Abstract
Nutraceuticals are products that are present in food, which apart from providing nutritive value also act as potential drugs. They bestow physiological benefits or may protect against chronic disease. Nutraceuticals may be used to improve the quality of life by delaying the ageing process, preventing chronic diseases, increasing life expectancy, or supporting the structure or function of the body. The spices and herbs that form a part of the traditional cuisines have numerous health benefits, and a diet balanced with requisite nutraceuticals derived from food can play a vital role in ensuring a healthy and long life.
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Further Reading
Amalraj A, Gopi S (2017) Biological activities and medicinal properties of Asafoetida: a review. J Tradit Complement Med 7(3):347–359. https://doi.org/10.1016/j.jtcme.2016.11.004
Bahmani M, Shirzad H, Mirhosseini M, Mesripour A, Rafieian-Kopaei M (2016) A review on ethnobotanical and therapeutic uses of fenugreek (Trigonella foenum-graceum L). J Evid Based Complement Alternat Med 21(1):53–62. https://doi.org/10.1177/2156587215583405
Basch E, Ulbricht C, Kuo G, Szapary P, Smith M (2003) Therapeutic applications of fenugreek. Altern Med Rev 8(1):20–27. http://inconnate.com/Download/Fenugreek/document3.pdf
Beatty SJ, Mehta BH, Rodis JL (2005) Decreased warfarin effect after initiation of high-protein, low-carbohydrate diets. Ann Pharmacother 39(4):744–747. https://doi.org/10.1345/aph.1E454
Bhattacharya A, Tiwari P, Sahu PK, Kumar S (2018) A review of the phytochemical and pharmacological characteristics of Moringa oleifera. J Pharm Bioallied Sci 10(4):181–191. https://doi.org/10.4103/JPBS.JPBS_126_18
Bruha R, Dvorak K, Petrtyl J (2012) Alcoholic liver disease. World J Hepatol 4(3):81–90. https://doi.org/10.4254/wjh.v4.i3.81
Center for Drug Evaluation, & Research (2020) Drug interactions: what you should know. U.S. Food and Drug Administration, Bethesda https://www.fda.gov/drugs/resources-you-drugs/drug-interactions-what-you-should-know
Chattopadhyay I, Biswas K, Bandyopadhyay U, Banerjee RK (2004) Turmeric and curcumin: biological actions and medicinal applications. Curr Sci 87(1):44–53
Cohen MM (2014) Tulsi—Ocimum sanctum: a herb for all reasons. J Ayurveda Integr Med 5(4):251–259. https://doi.org/10.4103/0975-9476.146554
Dahan A, Altman H (2004) Food-drug interaction: grapefruit juice augments drug bioavailability—mechanism, extent and relevance. Eur J Clin Nutr 58(1):1–9. https://doi.org/10.1038/sj.ejcn.1601736
Dolińska B, Ostróżka-Cieślik A, Caban A, Rimantas K, Leszczyńska L, Ryszka F (2012) Influence of trace elements on stabilization of aqueous solutions of ascorbic acid. Biol Trace Elem Res 150(1–3):509–512. https://doi.org/10.1007/s12011-012-9524-4
Duke JA (2003) CRC handbook of medicinal spices. CRC, Boca Raton
Flickr (n.d.) Fenugreek (mehthi). Flickr. https://www.flickr.com/photos/ajay_suresh/49695827261. Accessed 30 Aug 2022
Food.ndtv.com (n.d.) https://food.ndtv.com/food-drinks/gondh-ka-laddoo-why-indian-mothers-are-served-this-high-calorie-ladoo-post-pregnancy-1731813
Gibson GR, Wang X (1994) Regulatory effects of bifidobacteria on the growth of other colonic bacteria. J Appl Bacteriol 77(4):412–420. https://doi.org/10.1111/j.1365-2672.1994.tb03443.x
González-Reimers E, Durán-Castellón MC, López-Lirola A, Santolaria-Fernández F, Abreu-González P, Alvisa-Negrín J, Sánchez-Pérez MJ (2010) Alcoholic myopathy: vitamin D deficiency is related to muscle fibre atrophy in a murine model. Alcohol Alcohol 45(3):223–230. https://doi.org/10.1093/alcalc/agq010
Heggers JP, Kucukcelebi A, Listengarten D, Stabenau J, Ko F, Broemeling LD, Robson MC, Winters WD (1996) Beneficial effect of aloe on wound healing in an excisional wound model. J Altern Complement Med 2(2):271–277. https://doi.org/10.1089/acm.1996.2.271
Hopkinsmedicine.Org (2019) Food-drug interactions. Hopkinsmedicine.Org. https://www.hopkinsmedicine.org/health/conditions-and-diseases/fooddrug-interactions
