Skip to main content
SpringerLink
Log in

Aging: Impact of Gut Microbiota

  • Chapter
  • First Online:
Gut Microbiome in Neurological Health and Disorders

Part of the book series: Nutritional Neurosciences ((NN))

  • 644 Accesses

Abstract

The worldwide population of elderlies is rapidly accelerating and the health status of this elderly population warrants an immediate attention. Age-associated gut microbiota modulations are linked to immunosenescence and inflammaging which perturbs the gut microbiotal ecosystem. Several studies have correlated the human gut microbiota with the aging process and found that various factors are associated with variation in the gut microbial composition during aging. Among them, the crucial role players are diet, geographical origin, and intervention of pre/probiotics. To conclude with, the gut microbiota can be a potential target contributing toward the health status of the elderly population. In this chapter, we have attempted to highlight the updates regarding the possible factors associated with changes in GM composition during the aging process.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 189.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 249.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 249.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

Abbreviations

GIT:

Gastrointestinal tract

GM:

Gut microbiota

References

  • Ahmadi S, Wang S, Nagpal R, Wang B, Jain S, Razazan A et al (2020) A human-origin probiotic cocktail ameliorates aging-related leaky gut and inflammation via modulating the microbiota/taurine/tight junction axis. JCI Insight 5(9) e132055

    Google Scholar 

  • Albouery M, Buteau B, Gregoire S, Cherbuy C, Barros J, Martine L et al (2020) Age-related changes in the gut microbiota modify brain lipid composition. Front Cell Infect Microbiol 9:444

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Alcedo J, Kenyon C (2004) Regulation of C. elegans longevity by specific gustatory and olfactory neurons. Neuron 41:45–55

    Article  CAS  PubMed  Google Scholar 

  • Alic N, Partridge L (2011) Death and dessert: nutrient signalling pathways and ageing. Curr Opin Cell Biol 23:738–743

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Anderson OS, Sant KE, Dolinoy DC (2012) Nutrition and epigenetics: an interplay of dietary methyl donors, one-carbon metabolism and DNA methylation. J Nutr Biochem 23:853–859

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Arboleya S, Watkins C, Stanton C, Ross RP (2016) Gut bifidobacteria populations in human health and aging. Front Microbiol 7(1204):1–9

    CAS  Google Scholar 

  • Arumugam M, Raes J, Pelletier E, Le Paslier D, Yamada T, Mende DR et al (2011) Enterotypes of the human gut microbiome. Nature 473:174–180

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Backhed F, Levy RE, Sonnenburg JL, Peterson DA, Gordon JI (2005) Host-bacterial mutualism in the human intestine. Science 307:1915–1920

    Article  PubMed  CAS  Google Scholar 

  • Bamia C, Trichopoulos D, Ferrari P, Overvad K, Bjerregaard L, Tjonnelang A et al (2007) Dietary patterns and survival of older Europeans: the EPIC-elderly study (European Prospective Investigation into Cancer and Nutrition). Public Health Nutr 10(6):590–598

    Article  PubMed  Google Scholar 

  • Belkaid Y, Naik S (2013) Compartmentalized and systemic control of tissue immunity by commensals. Nat Immunol 14(7):646–653

    Article  CAS  PubMed  Google Scholar 

  • Berendsen AAM, van de Rest O, Feskens EJM, Santoro A, Ostan R, Pietruszka B et al (2018) Changes in dietary intake and adherence to the NU-AGE diet following a one-year dietary intervention among European older adults: results of the NU-AGE randomized trial. Nutrients 10:E1905

    Article  PubMed  CAS  Google Scholar 

  • Biagi E, Candela M, Fairweather-Tait S, Franceschi C, Brigidi P (2012) Ageing of the human metaorganism: the microbial counterpart. Age 34:247–267

    Article  PubMed  Google Scholar 

  • Biagi E, Candela M, Turroni S, Garagnani P, Franceschi C, Brigidi P (2013) Ageing and gut microbes: perspectives for health maintenance and longevity. Pharmacol Res 69:11–20

    Article  PubMed  Google Scholar 

  • Biagi E, Franceschi C, Rampelli S, Severgnini M, Ostan R, Turroni S et al (2016) Gut microbiota and extreme longevity. Curr Biol 26:1480–1485

    Article  CAS  PubMed  Google Scholar 

  • Bischoff SC (2016) Microbiota and aging. Curr Opin Clin Nutr Metab Care 19(1):26–30

