.org/10.1002/JCB.29542
Ma C, Wu G, Zhu Q et al (2017) Long intergenic non-coding RNA 00673 promotes non-small-cell lung cancer metastasis by binding with EZH2 and causing epigenetic silencing of HOXA5. Oncotarget 8:32696–32705. https://doi.org/10.18632/ONCOTARGET.16158
Wang J, Zhang X, Chen W et al (2020) Regulatory roles of long non-coding RNAs implicated in cancer hallmarks. Int J Cancer 146:906–916. https://doi.org/10.1002/IJC.32277
Zhou Y, Si L, Liu Z et al (2020) Long noncoding RNA ZFAS1 promotes progression of NSCLC via regulating of miR-590-3p. Cell Transplant. https://doi.org/10.1177/0963689720919435
Wang R, Chen X, Xu T et al (2016) MiR-326 regulates cell proliferation and migration in lung cancer by targeting phox2a and is regulated by HOTAIR. Am J Cancer Res 6:173
Cantile M, Di Bonito M, De Bellis MT, Botti G (2021) Functional interaction among lncRNA HOTAIR and MicroRNAs in cancer and other human diseases. Cancers 13:570. https://doi.org/10.3390/CANCERS13030570
Chiyomaru T, Fukuhara S, Saini S et al (2014) Long non-coding RNA HOTAIR is targeted and regulated by miR-141 in human cancer cells. J Biol Chem 289:12550–12565. https://doi.org/10.1074/JBC.M113.488593
Jiang C, Yang Y, Yang Y et al (2018) Long noncoding RNA (lncRNA) HOTAIR affects tumorigenesis and metastasis of non-small cell lung cancer by upregulating miR-613. Oncol Res 26:725–734. https://doi.org/10.3727/096504017X15119467381615
Yu W, Peng W, Jiang H et al (2017) LncRNA HOXA11-AS promotes proliferation and invasion by targeting miR-124 in human non–small cell lung cancer cells. Tumor Biol 39:1–8. https://doi.org/10.1177/1010428317721440
Xing Y, Ruan G, Ni H et al (2021) Tumor immune microenvironment and its related miRNAs in tumor progression. Front Immunol 12:1806. https://doi.org/10.3389/FIMMU.2021.624725/BIBTEX
Cortez MA, Anfossi S, Ramapriyan R et al (2019) Role of miRNAs in immune responses and immunotherapy in cancer. Genes Chromosom Cancer 58:244–253. https://doi.org/10.1002/GCC.22725
Dai S, Liu T, Liu YY et al (2022) long non-coding rnas in lung cancer: the role in tumor microenvironment. Front Cell Dev Biol 9:3711. https://doi.org/10.3389/FCELL.2021.795874/BIBTEX
Pi YN, Qi WC, Xia BR et al (2021) Long non-coding rnas in the tumor immune microenvironment: biological properties and therapeutic potential. Front Immunol 12:2719. https://doi.org/10.3389/FIMMU.2021.697083/BIBTEX
Salmena L, Poliseno L, Tay Y et al (2011) A ceRNA hypothesis: the rosetta stone of a hidden RNA language? Cell 146:353–358. https://doi.org/10.1016/j.cell.2011.07.014
Zhou H, Feng B, Abudoureyimu M et al (2020) The functional role of long non-coding RNAs and their underlying mechanisms in drug resistance of non-small cell lung cancer. Life Sci 261:118362. https://doi.org/10.1016/J.LFS.2020.118362
Chen C, Liu WR, Zhang B et al (2020) LncRNA H19 downregulation confers erlotinib resistance through upregulation of PKM2 and phosphorylation of AKT in EGFR-mutant lung cancers. Cancer Lett 486:58–70. https://doi.org/10.1016/J.CANLET.2020.05.009
Herrera-Solorio AM, Peralta-Arrieta I, Armas López L et al (2021) LncRNA SOX2-OT regulates AKT/ERK and SOX2/GLI-1 expression, hinders therapy, and worsens clinical prognosis in malignant lung diseases. Mol Oncol 15:1110–1129. https://doi.org/10.1002/1878-0261.12875
Seo D, Kim D, Chae Y, Kim W (2020) The ceRNA network of lncRNA and miRNA in lung cancer. Genomics Inform 18:1–9. https://doi.org/10.5808/GI.2020.18.4.E36
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All authors have equally contributed to this manuscript, and KTR gave the outline of the manuscript. Later the data collection was done by SR, SJP, YS and PK concerning LncRNA and sponging effects. Pictorial representation was taken care of by MKJ. GM and KTR did the technical evaluation of the revision. All authors commented and approved the final manuscript.
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Rajakumar, S., Jamespaulraj, S., Shah, Y. et al. Long non-coding RNAs: an overview on miRNA sponging and its co-regulation in lung cancer. Mol Biol Rep 50, 1727–1741 (2023). https://doi.org/10.1007/s11033-022-07995-w
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DOI: https://doi.org/10.1007/s11033-022-07995-w