Hornsby LB, Hester EK, Donaldson AR (2008) Potential interaction between warfarin and high dietary protein intake. Pharmacotherapy 28(4):536–539. https://doi.org/10.1592/phco.28.4.536
India Brand Equity Foundation (n.d.) Indian spices, spices manufacturers and exporters in India—IBEF. https://www.ibef.org/exports/spice-industry-indias. Accessed 7 May 2022
International Alliance for Responsible Drinking (2018) Alcohol in the shadow economy. International Alliance for Responsible Drinking, Geneva https://www.iard.org/getattachment/1b56787b-cc6d-4ebb-989f-6684cf1df624/alcohol-in-the-shadow-economy.pdf
Ioannou GN, Dominitz JA, Weiss NS, Heagerty PJ, Kowdley KV (2004) The effect of alcohol consumption on the prevalence of iron overload, iron deficiency, and iron deficiency anemia. Gastroenterology 126(5):1293–1301. https://doi.org/10.1053/j.gastro.2004.01.020
Jesus JA, Lago JHG, Laurenti MD, Yamamoto ES, Passero LFD (2015) Antimicrobial activity of oleanolic and ursolic acids: an update. Evid Based Complement Alternat Med 2015:620472. https://doi.org/10.1155/2015/620472
Kajale N, Khadilkar A, Chiplonkar S, Unni J, Mansukhani N (2014) Impact of traditional food supplements on nutritional status of lactating mothers and growth of their infants. Nutrition 30(11–12):1360–1365. https://doi.org/10.1016/j.nut.2014.04.005
Kamal-Eldin A, Frank J, Razdan A, Tengblad S, Basu S, Vessby B (2000) Effects of dietary phenolic compounds on tocopherol, cholesterol, and fatty acids in rats. Lipids 35(4):427–435. https://doi.org/10.1007/s11745-000-541-y
Kamran U, Towey J, Khanna A, Chauhan A, Rajoriya N, Holt A (2020) Nutrition in alcohol-related liver disease: physiopathology and management. World J Gastroenterol 26(22):2916–2930. https://doi.org/10.3748/wjg.v26.i22.2916
Kanwar P, Sharma N (2011) Traditional pre and post-natal practices prevalent in Kangra district of Himachal Pradesh. Indian J Tradit Knowl 10(2):339–343
Kendrick SFW, Henderson E, Palmer J, Jones DEJ, Day CP (2010) Theophylline improves steroid sensitivity in acute alcoholic hepatitis. Hepatology 52(1):126–131. https://doi.org/10.1002/hep.23666
Khalafalla MM, Abdellatef E, Dafalla HM, Nassrallah AA, Aboul-Enein KM, Lightfoot DA, El-Deeb FE, El-Shemy HA (2016) Active principle from Moringa oleifera lam leaves effective against two leukemias and a hepatocarcinoma. Afr J Biotechnol 9(49):8467–8471
Laban TS, Saadabadi A (2021) Monoamine oxidase inhibitors (MAOI). In: StatPearls. StatPearls, Treasure Island, FL
Manning L, Kowalska A (2021) Illicit alcohol: public health risk of methanol poisoning and policy mitigation strategies. Foods 10(7):1625. https://doi.org/10.3390/foods10071625
McCormick Science Institute (n.d.) History of spices. McCormick Science Institute. https://www.mccormickscienceinstitute.com/resources/history-of-spices. Accessed 7 May 2022
Moghadamtousi SZ, Kadir HA, Hassandarvish P, Tajik H, Abubakar S, Zandi K (2014) A review on antibacterial, antiviral, and antifungal activity of curcumin. Biomed Res Int 2014:186864. https://doi.org/10.1155/2014/186864
Nasri H, Baradaran A, Shirzad H, Rafieian-Kopaei M (2014) New concepts in nutraceuticals as alternative for pharmaceuticals. Int J Prev Med 5(12):1487–1499
Nelson DL, Cox MM (2021) In: Freeman WH (ed) Lehninger principles of biochemistry, 8th edn. Springer, Cham
Nijhawan S, Thakur J, Malik D (n.d.) Curcumin: ayurveda and its reinvention by modern science. International Association of Sanskrit Studies, Bangkok
NLM, National Institutes of Health (2001) Classics of traditional Chinese medicine. NLM, National Institutes of Health, Bethesda https://www.nlm.nih.gov/exhibition/chinesemedicine/index.html
Nomani H, Moghadam AT, Emami SA, Mohammadpour AH, Johnston TP, Sahebkar A (2019) Drug interactions of cola-containing drinks. Clin Nutr 38(6):2545–2551. https://doi.org/10.1016/j.clnu.2019.01.029