    Article  CAS  PubMed  Google Scholar 

  • Bourlioux P, Koletzko B, Guarner F, Braesco V (2003) The intestine and its microflora are partners for the protection of the host: report on the Danone Symposium “The Intelligent Intestine”, held in Paris, June 14, 2002. Am J Clin Nutr 78:675–683

    Article  CAS  PubMed  Google Scholar 

  • Buford TW (2017) (Dis) Trust your gut: the gut microbiome in age-related inflammation, health, and disease. Microbiome 5(80):1–11

    Google Scholar 

  • Candela M, Biagi E, Brigidi P, O’Toole PW, De Vos WM (2014) Maintenance of a healthy trajectory of the intestinal microbiome during aging: a dietary approach. Mech Ageing Dev 136–137:70–75

    Article  PubMed  Google Scholar 

  • Chander AM, Yadav H, Jain S, Bhadada SK, Dhawan DK (2018) Cross-talk between gluten, intestinal microbiota and intestinal mucosa in celiac disease: recent advances and basis of autoimmunity. Front Microbiol 9:2597

    Article  PubMed  PubMed Central  Google Scholar 

  • Choi YJ, Lee DH (2016) Microbiota: a key for healthy aging. Ann Geriatr Med Res 20(4):168–176

    Article  Google Scholar 

  • Choi J, Hur TY, Hong Y (2018) Influence of altered gut microbiota composition on aging and aging-related diseases. J Lifestyle Med 8:1–7

    Article  PubMed  PubMed Central  Google Scholar 

  • Claesson MJ, Cusack S, O'Sullivan O, Greene-Diniz R, Weerd H, Flannery E et al (2011) Composition, variability, and temporal stability of the intestinal microbiota of the elderly. Proc Natl Acad Sci 108(1):4586–4591

    Article  CAS  PubMed  Google Scholar 

  • Clark RI, Walker DW (2018) Role of gut microbiota in aging-related health decline: insights from invertebrate models. Cell Mol Life Sci 75(1):93–101

    Article  CAS  PubMed  Google Scholar 

  • Clark RI, Salazar A, Yamada R, Fitz-Gibbon S, Morselli M, Alcaraz J et al (2015) Distinct shifts in microbiota composition during Drosophila aging impair intestinal function and drive mortality. Cell Rep 12:1656–1667

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Clements SJ, Carding SR (2018) Diet, the intestinal microbiota, and immune health in aging. Crit Rev Food Sci Nutr 58(4):651–661

    Article  PubMed  Google Scholar 

  • Collado MC, Rautava S, Aakko J, Isolauri E, Salminen S (2016) Human gut colonisation may be initiated in utero by distinct microbial communities in the placenta and amniotic fluid. Sci Rep 6:23129

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Cotillard A, Kennedy SP, Kong LC, Prifti E, Pons N, Le Chatelier E et al (2013) Dietary intervention impact on gut microbial gene richness. Nature 500:585–588

    Article  CAS  PubMed  Google Scholar 

  • Davenport ER, Mizrahi-Man O, Michelini K, Barreiro LB, Ober C, Gilad Y (2014) Seasonal variation in human gut microbiome composition. PLoS One 9(3) e90731

    Google Scholar 

  • De Filippo C, Cavalieri D, Di Paola M, Ramazzotti M, Poullet JB, Massart S et al (2010) Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa. Proc Natl Acad Sci U S A 107(33):14691–14696

    Article  PubMed  PubMed Central  Google Scholar 

  • Ding RX, Goh WR, Wu RN, Yue XQ, Luo X, Khine WWT et al (2019) Revisit gut microbiota and its impact on human health and disease. J Food Drug Anal 27(3):623–631

    Article  CAS  PubMed  Google Scholar 

  • Duranti S, Milani C, Lugli GA, Mancabelli L, Turroni F, Ferrario C et al (2016) Evaluation of genetic diversity among strains of the human gut commensal Bifidobacterium adolescentis. Sci Rep 6:23971

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Escobar JS, Klotz B, Valdes BE, Agudelo GM (2014) The gut microbiota of Colombians differs from that of Americans, Europeans and Asians. BMC Microbiol 14:311

