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The Variations of Metabolic Detoxification Enzymes Lead to Recurrent Miscarriage and Their Diagnosis Strategy

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Environment and Female Reproductive Health

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1300))

Abstract

Spontaneous abortion has been a common obstetrical and gynecological disease, which occurs in 10–15% of all pregnancies. Recurrent miscarriage (RM) refers to the occurrence of three or more times abortions with the same partner. It is generally believed that environmental pollution associated with economic development may cause infertility and RM. When xenobiotics from the environment enter the body, they must be cleared from the body by various metabolic enzymes in the body. The absence or variation of these enzymes may be the genetic basis of RM caused by environmental pollution. The variation of metabolic detoxification enzyme can directly affect the removal of harmful substances from internal and external sources. Therefore, the determination of metabolic enzyme activity may become an important factor in the diagnosis of RM etiology and seeking methods to improve the detoxification ability has a great significance for the treatment of RM.

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Authors and Affiliations

  1. Center for Reproductive Medicine, Department of Obstetrics and Gynecology, The Sixth Medical Center of Chinese PLA General Hospital, Beijing, China

    Chunlan Song & Wei Shang

  2. Department of Obstetrics and Gynecology, Chinese PLA General Hospital, Beijing, China

    Chunlan Song & Wei Shang

  3. Medical School of Chinese PLA, Chinese PLA General Hospital, Beijing, China

    Wei Shang

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  1. Public Health School of West China, Sichuan University, Chengdu, Sichuan, China

    Huidong Zhang

  2. Reproductive Medicine Center, Peking University Third Hospital, Beijing, China

    Jie Yan

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Song, C., Shang, W. (2021). The Variations of Metabolic Detoxification Enzymes Lead to Recurrent Miscarriage and Their Diagnosis Strategy. In: Zhang, H., Yan, J. (eds) Environment and Female Reproductive Health. Advances in Experimental Medicine and Biology, vol 1300. Springer, Singapore. https://doi.org/10.1007/978-981-33-4187-6_12

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