OECD Task Force on Countering Illicit Trade (n.d.) Crisis policy, illicit alcohol and lessons learned from lockdown. https://www.oecd.org/gov/illicit-trade/summary-note-crisis-policy-illicit-alcohol.pdf
Oklahoma State University (2019) Drug—nutrient interactions. Okstate.Edu, Stillwater https://extension.okstate.edu/fact-sheets/drug-nutrient-interactions.html
Openfoodfacts.org (n.d.) Turmeric—Kora Georgia—100 gr. Openfoodfacts.org. https://world.openfoodfacts.org/product/4864394070096/turmeric-kora-georgia. Accessed 30 Aug 2022
Osna NA, Donohue TM Jr, Kharbanda KK (2017) Alcoholic liver disease: pathogenesis and current management. Alcohol Res 38(2):147–161
Padayachee B, Baijnath H (2020) An updated comprehensive review of the medicinal, phytochemical and pharmacological properties of Moringa oleifera. S Afr J Bot 129:304–316. https://doi.org/10.1016/j.sajb.2019.08.021
Pan S-Y, Litscher G, Gao S-H, Zhou S-F, Yu Z-L, Chen H-Q, Zhang S-F, Tang M-K, Sun J-N, Ko K-M (2014) Historical perspective of traditional indigenous medical practices: the current renaissance and conservation of herbal resources. Evid Based Complement Alternat Med 2014:525340. https://doi.org/10.1155/2014/525340
Penn State Extension (n.d.) Herb and spice history. Penn State Extension. https://extension.psu.edu/herb-and-spice-history. Accessed 7 May 2022
Pixabay.com (n.d.-a) Pixabay.com. https://pixabay.com/photos/fenugreek-methi-fresh-green-indian-2932921/. Accessed 30 Aug 2022
Pixabay.com. (n.d.-b) Pixabay.com. https://pixabay.com/photos/gooseberry-fruits-kitchen-food-6131602/. Accessed 30 Aug 2022
Poltanov EA, Shikov AN, Dorman HJD, Pozharitskaya ON, Makarov VG, Tikhonov VP, Hiltunen R (2009) Chemical and antioxidant evaluation of Indian gooseberry (Emblica officinalis Gaertn., syn. Phyllanthus emblica L) supplements. Phytother Res 23(9):1309–1315. https://doi.org/10.1002/ptr.2775
Ravikumar P, Anuradha CV (1999) Effect of fenugreek seeds on blood lipid peroxidation and antioxidants in diabetic rats. Phytother Res 13(3):197–201. https://doi.org/10.1002/(SICI)1099-1573(199905)13:3<197::AID-PTR413>3.0.CO;2-L
Raymond JL, Morrow K (2020) Krause’s food & the nutrition care process, 15th edn. Elsevier, Amsterdam
Ríos J-L, Giner RM, Marín M, Recio MC (2018) A pharmacological update of ellagic acid. Planta Med 84:1068. https://doi.org/10.1055/a-0633-9492
Rose K, Wan C, Thomas A, Seeram NP, Ma H (2018) Phenolic compounds isolated and identified from amla (Phyllanthus emblica) juice powder and their antioxidant and neuroprotective activities. Nat Prod Commun 13(10):1934578X1801301. https://doi.org/10.1177/1934578x1801301019
Rosengarten F (1973) Book of spices. Jove Books, New York
Sachan AKR, Kumar S, Kumari K, Singh D (2018) Medicinal uses of spices used in our traditional culture: worldwide. J Med Plants Stud 6(3):116–122
Saha S, Ghosh S (2012) Tinospora cordifolia: one plant, many roles. Anc Sci Life 31(4):151–159. https://doi.org/10.4103/0257-7941.107344
Sangeetha MK, Balaji Raghavendran HR, Gayathri V, Vasanthi HR (2011) Tinospora cordifolia attenuates oxidative stress and distorted carbohydrate metabolism in experimentally induced type 2 diabetes in rats. J Nat Med 65(3–4):544–550. https://doi.org/10.1007/s11418-011-0538-6
Sciencedirect.Com (n.d.) Encyclopedia of food sciences and nutrition. Sciencedirect.Com. https://www.sciencedirect.com/referencework/9780122270550/encyclopedia-of-food-sciences-and-nutrition. Accessed 7 May 2022
Sharma U, Bala M, Kumar N, Singh B, Munshi RK, Bhalerao S (2012) Immunomodulatory active compounds from Tinospora cordifolia. J Ethnopharmacol 141(3):918–926. https://doi.org/10.1016/j.jep.2012.03.027
Staticflickr.com (n.d.) Staticflickr.com. https://live.staticflickr.com/8355/8410461731_de83f08566_b.jpg. Accessed 30 Aug 2022
Stickel F, Seitz HK (2010) Alcoholic steatohepatitis. Best Pract Res Clin Gastroenterol 24(5):683–693. https://doi.org/10.1016/j.bpg.2010.07.003
Stohs SJ, Hartman MJ (2015) Review of the safety and efficacy of Moringa oleifera: Moringa oleifera safety and efficacy. Phytother Res 29(6):796–804. https://doi.org/10.1002/ptr.5325
