Abstract
Biomaterials are materials that exhibit a high level of biocompatibility and are designed to interact with biological systems in a variety of ways, such as tissues, organs, cells, and molecules. Biomaterials can be classified into: (i) natural (e.g. collagen, chitosan, dextran, and silk), offer inherent biocompatibility and bioactivity and: (ii) synthetic (e.g. polypropylene, polyurethanes, metals), provide the advantage of precise control over material properties, allowing for customization based on specific applications. For tissue engineering, drug delivery, and other biomedical applications, natural polymers based on proteins and polysaccharides show a lot of promise. Mammalian-derived polymers are preferred over non-mammalian sources because they have a multitude of physiologically active designs and favourable host-material responses. Compared to mammalian collagen, marine collagen (MC), which comes from marine organisms, has excellent physical and chemical robustness, and is readily available in huge amounts. In recent years, tissue engineering and regenerative medicine opt for collagen-based materials over other types of biomaterials on account of their high biocompatibility, low immunogenicity, and structural versatility. This chapter discusses the significance and classification of biomaterials; protein-based and polysaccharide-based biomaterials and the application biomaterials with a special focus on marine-derived collagen.
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References
Ahmed MJ, Hameed BH, Hummadi EH (2020) Review on recent progress in chitosan/chitin-carbonaceous material composites for the adsorption of water pollutants. Carbohydr Polym 247:116690
Anraku M, Fujii T, Kondo Y, Kojima E, Hata T, Tabuchi N et al (2011) Antioxidant properties of high molecular weight dietary chitosan in vitro and in vivo. Carbohydr Polym 83(2):501–505
Aszódi A, Legate KRN, Fässler I, R. (2006) What mouse mutants teach us about extracellular matrix function. Annu Rev Cell Dev Biol 22:591–621
Augst AD, Kong HJ, Mooney DJ (2006) Alginate hydrogels as biomaterials. Macromol Biosci 6(8):623–633
Basa S, Nampally M, Honorato T, Das SN, Podile AR, El Gueddari NE, Moerschbacher BM (2020) The pattern of acetylation defines the priming activity of chitosan tetramers. J Am Chem Soc 142(4):1975–1986
Bello AB, Kim D, Kim D, Park H, Lee SH (2020) Engineering and functionalization of gelatin biomaterials: from cell culture to medical applications. Tissue Eng Part B Rev 26(2):164–180
Bhattarai DP, Aguilar LE, Park CH, Kim CS (2018) A review on properties of natural and synthetic based electrospun fibrous materials for bone tissue engineering. Membranes 8(3):62
Carlström IE, Rashad A, Campodoni E, Sandri M, Syverud K, Bolstad AI, Mustafa K (2020) Cross-linked gelatin-nanocellulose scaffolds for bone tissue engineering. Mater Lett 264:127326
Chang SH, Wu CH, Tsai GJ (2018) Effects of chitosan molecular weight on its antioxidant and antimutagenic properties. Carbohydr Polym 181:1026–1032
Chen FM, Liu X (2016) Advancing biomaterials of human origin for tissue engineering. Prog Polym Sci 53:86–168
Cho YI, No HK, Meyers SP (1998) Physicochemical characteristics and functional properties of various commercial chitin and chitosan products. J Agric Food Chem 46(9):3839–3843
Choi SM, Chaudhry P, Zo SM, Han SS (2018) Advances in protein-based materials: from origin to novel biomaterials. In: Cutting-edge enabling technologies for regenerative medicine, pp 161–210
Coppola D, Oliviero M, Vitale GA, Lauritano C, D’Ambra I, Iannace S, de Pascale D (2020) Marine collagen from alternative and sustainable sources: extraction, processing and applications. Mar Drugs 18(4):214
Cui B, Zhang C, Gan B, Liu W, Liang J, Fan Z, Zhou Y (2020) Collagen-tussah silk fibroin hybrid scaffolds loaded with bone mesenchymal stem cells promote skin wound repair in rats. Mater Sci Eng C 109:110611
de Alvarenga ES, de Oliveira CP, Bellato CR (2010) An approach to understanding the deacetylation degree of chitosan. Carbohydr Polym 80(4):1155–1160
Dimitriou R, Jones E, McGonagle D, Giannoudis PV (2011) Bone regeneration: current concepts and future directions. BMC 9(1):1–10