    Article  PubMed  PubMed Central  Google Scholar 

  • Ghosh TS, Rampelli S, Jeffery IB, Santoro A, Neto M, Capri M et al (2020) Mediterranean diet intervention alters the gut microbiome in older people reducing frailty and improving health status: the NU-AGE 1-year dietary intervention across five European countries. Nutrition 69(7):1218–1228

    CAS  Google Scholar 

  • Gill SR, Pop M, Deboy RT, Eckburg PB, Turnbaugh PJ, Samuel BS et al (2006) Metagenomic analysis of the human distal gut microbiome. Science 312:1355–1359

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gusarov I, Gautier L, Smolentseva O, Shamovsky I, Eremina S, Mironov A et al (2013) Bacterial nitric oxide extends the lifespan of C. elegans. Cell 152:818–830

    Article  CAS  PubMed  Google Scholar 

  • Heintz C, Mair W (2014) You are what you host: Microbiome modulation of the aging process. Cell 156(3):408–411

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hill C, Guarner F, Reid G, Gibson GR, Merenstein DJ, Pot B et al (2014) Expert consensus document: the international scientific association for probiotics and prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol 11:506–514

    Article  PubMed  Google Scholar 

  • Hopkins MJ, Sharp R, Macfarlane GT (2002) Variation in human intestinal microbiota with age. Dig Liver Dis 34(2):S12–S18

    Article  PubMed  Google Scholar 

  • Human Microbiome Project Consortium (2012) Structure, function and diversity of the healthy human microbiome. Nature 486(7402):207–214

    Article  CAS  Google Scholar 

  • Jayanama K, Theou O (2020) Effects of probiotics and prebiotics on frailty and ageing: a narrative review. Curr Clin Pharmacol 15:1–10

    Google Scholar 

  • Karlsson FH, Tremaroli V, Nookaew I, Bergstrom G, Behre CJ, Fagerberg B et al (2013) Gut metagenome in European women with normal, impaired and diabetic glucose control. Nature 498:99–103

    Article  CAS  PubMed  Google Scholar 

  • Keenan MJ, Marco ML, Ingram DK, Martin RJ (2015) Improving healthspan via changes in gut microbiota and fermentation. Age 37(5):98

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Kenyon CJ (2010) The genetics of ageing. Nature 464:504–512

    Article  CAS  PubMed  Google Scholar 

  • Kerry RG, Patra JK, Gouda S, Park Y, Shin HS, Das G (2018) Benefaction of probiotics for human health: a review. J Food Drug Anal 26(3):927–939

    Article  CAS  Google Scholar 

  • Kim S, Jazwinski SM (2018) The gut microbiota and healthy aging: a mini-review. Gerontology 64:513–520

    Article  CAS  PubMed  Google Scholar 

  • Koenig JE, Spor A, Scalfone N, Fricker AD, Stombaugh J, Knight R et al (2011) Succession of microbial consortia in the developing infant gut microbiome. Proc Natl Acad Sci U S A 108(1):4578–4585

    Article  CAS  PubMed  Google Scholar 

  • Kumar M, Babaei P, Ji B, Nielsen J (2016) Human gut microbiota and healthy aging: recent developments and future prospective. Nutr Healthy Aging 4(1):3–16

    Article  PubMed  PubMed Central  Google Scholar 

  • Lagier JC, Hugon P, Khelaifia S, Fourrnier PE, La Scola B, Raoult D et al (2015) The rebirth of culture in microbiology through the example of culturomics to study human gut microbiota. Clin Microbiol Rev 28:237–264

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Landete JM, Gaya P, Rodriguez E, Langa S, Peiroten A, Medina M et al (2017) Probiotic bacteria for healthier aging: immunomodulation and metabolism of phytoestrogens. Biomed Res Int 2017:5939818

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Li H, Qi Y, Jasper H (2016) Preventing age-related decline of gut compartmentalization limits microbiota dysbiosis and extends lifespan. Cell Host Microbe 19:240–253

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Libert S, Chao Y, Chu X, Pletcher SD (2006) Tradeoffs between longevity and pathogen resistance in Drosophila melanogaster are mediated by NFkappaB signaling. Aging Cell 5:533–543

    Article  CAS  PubMed  Google Scholar 

  • Lloyd-Price J, Abu-Ali G, Huttenhower C (2016) The healthy human microbiome. Genome Med 8:51

    Article  PubMed  PubMed Central  Google Scholar 

  • Lozupone CA, Stombaugh JI, Gordon JI, Jansson JK, Knight R (2012) Diversity, stability and resilience of the human gut microbiota. Nature 489:220–230

