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Functional Bone Regeneration in Oral and Maxillofacial Surgery: History, Definition, and Indications

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Emerging Technologies in Oral and Maxillofacial Surgery

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Abstract

Traditional methods of bone grafting have specified shortcomings and limitations. Recent advances in tissue engineering-based approaches have made it possible to regenerate bone in defective areas. Functional bone regeneration as a subgroup of patient-specific implants uses a tailored, exclusively designed scaffold to be placed in the defect and replaced with natural bone over time. Modern technologies like computer-aided design/computer-aided manufacturing (CAD/CAM) and additive manufacturing are employed to produce a scaffold with high adaptation to the anatomy of defective area, appropriate mechanical properties, desired microstructure and porosity, and degradation kinetics. Various materials have been used in scaffold fabrication; however, regarding the bone’s innate architecture and composition and insufficient features of a single material, polymer-ceramic composites are the best practical option. Polycaprolactone (PCL) and hydroxyapatite (HA) are among the most frequently utilized polymers and ceramics, respectively. Like materials, several 3D printing techniques could be used in scaffold production. Fused deposition modeling (FDM), the most common 3D printing used, is consonant with many materials and can produce scaffolds with favorable characteristics. Even though we are at the beginning of the path, reported cases of functional bone regeneration have demonstrated successful long-term outcomes.

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Authors and Affiliations

  1. School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Parham Hazrati

  2. Department of Oral and Maxillofacial Surgery, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Arash Khojasteh

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  1. Parham Hazrati
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  1. Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sc, Tehran, Iran

    Arash Khojasteh

  2. School of Medicine, University of Glasgow, Glasgow, UK

    Ashraf F. Ayoub

  3. Department of Maxillofacial Surgery, University of Antwerp, Antwerp, Belgium

    Nasser Nadjmi

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Hazrati, P., Khojasteh, A. (2023). Functional Bone Regeneration in Oral and Maxillofacial Surgery: History, Definition, and Indications. In: Khojasteh, A., Ayoub, A.F., Nadjmi, N. (eds) Emerging Technologies in Oral and Maxillofacial Surgery . Springer, Singapore. https://doi.org/10.1007/978-981-19-8602-4_8

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