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Underpinning the Cellular and Molecular Mechanisms with Nanotheranostics for Lung Cancer

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Targeting Cellular Signalling Pathways in Lung Diseases

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Abstract

Out of all the cancers, lung cancer is the most devastating causing mortality worldwide out of which ~90% of deaths are from non-small-cell lung cancer (NSCLC). Early diagnosis and ineffective traditional therapies lead to poor prognosis and percent survival in patients suffering from lung cancer. Redox signalling enacts a crucial role in controlling numerous disease biology and cellular signalling pathways. Lately, nanomedicine (application of nanotechnology in biology and medicine) has been revealed to normalize the growth of cancer. With the dawn of robust proteomics and sequencing techniques, immunohistochemistry and identification of novel conclusive biomarkers coupled with improved understanding of the molecular mechanisms regarding cancer are quintessential for targeting redox biology. Herein, a detailed overview of the recent advances in therapeutics includes nano-strategies over conventional therapeutics for targeting redox biology thereby affecting the various cell death mechanisms.

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Authors and Affiliations

  1. Nanobiotech Lab, Department of Zoology, Kirori Mal College, University of Delhi, New Delhi, India

    Asiya Mahtab, Monika Yadav, Karishma Niveria & Anita Kamra Verma

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  1. Asiya Mahtab
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  2. Monika Yadav
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  3. Karishma Niveria
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  4. Anita Kamra Verma
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Correspondence to Anita Kamra Verma .

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Editors and Affiliations

  1. Graduate School of Health, Discipline of Pharmacy, University of Technology Sydney, Sydney, NSW, Australia

    Kamal Dua

  2. Drug Development and Innovation Centre, University of Alberta, Edmonton, AB, Canada

    Raimar Löbenberg

  3. Haematology and Hemotherapy Center, State University of Campinas, Campinas, São Paulo, Brazil

    Ângela Cristina Malheiros Luzo

  4. Graduate School of Health, Discipline of Pharmacy, University of Technology Sydney, Sydney, NSW, Australia

    Shakti Shukla

  5. School of Pharmaceutical Sciences & Division of Research & Development, Lovely Professional University, Phagwara, Punjab, India

    Saurabh Satija

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Mahtab, A., Yadav, M., Niveria, K., Verma, A.K. (2021). Underpinning the Cellular and Molecular Mechanisms with Nanotheranostics for Lung Cancer. In: Dua, K., Löbenberg, R., Malheiros Luzo, Â.C., Shukla, S., Satija, S. (eds) Targeting Cellular Signalling Pathways in Lung Diseases. Springer, Singapore. https://doi.org/10.1007/978-981-33-6827-9_11

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