Dong C, Lv Y (2016) Application of collagen scaffold in tissue engineering: recent advances and new perspectives. Polymers 8(2):42
Ghomi F, Daliri M, Godarzi V, Hemati M (2021) A novel investigation on the characterization of bioactive glass cement and chitosan-gelatin membrane for jawbone tissue engineering. J Nanoanalysis 8(4):292–301
Han Y, Jiang Y, Hu J (2020) Tea-polyphenol treated skin collagen owns coalesced adaptive-hydration, tensile strength and shape-memory property. Int J Biol Macromol 158:1–8
Hashmi MP, Koester TM (2018) Applications of synthetically produced materials in clinical medicine. In: Reference module in materials science and materials engineering. Elsevier. (in press). https://doi.org/10.1016/B978-0-12-803581-8.10258-9
Howling GI, Dettmar PW, Goddard PA, Hampson FC, Dornish M, Wood EJ (2001) The effect of chitin and chitosan on the proliferation of human skin fibroblasts and keratinocytes in vitro. Biomaterials 22(22):2959–2966
Hu CH, Yao CH, Chan TM, Huang TL, Sen Y, Huang CY, Ho CY (2016) Effects of different concentrations of collagenous peptide from fish scales on osteoblast proliferation and osteoclast resorption. Chin J Physiol 59:191–201
Inamdar NN, Mourya V (2014) Chitosan and low molecular weight chitosan: biological and biomedical applications. Adv Biomater Biodev:183–242
Islam S, Bhuiyan MR, Islam MN (2017) Chitin and chitosan: structure, properties and applications in biomedical engineering. J Polym Environ 25:854–866
Jankangram W, Chooluck S, Pomthong B (2016) Comparison of the properties of collagen extracted from dried jellyfish and dried squid. Afr J Biotechnol 15(16):642–648
Joyce K, Fabra GT, Bozkurt Y, Pandit A (2021) Bioactive potential of natural biomaterials: identification, retention and assessment of biological properties. Signal Transduct Target Ther 6(1):122
Kaczmarek B, Sionkowska A (2018) Chitosan/collagen blends with inorganic and organic additive—a review. Adv Polym Technol 37(6):2367–2376
Khan R, Khan MH (2013) Use of collagen as a biomaterial: an update. J Indian Soc Periodontol 17(4):539
Klemm D, Schumann D, Kramer F, Heßler N, Koth D, Sultanova B (2009). Nanocellulose materials–different cellulose, different functionality. In: Macromolecular symposia, vol 280, no 1. Wiley-VCH Verlag, Weinheim, pp 60–71
Kumari S, Annamareddy SHK, Abanti S, Rath PK (2017) Physicochemical properties and characterization of chitosan synthesized from fish scales, crab and shrimp shells. Int J Biol Macromol 104:1697–1705
Lee KY, Mooney DJ (2012) Alginate: properties and biomedical applications. Prog Polym Sci 37(1):106–126
Lee BH, Lum N, Seow LY, Lim PQ, Tan LP (2016) Synthesis and characterization of types A and B gelatinmethacryloyl for bioink applications. Materials 9(10):797
Letchford K, Södergard A, Plackett D, Gilchrist SE, Burt HM (2011) Lactide and glycolide polymers. In: Biodegradable polymers in clinical use and clinical development, pp 317–365
Levingstone TJ, Ramesh A, Brady RT, Brama PA, Kearney C, Gleeson JP, O'Brien FJ (2016) Cell-free multi-layered collagen-based scaffolds demonstrate layer specific regeneration of functional osteochondral tissue in caprine joints. Biomaterials 87:69–81
Li Z, Cao H, Xu Y, Li X, Han X, Fan Y, Zhang X (2021) Bioinspired polysaccharide hybrid hydrogel promoted recruitment and chondrogenic differentiation of bone marrow mesenchymal stem cells. Carbohydr Polym 267:118224
Lim YS, Ok YJ, Hwang SY, Kwak JY, Yoon S (2019) Marine collagen as a promising biomaterial for biomedical applications. Mar Drugs 17(8):467
Lin N, Dufresne A (2014) Nanocellulose in biomedicine: current status and future prospect. Eur Polym J 59:302–325
Liu D, Zhou P, Li T, Regenstein JM (2014) Comparison of acid-soluble collagens from the skins and scales of four carp species. Food Hydrocoll 41:290–297
Liu X, Zheng C, Luo X, Wang X, Jiang H (2019) Recent advances of collagen-based biomaterials: multi-hierarchical structure, modification and biomedical applications. Mater Sci Eng C 99:1509–1522
Lodhi G, Kim YS, Hwang JW, Kim SK, Jeon YJ, Je JY et al (2014) Chitooligosaccharide and its derivatives: preparation and biological applications. BioMed Res Int 2014:654913
