Advances in 3D Printing Technology for Tissue Engineering

Dadhich, Prabhash; Kumar, Parveen; Roy, Anirban; Bitar, Khalil N.

doi:10.1007/978-981-19-6008-6_9

Prabhash Dadhich³,
Parveen Kumar⁴,
Anirban Roy⁵ &
…
Khalil N. Bitar³

555 Accesses

Abstract

Additive manufacturing has emerged as an advanced technology for the precise 3D construction of complex tissue engineering products. Different platforms such as laser-assisted printing, extrusion printing, and inkjet printing have been developed to achieve the desired printability, cytocompatibility, and mechanical properties for complex applications. This chapter reviewed and summarized the recent progress on different printing technologies, with fundamental mechanisms, characteristics, advantages, and limitations. Each printing technology is dependent on particular ink for the specific types of application, the chapter analyzed the challenges of different types of biomaterial inks used in 3D printing. Finally, we have also recited the recent advances and applications of 3D printing technology in different tissue engineering products.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Chapter: USD 29.95; Price excludes VAT (USA)

eBook: USD 169.00; Price excludes VAT (USA)

Softcover Book: USD 219.99; Price excludes VAT (USA)

Hardcover Book: USD 219.99; Price excludes VAT (USA)

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

Admane P et al (2019) Direct 3D bioprinted full-thickness skin constructs recapitulate regulatory signaling pathways and physiology of human skin. Bioprinting 15:e00051. https://doi.org/10.1016/j.bprint.2019.e00051
Article Google Scholar
Ahn BY et al (2009) Omnidirectional printing of flexible, stretchable, and spanning silver microelectrodes. Science 323(5921):1590–1593. https://doi.org/10.1126/science.1168375
Article CAS Google Scholar
Akkineni AR et al (2015) 3D plotting of growth factor loaded calcium phosphate cement scaffolds. Acta Biomater 27:264–274. https://doi.org/10.1016/j.actbio.2015.08.036. England
Article CAS Google Scholar
Albanna M et al (2019) In situ bioprinting of autologous skin cells accelerates wound healing of extensive excisional full-thickness wounds. Sci Rep 9(1):1856. https://doi.org/10.1038/s41598-018-38366-w
Article CAS Google Scholar
Alge DL, Chu T-MG (2010) Calcium phosphate cement reinforcement by polymer infiltration and in situ curing: a method for 3D scaffold reinforcement. J Biomed Mater Res A 94(2):547–555. https://doi.org/10.1002/jbm.a.32742. United States
Article CAS Google Scholar
Amini AR, Laurencin CT, Nukavarapu SP (2012) Bone tissue engineering: recent advances and challenges. Crit Rev Biomed Eng 40(5):363–408. https://doi.org/10.1615/CritRevBiomedEng.v40.i5.10
Article Google Scholar
Arefin AME et al (2021) Polymer 3D printing review: materials, process, and design strategies for medical applications. Polymers 13(9):1499. https://doi.org/10.3390/polym13091499. MDPI
Article CAS Google Scholar
Bahcecioglu G et al (2019) A 3D printed {PCL}/hydrogel construct with zone-specific biochemical composition mimicking that of the meniscus. Biofabrication 11(2):25002. https://doi.org/10.1088/1758-5090/aaf707. {IOP} Publishing
Article CAS Google Scholar
Beluze L, Bertsch A, Renaud P (1999) Microstereolithography: a new process to build complex 3D objects. In: Courtois B et al (eds) {SPIE} Proceedings. SPIE. https://doi.org/10.1117/12.341277
Chapter Google Scholar
Bertsch A et al (2000) Rapid prototyping of small size objects. Rapid Prototyp J 6(4):259–266. https://doi.org/10.1108/13552540010373362. MCB UP Ltd
Article Google Scholar
Billiet T et al (2012) A review of trends and limitations in hydrogel-rapid prototyping for tissue engineering. Biomaterials 33(26):6020–6041. https://doi.org/10.1016/j.biomaterials.2012.04.050. Netherlands
Article CAS Google Scholar
Billiet T et al (2014) The 3D printing of gelatin methacrylamide cell-laden tissue-engineered constructs with high cell viability. Biomaterials 35(1):49–62. https://doi.org/10.1016/j.biomaterials.2013.09.078. Netherlands
Article CAS Google Scholar
Blaeser A et al (2016) Controlling shear stress in 3D bioprinting is a key factor to balance printing resolution and stem cell integrity. Adv Healthc Mater 5(3):326–333. https://doi.org/10.1002/adhm.201500677
Article CAS Google Scholar
Bohandy J, Kim BF, Adrian FJ (1986) Metal deposition from a supported metal film using an excimer laser. J Appl Phys 60(4):1538–1539. https://doi.org/10.1063/1.337287
Article CAS Google Scholar
Boland T et al (2007) Drop-on-demand printing of cells and materials for designer tissue constructs. Mater Sci Eng C 27(3):372–376. https://doi.org/10.1016/j.msec.2006.05.047
Article CAS Google Scholar
