Abstract
Abnormal changes in glycosylation have been positively correlated with tumorigenesis and progression in cancer. In particular, an elevation in the level of core fucosylation has been observed. Core fucosylation is driven by fucosyltransferase 8 (FUT8), which catalyzes transfer of the fucosyl moiety from GDP-fucose to the innermost GlcNAc residue of N-glycans via an α1,6-linkage. Core fucosylation is known to be critical for various biological processes including inflammation and immune response, tumor initiation, and metastasis as well as in central nervous system diseases. FUT8 and/or core-fucosylated glycoproteins serve as important diagnosis biomarkers that provide a set of specific targets for therapeutic intervention. In this review, we summarize the existing evidence for the influence of core fucosylation in regulating cell surface protein stability and functional expression, as well as cancer cell signal transduction pathways in pancreatic cancer (PC) and in other cancers. In addition, we also discuss the relevance between FUT8 and cancer stemness, which is another aspect of FUT8 that could be applied to tumor therapy.
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Acknowledgments
This work was supported in part by a Grants-in-Aid for Scientific Research (19H03184 to J.G.) from the Japan Society for the Promotion of Science and by a Grants-in-Aid for Scientific Research on Innovative Areas (20H04909 to J.G.) from the Ministry of Education, Culture, Sports, Science, and Technology of Japan.
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Liang, C., Song, W., Gu, J. (2023). Significance of FUT8 in Pancreatic Cancer and Others. In: Furukawa, K., Fukuda, M. (eds) Glycosignals in Cancer. Springer, Singapore. https://doi.org/10.1007/978-981-19-7732-9_6
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