Magadala P, Amiji M (2008) Epidermal growth factor receptor-targeted gelatin-based engineered nanocarriers for DNA delivery and transfection in human pancreatic cancer cells. Am Assoc Pharm Scient J 10:565–576
Matsumoto R, Uemura T, Xu Z, Yamaguchi I, Ikoma T, Tanaka J (2015) Rapid oriented fibril formation of fish scale collagen facilitates early osteoblastic differentiation of human mesenchymal stem cells. J Biomed Mater Res A 103(8):2531–2539
Nair R, Sevukarajan M, Mohammed T, Badivaddin CK, Kumar A (2010) Collagen based drug delivery systems: a review. J Innov Pharm Sci 1:288–304
Naveed M, Phil L, Sohail M, Hasnat M, Baig MMFA, Ihsan AU et al (2019) Chitosan oligosaccharide (COS): an overview. Int J Biol Macromol 129:827-843
Narayanan D, Geena MG, Lakshmi H, Koyakutty M, Nair S, Menon D (2013) Poly-(ethylene glycol) modified gelatin nanoparticles for sustained delivery of the anti-inflammatory drug Ibuprofen-Sodium: An in vitro and in vivo analysis. Nanomedicine 9:818–828
NIBIB (2023) Biomaterials. National Institute of Biomedical Imaging & Bioengineering, US Department of Health and Human Services. https://www.nibib.nih.gov/science-education/science-topics/biomaterials
No HK, Meyers SP (1995) Preparation and characterization of chitin and chitosan—a review. J Aqua Food Product Technol 4(2):27–52
Normand V, Lootens DL, Amici E, Plucknett KP, Aymard P (2000) New insight into agarose gel mechanical properties. Biomacromolecules 1(4):730–738
Parenteau-Bareil R, Gauvin R, Berthod F (2010) Collagen-Based Biomaterials for Tissue Engineering Applications. Materials (Basel) 16;3(3):1863–87
Prang P, Müller R, Eljaouhari A, Heckmann K, Kunz W, Weber T, Weidner N (2006) The promotion of oriented axonal regrowth in the injured spinal cord by alginate-based anisotropic capillary hydrogels. Biomaterials 27(19):3560–3569
Rasweefali MK, Sabu S, Sunooj K, Sasidharan A, Xavier KM (2021) Consequences of chemical deacetylation on physicochemical, structural and functional characteristics of chitosan extracted from deep-sea mud shrimp. Carbohydr Polym Technol Appl 2:100032
Rasweefali MK, Sabu S, Azad KM, Rahman MR, Sunooj KV, Sasidharan A, Anoop KK (2022) Influence of deproteinization and demineralization process sequences on the physicochemical and structural characteristics of chitin isolated from deep-sea mud shrimp (Solenocerahextii). Adv Biomarker Sci Technol 4:12–27
Rinaudo M (2008) Main properties and current applications of some polysaccharides as biomaterials. Polym Int 57(3):397–430
RodrÃguez-Vázquez M, Vega-Ruiz B, Ramos-Zúñiga R, Saldaña-Koppel DA, Quiñones-Olvera LF (2015) Chitosan and its potential use as a scaffold for tissue engineering in regenerative medicine. Biomed Res Int 2015:1–15
Sabu S, Sasidharan A, Venugopal V (2022) Influence of isolation conditions on the physicochemical and biological properties of chitosan and chitosan oligosaccharides from marine crustacean shell wastes. In: Chitooligosaccharides: prevention and control of diseases. Springer International Publishing, Cham, pp 333–352
Schlotmann K, Kaeten M, Black AF, Damour O, Waldmann-Laue M, Förster T (2001) Cosmetic efficacy claims in vitro using a three-dimensional human skin model. Int J Cosmet Sci 23(5):309–318
Sharip NS, Ariffin H (2019) Cellulose nanofibrils for biomaterial applications. Mater Today Proc 16(4):1959–1968
Sharkawy A, Barreiro MF, Rodrigues AE (2021) New Pickering emulsions stabilized with chitosan/collagen peptides nanoparticles: synthesis, characterization and tracking of the nanoparticles after skin application. Colloids Surf A Physicochem Eng Asp 616:126327
Shirvan AR, Shakeri M, Bashari A (2019) Recent advances in application of chitosan and its derivatives in functional finishing of textiles. In: The impact and prospects of green chemistry for textile technology. Elsevier, pp 107–133
Singh BN, Pramanik K (2018) Generation of bioactive nano-composite scaffold of nanobioglass/silk fibroin/carboxymethyl cellulose for bone tissue engineering. J Biomater Sci Polym Ed 29(16):2011–2034
Sionkowska A, Wisniewski M, Skopinska J, Kennedy CJ, Wess TJ (2004) Molecular interactions in collagen and chitosan blends. Biomaterials 25(5):795–801