Sumbilla C, Lewis D, Hammerschmidt T, Inesi G (2002) The slippage of the Ca2+ pump and its control by anions and curcumin in skeletal and cardiac sarcoplasmic reticulum. J Biol Chem 277(16):13900–13906. https://doi.org/10.1074/jbc.M111155200
Sutton R, Shields R (1995) Alcohol and oesophageal varices. Alcohol Alcohol 30(5):581–589. https://doi.org/10.1093/oxfordjournals.alcalc.a045767
Swetha Dasaroju KMG (2014) Current trends in the research of Emblica officinalis (Amla): a pharmacological perspective. Int J Pharm Sci Rev Res 24(2):150–159. https://globalresearchonline.net/journalcontents/v24-2/25.pdf
Tapsell LC, Hemphill I, Cobiac L, Sullivan DR, Fenech M, Patch CS, Roodenrys S, Keogh JB, Clifton PM, Williams PG, Fazio VA, Inge KE (2006) Health benefits of herbs and spices: the past, the present, the future. Med J Aust 185(S4):S1–S24. https://doi.org/10.5694/j.1326-5377.2006.tb00548.x
The Editors of Encyclopedia Britannica (2020) Spice trade. In: Encyclopedia Britannica. Encyclopædia Britannica, Chicago
Translation: Shree Gulabkunverba Ayurvedic Society (1949) Charak Samhita. Shree Gulabkunverba Ayurvedic Society, Jamnagar
Variya BC, Bakrania AK, Patel SS (2016) Emblica officinalis (Amla): a review for its phytochemistry, ethnomedicinal uses and medicinal potentials with respect to molecular mechanisms. Pharmacol Res 111:180–200. https://doi.org/10.1016/j.phrs.2016.06.013
Vasudevan DM, Sreekumari S, Vaidyanathan K (2019) Textbook of biochemistry for medical students, 9th edn. Jaypee Brothers Medical, London
Vijayakumar MV, Singh S, Chhipa RR, Bhat MK (2005) The hypoglycaemic activity of fenugreek seed extract is mediated through the stimulation of an insulin signalling pathway: mechanism of action of fenugreek seed extract. Br J Pharmacol 146(1):41–48. https://doi.org/10.1038/sj.bjp.0706312
Wani SA, Kumar P (2018) Fenugreek: a review on its nutraceutical properties and utilization in various food products. J Saudi Soc Agric Sci 17(2):97–106. https://doi.org/10.1016/j.jssas.2016.01.007
Whitfield JB, Zhu G, Heath AC, Powell LW, Martin NG (2001) Effects of alcohol consumption on indices of iron stores and of iron stores on alcohol intake markers. Alcohol Clin Exp Res 25(7):1037–1045. https://doi.org/10.1097/00000374-200107000-00014
Williams R (2007) Review article: bacterial flora and pathogenesis in hepatic encephalopathy: review article: bacteria and the pathogenesis of hepatic encephalopathy. Aliment Pharmacol Ther 25(Suppl 1):17–22. https://doi.org/10.1111/j.1746-6342.2006.03217.x
Yaheya M, Ismail M (2009) Drug-food interactions and role of pharmacist. Asian J Pharm Clin Res 2(4):1–10 https://innovareacademics.in/journal/ajpcr/Vol2Issue4/226.pdf. Accessed 7 May 2022
Yang C-S, Tsai W-J, Lirng J-F (2005) Ocular manifestations and MRI findings in a case of methanol poisoning. Eye 19(7):806–809. https://doi.org/10.1038/sj.eye.6701641
Yeung AWK, Georgieva MG, Atanasov AG, Tzvetkov NT (2019) Monoamine oxidases (MAOs) as privileged molecular targets in neuroscience: research literature analysis. Front Mol Neurosci 12:143. https://doi.org/10.3389/fnmol.2019.00143
Yusharyahya SN, Bramono K, Hestiantoro A, Qanita Edwar S, Kusuma I (2020) Fenugreek (Trigonella foenum-graceum) increases postmenopausal fibroblast-associated COL1A1 and COL3A1 production dominantly through its binding to estrogen receptor beta. J Appl Pharm Sci 10(4):22–27. https://doi.org/10.7324/japs.2020.104004
Zhao T, Sun Q, Marques M, Witcher M (2015) Anticancer properties of Phyllanthus emblica (Indian gooseberry). Oxid Med Cell Longev 2015:950890. https://doi.org/10.1155/2015/950890
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Malik, D., Narayanasamy, N., Pratyusha, V.A., Thakur, J., Sinha, N. (2023). Food–Drug Interactions and Nutraceuticals. In: Textbook of Nutritional Biochemistry. Springer, Singapore. https://doi.org/10.1007/978-981-19-4150-4_13
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