Bose S, Roy M, Bandyopadhyay A (2012) Recent advances in bone tissue engineering scaffolds. Trends Biotechnol 30(10):546–554. https://doi.org/10.1016/j.tibtech.2012.07.005. Elsevier Ltd
Article CAS Google Scholar
Catros S et al (2011) Effect of laser energy, substrate film thickness and bioink viscosity on viability of endothelial cells printed by Laser-Assisted Bioprinting. Appl Surf Sci 257(12):5142–5147. https://doi.org/10.1016/j.apsusc.2010.11.049
Article CAS Google Scholar
Chahal D, Ahmadi A, Cheung KC (2012) Improving piezoelectric cell printing accuracy and reliability through neutral buoyancy of suspensions. Biotechnol Bioeng 109(11):2932–2940. https://doi.org/10.1002/bit.24562
Article CAS Google Scholar
Chen Z et al (2019) 3D printing of ceramics: a review. J Eur Ceram Soc 39(4):661–687. https://doi.org/10.1016/j.jeurceramsoc.2018.11.013
Article CAS Google Scholar
Choi JS et al (2009) Development of micro-stereolithography technology using a UV lamp and optical fiber. Int J Adv Manuf Technol 41(3–4):281–286. https://doi.org/10.1007/s00170-008-1461-1
Article Google Scholar
Chua CK, Leong KF (2015) 3D printing and additive manufacturing: principles and applications, 5th edn. World Scientific Publishing Co. https://doi.org/10.1142/10200
Book Google Scholar
Collins AM et al (2009) Bone-like resorbable silk-based scaffolds for load-bearing osteoregenerative applications. Adv Mater 21(1):75–78. https://doi.org/10.1002/adma.200802239. WILEY-VCH Verlag
Article CAS Google Scholar
Cui X et al (2010) Cell damage evaluation of thermal inkjet printed Chinese hamster ovary cells. Biotechnol Bioeng 106(6):963–969. https://doi.org/10.1002/bit.22762. United States
Article CAS Google Scholar
Dadhich P et al (2016) A simple approach for an eggshell-based 3D-printed osteoinductive multiphasic calcium phosphate scaffold. ACS Appl Mater Interfaces 8(19):11910–11924. https://doi.org/10.1021/acsami.5b11981. American Chemical Society
Article CAS Google Scholar
Dadhich P et al (2021) Direct 3D printing of seashell precursor toward engineering a multiphasic calcium phosphate bone graft. ACS Biomater Sci Eng 7(8):3806–3820. https://doi.org/10.1021/acsbiomaterials.1c00303. American Chemical Society
Article CAS Google Scholar
de Gruijl FR, van Kranen HJ, Mullenders LHF (2001) UV-induced DNA damage, repair, mutations and oncogenic pathways in skin cancer. J Photochem Photobiol B Biol 63(1):19–27. https://doi.org/10.1016/S1011-1344(01)00199-3
Article Google Scholar
Derr K et al (2019) Fully three-dimensional bioprinted skin equivalent constructs with validated morphology and barrier function. Tissue Eng Part C Methods 25(6):334–343. https://doi.org/10.1089/ten.tec.2018.0318
Article CAS Google Scholar
Do A-V et al (2015) 3D printing of scaffolds for tissue regeneration applications. Adv Healthc Mater 4(12):1742–1762. https://doi.org/10.1002/adhm.201500168
Article CAS Google Scholar
Dorozhkin SV (2011) Calcium orthophosphates: occurrence, properties, biomineralization, pathological calcification and biomimetic applications. Biomatter 1:121–164. https://doi.org/10.4161/biom.18790. United States
Article Google Scholar
Duarte Campos DF et al (2019) Corneal bioprinting utilizing collagen-based bioinks and primary human keratocytes. J Biomed Mater Res A 107(9):1945–1953. https://doi.org/10.1002/jbm.a.36702
Article CAS Google Scholar
Ducheyne P, Qiu Q (1999) Bioactive ceramics: the effect of surface reactivity on bone formation and bone cell function. Biomaterials 20(23–24):2287–2303. https://doi.org/10.1016/S0142-9612(99)00181-7
Article CAS Google Scholar
Egan PF (2019) Integrated design approaches for 3D printed tissue scaffolds: review and outlook. Materials 12(15):2355. https://doi.org/10.3390/ma12152355
Article CAS Google Scholar
El-Ghannam A (2005) Bone reconstruction: from bioceramics to tissue engineering. Expert Rev Med Devices 2(1):87–101. https://doi.org/10.1586/17434440.2.1.87. England
Article Google Scholar
England S et al (2017) Bioprinted fibrin-factor XIII-hyaluronate hydrogel scaffolds with encapsulated Schwann cells and their in vitro characterization for use in nerve regeneration. Bioprinting 5:1–9. https://doi.org/10.1016/j.bprint.2016.12.001
Article Google Scholar
Fox K et al (2020) High nanodiamond content-PCL composite for tissue engineering scaffolds. Nanomaterials 10(5):948. https://doi.org/10.3390/nano10050948
Article CAS Google Scholar
Frone AN et al (2020) Morpho-structural, thermal and mechanical properties of PLA/PHB/cellulose biodegradable nanocomposites obtained by compression molding, extrusion, and 3D printing. Nanomaterials 10(1):51. https://doi.org/10.3390/nano10010051
Article CAS Google Scholar
Gao C et al (2014) Current progress in bioactive ceramic scaffolds for bone repair and regeneration. Int J Mol Sci 15(3):4714–4732. https://doi.org/10.3390/ijms15034714