Sionkowska A, Kaczmarek B, Michalska M, Lewandowska K, Grabska S (2017) Preparation and characterization of collagen/chitosan/hyaluronic acid thin films for application in hair care cosmetics. Pure Appl Chem 89(12):1829–1839
Sionkowska A, Lewandowska K, Kurzawa M (2023) Chitosan-based films containing rutin for potential cosmetic applications. Polymers 15(15):3224
Smallman RE, Bishop RJ (1999) Modern physical metallurgy and materials engineering. Butterworth-Heinemann
Sood A, Gupta A, Bharadwaj R, Ranganath P, Silverman N, Agrawal G (2022) Biodegradable disulfide crosslinked chitosan/stearic acid nanoparticles for dual drug delivery for colorectal cancer. Carbohydr Polym 294:119833
Sophia Fox AJ, Bedi A, Rodeo SA (2009) The basic science of articular cartilage: structure, composition, and function. Sports Health 1(6):461–468
Sun J, Tan H (2013) Alginate-based biomaterials for regenerative medicine applications. Materials 6(4):1285–1309
Sun W, Liu W, Wu Z, Chen H (2020) Chemical surface modification of polymeric biomaterials for biomedical applications. Macromol Rapid Commun 41(8):1900430
Swiatkiewicz S, Swiatkiewicz M, Arczewska-Wlosek A, Jozefiak D (2015) Chitosan and its oligosaccharide derivatives (chito-oligosaccharides) as feed supplements in poultry and swine nutrition. J Anim Physiol Anim Nutr 99(1):1–12
Tarafder S, Lee CH (2016) Synovial joint: in situ regeneration of osteochondral and fibrocartilaginous tissues by homing of endogenous cells. In: In situ tissue regeneration. Academic Press, pp 253–273
Tekale SU, Kanagare AB, Dhirbassi AV, Domb AJ, Pawar RP (2022) Polysaccharide-based biomaterials: overview, Biomaterials science series. Royal Society of Chemistry, p 580
Tielens S, Declercq H, Gorski T, Lippens E, Schacht E, Cornelissen M (2007) Gelatin-based microcarriers as embryonic stem cell delivery system in bone tissue engineering: an in-vitro study. Biomacromolecules 8(3):825–832
Troy E, Tilbury MA, Power AM, Wall JG (2021) Nature-based biomaterials and their application in biomedicine. Polymers 13(19):3321
Ullah S, Chen X (2020) Fabrication, applications and challenges of natural biomaterials in tissue engineering. Appl Mater Today 20:100656
Van der Lubben IM, Kersten G, Fretz MM, Beuvery C, Verhoef JC, Junginger HE (2003) Chitosan microparticles for mucosal vaccination against diphtheria: oral and nasal efficacy studies in mice. Vaccine 21(13–14):1400–1408
Wang Q, Li X, Wang P, Yao Y, Xu Y, Chen Y, Zhang X (2020) Bionic composite hydrogel with a hybrid covalent/noncovalent network promoting phenotypic maintenance of hyaline cartilage. J Mater Chem B 8(20):4402–4411
Xu N, Peng XL, Li HR, Liu JX, Cheng JSY, Qi XY et al (2021) Marine-derived collagen as biomaterials for human health. Front Nutr 8:702108
Younes I, Rinaudo M (2015) Chitin and chitosan preparation from marine sources. Structure, properties and applications. Mar Drugs 13(3):1133–1174
Zang S, Zhang R, Chen H, Lu Y, Zhou J, Chang X, Yang G (2015) Investigation on artificial blood vessels prepared from bacterial cellulose. Mater Sci Eng C 46:111–117
Zhang D, Wu X, Chen J, Lin K (2018) The development of collagen based composite scaffolds for bone regeneration. Bioactive Mater 3(1):129–138
Zheng Z, Li M, Shi P, Gao Y, Ma J, Li Y, Yang L (2021) Polydopamine-modified collagen sponge scaffold as a novel dermal regeneration template with sustained release of platelet-rich plasma to accelerate skin repair: a one-step strategy. Bioactive Mater 6(8):2613–2628
Zhou Y, Yang D, Chen X, Xu Q, Lu F, Nie J (2008) Electrospun water-soluble carboxyethyl chitosan/poly (vinyl alcohol) nanofibrous membrane as potential wound dressing for skin regeneration. Biomacromolecules 9(1):349–354
Zhu J, Li Z, Zou Y, Lu G, Ronca A, D’Amora U, Liang J, Fan Y, Zhang, Sun, Y (2022) Advanced application of collagen-based biomaterials in tissue repair and restoration. Journal of Leather Science and Engineering 4(30)
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Sabu, S. (2024). Biomaterials. In: Raman, M., Sasidharan, A., Sabu, S., Rajan, D.P. (eds) Fish Structural Proteins and its Derivatives: Functionality and Applications. Springer, Singapore. https://doi.org/10.1007/978-981-97-2562-5_8
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