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mariat D, Firmesse O, Levenez F, Guimaraes V, Sokol H, Dore J et al (2009) The Firmicutes/Bacteroidetes ratio of the human microbiota changes with age. BMC Microbiol 9:123

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Maukonen J, Saarela M (2015) Human gut microbiota: does diet matter? Proc Nutr Soc 74:23–36

    Article  CAS  PubMed  Google Scholar 

  • Nagpal R, Mainali R, Ahmadi S, Wang S, Singh R, Kavanagh K et al (2018) Gut microbiome and aging: physiological and mechanistic insights. Nutr Healthy Aging 4(4):267–285

    Article  PubMed  PubMed Central  Google Scholar 

  • O’Toole PW, Jeffery IB (2015) Gut microbiota and aging. Science 350:1214–1215

    Article  PubMed  CAS  Google Scholar 

  • Odamaki T, Kato K, Sugahara H, Hashikura N, Takahashi S, Xiao JZ et al (2016) Age-related changes in gut Microbiota composition from newborn to centenarian: a cross-sectional study. BMC Microbiol 16:90

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Ple C, Breton J, Daniel C, Foligne B (2015) Maintaining gut ecosystems for health: are transitory food bugs stowaways or part of the crew? Int J Food Microbiol 213:139–143

    Article  PubMed  Google Scholar 

  • Qin J, Li R, Raes J, Arumugam M, Burgdorf KS, Manichanh C et al (2010) A human gut microbial gene catalogue established by metagenomic sequencing. Nature 464:59–65

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Roberfroid M, Gibson GR, Hoyles L, McCartney AL, Rastall R, Rowland I et al (2010) Prebiotic effects: metabolic and health benefits. Br J Nutr 104(2):S1–S63

    Article  CAS  PubMed  Google Scholar 

  • Rohr MW, Narasimhulu CA, Rudeski-Rohr TA, Parthasarathy S (2020) Negative effects of a high-fat diet on intestinal permeability: a review. Adv Nutr 11(1):77–91

    PubMed  Google Scholar 

  • Salazar N, Arboleya S, Valdes L, Stanton C, Ross P, Ruiz L et al (2014) The human intestinal microbiome at extreme ages of life. Dietary intervention as a way to counteract alterations. Front Genet 5:406

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Salazar N, Valdes-Varela L, Gonzalez S, Gueimonde M, Clara DLR-G (2017) Nutrition and the gut microbiome in the elderly. Gut Microbes 8(2):82–97

    Article  CAS  PubMed  Google Scholar 

  • Sanders ME, Merenstein DJ, Reid G, Gibson GR, Rastall RA (2019) Probiotics and prebiotics in intestinal health and disease: from biology to the clinic. Nat Rev Gastroenterol Hepatol 16(10):605–616

    Article  PubMed  Google Scholar 

  • Sivamaruthi BS, Kesika P, Chaiyasut C (2018) A review on anti-aging properties of probiotics. Int J App Pharm 10(5):23–27

    Article  CAS  Google Scholar 

  • Suzuki TA, Worobey M (2014) Geographical variation of human gut microbial composition. Biol Lett 10(2):20131037

    Article  PubMed  PubMed Central  Google Scholar 

  • Tabouy L, Getselter D, Ziv O, Karpuj M, Tabouy T, Lukic I et al (2018) Dysbiosis of microbiome and probiotic treatment in a genetic model of autism spectrum disorders. Brain Behav Immun 73:310–319

    Article  PubMed  Google Scholar 

  • Thomas JG, Percival SL (eds) (2009) Microbiology and aging. Indigenous microbiota and association with the host. Springer Science + Business Media, LLC, Cham

    Google Scholar 

  • Ticinesi A, Nouvenne A, Cerundolo N, Catania P, Prati B, Tana C et al (2019) Gut microbiota, muscle mass and function in aging: a focus on physical fraity and sarcopenia. Nutrients 11:1633

    Article  CAS  PubMed Central  Google Scholar 

  • Tiihonen K, Ouwehand AC, Rautonen N (2010) Human intestinal microbiota and healthy ageing. Ageing Res Rev 9(2):107–116

    Article  PubMed  Google Scholar 

  • Tracey TJ, Steyn FJ, Wolvetang EJ, Ngo ST (2018) Neuronal lipid metabolism: multiple pathways driving functional outcomes in health and disease. Front Mol Neurosci 11:10

