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Nanoparticles to Abate Antibiotic Resistance During the Management of Dental Diseases

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Nanotechnology Based Strategies for Combating Antimicrobial Resistance

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Abstract

The intensive use or inappropriate selection of systemic antibiotic therapy is identified as a significant factor in the development of antibiotic-resistant bacterial strains. Antibiotic-resistant bacterial species are associated with a more aggressive disease process, poorer responses to therapy and demonstrate potential for increasing mortality rates. When bacteria become resistant to antibiotics, they oppose the activity of a particular antimicrobial agent to which it was previously susceptible. Increasing attention is being directed towards the management of antibiotic-resistant bacteria. In dentistry, nanoparticle (NP)-based treatments present great promise for treating antibiotic-resistant strains. NP-based antimicrobials have demonstrated their efficacy against both planktonic and biofilm infections. Nanostructured materials can be utilized for carrying antimicrobials, aid in the delivery of novel drugs, and may even have antimicrobial activity on their own. NPs such as silver (Ag) NPs, metal oxides (MeOs), bimetallic NPs, zinc oxide, iron oxide, copper oxide, etc. have a potential toward drug resistance mechanisms in bacteria, inhibit biofilm formation or other important processes. Other approaches, such as combining plant-based antimicrobials and NPs to overcome toxicity issues, are being researched. This approach is also effective in inhibiting bacterial efflux pumps potential, formation of biofilms, interference of quorum sensing, and possibly plasmid curing. In this chapter, we will highlight present developments on NPs used to combat multidrug-resistant bacteria.

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Authors and Affiliations

  1. Department of Pedodontics and Preventive Dentistry, Faculty of Dental Sciences, M.S. Ramaiah University of Applied Sciences, Bengaluru, Karnataka, India

    C. Pushpalatha

  2. Department of Oral Medicine and Radiology, Faculty of Dental Sciences, M.S. Ramaiah University of Applied Sciences, Bengaluru, Karnataka, India

    Shwetha Venkataramana

  3. Department of Conservative Dentistry and Endodontics, Faculty of Dental Sciences, M.S. Ramaiah University of Applied Sciences, Bengaluru, Karnataka, India

    Poornima Ramesh & Shruthi Nagaraja

  4. Bowring and Lady Curzon Hospital, Bengaluru, Karnataka, India

    B. M. Kavya

  5. Department of Oral and Maxillo-Facial Surgery, Faculty of Dental Sciences, M.S. Ramaiah University of Applied Sciences, Bengaluru, Karnataka, India

    K. Vineeth Kumar

Authors
  1. C. Pushpalatha
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  2. Shwetha Venkataramana
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  3. Poornima Ramesh
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  4. B. M. Kavya
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  5. Shruthi Nagaraja
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  6. K. Vineeth Kumar
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Editor information

Editors and Affiliations

  1. Department of Chemistry, College of Science, University of Jeddah, Jeddah, Saudi Arabia

    Mohmmad Younus Wani

  2. P.G. Department of Chemistry, Government Degree College Anantnag, University of Kashmir, Srinagar, Jammu and Kashmir, India

    Irshad Ahmad Wani

  3. Center of Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal

    Akhilesh Rai

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Pushpalatha, C., Venkataramana, S., Ramesh, P., Kavya, B.M., Nagaraja, S., Kumar, K.V. (2024). Nanoparticles to Abate Antibiotic Resistance During the Management of Dental Diseases. In: Wani, M.Y., Wani, I.A., Rai, A. (eds) Nanotechnology Based Strategies for Combating Antimicrobial Resistance . Springer, Singapore. https://doi.org/10.1007/978-981-97-2023-1_17

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