Article CAS Google Scholar
Gao G et al (2015) Improved properties of bone and cartilage tissue from 3D inkjet-bioprinted human mesenchymal stem cells by simultaneous deposition and photocrosslinking in PEG-GelMA. Biotechnol Lett 37(11):2349–2355. https://doi.org/10.1007/s10529-015-1921-2
Article CAS Google Scholar
Garot C, Bettega G, Picart C (2021) Additive manufacturing of material scaffolds for bone regeneration: toward application in the clinics. Adv Funct Mater 31(5):2006967. https://doi.org/10.1002/adfm.202006967
Article CAS Google Scholar
Gauvin R et al (2012) Microfabrication of complex porous tissue engineering scaffolds using 3D projection stereolithography. Biomaterials 33(15):3824–3834. https://doi.org/10.1016/j.biomaterials.2012.01.048
Article CAS Google Scholar
Gibson I, Rosen DW, Stucker B (2010) Development of additive manufacturing technology. In: Additive manufacturing technologies: rapid prototyping to direct digital manufacturing. Springer US, Boston, pp 36–58. https://doi.org/10.1007/978-1-4419-1120-9_2
Chapter Google Scholar
Gori M et al (2020) Biofabrication of hepatic constructs by 3D bioprinting of a cell-laden thermogel: an effective tool to assess drug-induced hepatotoxic response. Adv Healthc Mater 9(21):2001163. https://doi.org/10.1002/adhm.202001163
Article CAS Google Scholar
Grigoryan B et al (2019) Multivascular networks and functional intravascular topologies within biocompatible hydrogels. Science 364(6439):458–464. https://doi.org/10.1126/science.aav9750
Article CAS Google Scholar
Gu Q et al (2016) Functional 3D neural mini-tissues from printed gel-based bioink and human neural stem cells. Adv Healthc Mater 5(12):1429–1438. https://doi.org/10.1002/adhm.201600095
Article CAS Google Scholar
Gudapati H et al (2014) Alginate gelation-induced cell death during laser-assisted cell printing. Biofabrication 6(3):35022. https://doi.org/10.1088/1758-5082/6/3/035022. {IOP} Publishing
Article Google Scholar
Guillemot F et al (2010) High-throughput laser printing of cells and biomaterials for tissue engineering. Acta Biomater 6(7):2494–2500. https://doi.org/10.1016/j.actbio.2009.09.029
Article CAS Google Scholar
Guillotin B et al (2010) Laser assisted bioprinting of engineered tissue with high cell density and microscale organization. Biomaterials 31(28):7250–7256. https://doi.org/10.1016/j.biomaterials.2010.05.055
Article CAS Google Scholar
Hodásová L et al (2021) Polymer infiltrated ceramic networks with biocompatible adhesive and 3D-printed highly porous scaffolds. Addit Manuf 39:101850. https://doi.org/10.1016/j.addma.2021.101850
Article CAS Google Scholar
Hopp B et al (2012) Femtosecond laser printing of living cells using absorbing film-assisted laser-induced forward transfer. Opt Eng 51(1):1–7. https://doi.org/10.1117/1.OE.51.1.014302
Article CAS Google Scholar
Hu Y et al (2016) 3D-engineering of cellularized conduits for peripheral nerve regeneration. Sci Rep 6(1):32184. https://doi.org/10.1038/srep32184
Article CAS Google Scholar
Huang J et al (2021) 3D printed gelatin/hydroxyapatite scaffolds for stem cell chondrogenic differentiation and articular cartilage repair. Biomater Sci 9(7):2620–2630. https://doi.org/10.1039/D0BM02103B. The Royal Society of Chemistry
Article CAS Google Scholar
Inzana JA et al (2014) 3D printing of composite calcium phosphate and collagen scaffolds for bone regeneration. Biomaterials 35(13):4026–4034. https://doi.org/10.1016/j.biomaterials.2014.01.064. Elsevier Ltd
Article CAS Google Scholar
Isaacson A, Swioklo S, Connon CJ (2018) 3D bioprinting of a corneal stroma equivalent. Exp Eye Res 173:188–193. https://doi.org/10.1016/j.exer.2018.05.010
Article CAS Google Scholar
Jang J, Yi H-G, Cho D-W (2016) 3D printed tissue models: present and future. ACS Biomater Sci Eng 2(10):1722–1731. https://doi.org/10.1021/acsbiomaterials.6b00129. American Chemical Society
Article CAS Google Scholar
Jang T et al (2018) 1. 3D printing of hydrogel composite systems-recent advances in technology for tissue engineering. p 1–28. http://ijb.whioce.com/index.php/int-j-bioprinting/article/view/126/pdf
John MJ et al (2021) Design and development of cellulosic bionanocomposites from forestry waste residues for 3D printing applications. Materials 14(13):3462. https://doi.org/10.3390/ma14133462
Article CAS Google Scholar
Kankala RK et al (2018) 3D-printing of microfibrous porous scaffolds based on hybrid approaches for bone tissue engineering. Polymers 10(7):807. https://doi.org/10.3390/polym10070807
Article CAS Google Scholar
Kim JA et al (2015) Collagen-based brain microvasculature model in vitro using three-dimensional printed template. Biomicrofluidics 9(2):24115. https://doi.org/10.1063/1.4917508