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Tripathi AK, Ray AK, Mishra SK (2022) Molecular and pharmacological aspects of piperine as a potential molecule for disease prevention and management: evidence from clinical trials. Beni-Suef Univ J Basic Appl Sci 11(1):1–24

    Article  Google Scholar 

  • Turnbaugh PJ, Ridaura VK, Faith JJ, Rey FE, Knight R, Gordon JI (2009) The effect of diet on the human gut microbiome: a metagenomic analysis in humanized gnotobiotic mice. Sci Transl Med 1(6):6ra14

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Turroni F, Peano C, Pass DA, Foroni E, Severgnini M, Claesson MJ et al (2012) Diversity of bifidobacteria within the infant gut microbiota. PLoS One 7. e36957

    Google Scholar 

  • Varlamov O, Bethea CL, Roberts CT (2015) Sex-specific differences in lipid and glucose metabolism. Front Endocrinol 5:241

    Article  Google Scholar 

  • Varricchi G, Bencivenga L, Poto R, Pecoraro A, Shamji MH, Rengo G (2020) The emerging role of T follicular helper (TFH) cells in aging: influence on the immune frailty. Ageing Res Rev 61:101071

    Article  CAS  PubMed  Google Scholar 

  • Vemuri R, Gundamaraju R, Shastri MD, Shukla SD, Kalpurath K, Ball M et al (2018) Gut microbial changes, interactions, and their implications on human lifecycle: an ageing perspective. Biomed Res Int 2018:4178607

    Google Scholar 

  • Voreades N, Kozil A, Weir TL (2014) Diet and the development of the human intestinal microbiome. Front Microbiol 5:494

    Article  PubMed  PubMed Central  Google Scholar 

  • Wilson M (2005) Microbial inhabitants of humans: their ecology and role in health and disease, 1st edn. Cambridge University Press, New York

    Google Scholar 

  • Wu W, Kong Q, Tian P, Zhai Q, Wang G, Liu X et al (2020) Targeting gut microbiota dysbiosis: potential intervention strategies for neurological disorders. Engineering 6(4):415–423

    Article  CAS  Google Scholar 

  • Zapata HJ, Quagliarello VJ (2015) The microbiota and microbiomein aging: potential implications in health and age-related diseases. J Am Geriatr Soc 63(4):776–781

    Article  PubMed  PubMed Central  Google Scholar 

  • Zhang R, Hou A (2013) Host-Microbe interactions in Caenorhabditis elegans. ISRN Microbiol 2013:356451

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgments

We acknowledge Ramaiah College of Arts, Science and Commerce and REVA University for providing the necessary facilities.

Author information

Authors and Affiliations

  1. Department of Biotechnology, School of Applied Sciences, REVA University, Bangalore, India

    Santosh Anand & Kannasandra Ramaiah Manjula

  2. Department of Biotechnology and Genetics, Ramaiah College of Arts, Science & Commerce, Bengaluru, India

    Ranoji Rao Narasinga Rao Lakshmikanth & Doddhakathanahalli Ramanath Jayashree

  3. Department of Biotechnology, Bangalore University, Bengaluru, India

    Tekupalli Ravikiran

Authors
  1. Santosh Anand
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ranoji Rao Narasinga Rao Lakshmikanth
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Kannasandra Ramaiah Manjula
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Doddhakathanahalli Ramanath Jayashree
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Tekupalli Ravikiran
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Santosh Anand .

Editor information

Editors and Affiliations

  1. Clinical Research Division, School of Basic and Applied Science, Galgotias University, Greater Noida, Uttar Pradesh, India

    Amit Kumar Tripathi

  2. Personal Care Division – Health and Hygiene, ITC Life Sciences and Technology Centre, Bangalore, Karnataka, India

    Malini Kotak

Rights and permissions

Reprints and permissions

Copyright information

© 2022 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Anand, S., Lakshmikanth, R.R.N.R., Manjula, K.R., Jayashree, D.R., Ravikiran, T. (2022). Aging: Impact of Gut Microbiota. In: Tripathi, A.K., Kotak, M. (eds) Gut Microbiome in Neurological Health and Disorders. Nutritional Neurosciences. Springer, Singapore. https://doi.org/10.1007/978-981-19-4530-4_5

Download citation

Publish with us

Policies and ethics

Search

Navigation