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Hepatitis E as a Zoonosis

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Hepatitis E Virus

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1417))

Abstract

Hepatitis E viruses in the family of Hepeviridae have been classified into 2 genus, 5 species, and 13 genotypes, involving different animal hosts of different habitats. Among all these genotypes, four (genotypes 3, 4, 7, and C1) of them are confirmed zoonotic causing sporadic human diseases, two (genotypes 5 and 8) were likely zoonotic showing experimental animal infections, and the other seven were not zoonotic or unconfirmed. These zoonotic HEV carrying hosts include pig, boar, deer, rabbit, camel, and rat. Taxonomically, all the zoonotic HEVs belong to the genus Orthohepevirus, which include genotypes 3, 4, 5, 7, 8 HEV in the species A and genotype C1 HEV in the species C. In the chapter, information of zoonotic HEV such as swine HEV (genotype 3 and 4), wild boar HEV (genotypes 3–6), rabbit HEV (genotype 3), camel HEV (genotype 7 and 8), and rat HEV (HEV-C1) was provided in detail. At the same time, their prevalence characteristics, transmission route, phylogenetic relationship, and detection technology were discussed. Other animal hosts of HEVs were introduced briefly in the chapter. All these information help peer researchers have basic understanding of zoonotic HEV and adopt reasonable strategy of surveillance and prevention.

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Abbreviations

aHEV:

Avian HEV

BcHEV:

Bactrian camel HEV

BLS:

Big liver and spleen disease

dcHEV:

Dromedary camel HEV

ELISA:

Enzyme-linked immunosorbent assay

HE:

Hepatitis E

HEV:

Hepatitis E Virus

HRHS:

Hepatic rupture hemorrhage syndrome

HSS:

Hepatitis–splenomegaly syndrome

NCRs:

Non-coding regions

ORF:

Open reading frame

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Authors and Affiliations

  1. Institute of Animal Husbandry and Veterinary Science, Shanghai Academy of Agricultural Sciences, Shanghai, China

    Fusheng Si, Shijuan Dong & Zhen Li

  2. The National Veterinary Institute (SVA), Uppsala, Sweden

    Frederik Widén

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  1. Fusheng Si
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  2. Frederik Widén
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  3. Shijuan Dong
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  4. Zhen Li
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Corresponding authors

Correspondence to Shijuan Dong or Zhen Li .

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Editors and Affiliations

  1. Institute of Medical Biology, Chinese Academy of Medical Science & Peking Union Medical College, Kunming, China

    Youchun Wang

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Si, F., Widén, F., Dong, S., Li, Z. (2023). Hepatitis E as a Zoonosis. In: Wang, Y. (eds) Hepatitis E Virus. Advances in Experimental Medicine and Biology, vol 1417. Springer, Singapore. https://doi.org/10.1007/978-981-99-1304-6_4

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