Article CAS Google Scholar
Kim HS et al (2019) Advanced drug delivery systems and artificial skin grafts for skin wound healing. Adv Drug Deliv Rev 146:209–239. https://doi.org/10.1016/j.addr.2018.12.014
Article CAS Google Scholar
Kim J-W et al (2020) Bone regeneration capability of 3D printed ceramic scaffolds. Int J Mol Sci 21(14):4837. https://doi.org/10.3390/ijms21144837
Article CAS Google Scholar
Koch L et al (2010) Laser printing of skin cells and human stem cells. Tissue Eng Part C Methods 16(5):847–854. https://doi.org/10.1089/ten.tec.2009.0397
Article CAS Google Scholar
Kołbuk D et al (2020) Novel 3D hybrid nanofiber scaffolds for bone regeneration. Polymers 12(3):544. https://doi.org/10.3390/polym12030544
Article CAS Google Scholar
Kolesky DB et al (2014) 3D bioprinting of vascularized, heterogeneous cell-laden tissue constructs. Adv Mater 26(19):3124–3130. https://doi.org/10.1002/adma.201305506
Article CAS Google Scholar
Koons GL et al (2021) Effect of 3D printing temperature on bioactivity of bone morphogenetic protein-2 released from polymeric constructs. Ann Biomed Eng 49(9):2114–2125. https://doi.org/10.1007/s10439-021-02736-9
Article Google Scholar
Landers R, Mülhaupt R (2000) Desktop manufacturing of complex objects, prototypes and biomedical scaffolds by means of computer-assisted design combined with computer-guided 3D plotting of polymers and reactive oligomers. Macromol Mater Eng 282:17–21
Article CAS Google Scholar
Lawlor KT et al (2021) Cellular extrusion bioprinting improves kidney organoid reproducibility and conformation. Nat Mater 20(2):260–271. https://doi.org/10.1038/s41563-020-00853-9
Article CAS Google Scholar
Lee J-S et al (2014) 3D printing of composite tissue with complex shape applied to ear regeneration. Biofabrication 6(2):24103. https://doi.org/10.1088/1758-5082/6/2/024103. {IOP} Publishing
Article CAS Google Scholar
Lee H et al (2017) Development of liver decellularized extracellular matrix bioink for three-dimensional cell printing-based liver tissue engineering. Biomacromolecules 18(4):1229–1237. https://doi.org/10.1021/acs.biomac.6b01908. American Chemical Society
Article CAS Google Scholar
Lee J et al (2020) Bone-derived dECM/alginate bioink for fabricating a 3D cell-laden mesh structure for bone tissue engineering. Carbohydr Polym 250:116914. https://doi.org/10.1016/j.carbpol.2020.116914
Article CAS Google Scholar
Leukers B et al (2005) Hydroxyapatite scaffolds for bone tissue engineering made by 3D printing. J Mater Sci Mater Med 16(12):1121–1124. https://doi.org/10.1007/s10856-005-4716-5. United States
Article CAS Google Scholar
Li J et al (2016) Recent advances in bioprinting techniques: approaches, applications and future prospects. J Transl Med 14(1):271. https://doi.org/10.1186/s12967-016-1028-0
Article CAS Google Scholar
Lim KS et al (2018) Bio-resin for high resolution lithography-based biofabrication of complex cell-laden constructs. Biofabrication 10(3):34101. https://doi.org/10.1088/1758-5090/aac00c. England
Article CAS Google Scholar
Liu L et al (2009) A novel osteochondral scaffold fabricated via multi-nozzle low-temperature deposition manufacturing. J Bioact Compat Polym. https://doi.org/10.1177/0883911509102347
Liu C et al (2019) Low-temperature deposition manufacturing: a versatile material extrusion-based 3D printing technology for fabricating hierarchically porous materials. J Nanomater 2019:1291067. https://doi.org/10.1155/2019/1291067. Edited by A. Nasibulin. Hindawi
Article CAS Google Scholar
Lorber B, Hsiao W-K, Martin KR (2016) Three-dimensional printing of the retina. Curr Opin Ophthalmol 27(3):262–267. https://journals.lww.com/co-ophthalmology/Fulltext/2016/05000/Three_dimensional_printing_of_the_retina.13.aspx
Article Google Scholar
Lovell LG et al (2001) The effect of cure rate on the mechanical properties of dental resins. Dent Mater 17(6):504–511. https://doi.org/10.1016/S0109-5641(01)00010-0
Article CAS Google Scholar
Luo Y et al (2013) Well-ordered biphasic calcium phosphate–alginate scaffolds fabricated by multi-channel 3D plotting under mild conditions. J Mater Chem B 1(33):4088. https://doi.org/10.1039/c3tb20511h
Article CAS Google Scholar
Ma PX (2004) Scaffolds for tissue fabrication. Mater Today 7(5):30–40. https://doi.org/10.1016/S1369-7021(04)00233-0
Article CAS Google Scholar
Ma X et al (2016) Deterministically patterned biomimetic human iPSC-derived hepatic model via rapid 3D bioprinting. Proc Natl Acad Sci 113(8):2206–2211. https://doi.org/10.1073/PNAS.1524510113. National Academy of Sciences
Article CAS Google Scholar
Ma H et al (2018) 3D-printed bioceramic scaffolds: from bone tissue engineering to tumor therapy. Acta Biomater 79:37–59. https://doi.org/10.1016/j.actbio.2018.08.026
Article CAS Google Scholar
Mabrouk M, Beherei HH, Das DB (2020) Recent progress in the fabrication techniques of 3D scaffolds for tissue engineering. Mater Sci Eng C Mater Biol Appl 110:110716. https://doi.org/10.1016/j.msec.2020.110716. Netherlands
Article CAS Google Scholar
Mannoor MS et al (2013) 3D printed bionic ears. Nano Lett 13(6):2634–2639. https://doi.org/10.1021/nl4007744. American Chemical Society
Article CAS Google Scholar
Mao Q et al (2020) Fabrication of liver microtissue with liver decellularized extracellular matrix (dECM) bioink by digital light processing (DLP) bioprinting. Mater Sci Eng C 109:110625. https://doi.org/10.1016/j.msec.2020.110625
Article CAS Google Scholar
Mei J, Lovell MR, Mickle MH (2005) Formulation and processing of novel conductive solution inks in continuous inkjet printing of 3-D electric circuits. IEEE Trans Electron Packag Manuf 28(3):265–273. https://doi.org/10.1109/TEPM.2005.852542
Article CAS Google Scholar
Melchels FPW, Feijen J, Grijpma DW (2010) A review on stereolithography and its applications in biomedical engineering. Biomaterials 31(24):6121–6130. https://doi.org/10.1016/j.biomaterials.2010.04.050
Article CAS Google Scholar
Michael S et al (2013) Tissue engineered skin substitutes created by laser-assisted bioprinting form skin-like structures in the dorsal skin fold chamber in mice. PLoS One 8(3):1–12. https://doi.org/10.1371/journal.pone.0057741. Public Library of Science
Article CAS Google Scholar
Mironov V, Kasyanov V, Markwald RR (2011) Organ printing: from bioprinter to organ biofabrication line. Curr Opin Biotechnol 22(5):667–673. https://doi.org/10.1016/j.copbio.2011.02.006
Article CAS Google Scholar
Müller P et al (2008) Calcium phosphate surfaces promote osteogenic differentiation of mesenchymal stem cells. J Cell Mol Med 12(1):281–291. https://doi.org/10.1111/j.1582-4934.2007.00103.x
Article CAS Google Scholar
Nakamura M et al (2005) Biocompatible inkjet printing technique for designed seeding of individual living cells. Tissue Eng 11(11–12):1658–1666. https://doi.org/10.1089/ten.2005.11.1658. United States
Article CAS Google Scholar
Neufurth M et al (2017) 3D printing of hybrid biomaterials for bone tissue engineering: calcium-polyphosphate microparticles encapsulated by polycaprolactone. Acta Biomater 64:377–388. https://doi.org/10.1016/j.actbio.2017.09.031
Article CAS Google Scholar
Nguyen AK, Narayan RJ (2017) Two-photon polymerization for biological applications. Mater Today 20(6):314–322. https://doi.org/10.1016/j.mattod.2017.06.004
Article CAS Google Scholar
Ni T et al (2020) 3D bioprinting of bone marrow mesenchymal stem cell-laden silk fibroin double network scaffolds for cartilage tissue repair. Bioconjug Chem 31(8):1938–1947. https://doi.org/10.1021/acs.bioconjchem.0c00298. American Chemical Society
Article CAS Google Scholar
Ning L, Chen X (2017) A brief review of extrusion-based tissue scaffold bio-printing. Biotechnol J 12(8):1600671. https://doi.org/10.1002/biot.201600671
Article CAS Google Scholar
Odde DJ, Renn MJ (1999) Laser-guided direct writing for applications in biotechnology. Trends Biotechnol 17(10):385–389. https://doi.org/10.1016/S0167-7799(99)01355-4
Article CAS Google Scholar
Oladapo BI, Zahedi SA, Adeoye AOM (2019) 3D printing of bone scaffolds with hybrid biomaterials. Compos Part B Eng 158:428–436. https://doi.org/10.1016/j.compositesb.2018.09.065
Article CAS Google Scholar
Ong CS et al (2018) 3D bioprinting using stem cells. Pediatr Res 83(1–2):223–231. https://doi.org/10.1038/pr.2017.252. Nature Publishing Group
Article CAS Google Scholar
Ouyang L et al (2015) 3D printing of HEK 293FT cell-laden hydrogel into macroporous constructs with high cell viability and normal biological functions. Biofabrication 7(1):15010. https://doi.org/10.1088/1758-5090/7/1/015010. England
Article CAS Google Scholar
Özcan M et al (2021) Materials and manufacturing techniques for polymeric and ceramic scaffolds used in implant dentistry. J Compos Sci 5(3):78. https://doi.org/10.3390/jcs5030078
Article CAS Google Scholar
Park SH et al (2012) Scaffolds for bone tissue engineering fabricated from two different materials by the rapid prototyping technique: PCL versus PLGA. J Mater Sci Mater Med 23(11):2671–2678. https://doi.org/10.1007/s10856-012-4738-8
Article CAS Google Scholar
Park JY et al (2015) 3D printing technology to control BMP-2 and VEGF delivery spatially and temporally to promote large-volume bone regeneration. J Mater Chem B 3(27):5415–5425. https://doi.org/10.1039/C5TB00637F. The Royal Society of Chemistry
Article CAS Google Scholar
Peña J, Vallet-Regı M (2003) Hydroxyapatite, tricalcium phosphate and biphasic materials prepared by a liquid mix technique. J Eur Ceram Soc 23(10):1687–1696. https://doi.org/10.1016/S0955-2219(02)00369-2
Article CAS Google Scholar
Pfister A et al (2004) Biofunctional rapid prototyping for tissue-engineering applications: 3D bioplotting versus 3D printing. J Polym Sci A Polym Chem 42(3):624–638. https://doi.org/10.1002/pola.10807
Article CAS Google Scholar
Rimann M et al (2016) Standardized 3D bioprinting of soft tissue models with human primary cells. J Lab Autom 21(4):496–509. https://doi.org/10.1177/2211068214567146
Article CAS Google Scholar
Roohani-Esfahani S-I, Newman P, Zreiqat H (2016) Design and fabrication of 3D printed scaffolds with a mechanical strength comparable to cortical bone to repair large bone defects. Sci Rep 6(1):19468. https://doi.org/10.1038/srep19468
Article CAS Google Scholar
Ruiz-Cantu L et al (2020) Multi-material 3D bioprinting of porous constructs for cartilage regeneration. Mater Sci Eng C 109:110578. https://doi.org/10.1016/j.msec.2019.110578
Article CAS Google Scholar
Russmueller G et al (2015) 3D printable biophotopolymers for in vivo bone regeneration. Materials 8(6):3685–3700. https://doi.org/10.3390/ma8063685
Article CAS Google Scholar
Saunders RE, Gough JE, Derby B (2008) Delivery of human fibroblast cells by piezoelectric drop-on-demand inkjet printing. Biomaterials 29(2):193–203. https://doi.org/10.1016/j.biomaterials.2007.09.032
Article CAS Google Scholar
Setti L et al (2004) Thermal inkjet technology for the microdeposition of biological molecules as a viable route for the realization of biosensors. Anal Lett 37(8):1559–1570. https://doi.org/10.1081/AL-120037587. Taylor & Francis
Article CAS Google Scholar
Seyednejad H et al (2011) Functional aliphatic polyesters for biomedical and pharmaceutical applications. J Control Release 152(1):168–176. https://doi.org/10.1016/j.jconrel.2010.12.016
Article CAS Google Scholar
Shi P et al (2018) A bilayer photoreceptor-retinal tissue model with gradient cell density design: a study of microvalve-based bioprinting. J Tissue Eng Regen Med 12(5):1297–1306. https://doi.org/10.1002/term.2661
Article CAS Google Scholar
Shie M-Y et al (2017) 3D printing of cytocompatible water-based light-cured polyurethane with hyaluronic acid for cartilage tissue engineering applications. Materials 10(2):136. https://doi.org/10.3390/ma10020136
Article CAS Google Scholar
Sinha RP, Häder DP (2002) UV-induced DNA damage and repair: a review. Photochem Photobiol Sci 1(4):225–236. https://doi.org/10.1039/b201230h. England
Article CAS Google Scholar
Skardal A et al (2012) Bioprinted amniotic fluid-derived stem cells accelerate healing of large skin wounds. Stem Cells Transl Med 1(11):792–802. https://doi.org/10.5966/sctm.2012-0088
Article CAS Google Scholar
Srivas PK et al (2017) Osseointegration assessment of extrusion printed Ti6Al4V scaffold towards accelerated skeletal defect healing via tissue in-growth. Bioprinting 6:8–17. https://doi.org/10.1016/j.bprint.2017.04.002. Elsevier B.V.
Article Google Scholar
Sun C et al (2005) Projection micro-stereolithography using digital micro-mirror dynamic mask. Sensors Actuators A Phys 121(1):113–120. https://doi.org/10.1016/j.sna.2004.12.011
Article CAS Google Scholar
Sun J et al (2009) Comparison of micro-dispensing performance between micro-valve and piezoelectric printhead. Microsyst Technol 15(9):1437–1448. https://doi.org/10.1007/s00542-009-0905-3
Article CAS Google Scholar
Suo H et al (2021) Low-temperature 3D printing of collagen and chitosan composite for tissue engineering. Mater Sci Eng C 123:111963. https://doi.org/10.1016/j.msec.2021.111963
Article CAS Google Scholar
Tartarisco G et al (2009) Polyurethane unimorph bender microfabricated with Pressure Assisted Microsyringe (PAM) for biomedical applications. Mater Sci Eng C 29(6):1835–1841. https://doi.org/10.1016/j.msec.2009.02.017
Article CAS Google Scholar
Unagolla JM, Jayasuriya AC (2020) Hydrogel-based 3D bioprinting: a comprehensive review on cell-laden hydrogels, bioink formulations, and future perspectives. Appl Mater Today 18:100479. https://doi.org/10.1016/j.apmt.2019.100479
Article Google Scholar
Vallet-Regi M, Arcos Navarrete DA (2008) Biomimetic nanoceramics in clinical use: from materials to application, 1st edn. RSC Publishing, The Royal Society of Chemistry (RSC Nanoscience & Nanotechnology), Cambridge. https://doi.org/10.1039/9781847558923
Book Google Scholar
Vozzi G et al (2002) Microsyringe-based deposition of two-dimensional and three-dimensional polymer scaffolds with a well-defined geometry for application to tissue engineering. Tissue Eng 8(6):1089–1098. https://doi.org/10.1089/107632702320934182. United States
Article CAS Google Scholar
Wang Z et al (2015) A simple and high-resolution stereolithography-based 3D bioprinting system using visible light crosslinkable bioinks. Biofabrication 7(4):45009. https://doi.org/10.1088/1758-5090/7/4/045009. {IOP} Publishing
Article Google Scholar
Wang X et al (2017) 3D printing of polymer matrix composites: a review and prospective. Compos Part B Eng 110:442–458. https://doi.org/10.1016/j.compositesb.2016.11.034
Article CAS Google Scholar
Watters MP, Bernhardt ML (2018) Curing parameters to improve the mechanical properties of stereolithographic printed specimens. Rapid Prototyp J 24(1):46–51. https://doi.org/10.1108/RPJ-11-2016-0180. Emerald Publishing Limited
Article Google Scholar
Wegst UGK et al (2014) Bioinspired structural materials. Nat Mater 14:23–36. https://doi.org/10.1038/nmat4089. Nature Publishing Group
Article CAS Google Scholar
Weiß T et al (2009) Two-Photon polymerization for microfabrication of three-dimensional scaffolds for tissue engineering application. Eng Life Sci 9(5):384–390. https://doi.org/10.1002/elsc.200900002
Article CAS Google Scholar
Williams EMSSHJCA (2003) United States Patent (19)
Google Scholar
Wu Y et al (2018) 3D bioprinting of liver-mimetic construct with alginate/cellulose nanocrystal hybrid bioink. Bioprinting 9:1–6. https://doi.org/10.1016/j.bprint.2017.12.001
Article Google Scholar
Wu Z et al (2020) In vitro and in vivo biocompatibility evaluation of a 3D bioprinted gelatin-sodium alginate/rat Schwann-cell scaffold. Mater Sci Eng C 109:110530. https://doi.org/10.1016/j.msec.2019.110530
Article CAS Google Scholar
Wu Y, Simpson MC, Jin J (2021) Fast hydrolytically degradable 3D printed object based on aliphatic polycarbonate thiol-yne photoresins. Macromol Chem Phys 222(6):2000435. https://doi.org/10.1002/macp.202000435
Article CAS Google Scholar
Xu C et al (2014) Study of droplet formation process during drop-on-demand inkjetting of living cell-laden bioink. Langmuir 30(30):9130–9138. https://doi.org/10.1021/la501430x. American Chemical Society
Article CAS Google Scholar
Yan Q et al (2018) A review of 3D printing technology for medical applications. Engineering 4(5):729–742. https://doi.org/10.1016/j.eng.2018.07.021. Chinese Academy of Engineering
Article CAS Google Scholar
Yang H et al (2021) Three-dimensional bioprinted hepatorganoids prolong survival of mice with liver failure. Gut 70(3):567–574. https://doi.org/10.1136/gutjnl-2019-319960. BMJ Publishing Group
Article CAS Google Scholar
Yankov E, Nikolova MP (2017) Comparison of the accuracy of 3D printed prototypes using the stereolithography (SLA) method with the digital CAD models. MATEC Web Conf 137:2014. https://doi.org/10.1051/matecconf/201713702014
Article Google Scholar
Yilgor P et al (2008) 3D plotted PCL scaffolds for stem cell based bone tissue engineering. Macromol Symp 269(1):92–99. https://doi.org/10.1002/masy.200850911
Article CAS Google Scholar
Yuan H, De Groot K (2004) Calcium phosphate biomaterial: an overview. In: Reis RL, Weiner S (eds) Learning from nature how to design implantable biomaterials. Kluwer Academic Publishers, Netherlands, pp 37–57
Google Scholar
Zaaba NF, Jaafar M (2020) A review on degradation mechanisms of polylactic acid: hydrolytic, photodegradative, microbial, and enzymatic degradation. Polym Eng Sci 60(9):2061–2075. https://doi.org/10.1002/pen.25511
Article CAS Google Scholar
Zaszczyńska A et al (2021) Advances in 3D printing for tissue engineering. Materials 14(12):3149. https://doi.org/10.3390/ma14123149
Article CAS Google Scholar
Zhang Y, Zhang M (2001) Synthesis and characterization of macroporous chitosan/calcium phosphate composite scaffolds for tissue engineering. J Biomed Mater Res 55(3):304–312. http://www.ncbi.nlm.nih.gov/pubmed/11255183
Article CAS Google Scholar
Zhang J et al (2020a) Digital light processing based three-dimensional printing for medical applications. Int J Bioprint 6(1):12–27. https://doi.org/10.18063/ijb.v6i1.242
Article CAS Google Scholar
Zhang J et al (2020b) Optimization of mechanical stiffness and cell density of 3D bioprinted cell-laden scaffolds improves extracellular matrix mineralization and cellular organization for bone tissue engineering. Acta Biomater 114:307–322. https://doi.org/10.1016/j.actbio.2020.07.016
Article CAS Google Scholar
Zhou X, Hou Y, Lin J (2015) A review on the processing accuracy of two-photon polymerization. AIP Adv 5(3). https://doi.org/10.1063/1.4916886
Zhu W et al (2018) Rapid continuous 3D printing of customizable peripheral nerve guidance conduits. Mater Today 21(9):951–959. https://doi.org/10.1016/j.mattod.2018.04.001
Article CAS Google Scholar
Zwawi M (2021) A review on natural fiber bio-composites, surface modifications and applications. Molecules 26(2):404. https://doi.org/10.3390/molecules26020404
Article CAS Google Scholar

Download references

Author information

Authors and Affiliations

Cellfbio LLC, Richmond, VA, USA
Prabhash Dadhich & Khalil N. Bitar
Department of Pharmaceutical Sciences, Shri Ram College of Pharmacy, Karnal, Haryana, India
Parveen Kumar
Department of Chemical Engineering, Birla Institute of Technology and Science, Pilani, K K Birla Goa Campus, Goa, India
Anirban Roy

Authors

Prabhash Dadhich
View author publications
You can also search for this author in PubMed Google Scholar
Parveen Kumar
View author publications
You can also search for this author in PubMed Google Scholar
Anirban Roy
View author publications
You can also search for this author in PubMed Google Scholar
Khalil N. Bitar
View author publications
You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

School of Medical Science and Technology, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal, India
Nishant Chakravorty
School of Medical Science and Technology, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal, India
Praphulla Chandra Shukla

Rights and permissions

Reprints and permissions

Copyright information

About this chapter

Cite this chapter

Dadhich, P., Kumar, P., Roy, A., Bitar, K.N. (2023). Advances in 3D Printing Technology for Tissue Engineering. In: Chakravorty, N., Shukla, P.C. (eds) Regenerative Medicine. Springer, Singapore. https://doi.org/10.1007/978-981-19-6008-6_9

Download citation

DOI: https://doi.org/10.1007/978-981-19-6008-6_9
Published: 31 January 2023
Publisher Name: Springer, Singapore
Print ISBN: 978-981-19-6007-9
Online ISBN: 978-981-19-6008-6
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)

Publish with us

Policies and ethics